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Influenza, Parainfluenza & RSV Dr Kamran Afzal Asst Prof Microbiology
Influenza
Influenza Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Influenza A Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure ,[object Object],[object Object],[object Object],[object Object],[object Object]
Virus Replication ,[object Object],[object Object],[object Object],[object Object],[object Object]
Virus Reservoirs ,[object Object],[object Object]
Antigenic Drift ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antigenic  Sh ift ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Where do “new” HA and NA come from? Nicholson KG et al. Lancet. 2003;362:1733-45
Why do we not have influenza B pandemics?  ,[object Object],[object Object]
Novel Influenza A (H1N1) 2009 Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Influenza
Influenza Pandemics in the Past ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Influenza: A Viral infection ,[object Object],[object Object],[object Object],[object Object]
Transmission ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Case Definition - Influenza ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pulmonary Complications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Non-pulmonary Complications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Reye’s syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mortality ,[object Object],[object Object],[object Object],[object Object]
Lab Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment Considerations ,[object Object],[object Object],[object Object],[object Object],[object Object]
Use of Antibiotics ,[object Object],[object Object]
Antiviral Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Infection control-Individual level ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vaccine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Parainfluenza
HPIV ,[object Object],[object Object],[object Object]
Clinical Features ,[object Object],[object Object],[object Object],[object Object]
Lab Diagnosis ,[object Object],[object Object],[object Object]
Respiratory Syncytial Virus
RSV ,[object Object],[object Object]
Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lab Diagnosis ,[object Object],[object Object],[object Object]
Prevention
 
Orthomyxoviruses Types A, B, C :  NP ,  M1  protein  Sub-types:  HA  or  NA  protein M1 protein helical nucleocapsid (RNA plus  NP protein)  HA - hemagglutinin  polymerase complex lipid bilayer membrane  NA - neuraminidase

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Influenza a b