1. By Dr. Shamanthakamani Narendran Immune System

8. Host Defenses Complement system Leuco/ Lymph Macro phage

9. Allergy Autoimmunity Rejection of organ transplant An immune cell undergoing an allergic reaction Protects against infectious agents

14. Themectomy TT given 1. Thymosin fraction V (Calf thymus) 2. Synthetic polypeptides Thymus

15. Ontogeny of Immune System Fetus T cells Functions at 7- 1/2 wks Thymus functions at 12 wks B cells Functions at 13 wks IgM First to develop. Rises in intrauterine infection Reaches adult levels by 1 yr IgG Develops at 4 years IgA At adolescence

16. T cell subpopulation Helper cells (IgA & IgG) Suppressor (Homeostasis) Killer cells (Kills invading organisms) B cell subpopulation IgM, IgG, IgA, IgD, & IgE Hay fever, Asthma, Autoimmune disorder (Hemolytic anemia)

18. Eosinophil Neutrophil

20. Lymphoid Precursor Cells Liver Bone marrow

21. Differentiation of lymphoid stem cells T cells (associated with thymus) B cells (associated with bone marrow)

22. Peripheral Lymphoid organs Spleen GI tract tissue

27. THE ALLERGIC RESPONSE allergen IgE release of histamine ALLERGIC REACTION Mast cell

30. PSYCHONEUROIMMUNOLOGY (BRAIN + IMMUNE SYSTEM) killer cells sudden stress increased killer cells reduced killer cells repeated stress

31. Diseases due to Immunologic deficiency Primary Secondary

32. AIDS Acquired immunodeficiency syndrome Pathophysiology Clinical diagnosis Treatment Prevention HIV, the virus that causes AIDS, is shown budding out of a human immune cell.

33. HIV Treating HIV infected woman during pregnancy Natural history of HIV infection Transmission Signs and symptoms of AIDS in new born How does pediatric AIDS differ from adult AIDS Management & Specific retroviral therapies AZT (3’ Azido, 2’ 3’ deoxythymdine) DDI (2’ 3’ Dideoxyinosine) Immunotherapy (Hyposensitization)