The document summarizes key features of the ocean floor topography. It describes four main ocean basins and how echo sounders and sonar are used to map the ocean floor and measure depths. It then outlines various topographical features found on the ocean floor, including abyssal hills, plains, trenches, and undersea volcanoes. It concludes by discussing different types of seafloor sediments and their distribution across oceans.
Seas and Oceans are blue beauties of the planet earth.
Oceans are vast body of saline water occupying the great depressions on the earth. The surface beneath the oceanic waters is characterized by a lot of relief features.
The structure, configuration and relief features of the oceans also vary from each other.On the basis of Bathymetry and other studies, the morphology of Ocean basins contains a lot of relief features. This module highlights many of those features.
Seas and Oceans are blue beauties of the planet earth.
Oceans are vast body of saline water occupying the great depressions on the earth. The surface beneath the oceanic waters is characterized by a lot of relief features.
The structure, configuration and relief features of the oceans also vary from each other.On the basis of Bathymetry and other studies, the morphology of Ocean basins contains a lot of relief features. This module highlights many of those features.
Oceans also contain a huge amount of mineral resources. Deep ocean basins are the zones of continuous sedimentation. The oceans are the final destination for many of all the sediments to be deposited. About 200 million years of earth history are available in the fossiliferous sediments deposited within the ocean basins. This module explains the characteristics of marine sediments.
Every continent or island is bordered by a long or short coastline. Coastline is the line separating the land and sea. Coastal zones are the transition zones between terrestrial and marine habitat. They form an interface between land and oceanic natural processes. Coastal areas also are varied in their topography, climate and vegetation. Some are sandy beaches, rocky shores, with or without tidal inlets. The climate of a coast are controlled by the land and sea breezes and the humidity controlled by marine water. Waves are powerful tools for constructive and destructive activities. Hence. the geomorphology of beach, materials and processes are always not constant due to the impact of everlasting action of tides, waves and currents.
Oceans also contain a huge amount of mineral resources. Deep ocean basins are the zones of continuous sedimentation. The oceans are the final destination for many of all the sediments to be deposited. About 200 million years of earth history are available in the fossiliferous sediments deposited within the ocean basins. This module explains the characteristics of marine sediments.
Every continent or island is bordered by a long or short coastline. Coastline is the line separating the land and sea. Coastal zones are the transition zones between terrestrial and marine habitat. They form an interface between land and oceanic natural processes. Coastal areas also are varied in their topography, climate and vegetation. Some are sandy beaches, rocky shores, with or without tidal inlets. The climate of a coast are controlled by the land and sea breezes and the humidity controlled by marine water. Waves are powerful tools for constructive and destructive activities. Hence. the geomorphology of beach, materials and processes are always not constant due to the impact of everlasting action of tides, waves and currents.
Written information are rightfully gathered from the internet. Kindly, use this properly including proper citation. This is a presentation made during our high school days.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. A-The vast world oceanA-The vast world ocean
Earth is often referred to as the blue
planet
•71% of Earth’s surface is represented
by oceans and marginal seas
•Continents and islands comprise the
remaining 29%
Oceans represent 97% of the
Hydrosphere
3. Four main ocean basinsFour main ocean basins
•Pacific Ocean - the largest and
deepest
•Atlantic Ocean – about half the
size of the Pacific Ocean
•Indian Ocean – slightly smaller
than the Atlantic
•Arctic Ocean – about 7 percent
the size of the Pacific
4. Mapping the ocean floorMapping the ocean floor
Bathymetry – measurement of ocean
depths and the shape or topography of
the ocean floor
Echo sounder (also referred to as sonar)
•Invented in the 1920s
•Primary instrument for measuring
depth
•Reflects sound from ocean floor
7. TopographyTopography
• Is the study of Earth's
surface shape and features.
• Ocean topography is the
study of the ocean floor
and the features of which.
8. Abyssal hillsAbyssal hills
• Hills along the ocean floor. Ranging in height and
diameter, these hills are much larger than the hills
we see on land. 100-2000 meters high and several
KM across.
9. Abyssal plainsAbyssal plains
• Abyssal plains are flat or very gently sloping areas of
the deep ocean basin floor. They generally lie
between the foot of a continental rise and a mid-
oceanic ridge.
10. Continental shelfContinental shelf
• The continental shelf is the extended perimeter of
each continent and associated coastal plain, and
was part of the continent during the glacial periods,
but is undersea during interglacial periods.
11. Continental slopeContinental slope
• The descending slope which connects the sea floor
to the Continental shelf. This is still considered to be
part of the Continent.
12. Continental riseContinental rise
• A gentle slope with a generally smooth
surface, built up by the shedding of
sediments from the continental block, and
located between the continental slope and
the abyssal plain.
13. GuyotGuyot
• A guyot also known as a tablemount, is a flat-
topped seamount. Their flatness is due to erosion by
waves, winds, and atmospheric processes.
14. Mid-Ocean ridgeMid-Ocean ridge
• A mid-ocean ridge is an underwater mountain
range, typically having a valley known as a rift
running along its spine, formed by plate tectonics. It
is usually an oceanic spreading center, which is
responsible for seafloor spreading.
15. TrenchTrench
• The oceanic trenches are hemispheric-scale (one
hemisphere to another) long but narrow
topographic depressions of the sea floor. They are
also the deepest parts of the ocean floor.
16. Mariana TrenchMariana Trench
• Is the deepest part of the
world's oceans, and the
deepest location on the
surface of the Earth's crust. It
has a maximum depth of
about 10,911meters, or 11
kilometers.
17. Sea MountSea Mount
• A seamount is a mountain rising from the ocean
seafloor that does not reach to the water's surface
(sea level), and thus is not an island. These are
typically formed from extinct volcanoes, that rise
abruptly.
18. OceanicOceanic IslandIsland
• One type of oceanic island is found in a
volcanic island arc. These islands arise from
volcanoes where the subduction of one
plate under another is occurring.
19. AtollAtoll
• An atoll is an island of coral that encircles a lagoon
partially or completely.
20. Volcanic fissureVolcanic fissure
• A linear volcanic vent through which lava erupts,
usually without any explosive activity. The vent is
usually a few meters wide and may be many
kilometers long
21. Hydrothermal VentHydrothermal Vent
• A hydrothermal vent is a fissure in a
planet's surface from which
geothermal heated water issues.
Hydrothermal vents are commonly
found near volcanically active
places, areas where tectonic plates
are moving apart, ocean basins,
and hotspots.
23. Active continentalActive continental
marginsmargins
• Continental slope descends abruptly into
a deep-ocean trench
• Located primarily around the Pacific
Ocean
• Accumulations of deformed sediment
and scraps of ocean crust form
accretionary wedges
• Some subduction zones have little or no
accumulation of sediments (narrow
beaches)
24. Seafloor sedimentsSeafloor sediments
Ocean floor is mantled with sediment
Sources
•Turbidity currents
•Sediment that slowly settles to the
bottom from above
Thickness varies
•Thickest in trenches – accumulations
may approach 10 kilometers
25. Thickness varies
•Pacific Ocean – about 600 meters or
less
•Atlantic Ocean – from 500 to 1000
meters thick
Mud is the most common sediment on
the deep-ocean floor
26. Types of seafloorTypes of seafloor
sedimentssediments
1. Terrigenous sediment
• Material weathered from
continental rocks
• Virtually every part of the ocean
receives some
• Fine particles remain suspended
for a long time
• Oxidation often produces red and
brown colored sediments
27. 2. Biogenous sediments
• Shells and skeletons of marine animals
and plants
• Most common are calcareous oozes
produced from microscopic organisms
that inhabit warm surface waters
• Siliceous oozes composed of skeletons
of diatoms and radiolarians
• Phosphate rich materials derived from
the bones, teeth, and scales of fish and
other marine organisms
28. 3. Hydrogenous sediment
• Minerals that crystallize directly
from seawater
• Most common types include
•Manganese nodules
•Calcium carbonates
•Metal sulfides
•Evaporites