Helminths, also known as parasitic worms, are multicellular eukaryotic parasites that live in and feed on living hosts. They include nematodes (roundworms), cestodes (tapeworms), trematodes (flukes), and monogeneans. Trematodes have two suckers, an oral and ventral sucker, and a simple digestive system without an anus. They reproduce through an intermediate host, often a snail, and then a definitive host, where they can cause disease. One example is Fasciola hepatica, the sheep liver fluke, which uses a snail and water plants as intermediate hosts before infecting the liver of mammals like sheep, cattle, and humans
Hookworm is one of the most important small intestinal nematodes causing iron deficiency anemia. This PPT illustrates hookworms associated with human diseases, life cycle, pathogenesis, laboratory diagnosis, treatment and prevention of hookworm infection.
Helminthology is such an important topic not only in India but worldwide. Here is an introduction to the medically important parasites causing diseases to man.
Hookworm is one of the most important small intestinal nematodes causing iron deficiency anemia. This PPT illustrates hookworms associated with human diseases, life cycle, pathogenesis, laboratory diagnosis, treatment and prevention of hookworm infection.
Helminthology is such an important topic not only in India but worldwide. Here is an introduction to the medically important parasites causing diseases to man.
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
This is a series of lectures on microbiology useful for undergraduate medical and paramedical students.. This lecture is a comprehensive coverage of all parasites, protozoa and helminths...
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
This is a series of lectures on microbiology useful for undergraduate medical and paramedical students.. This lecture is a comprehensive coverage of all parasites, protozoa and helminths...
prevalence of fasciola hepatica in domesticated animal and its control and pr...manojj123
Fasciola hepatica also called (Liver fluke) is a parasitic disease caused by infection of trematode belongs to genus (F. hepatica, F. gigentica). Fasciola hepatica is distributed worldwide and cause great economic loss in livestock sector. Infected animal become anemic and loss of significant amount of weight.
What is fascioliasis?
In what parts of the world if fascioliasis found?
How do people get infected with fascioliasis?
What are the signs and symptoms of Fasciola infection, and when do they begin?
How is Fasciola infection diagnosed?
Can Fascioliasis be treated?
How can fasciola infection be prevented?
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
3. (4)
Turbellaria
Helminthes
Are eukaryotic multicellular parasites living in and feeding on
living hosts, receiving nourishment and protection while disrupting
their hosts' nutrient absorption, causing weakness and disease.
(2)
Cestodes (tapeworms)
Roundworms
(3)
Trematodes (flukes)
Flatworms (Platyhelminthes)
(1)
Nematodes
Helminthes
(3)
Monogeneans
3Souzan Eassa
4. • Phylum Platyhelminthes
1- Class Cestoda (Tape worms)
2- Class Trematoda (Flukes or Flat worms)
• Phylum Nemathelminths
Class Nematoda (round worms)
4Souzan Eassa
6. There are about 9000 species of
trematodes all of which are parasitic. Most
Trematodes are parasites of vertebrates.
Trematods are multicellular eukaryotic
helminths unsegmented dorso-ventrally
flattened.
Most adult are bilaterally symmetric,
leaf-shaped or tongue-like and covered
with a cuticle (tegument).
The tegument may be smooth or spiny
and protects the parasite against its host
(e.g. against digestive enzymes).
General Morphology
6Souzan Eassa
7. Digestive tract
Have two suckers, an oral and a
ventral sucker.
Oral cavity leads to muscular
esophagus.
Intestine branches into
two cecae, which end
blindly near the
posterior end of the
worm.
Simple digestive
system, which is no
anus - waste
products are
regurgitated. 7Souzan Eassa
8. Reproductive system
Most are hermaphroditic and
capable of self-fertilization
except for schistosomes
(diecious).
Uterus is the largest organ and
they have a single ovary.
Dendritic testes.
a series of glandular structures
that produce egg shell
materials.
Uterus may be filled with
thousands of eggs.
8Souzan Eassa
9. General Reproducing
A snail is the first (or intermediate)
host and a vertebrate (include
human) the final (or definitive
host).
In some species there may be 2
or 3 intermediate hosts before the
definitive host is reached.
A series of generations occurs in
the intermediate host, resulting in
the liberation of larvae known as
cercariae,
1.free swimming larvae
2.given off by infected snail
3.penetrate the skin of the
human definitive host
9Souzan Eassa
10. Liver/ Lung:
• Fasciola hepatica
Blood:
• Schistosoma Spp.
mansoni
haematobium
• japonicum
Intestinal:
• Fasciolopsis buski
Trematodes (Flukes) of Human being
10Souzan Eassa
13. Fasciola hepatica
Fasciola hepatica, is the largest
flukes in the world, also known as
the common liver fluke or sheep
liver fluke.
Infects liver of various
mammals, including humans.
The disease caused by the fluke
is called fascioliasis.
F. hepatica is world-wide
distributed and causes great
economic losses in sheep and
cattle.
13Souzan Eassa
15. Fasciola hepatica
The adult (30mm-13mm), leaf
shape with anterior end being
broader than the posterior end and
has cone shaped projection.
he intestinal ceca are highly
dendritic and extend to near the
posterior end of the body.
Two sucker the oral and ventral.
The ovary and tests are highly
branched.
The eggs of Fasciola hepatica are
operculated and average 140 um-
7um
Egg and egg capsule with emerging miracidium
of Fasciola hepatica. 400x
15Souzan Eassa
16. People become infected
with Fasciolopsis when they
eat raw or undercooked
aquatic plants that have the
organism (metacercariae)
encysted on them.
Intermediate host is snail.
The final host is mammalian
mostly human, sheep and
cattle.
A form of infection known
as halzoun that is specific
to Middle East in
contracted by eating the
raw liver of infected animal
Fasciola hepatica
16Souzan Eassa
18. F. hepatica requires an aquatic snail as an intermediate host such as
Galba truncatula, in which the parasite can reproduce asexually.
From the snail, minute cercariae emerge and swim through pools of
water in pasture, and encyst as metacercariae on nearby vegetation.
From here, the metacercariae are ingested by the ruminant, or in some
cases, by humans eating un-cooked foods such as water-cress.
Contact with low pH in the stomach causes the early immature juvenile
to begin the process of excysment .
In the duodenum, the parasite breaks free of the metacercariae and
burrows through the intestinal lining into the peritoneal cavity.
The newly excysted juvenile does not feed at this stage, but once it finds
the liver parenchyma after a period of days, feeding will start.
This immature stage in the liver tissue is the pathogenic stage, causing
anaemia and clinical signs sometimes observed in infected animals.
The parasite browses on liver tissue for a period of up to 5-6 weeks and
eventually finds its way to the bile duct where it matures into an adult
and begins to produce eggs.
Up to 25,000 eggs per day per fluke can be produced, and in a light
infection, up to 500,000 eggs per day can be deposited onto pasture by a
single sheep.
Life cycle
18Souzan Eassa
19. Four Symptomatic Patterns
1. Acute Phase
2. Chronic Phase
3. Halzoun
4. Ectopic Infection
Acute Phase
Rarely seen in humans
Fever, tender hepatomegaly, and abdominal pain are
frequent symptoms.
Vomiting, diarrhea, and anemia may also be present 19Souzan Eassa
20. Chronic Phase
More common in human
population.
Symptoms include: bilary cholic,
abdominal pain, tender
hepatomegaly, and jaundice.
In children: severe anemia is
common.
Inflammation of the bile ducts
eventually leads to fibrosis and a
condition called “pipestem liver”.
Severe infections can lead to
death 20Souzan Eassa
21. Halzoun & Ectopic Infection
Occurs when an
individual consumes
infected raw liver.
The adult worms can
cause considerable pain,
edema, and bleeding that
can interfere with
respiration.
Adults can live in biliary
ducts and cause
symptoms for up to 10
years.
In frequent, but can occur
in peritoneal cavity,
intestinal wall, lungs,
subcutaneous tissue, and
very rarely in other
locations.
21Souzan Eassa
22. Diagnostic Tests
After 4 months of
infection: direct
examination F. hepatica
eggs in a stool sample.
Prior to 4 months:
serological tests can be
used.
Ultrasound can be
used to visualize adult
flukes in the bile ducts.
22Souzan Eassa
23. Treatment
Bithionol for 5-10 day course
of oral at 30mg/kg body
weight.
Along with pharmaceutical
therapy, surgery may be
necessary in very extreme
cases to clear the biliary tract
23Souzan Eassa
24. Molluscicides (pesticides against molluscs ):
application of malluscicides to decrease the population
of Lymnaea snails.
Avoiding ingestion of raw watercress grown in endemic
areas.
Avoid eat raw or uncooked liver
Prevention
24Souzan Eassa