This document discusses the application of nanocarriers in the delivery of biotechnologicals. It defines nanocarriers as colloidal particulate systems between 10-1000nm that have been used for diagnosis, treatment, and monitoring of diseases. The document then classifies and describes various types of nanocarriers - nanocapsules, nanoparticles, nanoemulsions, nanosomes, dendrimers, nanotubes, and nanosuspensions. It provides examples of each type and discusses their applications in areas like cancer treatment, food/nutraceutical usage, and drug delivery through oral, parenteral, and other routes. The document concludes by listing references used for more information on pharmaceutical applications of these nanoparticulate

1. Application of Nanocarriers in
Delivery of Biotechnologicals
Presented by,
Mr. MEHETRE AKSHAY DILIPRAO
F.Y. M.Pharm (Sem-II)
2016-2017
Shri Bhagwan College of
Pharmacy ,Aurangabad

2.  DEFINATION:-
Nanocarriers are colloidal particulate
system with size between 10-1000nm.
They have been successfully utililzed in
the diagnosis,treatment and monitoring of
various diseases.
NANOCARRIERS

3.  NANOCAPSULE
 NANOPARTICLES
 NANOEMULSION
 NANOSOMES
 DENDRIMERS
 NANOTUBES
 NANOSUSPENSION
classification

4.  DEFINATION:-
Nanocapsule is a nano-
vesicular systems that exhibit a typical
core-shell structure in which the drug is
confined to a reservoir or within a cavity
surrounded by a polymer membrane or
coating.
NANOCAPSULE

5. Fig. 1. Different nanocapsular structures: (a) liquid core, (b) polymer
matrix and (c) active substance in molecular dispersion

6.  In cancer
 Food usage
 Nutraceuticals
 Ethyl alcohol absorption
 Self healing materials
Applications OF NANOCAPSULE

7.  Nanoparticle – any particle that is sized between 1 and 100
nanometers (in terms of diameter)
 The use of nanoparticles
allows one to change the
pharmacokinetic properties
of the drug without
changing the active
compound.
nanoparticles

8.  Nanoparticles for oral delivery of peptides and
proteins-
 Nanoparticles for occular application
 Nanoparticles for pulmonary treatment
 Nanoparticles in treatment of vascular
thrombosis
Applications of nanoparticles

9.  Nanoemulsion is a heterogeneous system and it
consist of two immisible phase, one phase is oil
phase ,other is aqueous phase, while the droplet
is of sub micron size range of 5-200nm.
 Nanoemulsions are submicron sized emulsion
that is under extensive investigation as drug
carriers for improving the delivery of
therapeutic agents
nanoemulsion

10.  Use in Cosmetic
 Use as anti-microbial agent
 Parenteral delivery
 Oral delivery
 Ocular & pulmonary delivery
 Nanoemulsion in cancer therapy
Applications of nanoemulsion

11.  It is a very small liposomes.
 It is a so small, in the Nanometer range
 Defination:-
Nanodevices existing symbiotically inside
biological cells, doing mechanosynthesis &
disassembly for it and replicating with the cell
similar to nanochondria.
NANOSOMES

12.  Phospholipids- lecithin, water soluble & oil soluble
ingredients
 Vitamin-C,vit-E ,sod.citrate, pot.malate.
Some examples of nanosomes.

13.  In cosmetics- In skin care ,hair care
 Targeting
 Diagnosis
 Therapy
APPLICATIONS OF NANOSOMES

14.  It is a tree like ,highly branched,
polymeric compounds.
 It is a polymer than branches “a tiny
molecular structure that interacts with
cells enabling scientists to probe,
diagnose, cure or manipulate them on a
nanoscale”.
dendrimers

15.  In delivery of drug
 Useful in therapetic agents in the prevention of
bacterial & viral infections.
 As coating agents
 Gene therapy
Applications of dendrimers

16.  Carbon nanotubes are allotropes of carbon
with a cylindrical nano stucture
 Nanotubes can be single walled carbon
nanotubes or multiwalled carbon nanotubes
in concentric fashion.
 These are tubular structure like a sheet of
graphite rolled in to a cylinder capped at one/
both ends by a bulky ball
NANOTUBES

17.  Gene therapy
 Cancer therapy
 Vaccine production
Applications of nanotubes

18.  These are very finely colloid, biphasic,
dispersed, solid drug particles in an
aqueous vehicle.
 Size below 1 meter
Nanosuspension

19.  Oral drug delivery
 Parental drug delivery
 Pulmonary drug delivery
 Ocular drug delivery
Applications of nanosuspension

20.  Pharmaceutical Applications of Nanoparticulate Drug-
delivery systems by “ Deepak Thassu” Page no.185-203
 Theory & practice in Novel drug delivery system by
“S.P Vyas”
A review article” Pharmacie Globle” International
journal of comprehensive pharmacy
www.google.com
REFERENCES

21. THANK YOU