The hypothalamus is a small brain structure located below the thalamus that regulates many homeostatic functions including body temperature, hunger and thirst, circadian rhythms, hormone secretion, and the autonomic nervous system. It contains several nuclei that control these functions. The hypothalamus receives input from the limbic system and senses changes in the body to regulate the autonomic nervous system and pituitary gland to maintain homeostasis. Disorders of the hypothalamus can disrupt functions like sleep, emotions, temperature regulation, and hormone secretion.
The thalamus is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex and the regulation of consciousness, sleep, and alertness.
Describes the structure and functions of hypothalamus along with their clinical relevance. The physiological basis of hypothalamic regulations and functions are also described.
the ddep structure of brain, diencephalon, third ventricle, thalamus, hypothalamus, epithalamus, meta thalamus, boudaries of diencephalon, extent of diencephalon, boundaries of thalamus, boundaries of hypothalamus, functions of meta thalamus, functions of sub thalamus.components of epithalamus, functions of epithalamus, fornix, third ventricle, optic chiasma,
The thalamus is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex and the regulation of consciousness, sleep, and alertness.
Describes the structure and functions of hypothalamus along with their clinical relevance. The physiological basis of hypothalamic regulations and functions are also described.
the ddep structure of brain, diencephalon, third ventricle, thalamus, hypothalamus, epithalamus, meta thalamus, boudaries of diencephalon, extent of diencephalon, boundaries of thalamus, boundaries of hypothalamus, functions of meta thalamus, functions of sub thalamus.components of epithalamus, functions of epithalamus, fornix, third ventricle, optic chiasma,
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
5. Hypothalamus is
described as “The Head
ganglion of the autonomic
nervous system” by
“Sherrington”.
Stimulation of the
hypothalamus produces
autonomic response.
It is a small bilateral
structure extends from the
region of the optic chiasma to
the caudal border of the
mammillary bodies
6. It lies below the Thalamus
Forms the floor and inferior part of the lateral
walls of the 3rd ventricle.
It is an integrative centre for
regulation of cardiovascular system,
body temperature,
food and water intake and
endocrine secretion.
HT is only 0.3% of brain weight.(10 gms)
7. Hypothalamic Nuclei
It is typically divided into 4 regions from
rostral to caudal
Pre optic area
Supra optic area (anterior)
Tuberal area (middle )
Mamillary area ( posterior)
27. Functions of hypothalamus
Autonomic system
Food intake
Temperature
Thirst – Fluid regulation
Endocrine
Reproduction
Sleep and wakefulness
Emotion
Stress
Circadian rhythm
Visceral function
Somatic
Reward & Punishment
28. 1.Hypothalamic Control of the
Anterior Pituitary
Hormonal control rather than
neural.
Hypothalamic neurons
synthesize releasing and
inhibiting hormones.
Hormones are transported to
axon endings of median
eminence.
Hormones secreted into the
hypothalamo-hypophyseal
portal system regulate the
secretions of the anterior
pituitary
34. 3. Hypothalamic Control of the Autonomic
Nervous System
Descending projections from HT to autonomic
centers:
Paraventricular nuclei → via medial forebrain
bundle → to dorsolateral brainstem &
periaqueductal gray area
to parasympathetic & sympathetic
preganglionic neurons.
Controls CVS, GIT, Excretion, Respiration
and Reproduction
35. Other brainstem nuclei are also origins of descending
pathways controlling autonomic centers:
- Nucleus solitarius,
- noradrenergic nuclei (locus coeruleus),
- raphe nuclei,
-pontomedullary reticular formation
Inputs to HT that affect autonomic function
come mostly from the amygdala and limbic
cortex.
38. 4. Hypothalamic – Limbic Pathways
Amygdala has reciprocal connections with HT
via two pathways:
-Stria terminalis
-Ventral amygdalo fugal pathway
-participation in the eloboration of emotional
behavior, and experience of emotion.
Limbic – hypothalamic interconnections explain
why emotional behavior is often accompanied by
autonomic activation:
eg: -blushing when embarassed
-sweaty palms & dry mouth when anxious or
afraid
- HT functions in sexual desire / sex
preference
39. 5. Control of Hunger & Feeding
Feeding centre - Lateral hypothalamus
Stimulation increases the appetite
Lesion in this Nucleus makes the animal to starve and
cechaxic
Satiety centre – Ventromedial Nucleus
Stimulation suppresses appetite by inhibiting Lateral
nucleus
Lesion makes the animal to become Obese due to
voracious appetite –”Hypothalamic Obesity”
Both centres were described by B.K.Anand &
J.R.Brobeck
41. Hypothalamus and body weight
regulation:
Satiety
center
Electrolytic lesions:
Ventromedial nucleus (VMN)
Hyperphagia
Lateral hypothalamic area
(LHA)
Hunger
Anorexia
47. Mechanism
Hypothalamus regulates the setpoint for body
weight rather than food intake.
1.Glucostat Hypothesis:
Glucostat cells inside the satiety centre are
stimulated by ↑ blood glocose level
Satiety centre inhibits feeding centre →
↓ appetite → ↓ blood glucose
Satiety centre is depressed by ↓ blood
glucose level → feeding centre is activated
→
↑ appetite → ↑ blood glucose.
48. In Diabetes Mellitus Ventro Medial Nucleus
(VMN) is deprived of glucose due to the
deficiency of Insulin → ↑ activity of Feeding
centre → Hyperphagia
In lesions of Amygdala – moderate
hyperphagia for adulterated ,tainted food
49. Experimental Evidence in Rats
100
100
100100
0
200
0
100
200
0 3 6 9 0 3 96 0 3 6 9
F
o
o
d
Int-
-ake
%
Body
W
e
i
g
h
T
%
(a) (b) ( c )
Time ( weeks )
( a ) Force fed
( b ) Partially
Starved
( c ) Lesion made
At
Bilateral
Ventromedial
&
allowed for
free food
50. 2.Aminostatic Hypothesis
Food in the GIT releases polypeptides which
inhibit the food intake by acting on the
Hypothalamus (Gut peptide Hypothesis)
GI Hormones like CCK , GRP ,Glucagon, &
Somatostatin inhibit the food intake
Injection of CCK into the Hypothalamus
inhibit the food intake
51. 3.Lipostatic Hypothesis
Increased level of Fatty acids & Ketoacids also
act like glucose
Protein hormone LEPTIN is produced by fatty
tissues proportionate to the amount of Adipose
tissues in the body, acts on the Hypothalamus
& inhibits the food intake ( feed back
mechanism in obesity)
53. 4.Thermostatic Hypothesis
The thermostatic SET POINT in the
Hypothalamus may also be involved in the
regulation food intake
Appetite is increased by fall in the temperature
below the set point, & supressed when it rises
above the set point.
54. Modulators of feeding behavior
Name Site of production Effect
1. a-MSH Hypothalamus Inhibition
2 .Cocaine-
amphetamine-
Regulated
transcript (CART) Hypothalamus Inhibition
3. Leptin Adipose tissue Inhibition
56. 6. Regulation of Body temperature
Anterior HT detects increased body temp and
activates systems of heat dissipation ,like
vasodilation, sweating, & panting
Lesion here causes hyperthermia.
Posterior HT functions to conserve heat, by
vasoconstriction,& shivering heat gain
Lesions here cause poikilothermia, where body temp
matches environment temp.
Preoptic region acts as Thermostat while Post HT
nuclei correct any deviation in the thermostat
57. Pre optic region
warm cold
•Panting
•Sweating
•vasodilation
•Vasoconstriction
•Piloerection
•shivering
58. Temperature
Body temp
Cold receptor
Heat conservation
(Thermostat on)
Posterior hypo
Seratonergic
pathway
Body temp
Warm receptor
Thermostat off
Anterior hypo
Adrenergic pathway
59. 7. Control of Water intake & Thirst
By two mechamisms:
1.Osmoreceptors in the Supraoptic N are
sensitive to osmolarity changes of plasma &
ECF.
Excess water loss, & dehydration, causes an
in osmolarity of ECF stimulates osmo
receptors release ADH water
reabsorption normal osmolarity of ECF
Excess water intake osmoreceptors
ADH
60. 2.By thirst mechanism
A thirst centre is in the Lateral
Hypothalamus- stimulated by intracellular
dehydration – causes water drinking
Increase in plasma osmolarity, decrease in
ECF volume, Haemorrhage, Angiotensin II &
dryness of mouth promote water drinking &
thirst mechanism thus maintains water balance
63. 8. Functions of Selected Regions of
Hypothalamus
Suprachiasmatic nucleus regulates circadian
rhythms, biological clock
GABA neurons in ventral part of lateral
preoptic area function in non REM
sleep by inhibiting histamine neurons in tubero
mammillary nucleus.
71. 13.Circadian rhythm
In animal and in humans certain body functions
are tuned to the day & night cycle. These
fluctuation are referred to as diurnal or circadian
rhythm,which is mediated through retino –
hypothalamo – pineal system.
Example:
Cortisol secretion
Body temperature
ACTH secretion
Sleep and wakefulness
78. Disorders of Hypothalamus
Function affected
Sleep-lesion-Mammil.body
Emotional disturbances due
to Lesion in VMN & Post
lat N
Autonomic disturbances
Body temperature
disturbances
Endocrine-Hypogonadism,
hypothyroidism
Disturbances in water
balance
Sexual disfunction
Disturbance seen
Disorders of sleep-Narcolepsy
“Sham rage”
Diabetes Insipidus
Lesion in midhypothalamus