Hypernatremia is a serum sodium level over 145 mEq/L, occurring in 1% of hospitalized patients with high mortality regardless of acute or chronic onset. It can be caused by hypovolemia due to fluid losses exceeding intake, euvolemia from excess skin and lung losses, or hypervolemia from concentrated saline or mineralocorticoid excess. Symptoms include GI issues, dry skin and mucosa, neurologic changes like restlessness and seizures, and cardiovascular abnormalities depending on volume status. Treatment involves gradually decreasing sodium levels with hypotonic fluids and restricting dietary sodium intake.
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Chronic kidney disease (CKD) means your kidneys are damaged and can't filter blood the way they should. The disease is called “chronic” because the damage to your kidneys happens slowly over a long period of time.
Chronic kidney disease (CKD) consists of a spectrum of different pathophysiologic processes associated with abnormal kidney function, and a progressive decline in glomerular filtration rate (GFR).
Chronic kidney disease (CKD) means your kidneys are damaged and can't filter blood the way they should. The disease is called “chronic” because the damage to your kidneys happens slowly over a long period of time.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Triangles of Neck and Clinical Correlation by Dr. RIG.pptx
Hypernatremia
1.
2. Hypernatremia is a serum sodium level over 145 mEq/L.
It occurs in approx. 1% of hospitalized patients and
carries a high mortality rate regardless of whether it
has acute or chronic onset.
CAUSES:-
1) Hypovolemic hypernatremia:- Renal losses, osmotic
diuresis, severe hyperglycemia, extrarenal losses,
profuse diaphoresis, decreased thirst, diarrhea
occuring with inadequate volume replacement or fluid
replacement with hyperosmolar solutions.
3. 2) Euvolemic hypervolemia:- Excess fluid losses from the
skin and lungs. Hypodipsia in the elderly and infants.
Diabetes insipidus.
3) Hypervolemic hypernatremia:- Administration of
concerned saline solutions. Hypertonic feedings,
excess mineralocorticoids. Accidental or intentional
salt ingestions, commertiallly prepared soups and
canned vegetables.
4. CLINICAL MANIFESTATIONS:-
GI:- Anorexia, nausea, vomitting.
Integumentary:- Skin dry and flushed, mucus
membrane dry and rough, body temperature elevated.
Neurologic:- Restlessness, agitation, irritability,
lethargy, stupor, coma, Muscle twiching, tremor, hyper
reflexia, seizures, rigid paralysis in late stages.
Cardiovascular:- Tachycardia, hypotension or
hypertension, erratic heart rate and blood pressure
dependent on fluid status.
5. Renal:- Oliguria, dark and concentrated.
PATHOPHYSIOLOGIC BASIS:-
Fluid retension in gastric cells
↓
Decrease of interstitial fluid in tissues
↓
Less interstitial fluids to cool body by evaporation
↓
Neurologic symptoms are the result of cerebral cellular
dehydration
6. ↓
Neuromuscular irritability
↓
Blood pressure relative to the type of hypernatremia. If
hypovolemic, pressure will be decreased. If hypervolemic,
pressure will be increased
↓
Myocardial depression as sodium ions compete with
calcium ions in slow channels of heart
7. ↓
Compensatory mechanism
LABORATORY FINDINGS:-
- Hypernatremia is present when serum sodium level is
>145mEq/L.
- Sodium is major solute of fluid concentration,
hypernatremia increases serum osmilality.
MEDICAL MANAGEMENT:-
To decrease the total body sodium and replace fluid loss,
8. Either a hypo-osmolar electrolyte solution (0.2% or
0.45% NaCl) or D5W is administered. These solutions
will not cause considerable dilution of body sodium,
instead the serum sodium level will be gradually
decreased. D5W, when administered cntinuously, is
considered to be a hypo-osmolar solution because the
dextrose is metabolised quickly and only water
remains. When 5% dextrose solutions are given, they
must be given slowly to prevent osmotic diuresis,
which aggravates the hypertonic state.
9. Normal saline is used for volume depleted patient to
provide fluid resuscitation. The saline is hypotonic in
comparison with the serum and, therefore, allows the
sodium level to decrease slowly. If the serum sodium
level is lowered too rapidly, fluid will shift from
vascular space into cerebral cells, causing cerebral
edema. Water replacement should be administered to
reduce serum sodium levels not more than 2
mEq/L/hour for the first 48 hours.
10. PHARMACOLOGIC MANGEMENT
Hypernatremia caused by sodium excess can be treated
with D5W and a diuretic such as Frusemide.
DIETARY MANAGEMENT:-
- Restricted sodium in diet.
- Patients with renal disease may need to have sodium
intake resticted to 500-2000mg/day.
- Fluids should be restricted.
11. NURSING MANAGEMENT
Nursing diagnosis(1):- Hypernatremia r/t decreased
thirst or excessive administration of salt solutions or
impaired secretion of sodium and water.
Planning:- The nurse will monitor the patient for
response to IV fluids replacement of hypoosmolar
electrolyte solutions, absence of signs and symptoms
of hypernatremia and return of normal sodium level.
Implementation:- Water and fluids should be offered
frequently to elderly and to patients with debilitating
diseases in order to prevent body fluid loss and
12. hypernatremia.
- Increased fluid intake inpatients with congestive heart
failure or severe rennal disease is usually
contraindicated.
- The nurse should encourage patients to drink
decaffeinated fluids and to avoid alcohol.
- Caffeinated fluids and alcohol increase fluid loss,
which can result in an increase in serum sodium level.
- Overconsumption of fruit juices can also increase fluid
13. Loss
- Depending on client’s condition, vital signs should be
assessed every 8 hours. Intake and output should be
assessed daily.
- The nurse should monitor changes in serum sodium,
serum osmolality and symptoms of hypernatremia.
- Detection of early symptoms of altered mental status
(agitation, irritability, confusion) can prevent the
progression of hypernatremia.
- Seizure precautions should be initiated.
14. - Fluid replacement with or without sodium should be
closely monitored by the nurse.olume of oral secretion
- Nursing diagnosis(2):- Oral mucus membranes,
altered r/t inadequate volume of oral secretions.
- Planning:- Patient will have improved condition of
oral mucus membrane, as evidenced by moist and
intact oral mucus membranes, increased oral mucus
membrane score on assessment tool, report on no oral
discomfort, and ability to consume fluids without
pain.
15. Implementation:-
- The patient should be offered oral oral care every 2
hours with a non alcoholic mouth wash.
- Lemon glycerin swabs should also be avoided because
they dry the membranes and may cause pain.
- A soft tooth brush should be used to prevent injury to
mucosa.
- Lips should be moistened with a water soluble
lubricant. Cool, non acidic fluids such as apple juice
are generally tolerated.