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Isospora belli
Report by: Veronica Baje
Isospora belli
• Isospora belli is a protozoan parasite in the
Phylum Apicomplexa.
• This group of parasites are referred to as
coccidia.
Oocysts
Laboratory Diagnosis
• Fresh feces
• Duodenal contents
Life Cycle
• An oocyst with one sporoblast is released in stool of infected person
• After the oocyst has been released, the sporoblast matures further and divides into two
• After the sporoblasts divide they create a cyst wall and become sporocysts
• The sporocysts each divide twice, resulting in four sporozoites
• Transmission occurs when these mature oocysts are ingested
• The sporocysts excyst in the small intestine where sporozoites are released
• The sporozoites then invade epithelial cells and schizogony is initiated
• When the schizonts rupture, merozoites are released and continue to invade more
epithelial cells
• Trophozoites develop into schizonts, containing many merozoites
• After about one week, development of male and female gametocytes begin in the
merozoites
• Fertilization results in the development of oocysts, which are released in the stool.
Clinical Symptoms
• Asymptomatic – A number of infected
individuals remain asymptomatic.
• Isosporiasis – Infected patients may
complain of a number of symptoms:
• Mild gastrointestinal discomfort to
severe dysentery
• Weight loss
• Chronic diarrhea
• Abdominal pain
• Anorexia
• Weakness
• Malaise
Pathogenesis
• Marked villous atrophy
• Crypt hyperplasia in the small intestine
Epidemiology
• Africa
• Southeast Asia
• Central America
• Chile
Treatment
• Bland diet
• Plenty of rest
• Combination of trimethoprim
and sulfamethoxazole
• Perimethamine and
sulfadiazine
Prevention and Control
• Proper personal hygiene
• Adequate sanitation practices
• Protected sex

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Isospora belli

  • 2. Isospora belli • Isospora belli is a protozoan parasite in the Phylum Apicomplexa. • This group of parasites are referred to as coccidia.
  • 4. Laboratory Diagnosis • Fresh feces • Duodenal contents
  • 5. Life Cycle • An oocyst with one sporoblast is released in stool of infected person • After the oocyst has been released, the sporoblast matures further and divides into two • After the sporoblasts divide they create a cyst wall and become sporocysts • The sporocysts each divide twice, resulting in four sporozoites • Transmission occurs when these mature oocysts are ingested • The sporocysts excyst in the small intestine where sporozoites are released • The sporozoites then invade epithelial cells and schizogony is initiated • When the schizonts rupture, merozoites are released and continue to invade more epithelial cells • Trophozoites develop into schizonts, containing many merozoites • After about one week, development of male and female gametocytes begin in the merozoites • Fertilization results in the development of oocysts, which are released in the stool.
  • 6. Clinical Symptoms • Asymptomatic – A number of infected individuals remain asymptomatic. • Isosporiasis – Infected patients may complain of a number of symptoms: • Mild gastrointestinal discomfort to severe dysentery • Weight loss • Chronic diarrhea • Abdominal pain • Anorexia • Weakness • Malaise
  • 7. Pathogenesis • Marked villous atrophy • Crypt hyperplasia in the small intestine
  • 8. Epidemiology • Africa • Southeast Asia • Central America • Chile
  • 9. Treatment • Bland diet • Plenty of rest • Combination of trimethoprim and sulfamethoxazole • Perimethamine and sulfadiazine
  • 10. Prevention and Control • Proper personal hygiene • Adequate sanitation practices • Protected sex

Editor's Notes

  1. Unprotected oral-anal sexual contact has been suggested as the mode of parasite transmission