Serotonin is a neurotransmitter synthesized from tryptophan. It activates G protein-coupled serotonin receptors and ligand-gated ion channels. Serotonin is involved in various physiological processes like respiration, gastrointestinal motility, cardiovascular function, and central nervous system functions such as mood, sleep, and pain perception. Migraine is a neurological disease characterized by recurrent moderate to severe headaches. Treatment involves acute medications for mild attacks and prophylactic drugs like beta-blockers for more frequent attacks.