The document discusses targeted drug delivery using nanoparticles. It describes various methods for preparing nanoparticles, including cross-linking of polymers, emulsion polymerization, and solvent evaporation. Nanoparticles can be engineered using these methods to encapsulate drugs and release them in a targeted manner in the body.
NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
Polymeric micelle formation , mechanism , Case study , applications , Factors affecting formation of Polymeric Micelle , Method of preparation , Types of polymers used in Polymeric micelle
Sr no Contents
1 Introduction
2 Advantages and disadvantages
3 Types of nanoparticle
4 Classification of Nanoparticle
5 Polymers used in nanoparticles
6 Method of preparation
7 Evaluation of nanoparticles
8 Application of nanoparticles
9 References
Nanoparticles is derived from the Greek word Nano means extremely small.
Nanoparticles are sub Nano sized colloidal drug delivery systems .
Particle size ranges from 10-1000 nm in diameter .
They are made up of natural, synthetic or semi synthetic polymers carrying drugs or proteinaceous substances, i.e. antigen(s) .
Drugs are entrapped either in the polymer matrix as a particulates or solid solutions or may be bound to particle surface by physical adsorption or by chemical reaction.
Drug can be added during preparation of nanoparticles or to the previously prepared nanoparticles
Nanoparticles can act as controlled release system depending on their polymeric composition.
As a targeted drug carrier nanoparticles reduce drug toxicity
Less amount of dose required.
They enhance aqueous solubility of poorly soluble drug therefore increase its bioavailability, therapeutic efficacy and Reduces side effects.
Nanoparticles can be administer by various routes including oral, nasal, parenteral, intra-ocular etc.
A) AMPHIPHILIC MACROMOLECULE CROSS-LINKING
B) Polymerization method
C)Polymer precipitation method
Heat cross-linking
Chemical cross-linking
Emulsion chemical dehydration
By Crosslinking in W/O Emulsion
PH-induced aggregation
Counter ion induced aggregation
Emulsion polymerization a)Micellar nucleation and polymerization b)Homogenous nucleation and polymerization)
Dispersion polymerization
Interfacial polymerization
Emulsion solvent evaporation method
Double emulsion and evaporation method
Solvent displacement
Salting out
Nanoprecipitation
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
Polymeric micelle formation , mechanism , Case study , applications , Factors affecting formation of Polymeric Micelle , Method of preparation , Types of polymers used in Polymeric micelle
Sr no Contents
1 Introduction
2 Advantages and disadvantages
3 Types of nanoparticle
4 Classification of Nanoparticle
5 Polymers used in nanoparticles
6 Method of preparation
7 Evaluation of nanoparticles
8 Application of nanoparticles
9 References
Nanoparticles is derived from the Greek word Nano means extremely small.
Nanoparticles are sub Nano sized colloidal drug delivery systems .
Particle size ranges from 10-1000 nm in diameter .
They are made up of natural, synthetic or semi synthetic polymers carrying drugs or proteinaceous substances, i.e. antigen(s) .
Drugs are entrapped either in the polymer matrix as a particulates or solid solutions or may be bound to particle surface by physical adsorption or by chemical reaction.
Drug can be added during preparation of nanoparticles or to the previously prepared nanoparticles
Nanoparticles can act as controlled release system depending on their polymeric composition.
As a targeted drug carrier nanoparticles reduce drug toxicity
Less amount of dose required.
They enhance aqueous solubility of poorly soluble drug therefore increase its bioavailability, therapeutic efficacy and Reduces side effects.
Nanoparticles can be administer by various routes including oral, nasal, parenteral, intra-ocular etc.
A) AMPHIPHILIC MACROMOLECULE CROSS-LINKING
B) Polymerization method
C)Polymer precipitation method
Heat cross-linking
Chemical cross-linking
Emulsion chemical dehydration
By Crosslinking in W/O Emulsion
PH-induced aggregation
Counter ion induced aggregation
Emulsion polymerization a)Micellar nucleation and polymerization b)Homogenous nucleation and polymerization)
Dispersion polymerization
Interfacial polymerization
Emulsion solvent evaporation method
Double emulsion and evaporation method
Solvent displacement
Salting out
Nanoprecipitation
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Nanoparticles, types, preparation and evaluation ppt.pptxmanjureddy62
This ppt consists of information related to nanoparticles, their types and preparation and evaluation. it also consists of questions from the previous years exams conducted by RGUHS (Karnataka) university. Targeted drug delivery.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
1. Targeted Drug Delivery System NANOPARTICLES, LIPOSOMES, RESEALED ERYTHROCYTES Presented By: Mr. Amol B. Kokate. M.Pharm 1 st year. Department Pharmaceutics
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4. What is Nanotechnology? . . . .technologies, that measure, manipulate, or incorporate material or features with at least one critical dimension between ~ 1 nanometer and 100 nanometers . . . . . . whose applications exploit properties, distinct from bulk/macroscopic systems, that arise from their scale/critical dimension . . .
5. What are nanoparticles ? Coarse particle – smaller than 10 μm Fine particle – smaller than 2.5 μm Ultrafine particle – smaller than 0.1 μm (100nm) Nanoparticle – dimensions between 1 nm and 100 nm
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8. Matrix type structure in which a drug is dispersed Membrane wall structure with an oil core containing drug Nanoparticles Nanospheres Nanoencapsules
17. Aqueous protein (BSA) surfactant oil O/W emulsion Dilution with a preheated (at 100 o C) oil (heat cross linking) or addition of cross linking agent (chemical cross linking) Centrifugation and isolation of nanoparticles
45. Melting of the lipid Dissolution of the drug in the melted lipid Mixing of the preheated dispersion medium and the drug lipid melt Hot Homogenization Technique :
46. High pressure homogenization at a temperature above the lipids melting point O/W – nano emulsion Solidification of the nano emulsion by cooling down to room temperature to form SLN
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48. Grinding in a powder mill ( 50 – 100 particles ) Dispersion of the lipid in the cold aqueous dispersion medium Solid Lipid Nanoparticles
49. Nanocrystals : Drug Dispersion with agitation Surfactant solution Milling for few hours/day Nanocrystals
50. Nanosuspension : Drug Dispersion with high speed stirring Surfactant solution High pressure homognization 1500 bar pressure Nano – suspension
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52. Purification of nanoparticles : Gel filtration : Remark : High molecular weight substances and impurities are difficult to remove Schematic principle Nanoparticle Impurity
58. Characterization of nanoparticles : Parameter Characterization method Particle size and size distribution Charge determination Laser Doppler Anemometry Zeta potentiometer Chemical analysis of surface Static secondary ion mass spectrometry Sorptometer Carrier drug interaction Differential scanning calorimetry photon correlation spectroscopy Laser diffractometry Transmission electron microscopy Scanning electron microscopy Atomic force microscopy Drug satbility Bioassay of drug extracted from nanoparticles Chemical analysis of drug
59. In Vivo Fate and Biodistribution of Nanoparticles RES RES Phagocytosis recognition Dysopsonin adsorption Opsonin adsorption Avoidance of recognition Nanoparticle Nanoparticle
72. Energy: Nanocrystals are an ideal light harvester photovoltaic devices. They absorb sunlight more strongly than dye molecules or bulk semiconductor material. Automobiles: In 2001, Toyota started using nanocomposites in a bumper that makes it 60 percent lighter and twice as resistant to denting and scratching. Emerging Applications
73. Sports: Wilson Double Core tennis balls have a nanocomposite coating that keeps them bouncing twice as long as an old-style ball. Clothing: Eddie Bauer is currently using embedded nanoparticles to create stain-repellent khakis. Emerging Applications
74. Effective in pancreatic cancer treatment A retroviral vector carrying cytotoxic gene Rexin-G (Epeius Biotechnology corporation) Enhance dose tolerance and hence effect elimination of solvent associated toxicity Paclitaxel (anticancer drug) bound albumin particles Abraxane (American Biosciences, Inc.) Enhanced dissolution rate& bioavailability Nanocrystallied Rapamycin (immunosuppressant) in a tablet Rapamune (Wyeth-Ayerst Laboratories) Enhanced dissolution rate & bioavailability Nanocrystal aprepiant (antiemetic) in a capsule Emend (Merck & Co. Inc.) Advantages Description Brand name
75. More powerful antibiotics Nano-sized plastic spheres with drugs (active against methicillin-resistant staph (MRSA) bacteria) chemically bonded to their surface that allow the drug to be dissolved in water. Nano-balls (Univ. of South Florida) Better protection from infection Enhance the solubility and sustained release of silver nanocrystals SILCRYST (Nucryst Pharmaceuticals) enhanced MRI images at least 25 times better than current contrast agents MRI images Trimetaspheres (Luna Nanoworks) Offer better UV protection Contains added transparent, better protecting nano zinc oxide particles Olay Moisturizers (Proctor and Gamble)