Chemical based hazards in pharmaceuticalHari Haran
To convey the knowledge necessary to understand
issues related to different kinds of hazard and their management. Basic theoretical and practical discussions integrate the proficiency to handle the emergency situation in the pharmaceutical product development process.
Chemical based hazards in pharmaceuticalHari Haran
To convey the knowledge necessary to understand
issues related to different kinds of hazard and their management. Basic theoretical and practical discussions integrate the proficiency to handle the emergency situation in the pharmaceutical product development process.
A explained presentation on fire and explosion hazard and their prevention in pharmaceutical and other chemical industry and transportation of flammable and explosive goods which could be helpful for pharmaceutical and other student who has hazard and there management in their syllabus
Air Based Hazards, M.pharm, sem 2,Bhumi Suratiya,.pptxBhumiSuratiya
Air Based Hazard, M.Pharm, Sem 2,Bhumi Suratiya, Pharmaceutical Quality Assurance. Source of air based hazard, types of air based hazard, air circulation maintenance for sterile and non sterile area . Application of air circulation, HEPA filter, clean area classification.
A explained presentation on fire and explosion hazard and their prevention in pharmaceutical and other chemical industry and transportation of flammable and explosive goods which could be helpful for pharmaceutical and other student who has hazard and there management in their syllabus
Air Based Hazards, M.pharm, sem 2,Bhumi Suratiya,.pptxBhumiSuratiya
Air Based Hazard, M.Pharm, Sem 2,Bhumi Suratiya, Pharmaceutical Quality Assurance. Source of air based hazard, types of air based hazard, air circulation maintenance for sterile and non sterile area . Application of air circulation, HEPA filter, clean area classification.
Being a part of the chemical industries, you need to be very meticulous while performing any activity. So what type of safety training is provided by the chemical industries to ensure that the employees and other working staff are safe and secure? Read this PPT to know more about it!
SAFETY METHODS IN PHARMACEUTICAL INDUSTRYssuser5a17b2
SAFETY METHODS IN PHARMACEUTICAL INDUSTRY
(a)
(b)
Mechanical, chemical and fire hazards problems.
Inflammable gases and dusts.
Please provide feed back
I Have completed this assignment in 5-6 hours . I am helping others student as well.
chemical Based Hazard, M.Pharm, Sem 2, Bhumi Suratiya, my presentation contains Regulation for chemical hazard,
Management of over-Exposure to chemicals ,
TLV concept.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. PHARMACEUTICAL INDUSTRIAL
SAFETY
Compiled and delivered
by,
Mr. Namdeo G. Shinde
M. Pharm.
Assistant professor
Satara College of Pharmacy, Satara.
Shivaji University, Kolhapur.
Maharashtra INDIA 415004.
25-Aug-15 1SATARA COLLEGE OF PHARMACY, SATARA.
3. • Don’t wait for a major accident to identify need to improve
major hazard management.
• Need to learn lessons from accidents (Hindsight) but don’t
rely on this approach
• Manage risks via Foresight rather than Hindsight ie be
proactive rather than reactive.
Why Do we need Safety?
25-Aug-15 3SATARA COLLEGE OF PHARMACY, SATARA.
4. BP Texas Refinery
• BP AMOCO Refinery is on
1,200 acres with 30 refinery
units and is 71 years old.
• 1800 people work at the
refinery plus contractors
• It is BP’s largest plant, and the
USA’s third largest refinery,
processing 460,000 barrels of
crude oil/day, around 3% of
US gasolene supplies
25-Aug-15 4SATARA COLLEGE OF PHARMACY, SATARA.
5. BP Texas Refinery – The Aftermath
25-Aug-15 5SATARA COLLEGE OF PHARMACY, SATARA.
8. Piper Alpha – After the fire
25-Aug-15 8SATARA COLLEGE OF PHARMACY, SATARA.
9. Texas City Explosion – 23 March 2005
Direct Root Cause: Level Indicator Failure and
High Level Alarm failure
Buncefield UK Explosion – 11December 2005
Direct Root Cause: Level Indicator Failure and
High Level Alarm failure
It cant happen to us!!!
25-Aug-15 9SATARA COLLEGE OF PHARMACY, SATARA.
10. • Finding out what people are doing that leads to incidents
and stopping them doing it. Or…
• Finding out what people are doing to avoid incidents and
getting everyone to do it
• Behaviour (unlike attitude) is visible, measurable and can
be directly influenced
Behaviour Safety is based on:
25-Aug-15 10SATARA COLLEGE OF PHARMACY, SATARA.
11. • Planning Stage
• Design stage
• Construction
• Pre commissioning / Commissioning
• Operations stage
• Decommissioning and abandonment.
Safety at various Stages
25-Aug-15 11SATARA COLLEGE OF PHARMACY, SATARA.
13. Bhopal Gas Disaster
The Union Carbide Pesticide Plant in Bhopal, released 40
tons of Methyl Isocyanate (MIC) gas, killing between
2,500 to 5,000 people in the early hours of the morning.
The World’s worst Industrial Disaster
25-Aug-15 13SATARA COLLEGE OF PHARMACY, SATARA.
14. The gas being heavier than air, started entering into the
homes of the unwary population. Many who panicked
and ran out also got crushed in stampedes.
Around 500,000 were estimated to be exposed to the
gas & around 20,000 have died as a result. Over
120,000 continue to suffer from the from the effects of
the disaster.
25-Aug-15 14SATARA COLLEGE OF PHARMACY, SATARA.
15. Doctors and Hospitals were unaware of the nature of
the Gas, nor were they informed of the proper
treatment of the inhalation of MIC gas, being merely
asked to give cough medicine & eye drops.
If they were informed about the same, proper
treatment could have been instituted & a lot of lives
could have been saved.
25-Aug-15 15SATARA COLLEGE OF PHARMACY, SATARA.
16. Post Bhopal Gas Disaster
Factories Act was amended to assign
responsibility for workplace safety to the
Occupier.
Environment Protection Act was introduced in
1986.
The Manufacture, Storage & Import of
Hazardous Chemicals Rules,1989.
The Chemical Accidents, Emergency Planning,
Preparedness and Response,1996 introduced.
25-Aug-15 16SATARA COLLEGE OF PHARMACY, SATARA.
17. India at present is achieving new milestones, major
economic breakthroughs and moving ahead towards
the vision of a developed nation. A sustained
industrial growth including progress of the chemical
sector is crucial to attaining this goal.
The growth of the chemical sector has led to increase
in the manufacture, storage and use of Hazardous
chemicals (Hazchem) resulting in enhanced threats of
accidents. Occurrence of accidents remains a cause
of concern.
25-Aug-15 17SATARA COLLEGE OF PHARMACY, SATARA.
18. The Indian Chemical Industry contributes to 6.7% of the
GDP.
Indian Fertilizer Industry is the fourth largest in the
world.
Largest manufacturer of Pesticides in Asia second only to
Japan.
Indian Pharmaceutical industry is the largest in the
developing world
25-Aug-15 18SATARA COLLEGE OF PHARMACY, SATARA.
19. 1.INTRODUCTION
DEFENITION OF INDUSTRIAL SAFETY
Industrial safety refers to reduce the risk of injury or
loss and danger to persons, property from the industrial
hazards. (Shah Prakashan,2007).
WHAT DOES A INDUSTRIAL HAZARD MEANT?
Hazard is a term associated with a substance,
That is likely to cause injury to a personnel,
(or)
One which may lead to loss of property, products etc;
(or)
A substance that might prove fatal to the personnel.
25-Aug-15 19SATARA COLLEGE OF PHARMACY, SATARA.
20. Toxic corrosive chemicals, fire explosions and personnel
falling into accident are major health and safety hazards
encountered in the operations of chemical and pharmaceutical
industries.
Identification of hazards and employing protective measures to
control the hazards are important to protect the people from
their consequences.
25-Aug-15 20SATARA COLLEGE OF PHARMACY, SATARA.
21. OBJECTIVES OF INDUSTRIAL SAFETY
Understand the harmful effects of industrial hazards
Define the relationship between hazard and risk
Explore the routes of exposure to industrial hazards
Shed lights on type of toxicity by industrial hazards
Know the most toxic environmental hazardous substances.
25-Aug-15 21SATARA COLLEGE OF PHARMACY, SATARA.
22. INDUSTRIAL HAZARD V/S RISK
Hazard is the potential of a substance to cause damage.
Toxicity is the hazard of a substance which can cause
poisoning.
Risk is a measure of the probability that harm will occur under
defined conditions of exposure to a chemical. (Patrick et al.,
1986).
25-Aug-15 22SATARA COLLEGE OF PHARMACY, SATARA.
23. R = f (H x E) = f (H x D x t)
Where R=Risk, f=function, H=Hazard, E= Exposure ,D=Dose,
t=time.
Thus, chemicals which pose only a small hazard but to which
there is frequent or excessive exposure may pose as much risk
as chemicals which have a high degree of hazard but to which
only limited exposure occurs
Reducing risk is based on reducing exposure
25-Aug-15 23SATARA COLLEGE OF PHARMACY, SATARA.
24. WHAT IS AN ACCIDENT ???
“An accident is an
unplanned &
uncontrolled event
which causes or is likely
to cause an injury”.
It is some thing which un-expected ,
un-predictable or intended or not
desired.
An accidents may cause a result of some
unsafe activity, act, working condition
etc ,…..
25-Aug-15 24SATARA COLLEGE OF PHARMACY, SATARA.
25. Hazards may arise when impure or contaminated chemicals
are used.
By products may accumulate relatively high concentrations in
parts of the plant and cause un expected effects.
In pharmaceutical industry most of the dermatitis can be
attributed to synthetic drugs, especially acridines and
phenothiazines.
25-Aug-15 25SATARA COLLEGE OF PHARMACY, SATARA.
26. Industrial Hazards
Large exposures to chemicals can affect human
health directly or indirectly.
disrupting ecological systems that exist in rivers,
lakes, oceans, streams, and wetlands
The release of chemicals into the environment
can have global impacts
Chemicals can be transported throughout the
atmosphere and are not bound by borders
25-Aug-15 26SATARA COLLEGE OF PHARMACY, SATARA.
27. Industrial Hazards
All the changes that occur in the
environment affect people.
Ultimately people can be exposed to any
substance that enters the environment
25-Aug-15 27SATARA COLLEGE OF PHARMACY, SATARA.
28. Routes of Industrial hazards
Entry into the Body
There are three main routes by which hazardous
chemicals enter the body:
absorption through the respiratory tract
through inhalation.
absorption or injection through the skin or
eyes.
absorption through the digestive tract. This
can occur through eating or smoking with
contaminated hands or in contaminated work
areas.
25-Aug-15 28SATARA COLLEGE OF PHARMACY, SATARA.
29. Types of Hazards Toxicity
Acute poisoning is characterized by rapid absorption of
the substance and the exposure is sudden &
severe. Normally, a single large exposure is
involved. Examples: carbon monoxide or cyanide
poisoning.
Chronic poisoning is characterized by prolonged or
repeated exposures of a duration measured in days,
months or years. Symptoms may not be immediately
apparent, but tend to build up in the body as a result of
chronic exposure. The effects are not seen until a critical
body burden is reached. Examples: lead or mercury
poisoning or pesticide exposure.
25-Aug-15 29SATARA COLLEGE OF PHARMACY, SATARA.
30. 2007
Ran
k
SUBSTANCE NAME
2005
RANK
1 ARSENIC 1
2 LEAD 2
3 MERCURY 3
4 VINYL CHLORIDE 4
5 POLYCHLORINATED BIPHENYLS 5
6 BENZENE 6
7 CADMIUM 8
8
POLYCYCLIC AROMATIC
HYDROCARBONS
7
9 BENZO(A)PYRENE 9
10 BENZO(B)FLUORANTHENE 10
2007 Most Toxic Hazardous
Substances List (ATSDR)
25-Aug-15 30SATARA COLLEGE OF PHARMACY, SATARA.
31. 2.TYPES OF HAZARDS
• Fire hazards
• Chemical hazards
• Electrical hazards
• Mechanical hazards and
• pharmaceutical hazards.
25-Aug-15 31SATARA COLLEGE OF PHARMACY, SATARA.
32. FIRE HAZARDS
Fire:
The self-sustaining process of rapid oxidation of a fuel which
produces heat and light.
Fire is an exothermic chemical reaction between oxygen
and fuel at certain temperature.
Three things essential for the combustion of fire are
Fuel (any combustible material)
Oxygen (At concentrations above 23 %
in air, the situation becomes
dangerous due to the
increased fire hazard)
Temperature.
25-Aug-15 32SATARA COLLEGE OF PHARMACY, SATARA.
33. SOURCES OF FIRE HAZARDS
Fuels include solids, liquids, vapours and gases.
solid fuels
wood, fabrics, synthetic materials, packing materials, papers
etc.,.
Liquid fuels
flammable liquids (e.g., nitrophenol, ammonium nitrate and
pottassium chlorate, paint and oil soaked rags, cotton or
cellulose soaked with sulphuric acid etc.,.).
Other sources include flame, sparks, spontaneous ignition
and self combustible chemicals. (Khanna,1992).
25-Aug-15 33SATARA COLLEGE OF PHARMACY, SATARA.
34. Causes
Smoking in the factory
Defective heating equipment, electrical equipment &
wiring.
Explosive gas leakage.
Inadequate protection of electric motors
Sparking of electric wires & equipment
Protection & prevention
Types of fire
25-Aug-1534 SATARA COLLEGE OF PHARMACY,
SATARA.
Fire & explosion hazards
35. CLASSIFCATION OF FIRES
Most fires that occur will fall into
one or more of the following
categories
Class A
Fires involving ordinary
combustible materials, such as Paper,
wood, and textile fibers, where a
cooling, blanketing, or wetting
extinguishing agent is needed.
25-Aug-15 35SATARA COLLEGE OF PHARMACY, SATARA.
36. Class B:
Fires involving flammable
liquids such as gasoline, thinners,
oil-based paints and greases.
Extinguishers for this type of fire
include carbon dioxide, dry
chemical* and halogenated agent
types.
25-Aug-15 36SATARA COLLEGE OF PHARMACY, SATARA.
37. Class C
Fires involving energized
electrical equipment, where a non
conducting gaseous clean agent or
smothering agent is needed. The
most common type of extinguisher
for this class is a carbon dioxide
exinguisher.
25-Aug-15 37SATARA COLLEGE OF PHARMACY, SATARA.
38. Class D
Fires involving
combustible metals such as
magnesium, sodium, potassium,
titanium, and aluminum. Special
dry powder extinguishing
agents are required for this class
of fire, and must be tailored to
the specific hazardous metal.
25-Aug-15 38SATARA COLLEGE OF PHARMACY, SATARA.
39. Class K
Fires involving commercial
cooking appliances with vegetable
oils, animal oils or fats at high
temperatures. A wet potassium
acetate, low pH-based agent is
used for this class of fire.
25-Aug-15 39SATARA COLLEGE OF PHARMACY, SATARA.
40. DETECTION OF FIRE HAZARDS
Many automatic fire detection systems are used today in industry.
Some include
• Thermal expansion detectors,
• Heat sensitive insulation,
• Photoelectric fires,
• Ionization or radiation sensors and
• Ultraviolet or I .R detectors.
These sound an alarm through which fire flames are detected.
25-Aug-15 40SATARA COLLEGE OF PHARMACY, SATARA.
42. PREVENTION OF FIRE HAZARDS
Well planned design and layout
Proper ventilated systems
Chemical data sheets
Proper training of personnel
Proper maintenance of
surroundings
use of fire extinguishers,
alarms ,sensors, detectors
Fire fighting equipment
Sprinkler systems
25-Aug-15 42SATARA COLLEGE OF PHARMACY, SATARA.
43. Preventive measures
Prohibition of smoking in manufacturing areas.
Oxygen present in the inflammable atmosphere may
be ↓by dilution with gases such as nitrogen, co2,steam
or combination of these.
Hazardous operation should be isolated
Eliminating the ignition sources
Using fire resistant material in construction
Suitable emergency exits
Adequate venting
25-Aug-1543 SATARA COLLEGE OF PHARMACY,
SATARA.
Fire & explosion hazards
44. Automatic sprinklers
Equipment should design to meet the specifications &
code of recognized authorities, such as ISA, API
&ASME
The design & construction of pressure vessels &
storage tanks should follow API & ASME codes.
Inspection
25-Aug-1544 SATARA COLLEGE OF PHARMACY,
SATARA.
Fire & explosion hazards
45. FIRE SUPRESSION
It is done by using hydrant systems/water sprinkler systems
and fire extinguishers.
Hydrant systems include
Water sprinklers
Semi automatic hydrant system
Automatic sprinkler and
Manually hydrant system.
25-Aug-15 45SATARA COLLEGE OF PHARMACY, SATARA.
46. Fire extinguishers include
Water and water based extinguishers
• portable extinguishers
• soda acid extinguishers
• antifreeze extinguishers.
Foam extinguishers.
Dry chemical extinguishers.
Carbon dioxide extinguishers.
Halon extinguishers
• Halon1301( bromo tri fluoromethane)
• Vaporizing liquid.
25-Aug-15 46SATARA COLLEGE OF PHARMACY, SATARA.
47. Halotron 1 Fire extiguisher
Non-Magnetic stored pressure
deionized water mist fire
extinguisher
ABC Dry chemical fire
extinguisher
Carbon dioxide (CO2)
Portable fire
extinguisher
K Class Wet chemical
extinguisher.
Spinkler systems
25-Aug-15 47SATARA COLLEGE OF PHARMACY, SATARA.
48. CHEMICAL HAZARDS
Many chemicals can cause severe burns, if these coming to
contact with living tissue or other routes like inhalation.
Living tissue may be destroyed by chemical reactions such as
dehydration, digestion, oxidation etc.
Eye and mucus membrane of the throat are particularly
susceptible to the effect of corrosive dust, mist and gases.
Chloroform, benzene, chlorinated hydro carbons, low boiling
fractions of petroleum are some of the common organic
solvents used in pharmaceutical industry.(Muir,2002).
25-Aug-15 48SATARA COLLEGE OF PHARMACY, SATARA.
49. SOURCES OF CHEMICAL HAZARDS
AIR BORN TOXICS
Irritants
Ipecac,podophyllumetc .,.
Asphyxiants
Carbondioxide, monoxide, methane, ethane, hydrogen cyanide,
hydrogen sulphide, helium,nitrogen etc.,.
Narcotics/anaesthetics
Acetone, ether, chloroform, methyl-ethyl ketone etc.,.
CARCINOGENS
Coaltar, cresote oil, anthracene oil, parafin oils, chromium,
nickel, cobalt etc.,.
25-Aug-15 49SATARA COLLEGE OF PHARMACY, SATARA.
50. Benzo[a]pyrene (BaP)
One of the best-studied examples of PAHs is
benzo[a]pyrene (BaP).
It does not attack DNA itself, but reactive
intermediates are formed within cells, with a
reactive epoxide ring.
This modified molecule is perfectly designed to
be a mutagen.
The flat, planar ring looks just like a DNA base,
so the molecule slips into the stack of bases
comfortably. Then, the reactive epoxide attacks
a neighboring adenine or guanine nucleotide,
forming a covalent bond.25-Aug-15 50SATARA COLLEGE OF PHARMACY, SATARA.
51. Benzo[a]pyrene
Upon oxidation, PAHs
produce highly reactive
diol epoxide enantiomers.
Upon binding chemically
to DNA, it gives rise to
DNA adducts with very
different structures and
biological activities.
The DNA adducts is a
bulky aromatic ring
attached to the base of
DNA, block replication
and transcription.
Benzo[a]pyrene
25-Aug-15 51SATARA COLLEGE OF PHARMACY, SATARA.
52. Heavy Metals
Metals comprise three-fourths of the elements in the
periodic table.
A few of the metals are essential for life. Most of the
known metals are quite toxic to living organisms when
present in excess.
25-Aug-15 52SATARA COLLEGE OF PHARMACY, SATARA.
53. Metals Classification
Class B
(Sr)
Class C
(Zn, Cu)
Class D
(Hg, Pb)
Class A
(Fe)
Toxicity
BiologicalFunction
Foulkes EC., Proc Soc Exp Biol Med. 223: 234-40, 2000.
25-Aug-15 53SATARA COLLEGE OF PHARMACY, SATARA.
54. Exposure to Heavy Metals
Breathing vapors
ATSDR (2005), www.atsdr.cdc.gov/cxcx3.html
CEPA (2006), www.ec.gc.ca/CEPARegistry/subs_list/Toxicupdate.cfm
Industrial Activities & Waste
Dental Amalgam Contaminated Solis
25-Aug-15 54SATARA COLLEGE OF PHARMACY, SATARA.
55. Mechanisms of Heavy
Metals Toxicities
Inhibition of heme biosynthesis, heme is
the essential structural component of
hemoglobin, myoglobin and cytochromes
(Pb)
Binds to sulfhydryl groups (-SH groups) of
proteins and enzymes.
Inhalation: lung - local irritation and
inhibition of alpha1-antitrypsin associated
with emphysema (Cd)
25-Aug-15 55SATARA COLLEGE OF PHARMACY, SATARA.
56. Treatment strategies
Removal of the subject from the source(s) of
exposure.
Treatment with chelating agents, such as EDTA,
Succimer, and Cysteine and N-Acetyl Cysteine
(NAC)
Hemodialysis and/or chelating agent
Administration of some antioxidants, Vitamin C, E
25-Aug-15 56SATARA COLLEGE OF PHARMACY, SATARA.
57. Formaldehyde
Formaldehyde is also known as methanal, is a
gas with a strong pungent smell.
Formaldehyde readily results from the
incomplete combustion of carbon-containing
materials.
Formaldehyde is produced industrially by the
catalytic oxidation of methanol. It may be found
in the smoke from forest fires, in automobile
exhaust, and in tobacco smoke.
Formaldehyde is readily oxidized by atmospheric
oxygen to form formic acid25-Aug-15 57SATARA COLLEGE OF PHARMACY, SATARA.
58. Formaldehyde
Most formaldehyde is used in the production of
polymers and other chemicals, in many
construction materials, including carpet, and
spray-on insulating foams.
formaldehyde is one of the more common indoor
air pollutants.
Formaldehyde is classified as a probable human
carcinogen by the U.S. Environmental Protection
Agency. The International Agency for Research
on Cancer
25-Aug-15 58SATARA COLLEGE OF PHARMACY, SATARA.
59. Formaldehyde Toxicities
Carcinogenicity: although the risk is small or non-
existent, the possibility that formaldehyde is a human
carcinogen cannot be excluded.
Urinary Tract Disease: dysuria, suprapubic pain,
ureteric and bladder fibrosis, hydronephrosis,
vesicoureteral reflux
Hypersensitivity : Hypersensitivity to
formaldehyde has had several manifestations
acute exacerbation of eczema after injection of
hepatitis B vaccine containing formaldehyde
Skin pruritus, burning, and redness
Painful, enlarged, and haemorrhagic gingival margins
25-Aug-15 59SATARA COLLEGE OF PHARMACY, SATARA.
60. Treatment of Formaldehyde
Toxicities
Treat signs and symptoms; no known antidote
Contaminated skin should be washed with soap
and water
After ingestion water, milk, and/or charcoal,
should be given
Acidosis, resulting from metabolism of
formaldehyde to formic acid, may require IV
NaHCO3 or Na lactate.
Haemodialysis could be beneficial
If seizure occurred, IV benzodiazepines or
barbiturates could be given.25-Aug-15 60SATARA COLLEGE OF PHARMACY, SATARA.
61. Methanol
Methyl alcohol is used as a pharmaceutical
and industrial solvent.
It is also used as `wood naphtha' to
denature ethanol in the preparation of
industrial methylated spirits.
Methyl alcohol is also used as an
extraction solvent in food processing.
Methyl alcohol is readily absorbed from
the gastrointestinal tract and distributed
throughout the body fluids.
25-Aug-15 61SATARA COLLEGE OF PHARMACY, SATARA.
62. Methanol Toxicity
Characteristic symptoms of methyl alcohol
poisoning are caused by toxic metabolites and
develop after a latent period of about 12 to 24
hours, or longer
metabolic acidosis with rapid, shallow
breathing
visual disturbances which often proceed to
irreversible blindness,
severe abdominal pain, gastrointestinal
disturbances, pain in the back and extremities
coma which in severe cases may terminate in
death due to respiratory failure or, rarely, to
circulatory collapse
25-Aug-15 62SATARA COLLEGE OF PHARMACY, SATARA.
63. Treatment of Methanol
Toxicities
Gastric lavage may be considered if the patient
presents within 1 hour of ingesting methyl alcohol
Activated charcoal is probably of little use as it does
not absorb significant amounts of methyl alcohol
Metabolic acidosis should be corrected immediately with
intravenous sodium bicarbonate.
Haemodialysis may be indicated to increase the
removal of methyl alcohol and its toxic metabolites
25-Aug-15 63SATARA COLLEGE OF PHARMACY, SATARA.
64. Treatment of Methanol
Toxicities
Fomepizole, an inhibitor of alcohol
dehydrogenase, is also used; it inhibits the
metabolism of methyl alcohol to its toxic
metabolites.
Folinic acid and folic acid have been
given in the treatment of methyl alcohol
toxicity because they may enhance the
metabolism of formic acid.
25-Aug-15 64SATARA COLLEGE OF PHARMACY, SATARA.
65. Ethylene Glycol
Ethylene glycol is commonly encountered
in antifreeze solutions and has been used
illicitly to sweeten some wines
Ethylene glycol is absorbed from the
gastrointestinal tract and is metabolised,
chiefly in the liver, by alcohol
dehydrogenase
25-Aug-15 65SATARA COLLEGE OF PHARMACY, SATARA.
66. Ethylene Glycol Toxicities
Toxic effects arising from ingestion of ethylene
glycol result from its major metabolites:
aldehydes, glycolate, lactate, and oxalate
Clinical features may be divided into three
stages depending on the time elapsed since
ingestion:
0 -12 hours: the patient may show signs of
drunkenness, nausea, vomiting, convulsions and
neurological defects.
12 - 24 hours: tachycardia, mild hypertension,
pulmonary oedema, and heart failure.
24 - 72 hours: flank pain, proteinuria, oxaluria,
haematuria, renal failure, respiratory failure,
cardiovascular collapse, and sometimes coma and
death
25-Aug-15 66SATARA COLLEGE OF PHARMACY, SATARA.
67. Treatment of Ethylene
Glycol Toxicities
The stomach should be emptied by lavage
if ingestion of ethylene glycol was within
the preceding hour.
metabolic acidosis should be corrected
with sodium bicarbonate intravenously
and hypocalcaemia corrected with calcium
gluconate
Haemodialysis or peritoneal dialysis may
be of value
25-Aug-15 67SATARA COLLEGE OF PHARMACY, SATARA.
68. BENZENE
Benzene occurs as a volatile, colorless, highly
flammable liquid that dissolves easily in water.
Benzene is used as a constituent in motor fuels;
as a solvent for fats, waxes, resins, oils, inks,
paints, plastics, and rubber; in the extraction of
oils from seeds.
It is also used as a chemical intermediate, in the
manufacture of detergents, explosives,
pharmaceuticals, and dyestuffs.
25-Aug-15 68SATARA COLLEGE OF PHARMACY, SATARA.
69. Benzene Toxicities
Acute
Coexposure to benzene with ethanol increase benzene
toxicity.
Inhalation of benzene causes drowsiness, dizziness,
headaches, and unconsciousness in humans.
Ingestion of large amounts of benzene may result in
vomiting, dizziness, convulsions, and death in humans.
Exposure to liquid and vapor may irritate the skin (red
skin), eyes, and upper respiratory tract.
Death may result from exposure to very high levels of
benzene.
25-Aug-15 69SATARA COLLEGE OF PHARMACY, SATARA.
70. Benzene Toxicities
Chronic
Long-term inhalation of benzene causes disorders in
the blood in humans. specifically affects bone
marrow causing aplastic anemia.
Excessive bleeding.
Damage to the immune system.
changes in blood levels of antibodies
leukopenia.
25-Aug-15 70SATARA COLLEGE OF PHARMACY, SATARA.
71. Benzene Toxicities
Chronic
Structural and numerical chromosomal
aberrations in humans.
Menstrual disorders and a decreased size of
ovaries.
Teratogenecity such as low birth weight, delayed
bone formation, and bone marrow damage.
Leukemia has been observed in humans
occupationally exposed to benzene.
25-Aug-15 71SATARA COLLEGE OF PHARMACY, SATARA.
72. Nitrobenzene
Nitrobenzene is an oily yellow liquid with
an almond-like or shoe-polish smell.
The majority of nitrobenzene is used to
manufacture aniline, which is a chemical
used in the manufacture of polyurethane.
Nitrobenzene is also used to produce
lubricating oils and in the manufacture of
dyes, drugs, pesticides, and synthetic
rubber.
25-Aug-15 72SATARA COLLEGE OF PHARMACY, SATARA.
73. Nitrobenzene Toxicities
Acute / Chronic
Methemoglobinemia:
conversion of hemoglobin to methemoglobin in
the blood, which lowers the oxygen released to
the tissues of the body.
it is associated with fatigue, weakness, dyspnea,
headache, dizziness, bluish color skin, and you
may have nausea, vomiting.
Detected by measuring methemoglobin level.
Respiratory failure, bluish-gray skin, disturbed
vision, coma, and ultimately death may occur.
25-Aug-15 73SATARA COLLEGE OF PHARMACY, SATARA.
74. Nitrobenzene Toxicities
Acute / Chronic
Reproductive toxicities such as a decrease in
fertility, reduced testicular weights, and
decreased sperm production have been noted in
inhalation and oral animal studies.
Animal studies indicate that inhalation exposure
to nitrobenzene does not result in
developmental effects, such as birth defects or
embryotoxic effects.
25-Aug-15 74SATARA COLLEGE OF PHARMACY, SATARA.
75. Treatment of Nitrobenzene
Toxicities
Immediate removal from the exposure and
transport to medical facilities.
Oxygen should be administered with assisted
ventilation of necessary.
Methylene blue given IV at 1-2 mg/kg as 1%
solution to reduce the methemoglobin half-life.
Contaminated clothing should be removed and
the patient washed to remove skin
contaminations.25-Aug-15 75SATARA COLLEGE OF PHARMACY, SATARA.
76. Carbon Tetrachloride
Carbon tetrachloride is a clear, nonflammable
liquid which is almost insoluble in water.
Carbon tetrachloride is used as a solvent for
oils, fats, rubber waxes, and resins and as a
starting material in the manufacture of
organic compounds.
Carbon tetrachloride was formerly used as a
dry cleaning agent, and pesticide.
25-Aug-15 76SATARA COLLEGE OF PHARMACY, SATARA.
77. Carbon Tetrachloride
Toxicities Acute
liver and kidneys damages.
CNS depression: headache, weakness, lethargy,
nausea, and vomiting.
Pulmonary edema.
Chronic
Chronic inhalation or oral exposure to carbon
tetrachloride produces liver and kidney damage in
humans and animals.
Birth defects have not been observed in animals
exposed to carbon tetrachloride by inhalation or
ingestion.
25-Aug-15 77SATARA COLLEGE OF PHARMACY, SATARA.
78. Asbestos
Asbestos are composed of minerals which are made up of
long, thin fibers that are somewhat similar to fiberglass.
Asbestos is neither volatile nor soluble; however, small
fibers may occur in suspension in both air and water.
The main uses of asbestos are in building materials, paper
products, asbestoscement products, textiles, packings and
asbestosreinforced plastics.
Asbestos use is currently decreasing.
25-Aug-15 78SATARA COLLEGE OF PHARMACY, SATARA.
79. Asbestos Toxicities
Chronic inhalation exposure to asbestos in humans can
lead to:
Asbestosis: is a diffuse fibrous scarring of
the lungs.
Symptoms of asbestosis include shortness of
breath, difficulty in breathing, and coughing.
Asbestosis is a progressive disease, i.e., the
severity of symptoms tends to increase with time,
even after the exposure has stopped.
In severe cases, this disease can lead to death,
due to impairment of respiratory function.
Pulmonary hypertension
Immunological diseases.
25-Aug-15 79SATARA COLLEGE OF PHARMACY, SATARA.
80. Asbestos Toxicities
Occupational studies have reported that
exposure to asbestos via inhalation can cause
lung cancer and Mesothelioma
Mesothelioma is a asbestos-induced cancer
develop in the mesothelium, a protective
lining that covers most of the body's internal
organs.
No studies were located on the developmental
or reproductive effects of asbestos in animals or
humans via inhalation.
Birth defects were not noted in the offspring of
animals exposed to asbestos in the diet during
pregnancy.25-Aug-15 80SATARA COLLEGE OF PHARMACY, SATARA.
81. SAFETY ASPECTS IN CHEMICAL HAZARDS
Application of barrier creams before commencing the work
has been found useful in protecting individuals from hazardous
chemicals.
While using the high vapor pressure solvents and grinding of
vegetable drugs (e.g., capsicum and podophyllum) safety
goggles are to be worn. Because these will effects the eyes.
25-Aug-15 81SATARA COLLEGE OF PHARMACY, SATARA.
82. We must know the exposure limits and toxicity of different
chemicals.
chemicals Exposure limit
(ppm)
Ethyl alcohol 1000ppm
acetone 1000ppm
Methyline
chloride
125ppm
Isopropyl alcohol 400ppm
25-Aug-15 82SATARA COLLEGE OF PHARMACY, SATARA.
83. Tolerance levels for toxic chemicals should be followed as set
by Federal regulations.
Occupational safety and health administration also include to
Check
• Compiling of process safety information
• Maintaining safe operating procedures
• Training and educating employees
• Conducting incident investigations
• Developing safety compliance audits
• Conducting emergency response plans. (Niosh,2005).
25-Aug-15 83SATARA COLLEGE OF PHARMACY, SATARA.
84. MECHANCAL HAZARDS
• These are associated with powers-driven machine, whether
automated or manually operated by steam, hydraulic and/or
electric power introduced new hazards into work place.
• Mechanical hazards are exacerbated by the large number and
different designs of equipment, crowded work place conditions
and different interaction between workers and equipment.
• Hazardous electrical and pneumatic thermal energy must be
released or controlled before working on active equipment.
• High sound levels may be generated by manufacturing
equipment (e.g., ball mill) there by increasing their exposure to
noise.
• Injuries like cutting, tearing, shearing, puncturing and crushing
may occur with moving machinery. (Barbara et al.,2005).25-Aug-15 84SATARA COLLEGE OF PHARMACY, SATARA.
85. PREVENTON OF MECHANICAL HAZARDS
Mechanical hazards can be reduced by the application of
appropriate safeguards.
REQUIREMENTS OF SAFEGUARDS
• Prevent contact
• Securable and durable
• Protect against falling objects
• Do not create new hazard
• Do not create interference
• Allow safe mantainance.
TYPES OF SAFEGUARDS
Point of operation guards-Fixed guards, interlocked guards and
adjustable guards.
25-Aug-15 85SATARA COLLEGE OF PHARMACY, SATARA.
86. Biological hazards
Disease due to biological hazards
Brucellosis (dairy industry)
Byssinosis (textile industry)
Bagassosis (sugar-cane)
Loco motor disorder
Preventive measures
Periodic health check up
Personal protection
The manufacturer should also provide
First aid facilities
Initial examination
Facility for vaccination
Routine sanitation programme
25-Aug-1586 SATARA COLLEGE OF PHARMACY,
SATARA.
87. Mechanical hazards
Accidents usually take place by the combination of unsafe
condition & carelessness.
Most of industrial accidents are due to
Faulty inspection
Inability of employee
Poor discipline
Lack of concentration
Unsafe practice
Mental & physical unfitness for job
Faulty equipment or improper working condition
Improper training regarding the safety aspects
25-Aug-1587 SATARA COLLEGE OF PHARMACY,
SATARA.
88. Building planning
Floors must be of unskid/non-slippery type.
Enough space for employees to work.
Passages between working places.
Proper arrangements of temperature control; like fans,
A.C., heaters.
25-Aug-1588 SATARA COLLEGE OF PHARMACY,
SATARA.
89. Careless handling of heavy materials and components
should be avoided.
Full use of mechanical material handling equipment.
All material handling equipments should be repaired
and maintained properly.
Containers employed to transport liquids should not
be defective or leaking.
Safe material handling
25-Aug-1589 SATARA COLLEGE OF PHARMACY,
SATARA.
90. Protection of head by using hard hats/helmets.
Protection of ears by using earmufffs and plugs.
Protection of face by using face marks, face
shields.
Personal protective devices
25-Aug-1590 SATARA COLLEGE OF PHARMACY,
SATARA.
91. Point of operation devices-photoelectric devices, radiofrequency
devices, pull back devices, restraint devices and safety trip
devices.
Feeding and ejection systems-automatic feed system, semi
automatic, automatic and semiautomatic ejection systems.
Robot safeguards.
LOCKOUT/TAGOUT SYSTEMS
Padlock systems
Tagout systems.
(Shah Prakashan,2007).
25-Aug-15 91SATARA COLLEGE OF PHARMACY, SATARA.
92. SAFETY ASPECTS IN MECHANICAL HAZARDS
All the operators should be trained in safe operation,
maintainance and emergency procedures to take care when
accidents occur.
Inspection ,adjustment repair and calibration of safe guards
should be carried out regularly.
Ear protection devices must be used to prevent the excessive
noise.
Effort should be made to reduce the noise to a safe level.
25-Aug-15 92SATARA COLLEGE OF PHARMACY, SATARA.
93. ELECTRICAL HAZARDS
Electrical hazards occurs when a person come in contact with
the conductor carrying current and simultaneously contacts
with the ground, usually known to be work place hazard.
SOURCES OF ELECTRCAL HAZARDS
Short circuts
Electrostatic hazards
Arcs and spark hazards
Combustible and explosive materials
Improper wiring
Insulation failure
25-Aug-15 93SATARA COLLEGE OF PHARMACY, SATARA.
94. Biological hazards
Disease due to biological hazards
Brucellosis (dairy industry)
Byssinosis (textile industry)
Bagassosis (sugar-cane)
Loco motor disorder
Preventive measures
Periodic health check up
Personal protection
The manufacturer should also provide
First aid facilities
Initial examination
Facility for vaccination
Routine sanitation programme
25-Aug-1594 SATARA COLLEGE OF PHARMACY,
SATARA.
95. Mechanical hazards
Accidents usually take place by the combination of unsafe
condition & carelessness.
Most of industrial accidents are due to
Faulty inspection
Inability of employee
Poor discipline
Lack of concentration
Unsafe practice
Mental & physical unfitness for job
Faulty equipment or improper working condition
Improper training regarding the safety aspects
25-Aug-1595 SATARA COLLEGE OF PHARMACY,
SATARA.
96. Building planning
Floors must be of unskid/non-slippery type.
Enough space for employees to work.
Passages between working places.
Proper arrangements of temperature control; like fans,
A.C., heaters.
25-Aug-1596 SATARA COLLEGE OF PHARMACY,
SATARA.
97. Careless handling of heavy materials and components
should be avoided.
Full use of mechanical material handling equipment.
All material handling equipments should be repaired
and maintained properly.
Containers employed to transport liquids should not
be defective or leaking.
Safe material handling
25-Aug-1597 SATARA COLLEGE OF PHARMACY,
SATARA.
98. Protection of head by using hard hats/helmets.
Protection of ears by using earmufffs and plugs.
Protection of face by using face marks, face
shields.
Personal protective devices
25-Aug-1598 SATARA COLLEGE OF PHARMACY,
SATARA.
99. DETECTION OF ELECTRICAL HAZARDS
Circuit tester
Receptance wiring tester.
PREVENTION OF ELECTRCAL HAZARDS
Grounding of electrical equipments
Prevention of static electricity
Bending and grounding
Humidification
Antistatic materials
Ionizers and electrostatic neutralizers
Radioactive neutralizers and
Magnetic circuit breaker.
25-Aug-15 99SATARA COLLEGE OF PHARMACY, SATARA.
100. Electrical hazards
Shocks
Sparking
Fire
Wiring faults
Preventive measures
Proper maintenance of wiring & equipment
High voltage equipment should be properly enclosed
Good house keeping
Water should not be used for dousing electric fire
Worker should avoid working in electric circuits or
equipment in wet clothing or shoes.
25-Aug-15100 SATARA COLLEGE OF PHARMACY,
SATARA.
101. SAFETY ASPECTS IN ELECTRICAL HAZARDS
Ensure that power has been disconnected from the system
working with it.
Do not wear conductive material like such as metal jewellary.
Perodically inspect insullation.
Verify circuit voltages.
Use only explosion proof devices and non sparkling switches
in flammable liquid storage areas.
All electrical parts should confirm ISI specifications.
Ensure all flexible wires and power cables are properly
insulated.
Installation of earth trip devices for all electrical equipments.
Safe guarding is essential for all electrical equipments.
(Niosh,1986).
25-Aug-15 101SATARA COLLEGE OF PHARMACY, SATARA.
102. PHARMACEUTICAL HAZARDS
Hazardous drugs that pose a potential health risk to health care
workers who may be exposed during drug manufacturing,
packing and storage.
CRITERIA FOR DEFINING HAZARDOUS DRUGS
Drugs that meet one or more of the following criteria should be
hazardous.
Carcinogenicity.
Teratogenicity.
Reproductive toxicity.
Organ toxicity at lower doses.
25-Aug-15 102SATARA COLLEGE OF PHARMACY, SATARA.
103. ROUTES OF EXPOSURE TO HAZARDOUS DRUGS
Inhalation of an aerosolized drug.
Dermal absorption.
Ingestion.
Injection.
TYPES OF HAZARDS TOXICITY
Acute poisoning.
Chronic poisoning.(Akunuru,1997).
25-Aug-15 103SATARA COLLEGE OF PHARMACY, SATARA.
104. SAFETY ASPECTS IN PHARMACEUTICAL HAZARDS
Personal protective equipment for hazardous drug handling
Disposable gowns made of fabric that has low permeability
to the agents in use, with closed fonts and cuffs,intended for
single use.
Powder free gloves, labeled and tested for drugs used with
chemotherapy , made of latex, nitrile or neoprene.
Face and eye protection when splashing is possible.
Approved respirator when there is a risk of inhaling drug
aerosols. The labelling of solvents to indicate their properties
and health and fire hazards, is an extremely important method
for controlling the hazards.
Substitution of more harmful material by one which is less
danger to health.
25-Aug-15 104SATARA COLLEGE OF PHARMACY, SATARA.
105. To prevent or reduce dangerous expose to toxic materials.
i. Gas releases should be vented outside buildings and away
work areas and other populated areas.
ii. Exhausts and ventilations should be provided to remove
emissions.
Every bulk drug and pharmaceutical unit must prepare its
disaster management plan.
25-Aug-15 105SATARA COLLEGE OF PHARMACY, SATARA.
106. 3.SAFETY ASPECTS IN PHARMA INDUSTRY
Standard operating procedures
Handling of hazardous materials
Water supply and drainage
Floors and floor coverings
Emergency exits
Back up plan if anything goes wrong
Specially trained personnel
Health polices and insurance
Written procedures
Safety audits
Risk analysis
Appropriate training and education to employee
Regular monitoring of workplace
Written documentation of policies
Create awareness of the environment.25-Aug-15 106SATARA COLLEGE OF PHARMACY, SATARA.
107. Pollution hazards
Types
a. Air pollution
b. Water pollution
c. Thermal pollution
d. Sound pollution
Air pollution
Sources
Automobiles
Industries
Domestic
25-Aug-15107 SATARA COLLEGE OF PHARMACY,
SATARA.
108. i. Those suitable for removing particulate matter
a. Ventilation
Exhaust ventilation
Plenum ventilation
b. Air purifying equipment
ii. Those associated with removing gaseous pollutants
Water pollution
1. Types of water pollutants
Physical
Chemical
Physiological
Biological 25-Aug-15108 SATARA COLLEGE OF PHARMACY,
SATARA.
Preventive measures
109. 2. Problems of water pollution
3. Preventive measure
a. Control of water pollution
i. Physical treatment
Storage
Filtration
ii. Chemical treatment
iii. Biological treatment
b. Treatment of industrial waste
Primary treatment
Secondary treatment
Tertiary treatment
25-Aug-15109 SATARA COLLEGE OF PHARMACY,
SATARA.
Preventive measures
110. c. Thermal pollution
Effects
Damage to aquatic environment
Reduction in assimilative capacity of organic waste
Various off stream cooling systems
i. Wet cooling towers
ii. Dry cooling towers
iii. Cooling ponds
iv. Spray ponds 25-Aug-15110 SATARA COLLEGE OF PHARMACY,
SATARA.
Preventive measures
111. Recommendations & suggestions
Proper treatment & disposal methods for effluents
should be adopted
An awareness program
Measures for increase efficiency of the water use
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SATARA.
112. Classification of signs according to use –
(1) Danger signs.
The DANGER header is used when there is a hazardous
situation which has a high probability of death or severe
injury. It should not be considered for property damage
unless personal injury risk is present.
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SATARA.
113. 2) Caution signs. (i)
The CAUTION header is used to indicate a hazardous
situation which may result in minor or moderate
injury. However, Caution should not be used when
there is a possibility of death or serious injury.
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SATARA.
114. (3) Safety instruction signs
General Safety Signs (SAFETY FIRST, BE
CAREFUL, THINK) should indicate general
instructions relative to safe work practices,
reminders of proper safety procedures, and the
location of safety equipment.
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SATARA.
115. (4) Biological hazard signs.
The biological hazard warning shall be used to
signify the actual or potential presence of a
biohazard and to identify equipment, containers,
rooms, materials, experimental animals, or
combinations thereof, which contain, or are
contaminated with, viable hazardous agents.
11525-Aug-15 SATARA COLLEGE OF PHARMACY, SATARA.
116. Pictograph
Pictograph means a pictorial representation used to
identify a hazardous condition or to convey a safety
instruction
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SATARA.