- Wuchereria bancrofti is a parasitic roundworm that causes lymphatic filariasis. It lives in the lymphatic vessels and lymph nodes of humans.
- The parasite has a two-host lifecycle, with humans as the definitive host and various mosquito species as the intermediate host. Microfilariae ingested by a mosquito develop into infective larvae that can be transmitted to another human.
- In humans, adult worms cause lymphangitis and lymphadenitis, leading to symptoms like lymph edema, hydrocele, and elephantiasis. Occult filariasis involves high eosinophilia without microfilaremia. Diagnosis involves microfilariae detection in blood
Wuchereria Bancrofti, the adult worm or parasites and its embryo microfilariae . The studies of microbiology. Its about Introduction, morphology, life cycle, pathogenesis, diagnosis and treatment
Wuchereria Bancrofti, the adult worm or parasites and its embryo microfilariae . The studies of microbiology. Its about Introduction, morphology, life cycle, pathogenesis, diagnosis and treatment
Entamoeba histolytica was first discovered by Losch in 1875.
It is worldwide distribution.
It is prevalent in tropical and subtropical countries where sanitary conditions are poor.
In india, it is prevalent in Chandigarh, Tamil Nadu & Maharashtra.
It is found in the colon of man.
It is monogenetic because the whole life cycle completed within a single host, i.e. man.
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
Entamoeba histolytica was first discovered by Losch in 1875.
It is worldwide distribution.
It is prevalent in tropical and subtropical countries where sanitary conditions are poor.
In india, it is prevalent in Chandigarh, Tamil Nadu & Maharashtra.
It is found in the colon of man.
It is monogenetic because the whole life cycle completed within a single host, i.e. man.
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
Filarial worms are thread-like nematodes of which there are at least 8 species for which humans, especially in tropical regions, are the definitive host
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Common name: Bancrofts
filaria
In 1863, Demarquay first demonstrated
the larval forms of W. bancrofti (microfilarie)
in hydrocele fluid from Cuba.
In 1866, Wucherer from brazil discovered
these larval forms in chylous urine.
In 1872, Lewis from India found the
microfilarae in the peripheral blood.
3. Geographical distribution: The
parasite is largely confined to the tropics and
subtropics occuring in India, WestIndies,
Japan, Central Africa and South America.
Habitat: Adults worm are found in the
lymphatics vessels and lymph nodes of man
only. Bancroftian filariasis is not a zoonotic
diseases.
4. Long, hair like, transparent (often creamy
white color) with smooth cuticular.
Filiform shaped.
Both ends are tapering with slightly swollen
head.
Male: 2.5-4cm x 0.1mm, 2 spicules at tail
end.
Female: 8-10cm x0.2-0.3mm, narrow,
pointed tail.
5. The female though liberating active embroys
are really ovo-viviporous.
Male and female remain coiled together and
can only be seperated with difficulty.(females
are usually numerous than males).
The life span of adult worms is several years
(5-10 ) years.
6.
7. Passing through the lymph node, the
embroys enter into the circulating blood.
They appear as colourless and transparent
bodies with blunt head and pointed tails.
Size measures 290um x 6-7um and is
covered by hyaline sheath.
When dead and stained by Romanowsky’s
stains , the embryo shows the following
morphological peculiarities.
8. # Hyaline sheath.
- Structureless sac.
- Sheath is longer than the larval body so
that larva can move forward and backwards
with in it.
# Somatic cells or nuclei:
- appear as granules in the central axis
of the body.
- extend from head to tail end.
9. Cephalic space: At the anterior end there is a
space, devoid of granules called cephalic
space.
The granules are broken at
definitive places serving as landmark for
identification of species. These include...
* Nerve ring
* Excretory system – EP and EC
* Genital cells (GC) 1,2,3 and 4
posterior.
10. The larval forms do not
undergo any further
development in human
body.
If these are not sucked by
the mosquito they die in
about 70 days.
11.
12. Periodicity:
Microfilariae circulation in blood is periodic.
Nocturnal Periodicity – microfilariae in blood
are high during 10pm-4am.
In most regions W. bancrofti exhibits
nocturnal periodicity- Culex fatigans.
In south pacific they exhibit diurnal
periodicity – Aedes polymensis (sub periodic)
13. During day time they retire
inside the capillaries of lungs,
kidneys, heart and big arteries
such as carotid.
The mechanism of nocturnal
periodicity is not yet clearly
known.
14. Wuchereria bancrofti passes its life cycle in
two hosts. i.e
Man (definitive host).
Mosquito ( intermediate host).
1. The definitive host:
The adult worms are harboured in
lymphatic system of man. The male fertilises
the female.
15. Live embroys (microfilariae) are discharged
which find their way into the blood stream.
The embroys(microfilariae) capable of living
in the peripheral blood for a considerable
time without undergoing any developmental
metamorphosis.
They are subsequently taken up by the
female mosquito during their blood meal.
16. 2. The intermediate host:
mosquito, in which the microfilariae undergo
further development after which they become
infective to man.
They cast off their sheaths in 2-6 hours and
penetrate the stomach walls and within 4-17
hours, reach thoracic muscle .
In next 2 days they metamorphose into first
stage larvae (short, sausage shaped with
short spiky tail.
17. In 3-7days, they moult once or twice to
become second stage larvae.
On 10th or 11th day, they are converted into
the third stage larvae which is infective.
The third stage larvae then migrate from
thoracic muscle to the proboscis sheath of
the mosquito.
A large no. of species of mosquito belong to
the genus culex, Aedes, and Anopheles acts
as a intermediate host for W. bancrofti.
18.
19. - Infection with this parasite is called
Wucheriasis (commonly called filariasis).
Mode of Infection: through the bite of
mosquito
Transmitting agent: female mosquito (culex,
Aedes or Anopheles).
Infective form : third stage larvae
portal of entry: skin
Site of localisation: lymphatic system.
20. The disease is of two types:
1. Classical filariasis.
2. Occult filariasis.
# Classical filariasis:
The pathogenic effects seen in Wucheriasis are
produced by the adult Wuchereria, living or dead.
It leads to lymphangitis, lymphadenitis,
lymphodema with hypertrophy with affected part
(elephantiasis), lymphangiovarix, hydrocele and
chyluria.
21. Lymphangitis (causes) :
i) Mechanical irritation caused by the
movement of adult parasite inside the
lymphatic system.
ii) Secretion of some toxic fluid by fertilised
female at the time of parturition.
Causes of lymphatic Obstruction:
i) Mechanical blocking of lumen by dead
worms ( single or bunch) which acts as an
embolus.
22. ii) Obliterative Endolymphangitis : Endothelial
proliferation and inflammatory thickening of
the walls of lymphatic vessels.
Effects:
a) Lymph varix - Varicosity of lymphatic
vessel
b) Elephantiasis – Hypertrophy of the
affected part.
23.
24. # Occult filariasis:
This is a condition in which
there is massive eosinophilia (30-80%),
hepatosplenomegaly, generalised
lymphadenopathy and pulmonary symptoms.
- Microfilariae are not found in the peripheral
blood as they are destroyed in the tissue.
25. Filarial fever: Rise of temperature
ranging from 103o C – 1040 C which may
continue for several days. (usually 3-5 days)
Hydrocele : Recurrent attacks of
Wuchererial Orchitis and Epididymitis
predispose to the occurrence of hydrocele
and this condition may exist with or without
elephantiasis of the scrotum.
26.
27. Chyluria: Escapes of chyle through urine due
to rupture of varicose chyle vessel through
the mucous membrane of urinary tract.
It is milk white in colour.
It contains fat particles, albumin and
fibrinogen.
Elephantiasis: The affected part becomes
enormously enlarged producing a tumour like
solidity. This the end result of Wuchereria
infection and usually follows years of
continuous infection.
28.
29. Samples:
Blood (at night or day time,
according to the periodicity of
microfilariae)
Urine
Hydrocele fluid
Biopsied tissue material.
30. 1. Detection of Microfilariae in blood :
It is done by thin and thick smears, stained
by Giemsa/ hematoxylin stain.
Blood samples should be collected at mid
night where there is nocturnal periodicity of
microfilariae.
2. Detection of microfilariae in urine:
It is done by wet preparation and fixed
stained smear preparation of centrifuged
deposit.
31. 3. Detection of adult worms in biopsied
tissue:
Microfilariae are not present in peripheral
blood under the following condition,
elephantitis.
4. Serological methods:
These include ELISA, CFT, IFA.
Immunochromatographic card test (ICT) are
now available for the detection of adult worm
infection. The specificity of these test is
about 99%.
32. Polymerase chain reaction (PCR):
- It can detect filarial DNA in the patient blood.
- The test is positive only when microfilariae are
present in peripheral blood. Hence the test is
negative in chronic filariasis.
X-ray examination shows
calcified adult worms.
33. DEC (Diethylcarbamazine)
is the drug of choice.
It is given orally in a dose of
6mg/kg body weight daily for a
period of 12days.
It kills microfilariae.
34. Protection against mosquito bites.
Control of vectors by spraying insectisides
such as DDT, malathion etc on to common
resting sites.
Treatment of cases and carriers.
Improvement in sanitary condition.