Glycogen is the storage form of carbohydrates in the body, mainly found in the liver and muscle. The liver stores glycogen to maintain blood glucose levels during fasting, while muscle glycogen acts as a fuel reserve for contraction. Glycogen metabolism involves both glycogenolysis, the breakdown of glycogen into glucose, and glycogenesis, the synthesis of glycogen from glucose. Key enzymes regulate these processes to maintain appropriate blood glucose levels. Genetic defects in glycogen metabolism can cause diseases like Von Gierke's disease.
Metabolism of glycogen and its clinical significance final.pptxrohini sane
A comprehensive presentation on Metabolism of Glycogen and its clinical significance MBBS , BDS, B Pharm & Biotechnology students to facilitate self- study.
Glycogen is the storage form of Glucose which maintain the blood glucose level under various condition. Glycogen Metabolism is the important pathway of carbohydrate metabolism which gives the information about the glycogen synthesis (Glycogenesis), Glycogen breakdown (Glucogenolysis). Glycogen metabolism also gives the information how this pathway is regulated. Their are various diseases which are associated with this metabolism, commonly known as Glycogen storage diseases.
Metabolism of glycogen and its clinical significance final.pptxrohini sane
A comprehensive presentation on Metabolism of Glycogen and its clinical significance MBBS , BDS, B Pharm & Biotechnology students to facilitate self- study.
Glycogen is the storage form of Glucose which maintain the blood glucose level under various condition. Glycogen Metabolism is the important pathway of carbohydrate metabolism which gives the information about the glycogen synthesis (Glycogenesis), Glycogen breakdown (Glucogenolysis). Glycogen metabolism also gives the information how this pathway is regulated. Their are various diseases which are associated with this metabolism, commonly known as Glycogen storage diseases.
Gluconeogenesis: Defined as biosynthesis of glucose from non-carbohydrate precursors
-Gluconeogenesis: an intro
-Thermodynamic Barriers (Each barrier detail explanation)
- Energetics of gluconeogenesis
-Substrates of gluconeogenesis (each substrate and pathway explained)
-Regulation of Gluconeogenesis, hormonal and transcriptional regulation
Glycogen is the storage from of glucose. The metabolism of glycogen both as glycogenolysis, breakdown of glycogen, and glycogenesis, formation of glycogen along with their regulation is briefed in the slides.
Under normal dietary intake the majority of the ingested fructose is metabolized by the enterocytes of the small intestine primarily to glucose which is then delivered to the systemic circulation. In addition to glucose, the carbon atoms from dietary fructose are converted, by intestinal enterocytes, into several other metabolites including glycerate, glutamate, glutamine, alanine, ornithine, and citrulline.
However, diets containing large amounts of sucrose, high fructose corn syrup, or fructose alone, overwhelm the ability of the small intestine to metabolize it all and under these conditions a significant amount of fructose is then metabolized by the liver and to a lesser extent by other organs such as skeletal muscle.
Gluconeogenesis: Defined as biosynthesis of glucose from non-carbohydrate precursors
-Gluconeogenesis: an intro
-Thermodynamic Barriers (Each barrier detail explanation)
- Energetics of gluconeogenesis
-Substrates of gluconeogenesis (each substrate and pathway explained)
-Regulation of Gluconeogenesis, hormonal and transcriptional regulation
Glycogen is the storage from of glucose. The metabolism of glycogen both as glycogenolysis, breakdown of glycogen, and glycogenesis, formation of glycogen along with their regulation is briefed in the slides.
Under normal dietary intake the majority of the ingested fructose is metabolized by the enterocytes of the small intestine primarily to glucose which is then delivered to the systemic circulation. In addition to glucose, the carbon atoms from dietary fructose are converted, by intestinal enterocytes, into several other metabolites including glycerate, glutamate, glutamine, alanine, ornithine, and citrulline.
However, diets containing large amounts of sucrose, high fructose corn syrup, or fructose alone, overwhelm the ability of the small intestine to metabolize it all and under these conditions a significant amount of fructose is then metabolized by the liver and to a lesser extent by other organs such as skeletal muscle.
This powerpoint gives detailed description and clear view about Glycogenesis and glycogenolysis . these two metabolic actions are very important for regulating blood glucose levels. it also explains about the glycogen storage
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
2. Glycogen metabolism
Function of glycogen
Glycogen is the storage form of carbohydrates in
the human body.
The major sites of storage are liver and muscle.
1. The major function of liver glycogen is to provide
glucose during starvation.
When blood glucose level lowers, liver glycogen is
broken down and helps to maintain blood glucose
level.
2. The function of muscle glycogen is to act as reserve
fuel for muscle contraction.
Muscle glycogen is depleted after prolonged exercise.
2
3. After taking food, blood sugar tends to
rise, which causes glycogen deposition in
liver. About 5 hours after taking food, the
blood sugar tends to fall. But, liver glycogen
is lyzed to glucose so that the energy needs
are met.
After about 18 hours fasting, most of the
liver glycogen is depleted, when depot fats
are hydrolyzed and energy requirement is
met by fatty acid oxidation.
3
5. Glycogenolysis
It is intracellular breakdown of glycogen to glucose.
Site and steps:
Its main site is the cytosol of liver and muscles.
It is catalyzed by: glycogen phosphorylase and two
other enzymes.
5
6. 1- Glycogen phosphorylase:
The enzyme glycogen phosphorylase
removes glucose units one at a time from the
non-reducing end of the glycogen molecule.
The product is glucose-1-phosphate.
Phosphorylase sequentially attacks alpha-1,4
glycosidic linkages, till it reaches a branch
point.
It cannot attack the 1,6 linkage at branch
point. 6
9. 2- Debranching needs two enzymes
With the help of glucan transferase and
debranching enzyme (alpha-1,6-
glucosidase), the branching point is also
hydrolyzed.
This glucose residue is released as free
glucose.
With the removal of branch,
phosphorylase enzyme can now proceed
with its action. 9
10. 3- Phosphoglucomutase:
Phosphorylation reaction produces glucose-
1-phosphate while debranching enzyme
releases glucose.
The glucose-1-phosphate is converted to
glucose-6-phosphate by
phosphglucomutase.
10
11. 4- Glucose-6-phosphatase in liver
Next, hepatic glucose-6-phosphatase
hydrolyzed glucose-6-phosphate to
glucose.
The product of hepatic glycogenolysis
is free glucose, which is released to the
blood stream.
11
12. 5- Muscle lacks Glucose-6-phosphatase:
But muscle will not release glucose to the blood
stream, because muscle tissue doesnot contain the
Glucose-6-phosphatase.
The energy yield from one glucose residue derived
from glycogen is 3 ATP molecules, because no ATP
is required for initial phosphorylation of glucose
(step 1 of glycolysis).
If glycolysis starts from free glucose only 2 ATPs are
produced.
12
13. Glycogenesis
The glycogen synthesis occurs by a pathway distinctly
different from the reversal of glycogen breakdown.
It is the intracellular synthesis of glycogen from glucose.
Site and steps:
The main site is the cytosol of liver and muscle cells. In the
liver it forms 8-10% of its wet weight and in muscle it forms
1-2% of its wet weight. Most other cells may store minute
amounts. 13
14. 1- Activation of Glucose:
UDP glucose is formed from glucose-1-phosphate
and UTP (uridine triphosphate) by the catalytic
activity of UDP-glucose pyrophosphorylase.
UDP-glucose-
pyrophosphorylase
Glucose-1- -------------------------------→ UDP-glucose
Phosphate
+ +
UTP PPi
14
15. 2- Glycogen synthase:
In the next step, activated glucose units are
sequentially added by the enzyme glycogen
synthase.
The glucose unit from UDP-glucose is transferred to
a glycogen primer molecule.
Glycogen primer (n)----------→ Glycogen (n+1)
+ +
UDP-glucose UDP
15
16. The glucose unit is added to the non reducing
(outer) end of the glycogen to form an alpha-1,4-
glycosidic linkage and UDP is liberated.
The primer is essential as the acceptor of the
glycosyl unit. The glycogen primer is formed by
glycosylation of glycogenin (a dimeric protein).
This molecule acts as the glycogen primer to which
glucose units are added by glycogen synthase.
16
17. 3- Brancher enzyme
A branching enzyme is needed to create
the alpha-1,6 linkages.
To this newly created branch, further
glucose units can be added in alpha-1,4
linkage by glycogen synthase.
Branching makes the molecule more
globular.
17
19. Regulation of glycogen
metabolism
The key enzyme for glycogenolysis is
phosphorylase, which is activated by
glucagon and adrenaline, under the stimulus of
hypoglycemia.
The key enzyme for glycogenesis is glycogen
synthase, the activity of which is decreased by
adrenaline but is enhanced by insulin, under
the stimulus of hyperglycemia.
19
20. Glycogen storage diseases
These are inborn-errors of metabolism; the
word is coined by Garrod in 1908.
Glycogen Storage Disease Type-I:
It is also called Von Gierke’s disease. Most
common type of glycogen storage disease is
type I.
20
21. Incidence is 1 in 100,000 live births.
Glucose-6-phosphatase is deficient.
Fasting hypoglycemia that does not respond to
stimulation by adrenaline. The glucose cannot be
released from the liver during over night fasting.
Hyperlipidemia, lactic acidosis and ketosis.
Glycogen gets deposited in liver. Massive liver
enlargement may lead to cirrhosis.
Children usually die in early childhood.
Treatment is to give small quantity of food at
frequent intervals.
21