This document discusses several medical conditions that affect blood vessels and other tissues: - Fibromuscular dysplasia causes high blood pressure and other issues due to narrowing of medium-sized arteries. Symptoms vary by which arteries are affected. - Monckeberg medial calcific sclerosis involves hardening of medium-sized arteries in the legs, typically in older adults, and often does not cause problems. - Homocystinuria results from an amino acid metabolism defect and can lead to problems affecting blood vessels, brain function, eyes, bones, and other tissues. - 11 beta hydroxylase deficiency is a type of congenital adrenal hyperplasia that causes high blood pressure and

1. Pathos logos

2. Fibromuscular Dysplasia
 Signs and symptoms
 Renal – Hypertension,ischemic
nephropathy , Kidney Failure
 Neurological –
1. Blurred vision or vision loss
2. Dizziness (vertigo)
3. Headache
4. Neck pain
5. Ringing in the ears (tinnitus)

4. Monckeberg medial calcific sclerosis
 Older than 50 yrs
 Mostly in Radial / Ulnar arteries
 Pipe stem arteries
 May have association with Osteoporosis
 Mostly not clinically significant

5. Homocystinemia

 Vascular abnormalities
 • Ischemic stroke and transient ischemic attack
 • Myocardial infarction
 • Peripheral vascular disease
 • Deep venous thrombosis
 • Pulmonary embolism
 • Cerebral venous thrombosis
 Neurologic abnormalities
 • Ischemic stroke and transient ischemic attack
 • Cerebral venous thrombosis
 • Mental retardation
 • Psychiatric disorders
 • Seizures
 Ocular abnormalities
 • Dislocation of lens
 • Myopia
 • Retinal Detachment
 • Glaucoma
 • Cataracts
 • Corneal abnormalities
 Skeletal abnormalities
 • Osteoporosis
 • Scoliosis
 • Increased length of long bones
 • Pes cavus
 • Arachnodactyly
 Other abnormalities
 • Fatty infiltration of liver
 • Endocrine abnormalities
 • Myopathy

7. 11 beta hydroxylase deficiency
 Form of Congenital Adrenal Hyperplasia
 11β-OH CAH results in hypertension due
to excessive mineralocorticoid effects. It
also causes excessive androgen production
both before and after birth and can virilize
a genetically female fetus or a child of
either sex.

8. Liddle Syndrome
 Pseudoaldosteronism
 AD
 early, and frequently severe, hypertension associated with
low plasma renin activity, metabolic alkalosis due to
hypokalemia, and hypoaldosteronism (low secretion of
aldosterone).[2] It is one of several conditions with this
unusual set of characteristics known collectively as
pseudohyperaldosteronism
 abnormal kidney function, with excess
reabsorption of sodium and loss of potassium
from the renal tubule,

11. Muir Torre Syndrome
 inherited cancer syndrome
 subtype of HNPCC.
 cancers of the colon, breast and
genitourinary tract, and skin lesions, such
as keratoacanthomas and sebaceous
tumours. The genes affected are MLH1 &
MSH2, and involved in DNA mismatch
repair.