This document discusses nanoparticles and their uses in drug delivery. It defines nanoparticles as particulate dispersions between 10-1000nm in size. Nanoparticles are classified based on their method of preparation into nanocapsules and nanospheres. Some common types of nanoparticles discussed are solid lipid nanoparticles, polymeric nanoparticles, ceramic nanoparticles, and hydrogel nanoparticles. The document outlines advantages like increased shelf stability and ability to control drug release. Evaluation parameters for nanoparticles include particle size, molecular weight and in vitro drug release. Finally, applications like targeted drug delivery to the brain and topical formulations are mentioned.

1. Presented By- Chetan Vishwanath Pawar
M. Pharmacy Sem – II
Guided By- Mrs. S. MUTHA
Department of Pharmaceutics
PDEA’s S.G.R.S. College of Pharmacy Saswad.
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2.  INTRODUCTION
 CLASSIFICATION OF NANOPARTICLES
 ADVANTAGES AND DISADVANTAGEF
 IDEAL CHARACTERISTICS
 METHOD OF PREPARATION
 EVALUATION PARAMETER OF NANOPARTICLES
 APPLICATION OF NANOPARTICLES :
 REFERENCES

3.  DEFINATION –
Nanoparticles are defined as particulate
dispersions or solid particles with a size in the
range of 10-1000nm.
OR
Nanoparticles are sub-nanosized colloidal
structures composed of synthetic or semi-
synthetic polymers.”

4.  Based On Method Of Preparation:
Nanocapsules:-
drug is confined to a cavity surrounded by
a unique polymer membrane.
Nanospheres:-
the drug is physically and uniformly dispersed.

6.  Solid Lipid Nanoparticles
 Polymeric Nanoparticles
 Ceramic Nanoparticles
 Hydrogel Nanoparticles
 Copolymerized Peptide Nanoparticles
 Nanocrystals and Nanosuspensions

7.  Solid Lipid Nanoparticles:
• New type of colloidal drug carrier system for i.v.
• Consists of spherical solid lipid particles in the
nm range, dispersed in water or in aqueous
surfactant solution.
 Polymeric nanoparticles (PNPs) - are defined as
particulate dispersions or solid particles with size
in the range of 10-1000nm.
• Biodegradable polymeric nanoparticles
Polylactic acid (PLA), polyglycolic acid (PGA),
Polylactic - glycolic acid (PLGA)

8.  Ceramic Nanoparticles:
These are the nanoparticles made up of
inorganic(ceramic) compounds silica, Exist in
size less than 50 nm, which helps them in
evading deeper parts of the body.
 Hydrogel nanoparticles:
Polymeric system involving the self-
assembly and self aggregation of natural
polymer cholesterol dextran and agarose
cholesterol groups provide cross linking
points.

9.  Copolymerized Peptide Nanoparticles:
Drug moiety is covalently bound to the
carrier instead of being physically entrapped.
 Nanocrystals And Nanosuspensions:
Pure drug coated with surfactant,
Aggregation of these particles in crystalline
form .Drug powder dispersed in aqueous
surfactant solution.

10.  1) They are suitable for different routes of
administration.
 2) Carrying capacity of nanoparticles is high.
 3) Shelf-stability of drug increases.
 4) Ability to sustain and control drug release
patterns.
 5) Suitable for combination therapy where two or
more drug can be co-delivered.

11.  1) High cost
 2)Productivity more difficult
 3) Reduced ability to adjust the dose
 4) Highly sophisticated technology
 5) Requires skills to manufacture

12.  It should be biochemical inert , non toxic .
 It should be stable both physically and
chemically in In vivo & in vitro conditions.
 Specific Therapeutic amount of drug release
must be possessed .
 The preparation of the delivery system should
be easy.

13.  Emulsion-Solvent Evaporation Method:
 Double Emulsion and Evaporation Method:
 Salting Out Method:
 Emulsions- Diffusion Method
 Solvent Displacement / Precipitation method:

19.  1. Particle size
 2. Density
 3. Molecular weight
 4. Structure and crystallinity
 5. Specific surface area
 6. Surface charge & electronic mobility
 7. Surface hydrophobicity
 8. In vitro release

20.  Targeting drug delivery by encapsulation .
 Nanoparticles for drug delivery into the brain.
 Nanoparticle for ophthalmic delivery.
 Topical formulation.
 Nanoparticles for oral delivery of peptides &
portions .

22.  JAPS Nanoparticle: An overview of preparation
and Characterization BY Sovan Lal Pal, Utpal
Jana, P. K. Manna, G. P. Mohanta, R.
Manavalan
 Pelagia Research Library Formulation,
Characterization and Application on
Nanoparticle: A Review Abhishek Garg*,
Sharad Visht, Nitin Kumar
 Tropical Journal of Pharmaceutical Research,
June 2006; 5 (1): 561-573Nanoparticles – A
Review VJ Mohanraj* and Y Chen