1. Pharmacophore mapping involves identifying common binding elements in active compounds, generating potential conformations, and determining the 3D spatial relationships between pharmacophoric elements. 2. Conformational searching is important for pharmacophore mapping to explore a molecule's energy surface and identify low-energy conformations. There are different approaches like systematic search, distance geometry, and molecular dynamics. 3. Systematic search deterministically varies torsion angles to generate conformations. Distance geometry randomly samples conformations and can consider flexibility across multiple molecules simultaneously. Clique detection searches for common inter-feature distance patterns within active molecules to identify pharmacophore combinations.