This document provides guidance on conducting key informant interviews (KIIs). It discusses when KIIs should be used, how to select informative key informants, and how to properly prepare for and conduct the interviews. The main points are: 1) KIIs are useful early in a project to inform planning or near completion to evaluate outcomes. They allow exploration of issues and confirmation of information. 2) Informative informants are those affected by policies, able to make decisions, or with unique perspectives on the issue. A variety of viewpoints should be included. 3) Proper preparation includes introducing yourself, your organization, purpose, and obtaining informed consent. Scheduling should offer flexible options and reminders