This document provides an overview of nanoparticles including their classification, methods of preparation, evaluation, advantages, disadvantages, and applications. Nanoparticles are particles between 1-100 nanometers in size that can be classified based on their dimensions. They can be prepared using various methods such as micellar nucleation, polymerization, or dispersion polymerization. Nanoparticles are evaluated based on parameters like particle size, molecular weight, structure, and in vitro drug release profile. They provide benefits like targeted drug delivery and reduced toxicity but also have challenges like particle aggregation and limited drug loading. Nanoparticles have potential applications in drug delivery.
NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
Formulation and evaluation of nanoparticles as a drug delivery systems Tarun Kumar Reddy
Nanomaterials fall into a size range similar to proteins and other macromolecular structures found inside living cells. As such, nanomaterials are poised to take advantage of existing cellular machinery to facilitate the delivery of drugs. Nanoparticles containing encapsulated, dispersed, absorbed or conjugated drugs have unique characteristics that can lead to enhanced performance in a variety of dosage forms.
Nanoparticles are defined as particulate dispersions or solid particles drug
carrier that may or may not be biodegradable. Several techniques are used for preparation of
nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion
Method, Nanoprecipitation, Coacervation method, Salting Out Method, Dialysis and
Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters
such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle
Size and Zeta Potential , Surface Morphology, Polydispersity index, In-vitro release Study,
Kinetic Study, Stability of nanoparticles
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
Formulation and evaluation of nanoparticles as a drug delivery systems Tarun Kumar Reddy
Nanomaterials fall into a size range similar to proteins and other macromolecular structures found inside living cells. As such, nanomaterials are poised to take advantage of existing cellular machinery to facilitate the delivery of drugs. Nanoparticles containing encapsulated, dispersed, absorbed or conjugated drugs have unique characteristics that can lead to enhanced performance in a variety of dosage forms.
Nanoparticles are defined as particulate dispersions or solid particles drug
carrier that may or may not be biodegradable. Several techniques are used for preparation of
nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion
Method, Nanoprecipitation, Coacervation method, Salting Out Method, Dialysis and
Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters
such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle
Size and Zeta Potential , Surface Morphology, Polydispersity index, In-vitro release Study,
Kinetic Study, Stability of nanoparticles
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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2. CONTENT:
2
• Introduction of nanoparticles.
• Classification of nanoparticles.
• Method of preparation.
• Evaluation of nanoparticles.
• Advantages and disadvantages of nanoparticles.
• Application.
• Reference.
3. INTRODUCTION:
3
• Nanoparticles are particles between 1 and 100 nanometres (nm) in size with a
surrounding interfacial layer.
• The interfacial layer is an integral part of nanoscale matter, fundamentally
affecting all of its properties.
• The interfacial layer typically consists of ions, inorganic and organic molecules.
• The colloidal carrier are based on biodegradable and biocompatible polymeric
systems like liposomes, nanoparticles and micro emulsion have largely
influenced the controlled and targeted drug delivery concept.
• Nanoparticles are sub-nanosized colloidal structures composed of synthetic or
semi-synthetic polymers.
4. BASED ON METHOD OF PREPARATION:
4
Nanocapsules:-
• Nanocapsules are systems in which the drug is confined to a cavity
surrounded by a unique polymer membrane.
Nanospheres:-
• Nanospheres are matrix systems in which the drug is physically and
uniformly dispersed.
6. CLASSIFICATION OF NANOPARTICLES:
6
• Zero dimension nanomaterial: All the dimensions are measured
within all the nanoscale ( no dimensions are larger than 100nm).
Mostly these are nanoparticles.
• One dimension nanomaterial: Here one dimension is outside the
nanoscale. This class includes nanotubes, nanorods and nanowires.
• Two dimension nanomaterial: Two dimensions are outside the
nanoscale. This class exhibits plate-like shapes and includes
nanocoatings, nanofilms etc.
7. 7
• Three- dimensional nanomaterials (3D): These are materials that are
not confined to the nanoscale in any dimension. This class can
contain bulk powders, bundle of nanowires etc.
8. CLASSIFICATION OF NANOPARTICLES:
8
Solid lipid nanoparticles:
• New type of colloidal drug carrier system for i.v.
• Consists of spherical solid lipid particles in the nm range, dispersed in water
or in aqueous surfactant solution.
9. 9
Polymeric nanoparticles are defined as particulate dispersions or solid
particles with size in the range of 10-1000nm. Composed of synthetic or
semi-synthetic Polymers. Biodegradable polymeric nanoparticles
polylactic acid(PLA), polyglycolic acid (PGA) etc.
Ceramics nanoparticles: These are the nanoparticles made up of inorganic
(ceramic) compounds silica, ( Inorganic/metal) titania and alumina. Exist
in size less than 50 nm, which helps them in evading deeper parts of the
body.
10. HYDROGEL NANOPARTICLES:
10
• Polymeric system involving the self-assembly and self aggregation of natural
polymer amphiphiles cholesteroyl pullulan , cholesteroyl dextran and agarose
cholesterol groups provide provide cross linking points. Nanocomposite
hydrogels (NC gels) are nanomaterial-filled, hydrated, polymeric networks that
exhibit higher elasticity and strength relative to traditionally made hydrogels.
• Copolymerized Peptide Nanoparticles: Drug moiety is covalently bound to
the carrier instead of being physically entrapped. A novel co-polymeric
nanoparticulate drug delivery system has been developed as a carrier for the oral
uptake of therapeutic peptides. The system was based on the co-polymerisation of
the active peptide.
.
11. 11
Functionalized Nanocarriers:
Biological materials like proteins, enzymes, peptides etc… are being utilized
as a carriers for the drug delivery.
Nanocrystals And Nanosuspensions:
• Drug nanocrystals are crystals with a size in the nanometer range, which means
they are nanoparticles with a crystalline character.
• Very finely colloid biphasic, dispersed and solid drug particles in aqueous
vehicle, size below 1µm without any matrix material stabilized by surfactant
and polymers and prepared by suitable methods for drug delivery applications
through various routes of administration”.
12. NANOTUBES AND NANOWIRES:
12
Nanotubes: A nanotube is a kind of nanoparticle, and may be large enough to
serve as a pipe through which other nanoparticles can be channeled, or, depending
on the material, may be used as an electrical conductor or an electrical insulator
.
• Nanowires are 1D nanostructures which generally have diameters of the
order of tens of nanometers, with unconstrained length scales! The length to
diameter ratio may be as much as 1000.
• Nanorods are also 1D nanostructures where each of their dimensions range
from 1–100 nm. Standard aspect ratios (length divided by width) are 3-5.
27. EVALUATION OF NANOPARTICLES :
27
1. Particle size.
2. Molecular weight,
3. Structure and crystallinity.
4. Specific surface area
5. Surface hydrophobicity.
6. Surface charge & electronic mobility
7. In vitro release.
8. Nanoparticle yield.
9. Drug entrapment efficiency.
28. 1. PARTICLE SIZE :
28
• It is one of the most important parameters of nanoparticles. Two main
techniques are being used to determine the particle size distribution of
nanoparticles and includes Photon correlation spectroscopy (PCS) (For
smaller particle) and electron microscopy. And letter include -
• Laser diffractro metry (For larger particle.)
• Electron microscopy (EM) : Required coating of conductive material such as
gold & limited to dry sample.
• Transmission electron microscopy (TEM) : Easier method & Permits
differntiation among nanocapsule & nanoparticle.
• Atomic force microscope, Scanning electron microscope, Laser force
microscope : High resolution microscpe. etc.
29. 2. Molecular weight :
29
• Determined by gel permeation chromatography using refractive index
detector.
• GPC separates based on the size or hydrodynamic volume of the analytes. This
differs from other separation techniques which depend upon chemical or physical
interactions to separate analytes. Separation occurs via the use of porous beads
packed in a column The smaller analytes can enter the pores more easily
and therefore spend more time in these pores, increasing their
retention time. These smaller molecules spend more time in the
column and therefore will elute last. Conversely, larger analytes spend
little if any time in the pores and are eluted quickly. All columns have a
range of molecular weights that can be separated.
30. 30
• If an analyte is either too large or too small, it will be
either not retained or completely retained, respectively.
31. 3.STRUCTURE & CRYSTALLINITY :
31
• Many method are used for determination of structure and crystallinity. Mainly
X ray diffraction method are used to determine the structure and crystallinity.
• X-ray imaging begins with a beam of high energy electrons crashing into a
metal target and x-rays are produced. A filter near the x-ray source blocks
these low energy rays, which means only the high energy rays pass through a
patient toward a sheet of photographic film. X-ray can penetrate liquids, gas
and solids. The point of penetration is based on the intensity, quality and
wavelength of the X-ray beams. The stronger the beam of X-ray and vise
versa. These electromagnetic radiations or X-ray work on the absorption of
low level radiation by parts of our body with higher density, making the
radiation not absorbed hit the photographic 'plate' to form a 'negative image”.
32. 4. SPECIFIC SURFACE AREA :
32
Sorptometer specific surface area A = 6 divided by Density
multiply into diameter of particle.
5. Surface charge & electronic mobility :
Surface charge of particle can be determined by measuring particle
velocity in electrical field. Laser Doppler Anemometry tech. are
also used for determination of Nanoparticles velocities. Surface
charge is also measured as electrical mobility. And charged
composition critically decides bio-distribution of nanoparticle .
Zeta potential can also be obtain by measuring the electronic
mobility.
33. 33
6. Surface Hydrophobicity :
The surface hydrophobicity of nanoparticles has an important influence on the
interaction of colloidal particles with biological environment.
Several method,
Important influence on interaction of nanoparticles with biological environment.
Several methods have been used,
1. Hydrophobic interaction chromatography
2. Two phase partition etc.
1.Hydrophobic interaction chromatography (HIC) separates molecules based on
their hydrophobicity. HIC is a useful separation technique for purifying proteins
while maintaining biological activity due to the use of conditions and matrices that
operate under less denaturing conditions.
34. 7. IN VITRO RELEASE:
34
• Mostly Diffusion cell is used to determine the in vitro release.
• Franz Cells are hand blown diffusion cells made of two borosilicate glass
components. Upper part is called the cell cap, cell top, donor chamber, or
donor compartment. Lower portion is called the body of the cell, or the
receptor chamber if not jacketed. The Franz Cell apparatus consists of two
primary chambers separated by a membrane. Although animal skin can be
used as the membrane, human skin is preferred. The upper surface of the cell
body and the mating lower surface of the donor chamber are together known as the
joint. The orifice of a Franz Cell is the area to which the donor and receptor chambers
are exposed. Size of the cell is the orifice diameter of the joint at the mating surface
and is not the outer diameter of the joint.
35. 35
• The test product is applied to the membrane via the top chamber. The
bottom chamber contains fluid from which samples are taken at
regular intervals for analysis. This testing determines the amount of
active that has permeated the membrane at each time point. The
chamber is maintained at a constant temperature of 37 degree
Centigrade. Depending on the vehicle, the rate of permeation for a
given drug as determined via Franz cell analysis can vary
significantly (perhaps from 10- to 50-fold).
8.Nanoparticle yield:
% yield = Actual weight of product divided by total weight of excipient & Drug .
9. Drug entrapment efficiency :
Drug entrapment % = Mass of drug in Nanoparticles divided by mass of drug
used in formulation multiply into 100.
36. ADVANTAGES OF NANOPARTICLES:
36
• Nano particle can be administered by parenteral, oral, nasal, occular routes.
• By attaching specific ligands on to their surfaces, Nano particles can be used
for directing the drugs to specific target cells.
• Improves stability and reduce toxic affects etc.
37. DISADVANTAGES OF NANOPARTICLES:
37
• Small size & large surface area can lead to particle aggregation.
• Physical handling is difficult.
• Limited drug loading.
• Toxic metabolites may form etc.
40. REFERENCE:
40
• Nanoparticles – A Review by VJ Mohanraj and Y Chen, Tropical
Journal of Pharmaceutical Research, June 2006; 5 (1): 561-573.
• www.slideshare.net/ reviews/nanoparticles/ slide by Amole
kokate.
• Vyas, S.P and Khar, R.K., Targeted and Controlled Drug
Delivery, CBS Publishers, New Delhi, 2002, ISBN 81-239-0799-0.
• Mohanraj VJ, Y Chen Nanoparticles – A Review. Trop J Pharm
Res, 5 (1): 561-573.