The electronic distribution of a drug molecule influences its distribution and biological activity. The Hammet constant quantifies electronic effects of substituents on aromatic rings based on dissociation rates of substituted benzoic acids. Steric parameters like Taft's steric parameter and molar refractivity relate a drug's shape/size to its activity. Hansch analysis uses quantitative structure-activity relationships to relate drug properties like hydrophobicity, polarizability, and steric effects to biological activity through mathematical equations. The Craig plot visually compares substituents' electronic properties.