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Gastroesophageal Reflux Disease (GERD)   ,[object Object],[object Object],[object Object],[object Object],[object Object]
High Prevalence of Gastroesophageal  Reflux Symptoms
 
Important Reasons to Diagnose and Treat GERD ,[object Object],[object Object],[object Object],[object Object]
Pathophysiology: ,[object Object],[object Object],[object Object],[object Object]
 
1.AbnormaL LES: ,[object Object],[object Object],[object Object]
2.HH: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2.HH: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
3.Delayed oesophageal clearance : ,[object Object],[object Object],[object Object]
4.Gastric contents ,[object Object]
5. Defective gastric emptying  ,[object Object],[object Object]
6. Others  ,[object Object]
7. Increased inra abd pressure: ,[object Object],[object Object]
6. Diet  / environmental factors : ,[object Object],[object Object]
Clinical features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical features ,[object Object],[object Object],[object Object],Clinical Presentations of GERD
 
Extraesophageal Manifestations of GERD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Potential Oral & Laryngopharyngeal Signs Associated with GERD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Vaezi MF, Hicks DM, Abelson TI, Richter JE. Clin Gastro Hep 2003;1:333-344.
Pathophysiology of Extraesophageal GERD
Complications: 1. Oesophagitis ,[object Object],[object Object],[object Object]
Complications:  Oesophagitis
Complications:2.Barrett's oesophagus  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Barrett Diagnosis:diagnosis   ,[object Object]
Barret:Management ,[object Object],[object Object],[object Object]
Barret:  Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications:3.  IDA ,[object Object],[object Object]
Complications: 4.Benign oesophageal stricture  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
GERD:Investigations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
When to Perform Diagnostic Tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnostic Tests for GERD ,[object Object],[object Object],[object Object],[object Object]
Barium Swallow ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Endoscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The LA Classification system – Grade A reflux esophagitis Stomach Grade A : One (or more) mucosal break, no longer than 5 mm,  that does not extend between the tops of two mucosal folds.
The LA Classification system – Grade B reflux esophagitis Stomach Grade   B : One (or more) mucosal break, more than 5 mm long, that does not extend between the tops of two mucosal folds.
The LA Classification system – Grade C reflux esophagitis Stomach Grade C : One (or more) mucosal break that is continuous between the tops of two or more mucosal folds, but which involves less than 75% of the circumference.
The LA Classification system – Grade D reflux esophagitis Stomach Grade D : One (or more) mucosal break that involves at least 75% of the esophageal circumference.
Ambulatory 24 hr. pH Monitoring ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ambulatory 24 hr. pH Monitoring Normal GERD
Wireless, Catheter-Free Esophageal pH Monitoring ,[object Object],[object Object],[object Object],[object Object],Potential Advantages
Esophageal Manometry ,[object Object],[object Object],[object Object],[object Object],Limited role in GERD
Treatment Goals for GERD ,[object Object],[object Object],[object Object],[object Object]
Management: Life-style ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management: antacids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Effectiveness of Medical Therapies for GERD Treatment Response Lifestyle modifications/antacids 20 % H 2 -receptor antagonists 50 % Single-dose PPI  80 % Increased-dose PPI up to 100 %
Treatment Modifications for  Persistent Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object]
GERD is a Chronic Relapsing Condition ,[object Object],[object Object],[object Object],[object Object]
GERD IN OLD AGE ,[object Object],[object Object],[object Object],[object Object]
 
Erosive Esophagitis
Peptic Stricture Barium Swallow Endoscopy
Esophageal Stricture: Dilating Devices
TTS Balloon Dilation of a Peptic Stricture
Barrett’s Esophagus
Esophageal Cancer Barium Swallow Endoscopy
 
When to Discuss Anti-Reflux Surgery with Patients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Endoscopic GERD Therapy   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Time is cruel:

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