5-HT1AR, which is expressed on granule cells in the dentate gyrus (DG) of the hippocampus. Activation of 5-HT1AR inhibits adenylyl cyclase (AC) and promotes neurogenesis in the DG.
The document discusses the hippocampus and serotonin receptors. It covers characteristics of the raphe nuclei which are clusters of serotonin-containing neurons located in the brainstem. These nuclei, including the dorsal and median raphe nuclei, project to various brain regions including the hippocampus. The document then reviews serotonin receptor subtypes and their signal transduction pathways. It also discusses how malfunctions in hippocampal neurogenesis may contribute to depression, and how serotonin projections from the raphe nuclei innervate the hippocampus.
Neurotransmitters- serotonin & dopamine by dr. rujul modiRujul Modi
This document provides information about neurotransmitters, focusing on dopamine and serotonin. It defines neurotransmitters and lists the key processes involved in their action. It classifies neurotransmitters and describes the biogenic amines dopamine and serotonin in detail. For each neurotransmitter, it discusses their synthesis, pathways in the brain, receptors, and roles in psychiatry. The document aims to comprehensively summarize the current understanding of dopamine and serotonin neurotransmission.
The patient is presenting with symptoms consistent with migraine including severe unilateral headache, nausea, and flashing lights. The probable diagnosis is migraine. For acute treatment, medications like NSAIDs, triptans like sumatriptan, and ergot alkaloids like ergotamine may be used. Prophylactic treatments include beta blockers, TCAs, calcium channel blockers, and anticonvulsants.
role of neurotransmitters in neuropsychriatric diseases Deepa Devkota
This document discusses the role of neurotransmitters in neuropsychiatric disorders. It begins by defining neuropsychiatry and describing common neuropsychiatric symptoms. It then focuses on two specific neurotransmitters - acetylcholine and serotonin. For acetylcholine, it describes its role in Alzheimer's disease, the stages of Alzheimer's, and treatments. For serotonin, it discusses its role in depression, migraine, biosynthesis, receptors, and treatments for depression.
Serotonin is a neurotransmitter that plays an important role in many physiological and psychological functions. It is synthesized from tryptophan and transported into presynaptic neurons by VMAT2. After release, it is terminated by reuptake via SERT or degradation by MAO and ALDH. Serotonin receptors are located throughout the brain and body. Serotonin is implicated in various psychiatric conditions like depression, anxiety, OCD, schizophrenia, and personality disorders. Drugs that affect serotonin levels, like SSRIs, SNRIs, TCAs, and MAOIs, are used to treat many of these disorders.
Serotonin is a monoamine neurotransmitter synthesized from tryptophan. It is found primarily in enterochromaffin cells in the GI tract, platelets, and the central nervous system. Serotonin acts through multiple receptor subtypes and has diverse physiological effects including regulation of mood, appetite, sleep, cognition, cardiovascular function, platelet aggregation, and intestinal motility. Imbalances in the serotonin system have been implicated in psychiatric conditions like depression and anxiety. Drugs that affect serotonin synthesis, reuptake, and receptor activity are used to treat mood disorders, migraine, nausea/vomiting, and other clinical conditions.
Serotonin receptors, also known as 5-hydroxytryptamine receptors, are found in the gastrointestinal tract, platelets, and central nervous system. There are 7 main classes of serotonin receptors (5-HT1 to 5-HT7) with multiple subtypes. The receptors have various functions like regulating mood, appetite, sleep, intestinal movements, vasoconstriction, and hemostasis. The biosynthesis of serotonin begins with the amino acid tryptophan being converted into 5-hydroxytryptamine in serotonergic neurons. Future research aims to better understand the specific roles of the different serotonin receptor subtypes to help develop more targeted drugs.
This is an overview of drugs used to treat migraine with an emphasis on serotonergic drugs. This presentation was for 2nd year pharmacy students as part of a pharmacology & toxicology course and accompanies Goodman & Gilman's (12e) chapter 46. A bit of general background on 5-HT is also included.
The document discusses the hippocampus and serotonin receptors. It covers characteristics of the raphe nuclei which are clusters of serotonin-containing neurons located in the brainstem. These nuclei, including the dorsal and median raphe nuclei, project to various brain regions including the hippocampus. The document then reviews serotonin receptor subtypes and their signal transduction pathways. It also discusses how malfunctions in hippocampal neurogenesis may contribute to depression, and how serotonin projections from the raphe nuclei innervate the hippocampus.
Neurotransmitters- serotonin & dopamine by dr. rujul modiRujul Modi
This document provides information about neurotransmitters, focusing on dopamine and serotonin. It defines neurotransmitters and lists the key processes involved in their action. It classifies neurotransmitters and describes the biogenic amines dopamine and serotonin in detail. For each neurotransmitter, it discusses their synthesis, pathways in the brain, receptors, and roles in psychiatry. The document aims to comprehensively summarize the current understanding of dopamine and serotonin neurotransmission.
The patient is presenting with symptoms consistent with migraine including severe unilateral headache, nausea, and flashing lights. The probable diagnosis is migraine. For acute treatment, medications like NSAIDs, triptans like sumatriptan, and ergot alkaloids like ergotamine may be used. Prophylactic treatments include beta blockers, TCAs, calcium channel blockers, and anticonvulsants.
role of neurotransmitters in neuropsychriatric diseases Deepa Devkota
This document discusses the role of neurotransmitters in neuropsychiatric disorders. It begins by defining neuropsychiatry and describing common neuropsychiatric symptoms. It then focuses on two specific neurotransmitters - acetylcholine and serotonin. For acetylcholine, it describes its role in Alzheimer's disease, the stages of Alzheimer's, and treatments. For serotonin, it discusses its role in depression, migraine, biosynthesis, receptors, and treatments for depression.
Serotonin is a neurotransmitter that plays an important role in many physiological and psychological functions. It is synthesized from tryptophan and transported into presynaptic neurons by VMAT2. After release, it is terminated by reuptake via SERT or degradation by MAO and ALDH. Serotonin receptors are located throughout the brain and body. Serotonin is implicated in various psychiatric conditions like depression, anxiety, OCD, schizophrenia, and personality disorders. Drugs that affect serotonin levels, like SSRIs, SNRIs, TCAs, and MAOIs, are used to treat many of these disorders.
Serotonin is a monoamine neurotransmitter synthesized from tryptophan. It is found primarily in enterochromaffin cells in the GI tract, platelets, and the central nervous system. Serotonin acts through multiple receptor subtypes and has diverse physiological effects including regulation of mood, appetite, sleep, cognition, cardiovascular function, platelet aggregation, and intestinal motility. Imbalances in the serotonin system have been implicated in psychiatric conditions like depression and anxiety. Drugs that affect serotonin synthesis, reuptake, and receptor activity are used to treat mood disorders, migraine, nausea/vomiting, and other clinical conditions.
Serotonin receptors, also known as 5-hydroxytryptamine receptors, are found in the gastrointestinal tract, platelets, and central nervous system. There are 7 main classes of serotonin receptors (5-HT1 to 5-HT7) with multiple subtypes. The receptors have various functions like regulating mood, appetite, sleep, intestinal movements, vasoconstriction, and hemostasis. The biosynthesis of serotonin begins with the amino acid tryptophan being converted into 5-hydroxytryptamine in serotonergic neurons. Future research aims to better understand the specific roles of the different serotonin receptor subtypes to help develop more targeted drugs.
This is an overview of drugs used to treat migraine with an emphasis on serotonergic drugs. This presentation was for 2nd year pharmacy students as part of a pharmacology & toxicology course and accompanies Goodman & Gilman's (12e) chapter 46. A bit of general background on 5-HT is also included.
The document discusses serotonin (5-HT) as a neurotransmitter. It notes that serotonin is synthesized from tryptophan and is found in highest concentrations in the gastrointestinal mucosa, with lower concentrations in platelets and the central nervous system. In the brain, serotonin-producing neurons are located in the raphe nucleus and their projections extend to areas like the cortex, hippocampus, and basal ganglia. The document outlines serotonin's role in various behaviors and functions like mood regulation, sleep, and cognition. It also describes serotonin receptor subtypes and their mechanisms of action.