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Chronic leukemia
This document discusses several types of hematologic malignancies including chronic leukemias, chronic myeloproliferative disorders, chronic lymphoproliferative disorders, and lymphomas. It provides details on chronic myeloid leukemia, chronic lymphocytic leukemia, polycythemia vera, essential thrombocythemia, chronic myelofibrosis, and their characteristic features, phases or stages of disease progression, treatment approaches, and typical prognosis. The document is an educational reference on several chronic blood cancers and disorders.
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Chronic leukemia
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- 2. Leukemias • Acute leukemias •Chronic leukemias Lymphomas • Hodgkin lymphoma • Non-Hodgkin lymphoma Plasma cell disorders • Multiple myeloma Hematologic Malignancies
- 4. Chronic myeloid leukemiaChronic lymphocytic leukemia
- 5. Leukemias • Acute leukemias •Chronic leukemias • Chronic myeloproliferative disorders • Chronic lymphoproliferative disorders Hematologic Malignancies
- 6. Leukemias • Acute leukemias •Chronic leukemias • Chronic myeloproliferative disorders Hematologic Malignancies
- 9. • Malignant proliferationof myeloid cells (not blasts, but maturing cells) in blood, bone marrow • Four disorders: CML, PV, ET, MF • Occur only in adults • Long course Chronic Myeloproliferative Disorders Things You Must Know
- 10. • Chronic myeloidleukemia • Polycythemia vera • Essential thrombocythemia • Myelofibrosis Four Chronic Myeloproliferative Disorders
- 11. • Occur onlyin adults • Long clinical course • WBC with left shift • Hypercellular marrow • Big spleen Features common to all 4 disorders:
- 12. • Neutrophilic leukocytosis •Basophilia • Philadelphia chromosome • Three phases Chronic Myeloid Leukemia Things You Must Know
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- 17. Chronic phase • Stablecounts • Easily controlled • 3-4 years (without therapy) Accelerated phase • Unstable counts • Fatal within months Blast crisis • Lots of blasts • Fatal within weeks Phases of CML
- 18. Treatment • Used tobe bone marrow transplant • Now, imatinib (Gleevec) Prognosis • Median survival used to be 5-6 years • Now: ?? Treatment and Prognosis of CML
- 19. • Panmyelosis… • …thenmarrow fibrosis • Extramedullary hematopoiesis • Teardrop red cells Chronic Myelofibrosis Things You Must Know
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- 22. • High RBC(makes blood sludgy) • Different from secondary polycythemia! Polycythemia Vera Things You Must Know
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- 24. • Very highplatelet count in blood • Different from secondary thrombocythemia! Essential Thrombocythemia Things You Must Know
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- 26. Leukemias • Acute leukemias •Chronic leukemias • Chronic myeloproliferative disorders • Chronic lymphoproliferative disorders Hematologic Malignancies
- 27. • Malignant proliferationof lymphocytes in blood, bone marrow • Many disorders; CLL most important • Occur only in adults • Long course; indolent but incurable Chronic Lymphoproliferative Disorders Things You Must Know
- 29. • Small, maturelymphocytes • = small lymphocytic lymphoma • Weird: B cells but CD5+ • Long but inexorable course Chronic Lymphocytic Leukemia Things You Must Know
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- 32. Treatment • Conservative • Reduceorganomegaly, infections Prognosis • “Counts,” adenopathy • BM pattern, chromosomal abnormalities • Mean survival: 9 years • Death usually from infection Treatment and Prognosis of CLL