Edward Jenner was an English physician born in 1749 who is considered the pioneer of smallpox vaccines and the father of immunology. In 1796, Jenner inoculated an 8-year old boy with cowpox matter from the hand of a milkmaid, producing immunity to smallpox. Over subsequent tests of 23 subjects, Jenner demonstrated that inoculation with cowpox provided effective protection against smallpox. Jenner's discovery led to worldwide vaccination programs and the eventual global eradication of smallpox by 1980.
It talks about Contribution of Antonie Van Leeuwenhoek to the society. It also talks about his life style like a story. It also explains the contribution about microscope and micro organisms.
Louis Pasteur was born on 27th december 1822, in dole, france. He was a soldier in napoleon’s army and his job was a gravedigger. As a child louis loved to paint but the age of 19, he decided to start a scientific career. He studied physics and chemistry and in 1846 he recived a PH.D in CHEMISTRY.He worked as a professor at the university of strasbourg,paris.Louis pasteur is known as the “FATHER OF MICROBIOLOGY & IMMUNOLOGY”
Microbiology essentially began with the development of the microscope. Although others may have seen microbes before him, it was Antonie van Leeuwenhoek, a Dutch draper whose hobby was lens grinding and making microscopes, who was the first to provide proper documentation of his observations.
History of Microbiology Discovery Era, Transition Era, Golden Era, Modern Era, Louis Pasteur, Antony Van Leevenhoek, Pasteurization, Alexander Fleming, fermentation, Agar,
It talks about Contribution of Antonie Van Leeuwenhoek to the society. It also talks about his life style like a story. It also explains the contribution about microscope and micro organisms.
Louis Pasteur was born on 27th december 1822, in dole, france. He was a soldier in napoleon’s army and his job was a gravedigger. As a child louis loved to paint but the age of 19, he decided to start a scientific career. He studied physics and chemistry and in 1846 he recived a PH.D in CHEMISTRY.He worked as a professor at the university of strasbourg,paris.Louis pasteur is known as the “FATHER OF MICROBIOLOGY & IMMUNOLOGY”
Microbiology essentially began with the development of the microscope. Although others may have seen microbes before him, it was Antonie van Leeuwenhoek, a Dutch draper whose hobby was lens grinding and making microscopes, who was the first to provide proper documentation of his observations.
History of Microbiology Discovery Era, Transition Era, Golden Era, Modern Era, Louis Pasteur, Antony Van Leevenhoek, Pasteurization, Alexander Fleming, fermentation, Agar,
1. Origin Of Epidemiology.
2. Definitions Of Epidemiology.
3. Objectives Of Epidemiology.
4. Branches Of Epidemiology.
5. Timeline Of Epidemiology.
6. John Graunt- The First Epidemiologist.
7. James Lind And Scurvy.
8. Edward Jenner And Small Pox.
9. Ignaz Semmelweis And Childbed Fever.
10. John Snow And Cholera
11. Conclusion
This presentation contains the history and classification of viruses on the basis of book titled "Molecular Biology, Pathogenesis and Control of Animal Viruses" by S.J. Flint.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
3. life of Jenner….
Born on 17th
May 1749(Berkeley)
From the age of 14yrs ,trained as
apprentice to Daniel Ludlow, a surgeon
In 1770-worked under surgeon John
Hunter at St.George’s hospital.
Returned to Berkeley in 1773,practised
as GP & surgeon.
Edward Jenner died of stroke at the age
of 73, on 26 January 1823
4. Small pox
Disease goes
through stages of
macules ,papules,
vesicles,pustules
over the skin.
Severe forms-
hemorrhagic
5. Greatly feared disease for thousands of years
Caused by Variola virus
1/3rd
of the patients died
Survivors –badly disfigured
10 yrs before eradication ,the disease was
present in 44 countries, with a global incidence
of around 10 million cases annually !!!
6. Jenner Vs Pox
Jenner’s initial theory-
The initial source of infection was a disease of
horses, called "the grease", and that this was
transferred to cows by farm workers,
transformed, and then manifested as cowpox.
He noted-Milkmaids don't generally get small
pox
He theorized it-pus in the blisters which
milkmaids received from cowpox (a disease
similar to smallpox, but much less virulent)
protected the milkmaids from smallpox.
7. On 14 May 1796,
Inoculated James Phipps, a young boy of 8
years (the son of Jenner's gardener), with
material from the cowpox blisters of the hand of
Sarah Nelmes, a milkmaid who had caught
cowpox from a cow called Blossom
produced a fever and some uneasiness but no
great illness
Injected Phipps with variolous material –No
disease followed
Again challenged with variolous material-but no
sign of infection
8. Why Jenner was successful??
Not only inoculated cowpox ,but also
proved that they are immune to small
pox
Demonstrated that the protective
cowpox could be effectively inoculated
from person to person, not just directly
from cattle.
He tested his theory on a series of 23
subjects. This aspect of his research
method increased the validity of his
evidence.
9. He continued his research and reported it
to the Royal Society, who did not publish
the initial report.
After improvement and further work, he
published a report of twenty-three cases
In 1803 in London he became involved
with the Jennerian Institution, a society
concerned with promoting vaccination to
eradicate smallpox.
10. Post- Jenner era
17 yrs after his death(1840), British
government banned variolation ( the
use of smallpox itself) and provided
vaccination (using cowpox )free of
charge.
In 1976,Global eradication programme
of Smallpox –initiated by WHO.
After 10 years-disease was wiped out ,
11. .
Last stock is in – USA and Russia
They were to be destroyed by June 30 ,
1999.
But fears of the possible use of small pox
in bioterrorism led to an indefinite
extension of the deadline.
Whole world was certified “small pox free
area” in October 1979.
Formally declared by WHO in 8th
May
1980
12. Remembering the great man…..
-Jenner's house is now a small museum
housing among other things the horns of
the cow, Blossom (Berkeley).
-Near the small Gloucestershire village of
Uley, Downham Hill is locally known as
'Smallpox Hill', with a possible connection
to Jenner's local work with the disease.
13. A statue was erected
in Trafalgar Square,
later moved to
Kensington Gardens.