Nano Particles can be engineered with distinctive compositions, sizes, shapes, and surface chemistries to enable noval techniques in a wide range of biological application

1. Nanoparticles

2. Content
 Introduction
 Definition
 Classificaton Of Nanoparticles
 Advantages Of Nanoparticles
 Disadvantages Of Nanoparticles
 Preparation of polymeric Nanoparticles
 Targeted Nanoparticles
 Equipments for Nanoparticles
 Evaluation of nanoparticles
 Conclusion
 References

3. Introduction
 Nanoparticles can be engineered with distinctive
compositions, sizes, shapes, and surface
chemistries to enable novel techniques in a wide
range of biological applications.
 The unique properties of nanoparticles and their
behavior in biological milieu also enable exciting
and integrative approaches to studying
fundamental biological questions. T

4. Definition
“ Nanoparticles are sub-nanosized colloidal
structures composed of synthetic or semi-
synthetic polymers.”
Size range : 10–1000 nm
The drug is dissolved, entrapped, encapsulated
or attached to a nanoparticle matrix
.Based On Method Of Preparation:
Nanocapsules:- Nanocapsules are systems in
which the drug is confined to a cavity surrounded
by a unique polymer membrane.
Nanospheres:- Nanospheres are matrix systems
in which the drug is physically and uniformly
dispersed.

5. Classificaton Of Nanoparticles
 Solid Lipid Nanoparticles
 Polymeric Nanoparticles
 Ceramic Nanoparticles
 Hydrogel Nanoparticles
 Copolymerized Peptide Nanoparticles
 Nanocrystals and Nanosuspensions
 Nanotubes And Nanowires
 Functionalized Nanocarriers
 Nanospheres
 Nanocapsules

6. Advantages Of Nanoparticles
 Nano particle can be administered by parenteral,
oral, nasal,occular routes.
 By attaching specific ligands on to their
surfaces,nano particles can be used for directing
the drugs to specific target cells.
 Improves stability and therapeutics index and
reduce toxic affects.
 Both active & passive drug targetting can be
achieved by manipulating the particel size and
surface characteristics of nano particles

7. Disadvantages Of Nanoparticles
 Small size & large surface area can lead to
particle aggregation .
 Physical handling of nano particles is difficult in
liquid and dry forms.
 Limited drug loading.
 Toxic metabolites may form.

8. Preparation of polymeric
Nanoparticles

9. Targeted Nanoparticles
 Passive Targeting
 Active Targeting

10. Equipments for Nanoparticles
• Homogenizer
• Ultra Sonicator
• Mills
• Spray Milling
• Supercritical Fluid Technology
• Electrospray
• Ultracentrifugation
• Nanofiltration

11. Evaluation of nanoparticles
1. Particle size
2. Density
3. Molecular weight
4. Structure and crystallinity
5. Specific surface area
6. Surface charge & electronic mobility
7. Surface hydrophobicity
8. Invitro release
9. Nanoparticle yield
10. Drug entrapment efficiency

12. Conclusion
Nanoparticles are one of the novel drug delivery
systems,which can be of potential use in
controlling and targeting drugdelivery as well as
in cosmetics textiles and paints. Judging bythe
current interest and previous successes,
nanoparticulatedrug delivery systems seems to
be a viable and promisingstrategy for the
biopharmaceutical industry.

13. References

14. Thanks