This document discusses heterocyclic compounds and their biological significance. It summarizes key points about pyridine, pyrimidine, purines, quinine, pteridines, and isoalloxazine. These compounds play important roles in biological processes as components of coenzymes, vitamins, and metabolites involved in cellular metabolism and energy production. Many also have therapeutic applications such as in treating malaria, cancer, microbial infections, and hyperthyroidism.
This slide discusses about basic indole nucleus, its chemistry, synthesis, reactions and medicinal uses of Indolyl derivatives..Indole is basically fused heterocyclic compound
This document discusses the properties and synthesis of pyrrole. Pyrrole is a colorless liquid that is weakly basic and more reactive than benzene. It undergoes electrophilic substitution reactions like halogenation and nitration. Pyrrole can be synthesized through several methods, including from furan over an alumina catalyst, from succinaldehyde and ammonia in a condensation reaction, and by passing acetylene and ammonia through a hot tube. Pyrrole has medicinal uses including in cardiac medications and as an antibacterial, antipsychotic, and anticancer agent.
Imidazole is an organic compound with the formula C3H4N2. It was first reported in 1858 and is an aromatic heterocycle that is classified as an alkaloid. The imidazole ring is present in important biological molecules like histidine and histamine. Many drugs contain imidazoles, such as antifungal, antiulcer, and antimicrobial agents. Imidazole has applications as an acid, a base, and in organic synthesis. It exhibits various pharmacological activities including antifungal, anti-inflammatory, antitubercular, and anticancer effects.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are volatile essential oils found in many plants and flowers which give them their distinctive fragrances. There are many different classes of terpenoids classified based on the number of isoprene units they contain, such as monoterpenoids, sesquiterpenoids, and diterpenoids. Common terpenoids include limonene, menthol, and camphor. Spectroscopic techniques such as UV, IR, NMR and mass spectrometry are used to determine terpenoid structures and functional groups.
Pyrimidine is a heterocycle that is the building block of many natural compounds including those found in RNA, DNA, antibiotics, and vitamins. It is resistant to electrophilic substitution reactions due to the electron deficient nature of its 2, 4, 6 positions. However, reactions can occur at the 5 position if an electron donating group is present. Pyrimidine undergoes nucleophilic addition reactions easily at its 2, 4, 6 positions and with oxidizing agents can form pyridine N-oxides, especially if an alkyl group is present. It is also synthesized through reactions with malonic esters, amidines, and from dichloropyrimidines. Many anticancer and antiviral
Triterpenes are classified based on the number of isoprene units they contain. Squalene is a 30-carbon triterpene containing six double bonds. Its structure was elucidated through reactions showing the presence of double bonds and the absence of conjugated double bonds. Oxidation and ozonolysis reactions provided further insight into its structure. Carotenoids are tetraterpenoids containing 9-11 double bonds that may terminate in rings. Alpha and beta carotene are prominent carotenoids, with beta carotene being the most well-known and a provitamin A.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are produced mainly by plants and play roles such as contributing fragrances to flowers and flavors to fruits. The document discusses the definition, classification, occurrence, biosynthesis, and chemistry of terpenoids. It notes that terpenoids are classified based on the number of isoprene units they contain and can range from simple hemiterpenes to more complex polyterpenes. Their biosynthesis occurs primarily via the mevalonate and non-mevalonate pathways which link isoprene units together.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. This document provides an introduction and overview of terpenoids, including their general properties, methods of isolation from plants, classification based on the number of isoprene units, and common analytical techniques used for structural elucidation such as determining functional groups, unsaturation, and the number of rings in the structure.
This slide discusses about basic indole nucleus, its chemistry, synthesis, reactions and medicinal uses of Indolyl derivatives..Indole is basically fused heterocyclic compound
This document discusses the properties and synthesis of pyrrole. Pyrrole is a colorless liquid that is weakly basic and more reactive than benzene. It undergoes electrophilic substitution reactions like halogenation and nitration. Pyrrole can be synthesized through several methods, including from furan over an alumina catalyst, from succinaldehyde and ammonia in a condensation reaction, and by passing acetylene and ammonia through a hot tube. Pyrrole has medicinal uses including in cardiac medications and as an antibacterial, antipsychotic, and anticancer agent.
Imidazole is an organic compound with the formula C3H4N2. It was first reported in 1858 and is an aromatic heterocycle that is classified as an alkaloid. The imidazole ring is present in important biological molecules like histidine and histamine. Many drugs contain imidazoles, such as antifungal, antiulcer, and antimicrobial agents. Imidazole has applications as an acid, a base, and in organic synthesis. It exhibits various pharmacological activities including antifungal, anti-inflammatory, antitubercular, and anticancer effects.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are volatile essential oils found in many plants and flowers which give them their distinctive fragrances. There are many different classes of terpenoids classified based on the number of isoprene units they contain, such as monoterpenoids, sesquiterpenoids, and diterpenoids. Common terpenoids include limonene, menthol, and camphor. Spectroscopic techniques such as UV, IR, NMR and mass spectrometry are used to determine terpenoid structures and functional groups.
Pyrimidine is a heterocycle that is the building block of many natural compounds including those found in RNA, DNA, antibiotics, and vitamins. It is resistant to electrophilic substitution reactions due to the electron deficient nature of its 2, 4, 6 positions. However, reactions can occur at the 5 position if an electron donating group is present. Pyrimidine undergoes nucleophilic addition reactions easily at its 2, 4, 6 positions and with oxidizing agents can form pyridine N-oxides, especially if an alkyl group is present. It is also synthesized through reactions with malonic esters, amidines, and from dichloropyrimidines. Many anticancer and antiviral
Triterpenes are classified based on the number of isoprene units they contain. Squalene is a 30-carbon triterpene containing six double bonds. Its structure was elucidated through reactions showing the presence of double bonds and the absence of conjugated double bonds. Oxidation and ozonolysis reactions provided further insight into its structure. Carotenoids are tetraterpenoids containing 9-11 double bonds that may terminate in rings. Alpha and beta carotene are prominent carotenoids, with beta carotene being the most well-known and a provitamin A.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are produced mainly by plants and play roles such as contributing fragrances to flowers and flavors to fruits. The document discusses the definition, classification, occurrence, biosynthesis, and chemistry of terpenoids. It notes that terpenoids are classified based on the number of isoprene units they contain and can range from simple hemiterpenes to more complex polyterpenes. Their biosynthesis occurs primarily via the mevalonate and non-mevalonate pathways which link isoprene units together.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. This document provides an introduction and overview of terpenoids, including their general properties, methods of isolation from plants, classification based on the number of isoprene units, and common analytical techniques used for structural elucidation such as determining functional groups, unsaturation, and the number of rings in the structure.
The document discusses alkaloids, which are naturally occurring chemical compounds that mostly contain basic nitrogen atoms. It covers their classification (including by biosynthesis, chemistry, pharmacology, and taxonomy), isolation, purification, biological activity, and structural determination. Methods for structural elucidation include functional group determination, degradation reactions like Hoffman exhaustive methylation, oxidation, and physical methods like spectroscopy. Specific alkaloids discussed include morphine, emetine, and reserpine.
1. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is colorless and hygroscopic, becoming yellow and brown over time when exposed to light.
2. Quinoline itself has few applications but many derivatives are useful, including quinine which is an important anti-malarial drug. Over 200 biologically active quinoline alkaloids have been identified.
3. The document discusses the structure, properties, synthesis methods like Skraup, Doebner-Miller, and Conrad-Limpach, reactions including electrophilic substitution, oxidation, and reduction, and applications of quinoline and its derivatives in dyes
This document discusses the properties and synthesis of pyridine. Pyridine is an aromatic heterocyclic compound containing a six-membered ring with one nitrogen atom. It has a planar structure and is aromatic according to Huckel's rule. Pyridine can be synthesized through several methods including the Hantzsch synthesis and from acetylene. It undergoes electrophilic substitution at the C-3 position and nucleophilic substitution at C-2 or C-4. Pyridine is used as a base in medicines such as isoniazid and omeprazole.
THIS PRESENTATION COVER INTRODUCTION, STRUCTURE, AROMATICITY, RESONANCE, BASICITY, PHYSICAL PROPERTIES, SYNTHESIS, CHEMICAL PROPERTIES AND MEDICAL USES OF PYRIDINE AND PYRIMIDINE
This document discusses asymmetric synthesis, which produces unequal amounts of stereoisomers from achiral precursors. It can be enantioselective or diastereoselective. There are two types: partial asymmetric synthesis, which forms a new chiral center from an achiral precursor using a chiral substrate, auxiliary, reagent, or catalyst; and absolute asymmetric synthesis, which uses no chiral precursors but instead relies on physical chirality like circularly polarized light. Common approaches include using a chiral pool substrate, chiral auxiliary, chiral reagent, or chiral catalyst. The mechanisms and examples of various methods are explained in detail.
This document discusses the heterocyclic compound pyrrole. It begins by defining pyrrole as an unsaturated five-membered ring containing nitrogen. Pyrrole is an important compound found naturally in substances like alkaloids, hemoglobin, and chlorophyll. The document then describes several methods for synthesizing pyrrole, including the Paal-Knorr, Hantzsch, and Knorr syntheses. It also discusses some reactions pyrrole undergoes, such as electrophilic substitution and reduction. Finally, it lists several medicinal uses of pyrrole derivatives, including the amino acid proline, the stimulant nicotine, and drugs used to treat Parkinson's disease and peptic
The document discusses various methods for resolving a racemic mixture into its pure enantiomers, including:
1) Mechanical separation, which separates crystal forms of enantiomers
2) Preferential crystallization, which seeds a solution with a pure enantiomer to induce crystallization
3) Biochemical separation using microorganisms that metabolize one enantiomer more quickly
4) Chromatographic separation exploiting differences in how enantiomers adsorb to a chiral support
5) Kinetic methods using reactions that proceed at different rates for each enantiomer
6) Precipitation of one enantiomer through reaction with a reagent
7) Formation of diastereomers with an opt
Carotenoids are tetra-terpenoid plant pigments that range in color from red to yellow. They have conjugated double bonds that allow them to absorb light and act as antioxidants. Carotenoids are precursors to vitamin A and can be classified as carotenes or xanthophylls depending on whether they contain oxygen. They play important roles in photosynthesis and protecting plants from photodamage.
This document discusses Traube purine synthesis and several purine derivatives including mercaptopurine, theophylline, and thioguanine. It provides information on:
- Traube first introduced purine synthesis in 1900 involving introduction of a one carbon fragment to bridge nitrogen atoms in pyrimidine rings.
- Mercaptopurine is used to treat cancers and autoimmune diseases but has side effects like bone marrow suppression and increased cancer risk.
- Theophylline is found in tea and used for respiratory issues like asthma as it relaxes bronchial muscles and stimulates the respiratory center.
- Thioguanine is used for certain cancers and inflammatory bowel disease.
This document summarizes an assignment on camphor. It provides camphor's chemical formula of C10H16O, describes its waxy white solid form with a strong aroma and low solubility in water. Camphor is obtained through distillation of camphor laurel trees, and it can also be synthesized from alpha-pinene or produced biosynthetically from geranyl pyrophosphate. Modern uses of camphor include as a plasticizer, moth repellent, antimicrobial, in embalming, and fireworks, while larger quantities can be toxic if ingested.
This document summarizes the Pinner pyrimidine synthesis reaction. The reaction involves the condensation of a non-N-substituted amidine and β-keto ester (β-diketone) in the presence of an acid catalyst to form a pyrimidine heterocyclic ring. The mechanism proceeds through protonation, nucleophilic attack, dehydration, and deprotonation steps. Pyrimidine derivatives synthesized via this reaction are used in drugs to treat conditions like malaria, viruses, and cancer.
Citral is an acyclic compound containing two double bonds and an aldehyde group. It exists as two cis-trans isomers that differ in the orientation of the aldehyde group relative to the double bond and methylene group. This isomerism is evidenced by citral forming two different semicarbazones and reducing to either geraniol or nerol depending on the isomer. NMR data also shows differences between the isomers due to magnetic shielding effects. The carbon skeleton of citral contains two isoprene units joined head to tail, which is revealed through its cyclization to p-cymene when heated.
Flavones are yellow plant pigments that occur either freely or as glycosides. They are hydroxylated derivatives of 2-phenyl-4-chromone. Flavones are yellow solids that are soluble in water and ethanol. Their structure was determined to be C15H10O2 based on analytical data and molecular weight determination. When boiled with alcoholic KOH, flavones produce a mixture of four compounds: salicylic acid, acetophenone, o-hydroxyacetophenone, and benzoic acid, explaining their core structure. Several methods can be used to synthesize flavones, including Kostanecki's, Robinson's, modified Claisen's condensation, Baker-Ven
Pyridazine is a heterocyclic organic compound with the formula C4H4N2. It contains a six-membered ring with two adjacent nitrogen atoms and is aromatic. Pyridazine derivatives have been synthesized and tested for various pharmacological activities, including anti-inflammatory, diuretic, antiasthmatic, antimicrobial, and anticancer effects. Specifically, 3,6-dichloro-pyridazine and N,N-(diphenylamino)-pyridazine have been studied for their activities. Pyridazine derivatives show potential as biologically active molecules and may help in developing new drugs to treat various conditions.
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It has 5 carbon atoms and 1 nitrogen atom arranged in a six-membered aromatic ring. Pyridine can be obtained from coal tar or synthesized by passing acetylene and hydrogen cyanide over a hot tube. It undergoes electrophilic aromatic substitution preferably at the carbon-3 position due to stabilization of the intermediate carbocation. Nucleophilic substitution also occurs, preferentially at the carbon-2 position. Pyridine is used as a solvent, in organic reactions, to denature alcohol, and in preparing certain drugs that contain a pyridine ring system.
1. Secondary metabolites are molecules produced by organisms that are not essential for growth but provide other important functions.
2. Alkaloids are an important class of secondary metabolites derived from amino acids. They have diverse pharmacological effects used in medicine.
3. Terpenoids are another major class of secondary metabolites derived from chains of isoprene units. They contribute flavors, scents, pigments and hormones in plants.
This document provides an overview of bitter principles, including their definition, classification, and examples. It discusses terpenoid bitters such as sesquiterpene lactones (-)-α-santonin and picrotoxin. (-)-α-santonin is obtained from wormseed and used as an anthelmintic, though it is toxic. Picrotoxin consists of picrotoxinin and picrotin and is obtained from fish berries. It acts as a CNS stimulant by blocking GABA receptors. The document also covers diterpene forskolin and triterpenes quassin and limonin, as well as the sesquiterpene lactone artem
The document discusses alkaloids, which are naturally occurring chemical compounds that mostly contain basic nitrogen atoms. It covers their classification (including by biosynthesis, chemistry, pharmacology, and taxonomy), isolation, purification, biological activity, and structural determination. Methods for structural elucidation include functional group determination, degradation reactions like Hoffman exhaustive methylation, oxidation, and physical methods like spectroscopy. Specific alkaloids discussed include morphine, emetine, and reserpine.
1. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is colorless and hygroscopic, becoming yellow and brown over time when exposed to light.
2. Quinoline itself has few applications but many derivatives are useful, including quinine which is an important anti-malarial drug. Over 200 biologically active quinoline alkaloids have been identified.
3. The document discusses the structure, properties, synthesis methods like Skraup, Doebner-Miller, and Conrad-Limpach, reactions including electrophilic substitution, oxidation, and reduction, and applications of quinoline and its derivatives in dyes
This document discusses the properties and synthesis of pyridine. Pyridine is an aromatic heterocyclic compound containing a six-membered ring with one nitrogen atom. It has a planar structure and is aromatic according to Huckel's rule. Pyridine can be synthesized through several methods including the Hantzsch synthesis and from acetylene. It undergoes electrophilic substitution at the C-3 position and nucleophilic substitution at C-2 or C-4. Pyridine is used as a base in medicines such as isoniazid and omeprazole.
THIS PRESENTATION COVER INTRODUCTION, STRUCTURE, AROMATICITY, RESONANCE, BASICITY, PHYSICAL PROPERTIES, SYNTHESIS, CHEMICAL PROPERTIES AND MEDICAL USES OF PYRIDINE AND PYRIMIDINE
This document discusses asymmetric synthesis, which produces unequal amounts of stereoisomers from achiral precursors. It can be enantioselective or diastereoselective. There are two types: partial asymmetric synthesis, which forms a new chiral center from an achiral precursor using a chiral substrate, auxiliary, reagent, or catalyst; and absolute asymmetric synthesis, which uses no chiral precursors but instead relies on physical chirality like circularly polarized light. Common approaches include using a chiral pool substrate, chiral auxiliary, chiral reagent, or chiral catalyst. The mechanisms and examples of various methods are explained in detail.
This document discusses the heterocyclic compound pyrrole. It begins by defining pyrrole as an unsaturated five-membered ring containing nitrogen. Pyrrole is an important compound found naturally in substances like alkaloids, hemoglobin, and chlorophyll. The document then describes several methods for synthesizing pyrrole, including the Paal-Knorr, Hantzsch, and Knorr syntheses. It also discusses some reactions pyrrole undergoes, such as electrophilic substitution and reduction. Finally, it lists several medicinal uses of pyrrole derivatives, including the amino acid proline, the stimulant nicotine, and drugs used to treat Parkinson's disease and peptic
The document discusses various methods for resolving a racemic mixture into its pure enantiomers, including:
1) Mechanical separation, which separates crystal forms of enantiomers
2) Preferential crystallization, which seeds a solution with a pure enantiomer to induce crystallization
3) Biochemical separation using microorganisms that metabolize one enantiomer more quickly
4) Chromatographic separation exploiting differences in how enantiomers adsorb to a chiral support
5) Kinetic methods using reactions that proceed at different rates for each enantiomer
6) Precipitation of one enantiomer through reaction with a reagent
7) Formation of diastereomers with an opt
Carotenoids are tetra-terpenoid plant pigments that range in color from red to yellow. They have conjugated double bonds that allow them to absorb light and act as antioxidants. Carotenoids are precursors to vitamin A and can be classified as carotenes or xanthophylls depending on whether they contain oxygen. They play important roles in photosynthesis and protecting plants from photodamage.
This document discusses Traube purine synthesis and several purine derivatives including mercaptopurine, theophylline, and thioguanine. It provides information on:
- Traube first introduced purine synthesis in 1900 involving introduction of a one carbon fragment to bridge nitrogen atoms in pyrimidine rings.
- Mercaptopurine is used to treat cancers and autoimmune diseases but has side effects like bone marrow suppression and increased cancer risk.
- Theophylline is found in tea and used for respiratory issues like asthma as it relaxes bronchial muscles and stimulates the respiratory center.
- Thioguanine is used for certain cancers and inflammatory bowel disease.
This document summarizes an assignment on camphor. It provides camphor's chemical formula of C10H16O, describes its waxy white solid form with a strong aroma and low solubility in water. Camphor is obtained through distillation of camphor laurel trees, and it can also be synthesized from alpha-pinene or produced biosynthetically from geranyl pyrophosphate. Modern uses of camphor include as a plasticizer, moth repellent, antimicrobial, in embalming, and fireworks, while larger quantities can be toxic if ingested.
This document summarizes the Pinner pyrimidine synthesis reaction. The reaction involves the condensation of a non-N-substituted amidine and β-keto ester (β-diketone) in the presence of an acid catalyst to form a pyrimidine heterocyclic ring. The mechanism proceeds through protonation, nucleophilic attack, dehydration, and deprotonation steps. Pyrimidine derivatives synthesized via this reaction are used in drugs to treat conditions like malaria, viruses, and cancer.
Citral is an acyclic compound containing two double bonds and an aldehyde group. It exists as two cis-trans isomers that differ in the orientation of the aldehyde group relative to the double bond and methylene group. This isomerism is evidenced by citral forming two different semicarbazones and reducing to either geraniol or nerol depending on the isomer. NMR data also shows differences between the isomers due to magnetic shielding effects. The carbon skeleton of citral contains two isoprene units joined head to tail, which is revealed through its cyclization to p-cymene when heated.
Flavones are yellow plant pigments that occur either freely or as glycosides. They are hydroxylated derivatives of 2-phenyl-4-chromone. Flavones are yellow solids that are soluble in water and ethanol. Their structure was determined to be C15H10O2 based on analytical data and molecular weight determination. When boiled with alcoholic KOH, flavones produce a mixture of four compounds: salicylic acid, acetophenone, o-hydroxyacetophenone, and benzoic acid, explaining their core structure. Several methods can be used to synthesize flavones, including Kostanecki's, Robinson's, modified Claisen's condensation, Baker-Ven
Pyridazine is a heterocyclic organic compound with the formula C4H4N2. It contains a six-membered ring with two adjacent nitrogen atoms and is aromatic. Pyridazine derivatives have been synthesized and tested for various pharmacological activities, including anti-inflammatory, diuretic, antiasthmatic, antimicrobial, and anticancer effects. Specifically, 3,6-dichloro-pyridazine and N,N-(diphenylamino)-pyridazine have been studied for their activities. Pyridazine derivatives show potential as biologically active molecules and may help in developing new drugs to treat various conditions.
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It has 5 carbon atoms and 1 nitrogen atom arranged in a six-membered aromatic ring. Pyridine can be obtained from coal tar or synthesized by passing acetylene and hydrogen cyanide over a hot tube. It undergoes electrophilic aromatic substitution preferably at the carbon-3 position due to stabilization of the intermediate carbocation. Nucleophilic substitution also occurs, preferentially at the carbon-2 position. Pyridine is used as a solvent, in organic reactions, to denature alcohol, and in preparing certain drugs that contain a pyridine ring system.
1. Secondary metabolites are molecules produced by organisms that are not essential for growth but provide other important functions.
2. Alkaloids are an important class of secondary metabolites derived from amino acids. They have diverse pharmacological effects used in medicine.
3. Terpenoids are another major class of secondary metabolites derived from chains of isoprene units. They contribute flavors, scents, pigments and hormones in plants.
This document provides an overview of bitter principles, including their definition, classification, and examples. It discusses terpenoid bitters such as sesquiterpene lactones (-)-α-santonin and picrotoxin. (-)-α-santonin is obtained from wormseed and used as an anthelmintic, though it is toxic. Picrotoxin consists of picrotoxinin and picrotin and is obtained from fish berries. It acts as a CNS stimulant by blocking GABA receptors. The document also covers diterpene forskolin and triterpenes quassin and limonin, as well as the sesquiterpene lactone artem
This document provides information about various vitamins. It discusses 13 vitamins - thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), cyanocobalamin (B12), ascorbic acid (C), retinol (A), ergocalciferol (D), tocopherol (E), and phylloquinone (K). For each vitamin, it mentions the chemical name, sources, functions, deficiency symptoms, absorption and any relevant chemistry. The document provides details on the roles of these vitamins
HydroCurcTM is a product containing curcuminoids, which are chemical compounds derived from turmeric. Curcuminoids such as curcumin are known to have various biological activities including antioxidant and anti-inflammatory properties. Research has shown curcuminoids may help reduce the risk of diseases like cancer and cardiovascular disease. However, curcumin itself has poor bioavailability and stability, limiting its potential medical uses. New formulations are being developed to improve the bioavailability of curcuminoids.
Secondary Metabolism is a term for pathways for small molecule and products of metabolism that are not absolutely required for the survival of the organism.
A secondary metabolite has an important ecological function.
Examples include antibiotics, mycotoxins etc.
1. Phytol is an acyclic diterpene alcohol that can be used as a precursor for synthetic vitamin E and K1. It is liberated from chlorophyll in plant materials and converted to phytanic acid in ruminant guts or pristane in shark livers.
2. Retinol, also known as vitamin A1, is a fat-soluble vitamin found in many foods. It is used to treat and prevent vitamin A deficiency and its complications. Retinol is converted in the body to retinal and retinoic acid to carry out its visual and non-visual functions.
3. Both phytol and retinol are discussed in terms of their structures, properties
This document discusses nitrogen-containing secondary plant metabolites. It begins by introducing secondary metabolites and their roles in plant defense and medicinal uses. It then focuses on nitrogen-containing compounds, including alkaloids and cyanogenic glucosides. Alkaloids are further classified and examples are given, including pyrrolizidine, tropane, and isoquinoline alkaloids. Common alkaloids and their medical applications are also mentioned.
This document discusses several classes of plant secondary metabolites including iridoids, naphthoquinones, gentian, artemisia, taxus, and carotenoids. Iridoids are monoterpenoids found in many plants and are derived from 8-oxogeranial. Naphthoquinones are related to naphthalene and include common isomers like 1,2-naphthoquinone and 1,4-naphthoquinone. Gentian contains iridoid glycosides like gentiopicrin which give it bitter properties. Artemisia contains essential oils and compounds like santonin. Taxus contains the potent anticancer compound taxol. Carotenoids
This document provides information on botanical insecticides. It discusses that over 2,400 plant species have pesticidal properties, with important families including Meliaceae, Rutaceae, Asteraceae, Labiatae and Canellaceae. Major botanical products used as insecticides include pyrethrum, rotenone, neem, and essential oils. Specific botanical insecticides discussed in more detail include neem, rotenone, sabadilla, ryania, nicotine, and pyrethrum. The document also compares the differences between pyrethrins and synthetic pyrethroids.
The document discusses various B vitamins, including their chemistry, food sources, roles in the body, and deficiency diseases. It provides information on vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), and B9 (folic acid). The key points made are that B vitamins serve as cofactors in many enzyme reactions involved in metabolism and must be obtained through the diet as humans cannot synthesize most of them. Deficiencies can result in diseases like beriberi, pellagra, and anemia.
This document discusses polysaccharides as building blocks for nanotherapeutics in drug delivery. It defines different types of carbohydrates like monosaccharides, oligosaccharides, and polysaccharides. It then classifies polysaccharides based on their origin as plant, animal, algal, microbial, or marine. Polysaccharides are also classified based on their monomer units as homo- or heteropolysaccharides. Examples of specific polysaccharides like starch, cellulose, chitosan, hyaluronic acid, dextran, and cyclodextrins are provided along with their properties and applications. Requirements for efficient drug delivery vehicles and important drug delivery systems are also summarized. The document concludes that polysaccharide nanop
Is the separation of medicinally active portions of plant (and animal) tissues using selective solvents through standard procedures.
The products so obtained from plants are relatively complex mixtures of metabolites, in liquid or semisolid state or in dry powder form (after removing the solvent), & are intended for oral or external use
The Medicinal plants constitute an effective source of both traditional and modern medicines, herbal medicine has been shown to have genuine utility and about 80% of rural population depends on it as primary health care. [WHO, (2005)]
AN INTRODUCTION TOPLANT SECONDARY METABOLITES :ITS APPLICATIONSSupriya Sankranthi
This presentation is about different types of secondary metabolites produced by the plants and thier applications in different fields like medicine,drugs,cosmetics and perfumery,plant defense,role in ecological balance,textile industries.
Lignans.pptx Use of microbes in industry. Production of Enzymes- General cons...Rakesh Barik
Lignans are a class of plant polyphenols composed of two linked phenylpropane units. They are found in various plant families and act as antioxidants and defenses against pathogens. The basic lignan structure consists of two phenylpropane units linked by a C-C bond between their central carbons. Major subclasses include furofuran, furan, and dibenzylbutane lignans. Lignans have various biological activities including anticancer, anti-inflammatory, and antioxidant effects. They are often present in plants as glycosylated derivatives and some common examples include secoisolariciresinol and podophyllotoxin.
Carboxylic Acid and Vitamin K and Chemical WorksSOMESHWARSRIMANY
Carboxylic acids contain a carbon double bonded to an oxygen and single bonded to a hydroxyl group. They are polar and can hydrogen bond. Carboxylic acids are used to make soaps, food products, drugs, and polymers. Important examples include fatty acids and salicylic acid. Vitamin K contains a naphthoquinone ring and plays a key role in blood clotting and bone health as it is required for activation of clotting factors and proteins involved in bone formation. The three major forms are K1 (phylloquinone), K2 (menaquinones), and K3 (menadione).
PHYTOCHEMISTRY ASSIGNMENT FOR PHARMACOGNOSYGanugavade
This document discusses the importance of alkaloids and glycosides found in herbal industries. It begins by classifying alkaloids based on their taxonomic, biosynthetic, pharmacological, and chemical properties. Common chemical tests used to detect alkaloids are described. Glycosides are then defined and classified based on their aglycone and sugar components. Several important medicinal plants containing alkaloids and glycosides are discussed, highlighting their anti-inflammatory, immune-supporting, antioxidant, and other therapeutic properties. In conclusion, alkaloids and glycosides provide significant medicinal benefits and are valuable components in herbal supplements and formulations.
This document provides an overview of the topics covered in a session on phytochemistry. It defines phytochemistry as the study of plant constituents and their applications in pharmacognosy. Primary metabolites like enzymes and chlorophyll are necessary for plant life, while secondary metabolites provide protection and include alkaloids, tannins, and compounds induced by stress. Specific secondary metabolite groups discussed include simple phenols and glycosides like cyanogenic glycosides; mucilages; essential oils composed of terpenoids and phenylpropanoids; and glucosinolates. The document concludes by previewing that the next session will continue covering phytochemistry.
Therapeutic and diagnostic applications of enzymes isozymes and coenzymesShubhrat Maheshwari
This document discusses therapeutic and diagnostic applications of enzymes, isoenzymes, and coenzymes. It provides examples of how enzymes are used therapeutically to aid digestion, act as anti-clotting agents, and treat various conditions. It also discusses how enzymes are used diagnostically to detect levels of substances like glucose, liver enzymes, and more. The document then explains isoenzymes and provides an example of lactate dehydrogenase isoenzymes. Finally, it discusses several important coenzymes like NAD, FAD, biotin, vitamin B12 and their roles in biochemical reactions and maintaining health.
Lignans are phenylpropanoid dimers found widely in plants. Podophyllum lignans from Podophyllum species have anticancer and antiviral properties. Their structure contains five rings. Phenylpropane units in lignans are derived from the phenylpropanoid pathway. Secoisolariciresinol diglucoside is a prominent lignan in flaxseed that has antioxidant and antiplatelet effects. Quassinoids from Quassia species have insecticidal, antibacterial, and antitumor properties. Their basic structure contains a beta-carbolinium ion.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...Travis Hills MN
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdfSelcen Ozturkcan
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
Immersive Learning That Works: Research Grounding and Paths ForwardLeonel Morgado
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
Authoring a personal GPT for your research and practice: How we created the Q...Leonel Morgado
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
2. DEFINITION
Incorporation of an oxygen, a nitrogen, a sulfur, or an atom of a related
element into an organic ring structure in place of a carbon atom gives rise to a
heterocyclic compound.
In other words, heterocyclic compounds are organic compounds that contain
one or more heteroatoms i.e., nitrogen, sulfur, oxygen in the ring structure.
Heterocyclic compounds can be classified based on their electronic structure.
3.
4. PYRIDINE
Chemical Formula : C5H5N
PYRIDINE is a six-membered ring structure composed of five carbon atoms and
one nitrogen atom.
Pyridine was isolated and characterized by Anderson in 1846, it was obtained
from bone oil and coal tar.
Pyridine is a clear colorless to light yellow liquid with a penetrating nauseating
odor.
5. BIOLOGICAL SIGNIFICANCE
Exhibits antiviral, anticancer, antimicrobial, antidiabetic, antidote, antileishmanial,
antioxidant, antithrombin, anticoagulant and Precursors to agrochemicals.
It occurs in azines and the vitamins niacin (Vitamin B3) and pyridoxine (Vitamin
B6).
It acts as prosthetic groups : Coenzymes of Dehydrogenases (NADP+ and
NAD+), acts as oxidant.
Pyridine and their derivatives are active against microbial diseased, viral
problems and variety of cancerous cells - by interacting with enzymes, proteins
and DNA.
6. BIOLOGICAL ACTIVITIES OF PYRIDINE DERIVATIVES
ANTIVIRAL ACTIVITY
4-(phenylamino)thieno[2, 3-b] pyridine derivative shows inhibitory activity against
Herpes simplex virus type-1 (HSV-1). [1]
The 1-(β-D-ribofuranosyl)-pyridine-2-thiones are found to be most active anti-HIV
agents. [1]
7. ANTICANCER ACTIVITY
Pyridine epothilones-couple with metals exhibit cytotoxic properties. [1]
ANTIMICROBIAL ACTIVITY
Schiff base ligands of type 1-phenyl-2,3-dimethyl-4-salicylalidene pyrazole-5-one, couple
with metal center such as Cu2+, Ni2+, Zn2+ and Fe3+ - exhibit antibacterial and antifungal
activities.
3-hydroxypyridine-4-ones and 3-hydroxy-pyran-4-ones containing pyridine ring
are active against Staphylococcus aureus, Aspergilus niger and Candida
albicans. [1]
8. OTHER APPLICATIONS
PESTICIDES
• Precursor to the herbicides paraquat and diquat.
• It is the starting compound for the preparation of pyrithione-based fungicides.
ANTISEPTIC
• Cetylpyridinium and laurylpyridinium, are used as antiseptic in oral and dental care
products.
SOLVENT
• Pyridine is used as a solvent in the manufacture of dyes and rubber.
• It is also used in the textile industry to improve network capacity of cotton.
• Pyridine is added to ethanol to make it unsuitable for consumption.
• In low doses - added to foods to give them a bitter flavor - approved by the US Food
and Drug Administration.
9. HEALTH ISSUES
The lowest known lethal dose for the ingestion of pyridine in humans is 500
mg.kg−1. In high doses, pyridine has a narcotic effect.
Pyridine is harmful if inhaled, swallowed or absorbed through the skin.
Effects of acute pyridine intoxication include
• Dizziness
• Headache
• lack of coordination
• Nausea
• Salivation
• loss of appetite.
10.
11. PYRIMIDINE
Chemical Formula : C4H4N2
Pyrimidines are simple aromatic, six-membered ring compound.
The carbon and nitrogen atoms are connected via alternating double and single
bonds, making the structure resonance stable.
The modifications of its derivatives can range from addition of a few atoms in
nucleic acids to complex structures in drugs and vitamins.
12. BIOLOGICAL SIGNIFICANCE
The three pyrimidine nitrogenous bases, act as the genetic material in all living
organisms.
Pyrimidine activated sugars are also involved in
• polysaccharide and phospholipid synthesis,
• glucuronidation in detoxification processes,
• glycosylation of proteins and lipids.
The pyrimidine derivative, neurotoxin tetrodotoxin found in Japanese puffer fish,
the blue-ringed octopus, prevents the transmission of nerve signals and can result
in paralysis and death.
Found in vitamins like, riboflavin, thiamine and folic acid.
13. BIOLOGICAL ACTIVITIES OF PYRIMIDINE
DERIVATIVES
Pyrimidine is present in barbituric acid and its several derivatives e.g. Veranal
which are used as hypnotics.
DRUGS FOR HYPERTHYROIDISM:
2-Thiouracil and its alkyl analogue, thiobarbital and Propylthiouracil
are effective drugs against hyperthyroidism. [2]
ANTHELMENTICS:
Pyrantel pamoate is a depolarizing neuromuscular blocking agent that is
employed in the treatment of infestations caused by pinworms and roundworms. [2]
14.
15. PURINES
Purine is an aromatic heterocyclic compound with two cycles: a six-membered
pyrimidine ring and a five-membered imidazole ring fused together.
Building blocks of all living things. In the human body, purines can be divided
into two categories:
• Exogenous purines that enter the body via food. It includes meat, certain
vegetables like asparagus, spinach, mushrooms, carrots and tomatoes in
varying concentrations.
16. • Endogenous purines that are synthesized by the body.
Examples: DNA and RNA (containing the purines adenine and
guanine), ATP, ADP, AMP, cyclic AMP, GTP and cGMP
GTP
17. BIOLOGICAL SIGNIFICANCE
Purines are critical elements of the energy metabolism molecules:
reduced nicotinamide adenine dinucleotide, nicotinamide adenine
dinucleotide phosphate (NADPH), and coenzyme Q.
Purines may also serve as direct neurotransmitters; for example,
adenosine.
18. BIOLOGICAL ACTIVITIES OF PURINE
ANALOGUES
ANTI-LEISHMANIAL ACTIVITY
Purine and its derivatives have cytotoxic activity and anti-leishmanial activity on Human
epidermoid carcinoma and Vero (African green monkey kidney) cells. [3]
ANTITUMOR ACTIVITY
Some derivatives of L-Ascorbic acid inhibit the growth of certain human malignant
tumor cell lines. [3]
ANTIPROTOZOAL ACTIVITY
Natural products having a hybrid terpene-purine from numerous genera of sponges
display high general toxicity towards protozoa. [3]
19. ROLE OF PURINES IN GOUT
Purines are substances in animal and plant foods that your body converts to
uric acid.
Too much uric acid in your body causes gout.
If uric acid cannot be flushed out through your kidneys, it can build up in the
bloodstream and be deposited as needle-shaped crystals in your joints,
causing severe inflammation and intense pain of a gout attack.
20.
21. QUININE
Chemical Formula : C20H24N2O2
Quinine is a natural white crystalline alkaloid derived from the bark of the
cinchona tree. It is a stereoisomer of quinidine.
Quinine is found to have antipyretic, anti-malarial with analgesic and anti-
inflammatory properties.
22. BIOLOGICAL SIGNIFICANCE
TREATMENT OF MALARIA
• Quinine is used parenterally to treat life-threatening infections caused
by chloroquine-resistant Plasmodium falciparum malaria.
• Malaria in pregnancy causes several adverse outcomes.
• The combination of quinine and clindamycin has efficacy against
multidrug-resistant strains of P. falciparum.
MODE OF ACTION
It is thought to act by inhibiting heme polymerase, thereby allowing
accumulation of its cytotoxic substrate, heme.
23. OTHER MEDICAL USES
Used for idiopathic muscle cramps.
Induces uterine contractions during childbirth.
NON MEDICINAL USES
In small amounts, quinine is a component of various drinks,
• ingredient of tonic drinks, acting as a bittering agent.
• flavor component of bitter lemon, and vermouth.
Quinine is often added to street drugs cocaine or ketamine in
order to "cut" the product and make more profit.
It is also used in photochemistry as a common fluorescence
standards.
24. SIDE EFFECTS OF QUININE
• Acute hypersensitivity reactions to quinine that include hepatic
involvement.
• Cinchonism or quinism is a pathological condition in humans caused by
an overdose of quinine or its natural source, cinchona bark.
• Quinine can cause paralysis if accidentally injected into a nerve. It is
extremely toxic in overdose.
25.
26. PTERIDINES
Pteridines belong to a class of nitrogen heterocyclic compound, consists of
pyrazine and pyrimidine ring.
Found in natural materials as pigments in the wings and eyes of insects, and
in the skin of fish, amphibia and reptiles.
27. BIOLOGICAL SIGNIFICANCE
Two important coenzymes are derived from pteridine:
• Pterin coenzyme
• Folic acid
PTERIN COENZYME
In eukaryotes, pterins play a role of redox cofactors.
Pterins also play biological roles in mediating process like protection from UV
damage and intercellular signaling.
In cyanobacteria Spirulina platensis, biopterin glucoside protect the components of
photosynthetic vesicles (chlorophyll a, phycocyanin and carotenoids) from UV
exposure.
28. FOLIC ACID
It is pteroylglutamic acid, consists of pteridine portion linked through p-benzoic acid
to L-glutamic acid.
Found in animal tissues and human red cells as a polyglutamate.
Tetrahydrofoliate (THF)-active form - synthesis depends on Vitamin C and NADPH.
The major functions of foliate co-enzymes is one carbon metabolism. THF is
required in cell division, lowering plasma homocysteine.
29. One-carbon groups are being added to or removed from THF and are changing
their nature while bound to THF.
Folic acid deficiency leads to,
• Megaloblastic anaemia
• Neural tube defects in fetus
• Hyperhomocysteinemia
30.
31. ISOALLOXAZINE
Chemical Formula : C10H6N4O2
The 2, 4-dioxoderivative of benzopteridine.
A yellow solid that is the precursor of various
flavins (such as riboflavin).
Riboflavin is part of coenzymes FAD and FMN.
32. FLAVIN COENZYMES
Commonly known as Vitamin B2. Its coenzyme forms are Flavin
mononucleotide (FMN) and Flavin adenine dinucleotide (FAD)
FAD and FMN act as intermediate Hydrogen acceptors in the
mitochondrial ETC.
Deficiency is often seen in chronic alcoholics due to their poor dietetic
habits.
Symptoms include glossitis, seborrhea, angular stomatitis.
33. BIOLOGICAL SIGNIFICANCE
The flavoproteins act as
• Oxidases
• Dehydrogenases
• Hydroxylases
• Oxidative carboxylases
Riboflavin and its coenzymes are involved in
• Growth and Tissue respiration
• Light adaption
• Conversion of pyridoxine to pyridoxal phosphate
• Cellular metabolism
• Enzymatic oxidation of glucose, amino acids, fatty acids, purines etc.
34. Riboflavin or Vitamin B2- required for red blood cell formation, antibody production
and regulating human growth and reproduction.
Aids in Beta oxidation in fat metabolism.
Neutralizes the free radicals in body and
help prevent heart disease and cancer.
Effective in treatment of
• Ariboflavinosis
• Migraine headaches
• Cataracts
• Rheumatoid arthritis
• Dermatitis
• Eczema
• Anemia
• Alzheimer’s disease
• Epilepsy
35. REFERENCES
1. Pyridine : A Versatile Nucleuse In Pharmaceutical Field, Ajit Chaubey, S.N.
Pandeya, Department of Pharmaceutical Sciences, Saroj Institute of Technology
and Management.
2. An Overview on Synthesis and Biological Activity of Pyrimidines, N.
Venkat Rao, Bhanu Vaisalini. N, B. Mounika, Lakshmi Harika. V, Pasanna Kumar
Desu, Sreekanth Nama,
Department of Pharmaceutical Sciences, PIPER.
3. Biological Activities of Purine Analogues: A Review, Sachan Dinesh,
Gangwar Shikha, Gangwar Bhavana, Sharma Nidhi, Sharma Dileep.
http://www.newworldencyclopedia.org/entry/Quinine
https://pubchem.ncbi.nlm.nih.gov
https://www.researchgate.net/publication/