Rhabdoviruses are enveloped viruses with single-stranded RNA genomes. They include important pathogens like rabies virus. Rabies virus causes rabies, a fatal viral disease of the nervous system transmitted via saliva. It is bullet-shaped with glycoprotein spikes. Rabies has an incubation period of 1-3 months usually and causes symptoms like increased salivation, abnormal behavior, paralysis and eventual death. Diagnosis involves antigen detection and virus isolation. Post-exposure prophylaxis includes wound cleansing, rabies immunoglobulin, and vaccination to prevent disease.
Clostridium is a genus of anaerobic, Gram-positive bacteria. Species of Clostridium inhabit soils and the intestinal tract of animals, including humans. This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
A presentation about Tuberculosis . This presentation composed of the definition, causes, pathophysiology, clinical feature, diagnosis, treatment, prognosis and prevention of Tuberculosis.
Clostridium is a genus of anaerobic, Gram-positive bacteria. Species of Clostridium inhabit soils and the intestinal tract of animals, including humans. This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
A presentation about Tuberculosis . This presentation composed of the definition, causes, pathophysiology, clinical feature, diagnosis, treatment, prognosis and prevention of Tuberculosis.
all about rabies
epidemiology of rabies,
pathogenesis of rabies,
clinical features of rabies,
treatment of rabies,
prevention of rabies,
rabies virus,
post exposure prophylaxis,
rabies in dogs
Caliciviridae is a family of viruses, members of Class IV of the Baltimore scheme. They are positive-sense, single stranded RNA which is non-segmented. There are currently seven species in this family, divided among 5 genera. Diseases associated with this family include: feline calicivirus: respiratory disease; rabbit hemorrhagic disease virus: often-fatal hemorrhages; norwalk group of viruses: gastroenteritis.Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/spherical and has icosahedral symmetry (T=1 or T=3[1]) with a diameter of 35–39 nm.
Caliciviruses are not very well studied because until recently they could not be grown in culture, and there is no suitable animal model. However, the recent application of modern genomic technologies has led to an increased understanding of the virus family.[3] A recent isolate from rhesus monkeys—Tulane virus—can be grown in culture and this system promises to increase our understanding of these viruses.
The name calicivirus is derived from the Greek word calyx meaning cup or goblet. This name is appropriate as many strains have visible cup-shaped depressions.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Rabies is a viral disease that causes acute encephalitis
(inflammation of the brain) in warm blooded animals. Rabies is a zoonotic disease (a disease that is transmitted to humans from animals) that is caused by a virus
all about rabies
epidemiology of rabies,
pathogenesis of rabies,
clinical features of rabies,
treatment of rabies,
prevention of rabies,
rabies virus,
post exposure prophylaxis,
rabies in dogs
Caliciviridae is a family of viruses, members of Class IV of the Baltimore scheme. They are positive-sense, single stranded RNA which is non-segmented. There are currently seven species in this family, divided among 5 genera. Diseases associated with this family include: feline calicivirus: respiratory disease; rabbit hemorrhagic disease virus: often-fatal hemorrhages; norwalk group of viruses: gastroenteritis.Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/spherical and has icosahedral symmetry (T=1 or T=3[1]) with a diameter of 35–39 nm.
Caliciviruses are not very well studied because until recently they could not be grown in culture, and there is no suitable animal model. However, the recent application of modern genomic technologies has led to an increased understanding of the virus family.[3] A recent isolate from rhesus monkeys—Tulane virus—can be grown in culture and this system promises to increase our understanding of these viruses.
The name calicivirus is derived from the Greek word calyx meaning cup or goblet. This name is appropriate as many strains have visible cup-shaped depressions.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Rabies is a viral disease that causes acute encephalitis
(inflammation of the brain) in warm blooded animals. Rabies is a zoonotic disease (a disease that is transmitted to humans from animals) that is caused by a virus
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
4. Rabies
• An acute contagious and fatal viral disease of the nervous system that
is caused by a rhabdovirus (species Rabies virus of the genus
Lyssavirus) usually transmitted through the saliva to human beings by
the bite of a rabid animal which causes inflammation of brain which
leads to following typical features
– increased salivation,
– abnormal behavior (Hydrophobia)
– Madness
– convulsions
– eventual paralysis and
– death.
5. Rabies Virus
• Morphology :
– Bullet shaped virus
– Size is 180 x 75 nm
– Has Lipoprotein envelop
– Knob like spikes /Glycoprotein
– Beneath lipoprotien envelop
Matrix (M) protein
– Nucleocapsid helical
symmetry negative sense RNA
and a RNA-dependent RNA
Polymerase
6.
7. Resistance
• Highly resistant against dryness, cold, decay
etc. and remain infective for many weeks in
the cadaver.
• Eveloped virus highly sensitive to lipid
solvent e.g.
– Ether
– Chloroform
– Acetone
• Sensitive to quarternary ammonium
compounds, ethanol and iodine
preparations , soaps and detergents.
8. • Is inactivated by
– Phenol
– Formalin
– BPL (Betapropiolactone)
– Sulight
– UV
– Heat
• at 500C for 1hr and
• 600C for 5 mins
9. Antigenic structure
• Rabies virus of man and animals are of single antigenic
type
• Suface spikes composed of glycoproteins G strongly
Agenic and Ab against it is protective
• Nucleoprotein induces Ab but not protective.
• Other Ags includes membrane proteins, glycolipid and
RNA dependent RNA polymerase
11. Animals Susceptibility and Culture
• Street virus
– isolated from natural human or animal infection called street
virus.
– Negri bodies can be demonstrated in brains of these animals
• Fixed virus
– Several serial intracerebral passages in rabbits
– Undergo certain changes & is termed as fixed virus
2. Chick embryos
– Grows in chick embryo & moi yolk sac
– Live attenuated vaccine strains
3. Tissue culture
– Grow in chick embryo fibroblasts, hamster kidney cells,
human diploid cells and vero cell cultures.
12. Sources of Infection
• Saliva of Rabid animal
• Dogs and cats-virus in saliva 3-
4 days before clinical
symptoms
13. Transmission
• Abrasions or scratches on skin.
• Mucous membrane exposed to saliva.
• Most frequently via deep penetrating
bite wounds.
• Other routes.
– Inhalation in bat infected caves.
– Ingestion of dead
/infected animal meat
– Corneal transplantation
14. Incubation Period
• Normally 1-3 months.
• May be short that is 7 days or may be prolonged for 3
years.
• Depends on-site of bite
– Severity of bite
– Number of wounds
– Amount of virus injected
– Site of bite
– Treatment taken
15.
16.
17. Saliva infective for several days upto weeks before signs appear Death
Salivary glands, skin, mucosal surfaces, gut, most other organs
Virus moves out through peripheral and cranial nerves
Multiplies in CNS Encephalitis
Virus travels up peripheral nerve to CNS
Virus multiplies locally in myocytes for weeks to months
Infection by the bite of rabid animal
18.
19. Symptoms
• Headache, fever, sore throat
• Nervousness, confusion
• Pain or tingling at the site of the bite
• Hallucinations
• Hydrophobia
• Paralysis
• Coma and death
20. Clinical Findings
• Bizarre behavior.
• Agitation
• Seizures.
• Difficulty in drinking.
• Patients will be able to eat solids
• Afraid of water - Hydrophobia.
• Spasms of Pharynx produces choking
• Death in 1 -6 days.
• Respiratory arrest / Death / Some may survive.
21. Stages of Rabies Infection
1. Non specific prodrome
2. Acute neurologic encephalitis
3. Coma
4. Death
22.
23. Non specific prodrome
• 1-2 days 1week
• Fever, headache, sore throat
• Anorexia, nausea, vomiting
• Agitation, depression
• Pain/tingling sensation at
bitten site
• Due to infection of dorsal
root or cranial sensory
ganglia
25. Encephalitic Rabies
• Fever, confusion, hallucinations, combativeness,
• Muscle spasms, hyperactivity, seizures.
• Autonomic dysfunction hypersalivation,
Excessive perspiration, gooseflesh, pupillary dilation,
Priapism.
• Hyperexcitability followed by periods of complete lucidity
• Hydrophobia and aerophobia
• “Foaming at the mouth”
• Due to dysfunction of infected brainstem neurons
• Severe brainstem damage coma Death
c
35. Local Treatment
• Wound should be thoroghly
washed with soap & water.
• Soap inactivates virus by
destroying its envelope
• Treat with quarternary
ammonium compound
(cetavlon) or tincture iodine or
alcohol (40-70%).
36. Post-Exposure prophylaxis
Antitetanus vaccine and
antibiotics used.
Antirabic hyperimmune serum
may be infiltrated around the
wound.
Biting animal should be watched,
if possible, for 10 days.
37. Hyperimmune serum
• HRIG :- 20IU/Kg body weight
• Half dose locally to wound and
other half intramuscularly
• Precautions
– Should not be given to
individuals who have had prior
active immunisation.
• May depress active immune
response to some extent.
39. S.N Vaccine Preparation Type Use
Neural
1 Semple vaccine Discontinued - Discontinued
2 BPL vaccine Discontinued - Discontinued
3 Infant brain vaccine Brain of suckling mice UV, BPL
phenol
South America
Non-neural
1 Duck egg vaccine Discontinued - Discontinued
2 Tissue culture vaccine Fixed virus grown in
HDCS eg. WI-38
BPL Highly Agenic,
free from side
effects, costly
3 Chick embro vaccine
i) Low egg passage
(LEP)
By 40-50 passage Live
attenuated
For dogs above
3 months
ii) High egg passage
(HEP)
By 180 passage Live
attenuated
For cattle and
cats
Subunit vaccine Surface glycoprotein cloned &
recombinant vaccine
Experimental
stage
40. 1. Semple vaccine
– Developed by semple (1911) at the
Central Research Institute (CRI),
Kasauli, India.
– 5% suspension of infected sheep
brain and inactivated by 5% phenol
at 370C, leaving no residual live virus.
2. Beta propiolactone (BPL) vaccine
– Modified semple vaccine with BPL as
ainactivationg agent instead of
phenol.
– Believed to be more Agenic.
41. Non-neural Vaccine
• Egg Vaccines
1. Duck egg vaccine
– BPL inacitivated
– Poor immunogenicity
– Discontinued
2. Live attenuated chick embryo vaccine
a) Low egg passage (LEP)
b) High egg passage (HEP)
42. • Cell cullture vaccines
a) Human diploid cell strain (HDCS)
– Growing fixed rabies virus on human diploid cells
(WI 38 or MRC 5)
– Inactivated with BPL
– Highly antigenic
– Free from side effects
– high cost
43. b) Purified chick embryo
cell culture (PCEC)
vaccine
– Equally effective as HDCS
vaccine
– Economical
– Brand name Rabipur
– Purified vero cell (PVC)
vaccine another
economical cell culture
vaccine.
44. Commonly used Non-neural
Antirabic vaccines
Vaccine Substrate to grow
fixed virus
Type
HDCS Human diploid cell Inactivated by BPL
PCEC vaccine Chick embryo cells Inactivated by BPL
PVC vaccine Vero cells Inactivated by BPL
45. Vaccination Schedules
• Pre-exposure vaccination
– For lab personnel
– 1 ml on days 0, 7 and 21 given intramuscularly
– Booster dose after 1yr and then one every five years.
• Postexposure vaccination
– 1 ml on days 0, 3,7,14 and 30 given intramuscularly
– Booster dose (optional) on day 90.
– Gives protection for at least 5 years, during which period any
further exposure may require only one to two doses (on days
0, 3).