24 hour pH monitoring of the esophagus involves placing a pH probe in the esophagus to measure acid exposure over time. Standard monitoring uses a single probe 5cm above the lower esophageal sphincter (LES). Newer methods include the Bravo capsule which is attached endoscopically and allows for longer monitoring, and combined multiple intraluminal impedance-pH monitoring which can detect both acid and non-acid reflux through measurement of impedance changes. Combined monitoring classifies reflux as acid, superimposed acid, weakly acidic, or weakly alkaline based on pH changes during reflux events.
This slides gives you the Facts & Salient features of Liver Cysts / Interesting Case Reports covering Main Departments of Clinical side with Recent Advances made in the treatment of Liver cyst & Key points.
Gastroesophageal Reflux Disease (GERD) is a common disorder that has undergone many paradigm changes in the last 15 years. We discuss the current paradigms in the pathophysiology, diagnosis and management of GERD.
This slides gives you the Facts & Salient features of Liver Cysts / Interesting Case Reports covering Main Departments of Clinical side with Recent Advances made in the treatment of Liver cyst & Key points.
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Tracheo oesophageal atresia and fistula A-Z for medical students
This powerpoint covers everything you need to know about tracheoesophageal fistula and atresia as a medical student.It is not intended for patients. Covers anatomy, embryology,types ,classification and treatment of tracheo-oesophageal fistula and atresia.
GERD is most common gastric problem in community affecting large number of people. Diagnosis and management is very simple with understanding.
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GERD is the commonest GI problem afflicting the mankind. The cause is lax LES which is just opposite to Achalasia cadia. That is why GERD is also known as Chalasia cardia.
Gastroesophageal reflux disease (GERD) is defined as the failure of the antireflux barrier, allowing abnormal reflux of gastric contents into the esophagus. It is a condition which develops when the reflux of stomach contents causes troublesome symptoms and complications.
Description of various ultrasound features of benign and suspicious thyroid nodules with multiple ultrasound systems for risk stratification of malignancy.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
4. Sites of 24 hour pH Monitoring
• Single monitoring site: 5 cm above LES
• Multiple monitoring sites: 5 & 20 cm above LES
• One in the esophagus & one in proximal stomach
• One or more in esophagus & another in hyopharynx
6. Why 5 cm above LES?
• Has been standard for many years
• Chosen to avoid catheter migration into stomach
• Moving by a 1 cm or two would not change results
• Moving it 10 cm above LES miss a number of patients
who are identified by the more distal location
8. Location of LES
• Manometric localization Reference method
• pH step-up method Sudden rise to pH > 4
• LES locator Prior to pH
• Fluoroscopic techniques Not accurate
• Endoscoic technique Not accurate
9. Ideal pH electrode
“No single probe meets all of these criteria”
• Small
• Firm enough
• Rapid response time between pH 7 to pH 1
• Minimally affected by temperature
• No hysteresis effect
• No drift during 24 hours
• Inexpensive
• Simple to calibrate or disposable
10. Which pH Electrode ?
Either can be used satisfactorily
Glass electrodes Antimony electrodes
40 – 50 studies 10 studies
Most linear response
Most rapid response Less response fidelity
Least recording drift
Large diameter Smaller
Siff bulky catheters More flexible
Expensive Less expensive
11. Indications of Esophageal pH Recording
• Normal endoscopic findings & reflux symptoms refractory to PPI
• Endoscopy-negative patient before surgical anti-reflux repair
• Patients suspected to have abnormal reflux after surgery
• Refractory reflux in pts with chest pain after cardiac evaluation
• Suspected ENT manifestations after failure of 4 weeks of PPI
• GERD in an adult onset non-allergic asthma
AGA Medical Position Statement. Gastroenterology 1996 ; 110 : 1981 - 96
12. No indications of esophageal pH recording
• Esophageal pH recording not indicated to detect or
verify reflux esophagitis (this is an endoscopic dg)
• Esophageal pH recording not indicated to evaluate
„„alkaline reflux‟‟
AGA Medical Position Statement. Gastroenterology 1996 ; 110 : 1981 - 1996
13. Why pH < 4?
• Defined early in development of the technology
• Its choice was based on:
- Marked difference from normal esophageal pH of 7
- Pepsinogen converted to pepsin at pH 4
- pH < 4 was one that tends to produce symptoms
• Some believe that drops in pH that do not reach level
of 4.0 still may represent reflux that these events
should also be used in calculations of indices
14. Composite scoring systems
Johnson & DeMeester is the most commonly used
Percentage of total time pH < 4
Percentage of upright time pH < 4
Percentage of supine time pH < 4
Number of reflux episodes
Number of reflux episodes >5 min
Longest reflux episode
DeMeester score
Normal < 14,72
15. Normal values of DeMeester’s score
50 healthy volunteers
DeMeester TR et al. Ann Surg 1976 ; 184 :459 – 470.
16. Normal 24 hours esophageal pH monitoring
Composite DeMeester score: 8.4
DeMeester normal < 14.72 (95th percentile)
Bremner CG et al. Esophageal disease & testing. Taylor & Francis Group, 2005.
18. Nocturnal acid breakthrough
• Defined arbitrarily as intragastric pH < 4 for > 1 h
overnight during administration of PPI
• Occurs even on twice-daily therapy
• Common enough: rule rather than exception
• Not without controversy: little to do with reflux
• Addition of H2RAs at bedtime to PPI bid controls
NAB better than PPI therapy alone?
19. Nocturnal acid breakthrough
Gastric pH < 4 for at least 1 h during the night in patients
with persistent heartburn on standard dose PPIs twice daily
Combined gastric & esophageal 24 hr pH monitoring
20. Qualitative analysis
Symptom–reflux correlation
• Symptom index: Positive if ≥ 50%
• Symptom sensitivity index: Positive if > 10 %
• Symptom association probability Positive if > 95%
Determine relationship between heartburn episodes & acid
reflux events, regardless if pH test is normal or abnormal
23. Symptom Association Probability Calculation
Positive if 95%
• Divides tracing into 2-min segments & looks at
whether a symptom & acid are present during each 2
minute segment
• The analysis uses contingency table analysis of 4
possible outcomes for each segment:
acid + symptom +
acid + symptom –
acid – symptom +
acid – symptom –
24. Overall amount of acid exposure & number of
reflux episodes are the focus of many studies
using ambulatory pH testing
Relationship between symptoms & esophageal
acid is equally (or perhaps more) important
25. 24 hour pH esophageal monitoring
On & off therapy
• Off therapy
Uncertainty about diagnosis of reflux
Mildest grades of esophagitis: redness - friability
Very short segments of BE
• On therapy
Patient who has failed a therapeutic trial
Patient has known reflux or highly likely to have reflux
pH probe in esophagus & another in stomach (NAB)
26. 24 hours pH monitoring & medications
• PPI should be stopped for 5 – 7 days
• Other medications should be stopped for 1 – 3 days
• Patient must not use antacids or other OTC
medications for duration of the study
27. Percentage of total time pH < 4
Normal values
• Off therapy
5 cm above LES
20 cm above LES 1 %
Periods of meals or acidic beverages excluded
• On therapy
5 cm above LES
20 cm above LES ?
* Based on 95% CI obtained in healthy subjects treated with omeprazole 40 mg qd
Kuo B et al. Am J Gastroenterol 1996 ; 91 : 1532 – 8.
4 – 5.5 %
1.6 – 4 %*
28. Abnormal acid exposure time in heartburn
Disease Percentage of total time pH < 4
Barrett‟s esophagus 93 %
* ENRD: Endoscpic Negative Reflux Disease
* *NERD: Non Erosive Reflux Disease
Erosive esophagitis 75 % (in one study)
ENRD*
NERD**
Functional heartburn
- SI > 50%
- SI < 50%
50 %
100 %
0 %
Hypersensitive esophagus
Non acid reflux or motor event
24 hr pH monitoring is not gold standard for diagnosis of GERD
30. Bravo system (Medtronics)
Esophageal Probe
25 x 6 x 5.5 mm
Battery
pH
electrode
Suction
chamber
Radio
transmitter
Delivery system
Receiver
100 x 70 x 30 mm - 165 g
31. Advantages of Bravo capsule
• Better tolerance by patients
• Fixed position of the capsule (6 cm above SCJ*)
• Prolonged monitoring under more physiologic
conditions (48 hours)
* SCJ: squamocolumnar junction
32. Bravo normal values
50 asymptomatic volunteers
1st 24 h 2nd 24 h
Mean
(+ SD)
95th
percentile
Mean
(+ SD)
95th
percentile
% total time at pH < 4 1.79 (2.16 5.89 1.78 (1.78) 5.64
% upright time at pH < 4 2.45 (3.14) 7.81 2.54 (2.57) 7.46
% supine time at pH < 4 0.37 (1.18) 1.58 0.34 (1.28) 1.29
Number of reflux episodes 21.2 (18.5) 55.30 22.3 (19.8) 56.15
No of reflux episodes >5 min 0.62 (1.21) 3.55 0.75 (1.15) 3.00
Longest reflux episode 3.79 (4.31) 11.23 5.95 (4.52) 17.03
DeMeester score 6.02 (4.82) 15.93 5.95 (4.52) 15.48
33. Conventional pH vs Bravo capsule
Head to head comparison – 40 patients
Bruley des Varannes S. Gut 2005 ; 54 ; 1682 – 1686.
34. Bravo capsule
Causes of under-recording
• Data drop-up
• Short reflux event not recorded
• Reflux events appear shorter
35. Bravo capsule
Data drop-out
Malfunctions in the electronics or the receiver
Interpreted as artifact & not represented in final pH report
Improved by 7 cm antenna & use of fiberglass
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 307 – 318.
38. Trouble shooting in Bravo capsule
• Severe odynophagia & chest pain (5%)
Chest radiography to exclude perforation
Viscous lidocaine
Endoscopic removal if symptoms continue
• Capsule detachment
• Failure to disloge
Endoscopic removal similar to polypectomy
39. Bravo capsule
Classic early detachment (10% of patients)
Easily recognized during inspection of pH tracing
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 307 – 318.
Sudden prolonged drop in pH represents capsule in stomach
Sharp rise as capsule enters small intestine through pylorus
40. Endoscopic removal of Bravo capsule
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 307 – 318.
42. Principle of “MII”
• 2 steel rings separated by isolator
• Alternating-current generator to apply electrical PD
• Circuit closed through electrical charges (ions)
contained in structures surrounding the catheter
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 – 264.
43. Impedance scale
Refluxate: High conductivity & low impedance
Air: Low conductivity & high impedance
Bremner CG et al. Esophageal disease & testing.
Taylor & Francis Group, New York, 1st edition, 2005.
44. Advantages of MII
• Content of refluxate Liquid – Gas – Mixed
• Direction of bolus Anterograde – retrograde
• Height of refluxate
• pH characteristics Acid
(combined MII-pH) Weekly acid
Weekly alkaline
Acid re-reflux
45. Liquid bolus
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 – 264.
1) Initial drop Liquid enters impedance-measuring segment
2) Rise Bolus cleared from this segment
3) Overshoot Decreased luminal cross-section during contraction
4) Return to baseline
46. Air bolus
(Belch, Air swallow)
1) Rapid rise Presence of air bolus inside esophagus
2) Rapid decrease Air bolus clears from this segment
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 - 264.
47. Mixed air – liquid Bolus
1) Rapid Rise Air in front of the bolus
2) Rapid drop Liquid component of mixed bolus
3) Rise Liquid being cleared from this segment
4) Return to baseline
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 – 264.
48. Antegrade bolus movement (MII)
Observed during swallowing
Progression of impedance from proximal to distal
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 – 264.
49. Retrograde bolus movement (MII)
Observed in reflux
Progression of impedance from distal to proximal
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 257 – 264.
50. Combined MII
• MII used clinically only in combination
– With esophageal manometry (MII-EM)
– With pH (MII-pH)
• MII not considered as replacement for manometry &
pH techniques but as complementary procedure that
expands diagnostic potential of esophageal function
testing & reflux monitoring
51. Combined MII-pH probe
• Impedance orifices
3, 5, 7, 9, 15, & 17 cm from the tip
• pH orifice
5 cm from the tip
• MII-pH probe = pH probe
Do not change patient comfort
Bremner CG et al. Esophageal disease & testing.
Taylor & Francis Group, NY, 1st edition, 2005.
52. “Sleuth” monitor – Sandhill
“Sleuth” monitor attached to the catheter
& worn around a belt during the recording period
53. GERD classification by combined MII-pH
Acid reflux
Reflux with drop of pH from above 4.0 to below 4.0
Superimposed acid reflux (Acid re-reflux)
Acid reflux occurs while pH < 4.0
Weakly acidic reflux
Reflux results in esophageal pH between 4.0 & 7.0
Weakly alkaline reflux
Reflux with nadir esophageal pH does not drop < 7.0
Sifrim D et al. Gut 2004 ; 53 ; 1024 – 1031.
55. GERD classification by combined MII-pH
Acid reflux
Reflux with drop of pH from above 4.0 to below 4.0
Superimposed acid reflux (Acid re-reflux)
Acid reflux occurs while pH < 4.0
Weakly acidic reflux
Reflux results in esophageal pH between 4.0 & 7.0
Weakly alkaline reflux
Reflux with nadir esophageal pH does not drop < 7.0
Sifrim D et al. Gut 2004 ; 53 ; 1024 – 1031.
57. GERD classification by combined MII-pH
Acid reflux
Reflux with drop of pH from above 4.0 to below 4.0
Superimposed acid reflux (Acid re-reflux)
Acid reflux occurs while pH < 4.0
Weakly acidic reflux
Reflux results in esophageal pH between 4.0 & 7.0
Weakly alkaline reflux
Reflux with nadir esophageal pH does not drop < 7.0
Sifrim D et al. Gut 2004 ; 53 ; 1024 – 1031.
58. Weakly acidic reflux (MII-pH)
Gastrointest Endoscopy Clin N Am 2005 ; 15 : 361 – 371.
59. GERD classification by combined MII-pH
Acid reflux
Reflux with drop of pH from above 4.0 to below 4.0
Superimposed acid reflux (Acid re-reflux)
Acid reflux occurs while pH < 4.0
Weakly acidic reflux
Reflux results in esophageal pH between 4.0 & 7.0
Weakly alkaline reflux
Reflux with nadir esophageal pH does not drop < 7.0
Sifrim D et al. Gut 2004 ; 53 ; 1024 – 1031.
61. Recommendations for MII-pH monitoring
• Endoscopy-negative patients with heartburn or
regurgitation despite PPI & performed on PPI therapy
• Utility of impedance in refractory reflux patients with
chest pain or extraesophageal symptoms unproven
• Current interpretation relies on SI, SSI or SAP
• Therapeutic implications of abnormal test unproven
ACG Practice Guidelines: Esophageal reflux testing.
Am J Gastroenterol 2007 ; 102 : 668 – 685.
62. Advantages of 3 major types of pH testing
pH Tubeless Combined
MII-pH
Comfort _ + _
Monitoring > 24 h _ + _
Nonacid reflux _ _ +
Normal values + _ _
Proximal reflux + ? +
Gastric monitoring + ? +
Intragastric pH Monitoring:The evidence supporting the clinical significance and applicability of gastric pH monitoring is insufficient to recommend its routine use inclinical practice.Proximal pH Recording:available evidence does not support the routine use of proximal pH monitoring in clinical practice.
Subgroups of Endoscopy-Negative reflux disease (ENRD)2 distinctive subgroups exist- Nonerosive reflux disease (NERD) Functional heartburnThese groups are separated by the presence or absence of abnormal levels of acid reflux.
Therefore, pH recordings using the wireless pH system improve patients’ ability to perform their daily activities and thus provide a more accurate picture of their acid exposure profile as well as improve their compliance with the study.
Using the wireless pH system, the 95th percentile for distal esophageal acid exposure for control subjects was 5.3%, a value higher than values reported in several although not all catheter-based system studies. The higher acid exposure threshold reported in healthy controls using the wireless pH system may be the consequence of less restriction in daily activities or the result of a thermal calibration error that existed in the pH catheter systems.The 48-h data could be interpreted using an average of the 2 days or only the 24-h period with the greatest acid exposure (worst day analysis). A significant increase in the sensitivity of pH testing and small decrease in specificity were evident when utilizingthe worst day data compared with either the initial 24-h or overall 48-h data in comparing controls with GERD patients.
Strong correlation in esophageal acid exposure between 2 systemsCFS under recorded acid exposure
Relatively new technique developed in early 1990s at Helmholtz Institute in Aachen (Germany)Silny* provided first description of this technique that assesses intraluminal bolus movement by measuring changes in conductivity of intraluminal content
A recent, multicenter study examined the impedance characteristics of 60 healthy subjects during 24-h ambulatory monitoring. Based on impedance values 5 cm above the LES, the median number of total reflux episodes per 24 h was 30, the majority of which occurred in the upright position.Approximately two-thirds of the episodes were acid and another third weakly acidic reflux. Weakly alkaline reflux was distinctly uncommon in this healthy cohort. Similar frequencies were recently reported from a multicenter European study. References:Shay S, Tutuian R, Sifrim D, et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: A multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol 2004;99:1037–43.Zerbib F, Bruley des Barannes S, Roman S, et al. 24 hour ambulatory esophageal multichannel intraluminal impedance-pH in healthy European subjects. Gastroenterology 2005;128:A396.