Fungi is a group of eukaryotic non-phototropic organisms with rigid cell walls, that includes unicellular yeasts and multicellular molds. These slides will provide you the basics of fungi, general properties , reproduction and types of fungi.
Fungi are a kingdom of usually multicellular eukaryotic organisms that are heterotrophs (cannot make their own food) and have important roles in nutrient cycling in an ecosystem. Fungi reproduce both sexually and asexually, and they also have symbiotic associations with plants and bacteria.
Classifications of Fungi
Characteristics of all Fungi
Structure of Fungi
Reproduction
Classification of Fungi
Basidiomycota
sexual reproduction occur by basidium , will be present spore is called basidiospore .
Asexual by budding ,fragementation, conidiospores.
Ascomycota
microscopic sexual structure in which nonmotile spores, called ascospores.
Mostly the ascomycota is sexual but some asexual it lacks the ascospore.
Zygomycota
Two spore
mitospores ( or) sporangiospore
chlamitospore (or) zygospore
Deuteromycota
Imperfect Fungi referring to our "imperfect" knowledge of their complete life cycles.
sexual life cycle that is either unknown or absent.
Asexual reproduction is by means of conidia or may be lacking.
culture media
SDA medium – sabouraud dextrose agar
Fungi are a kingdom of usually multicellular eukaryotic organisms that are heterotrophs (cannot make their own food) and have important roles in nutrient cycling in an ecosystem. Fungi reproduce both sexually and asexually, and they also have symbiotic associations with plants and bacteria.
Classifications of Fungi
Characteristics of all Fungi
Structure of Fungi
Reproduction
Classification of Fungi
Basidiomycota
sexual reproduction occur by basidium , will be present spore is called basidiospore .
Asexual by budding ,fragementation, conidiospores.
Ascomycota
microscopic sexual structure in which nonmotile spores, called ascospores.
Mostly the ascomycota is sexual but some asexual it lacks the ascospore.
Zygomycota
Two spore
mitospores ( or) sporangiospore
chlamitospore (or) zygospore
Deuteromycota
Imperfect Fungi referring to our "imperfect" knowledge of their complete life cycles.
sexual life cycle that is either unknown or absent.
Asexual reproduction is by means of conidia or may be lacking.
culture media
SDA medium – sabouraud dextrose agar
Obligate intracellular, unable to self-replicate.
Once inside living cells, viruses induce the host cell to synthesize virus particles.
The genome is either DNA or RNA (single or double stranded).
Viruses do not have a system to produce ATP.
Viruses range in size from 25 to 270 nm.
Viral tropism!!
The classification of viruses is based on nucleic acid type, size and shape of virion, and presence or absence of an envelope.
Viral Structure
I . Virion is the entire viral particle.
2. Capsid is the protein coat that encloses the genetic material.
3. Capsomer is the protein subunit that makes up the capsid.
4. Nucleocapsid is composed of the capsid and genetic material.
5. The envelope is the outer coating composed of a phospholipid bilayer, which is composed of viral-encoded glycoproteins and sometimes viral encoded matrix proteins. The envelope is derived from a host cell's membrane.
Some viruses use the plasma membrane, whereas others use endoplasmic reticulum, Golgi, or nuclear membranes. Naked nucleocapsids are viruses with no envelopes.
Biology I Presentation
FUNGI
We will learn
General characteristics of fungi
Structure of fungi
Economic Importance
Pathogenicity
Brief intro of some fungi
THE SIX KINGDOMS
Fungi are placed in a separate kingdom called the kingdom fungi
OF FUNGI
CHARACTERISTICS
The Characteristics of Fungi
Fungi are NOT plants
Nonphotosynthetic
Eukaryotes
Nonmotile
Most are saprobes (live on dead organisms)
The Characteristics of Fungi
Absorptive heterotrophs (digest food first & then absorb it into their bodies
Release digestive enzymes to break down organic material or their host
Store food energy as glycogen
The Characteristics of Fungi
Important decomposers & recyclers of nutrients in the environment
Most are multicellular, except unicellular yeast
Lack true roots, stems or leaves
fungi as a decomposers
The Characteristics of Fungi
Cell walls are made of chitin (complex polysaccharide)
Body is called the Thallus
Grow as microscopic tubes or filaments called hyphae
The Characteristics of Fungi
Some fungi are internal or external parasites
A few fungi act like predators & capture prey like roundworms
The Characteristics of Fungi
Some are edible, while others are poisonous
The Characteristics of Fungi
Produce both sexual and asexual spores
Classified by their sexual reproductive structures
The Characteristics of Fungi
Grow best in warm, moist environments
Mycology is the study of fungi
Mycologists study fungi
A fungicide is a chemical used to kill fungi
The Characteristics of Fungi
Fungi include puffballs, yeasts, mushrooms, toadstools, rusts, smuts, ringworm, and molds
The antibiotic penicillin is made by the Penicillium mold
FUNGI SIZE
NON-REPRODUCTIVE
Vegetative Structures
Hyphae
Tubular shape
ONE continuous cell
Filled with cytoplasm & nuclei
Multinucleate
Hard cell wall of chitin also in insect exoskeletons
Hyphae
Stolons – horizontal hyphae that connect groups of hyphae to each other
Rhizoids – rootlike parts of hyphae that anchor the fungus
Hyphae
Cross-walls called SEPTA may form compartments
Septa have pores for movement of cytoplasm
Form network called mycelia that run through the thallus (body)
Absorptive Heterotroph
Fungi get carbon from organic sources
Tips of Hyphae release enzymes
Enzymatic breakdown of substrate
Products diffuse back into hyphae
Modifications of hyphae
Fungi may be classified based on cell division (with or without cytokinesis)
Aseptate or coenocytic (without septa)
Septate (with septa)
Modifications of hyphae
Hyphal growth
Hyphae grow from their tips
Mycelium is an extensive, feeding web of hyphae
Mycelia are the ecologically active bodies of fungi
ASEXUAL & SEXUAL SPORES
REPRODUCTIVE STRUCTURES
REPRODUCTION
Most fungi reproduce Asexually and Sexually by spores
ASEXUAL reproduction is most common method & produces genetically identical organisms
Fungi reproduce SEXUALLY when conditions are poor & nutrients
Bacteria are the simplest, the smallest, and the most successful microorganisms.
They were first discovered by Anton Leeuwenhoek (1676).
In the five kingdom classification, they are placed in Kingdom Monera. Reproduction: Vegetative Reproduction, Sexual Reproduction & Asexual Reproduction.
1.INTRODUCTION
2.HISTORY
3.MORPHOLOGY
4.STRUCTURE
5.CLASSIFICATION
6.CHARACTERSTICS
7.DISEASES
8.CONCLUSION
REFRENCES
Mycoplasmas are prokaryotic , without cell wall & have been placed under the class Mollicutes & the order Mycoplasmatales.
Mycoplasma are the smallest microorganism which have been known to cause a number of disease in animals &human kind.
The cells are bounded by a soft trilamellar lipoproteinaceous unit membrane containing sterols. Because of their plasticity , they can pass through bacterial filters & have often been mistaken for viruses.
Obligate intracellular, unable to self-replicate.
Once inside living cells, viruses induce the host cell to synthesize virus particles.
The genome is either DNA or RNA (single or double stranded).
Viruses do not have a system to produce ATP.
Viruses range in size from 25 to 270 nm.
Viral tropism!!
The classification of viruses is based on nucleic acid type, size and shape of virion, and presence or absence of an envelope.
Viral Structure
I . Virion is the entire viral particle.
2. Capsid is the protein coat that encloses the genetic material.
3. Capsomer is the protein subunit that makes up the capsid.
4. Nucleocapsid is composed of the capsid and genetic material.
5. The envelope is the outer coating composed of a phospholipid bilayer, which is composed of viral-encoded glycoproteins and sometimes viral encoded matrix proteins. The envelope is derived from a host cell's membrane.
Some viruses use the plasma membrane, whereas others use endoplasmic reticulum, Golgi, or nuclear membranes. Naked nucleocapsids are viruses with no envelopes.
Biology I Presentation
FUNGI
We will learn
General characteristics of fungi
Structure of fungi
Economic Importance
Pathogenicity
Brief intro of some fungi
THE SIX KINGDOMS
Fungi are placed in a separate kingdom called the kingdom fungi
OF FUNGI
CHARACTERISTICS
The Characteristics of Fungi
Fungi are NOT plants
Nonphotosynthetic
Eukaryotes
Nonmotile
Most are saprobes (live on dead organisms)
The Characteristics of Fungi
Absorptive heterotrophs (digest food first & then absorb it into their bodies
Release digestive enzymes to break down organic material or their host
Store food energy as glycogen
The Characteristics of Fungi
Important decomposers & recyclers of nutrients in the environment
Most are multicellular, except unicellular yeast
Lack true roots, stems or leaves
fungi as a decomposers
The Characteristics of Fungi
Cell walls are made of chitin (complex polysaccharide)
Body is called the Thallus
Grow as microscopic tubes or filaments called hyphae
The Characteristics of Fungi
Some fungi are internal or external parasites
A few fungi act like predators & capture prey like roundworms
The Characteristics of Fungi
Some are edible, while others are poisonous
The Characteristics of Fungi
Produce both sexual and asexual spores
Classified by their sexual reproductive structures
The Characteristics of Fungi
Grow best in warm, moist environments
Mycology is the study of fungi
Mycologists study fungi
A fungicide is a chemical used to kill fungi
The Characteristics of Fungi
Fungi include puffballs, yeasts, mushrooms, toadstools, rusts, smuts, ringworm, and molds
The antibiotic penicillin is made by the Penicillium mold
FUNGI SIZE
NON-REPRODUCTIVE
Vegetative Structures
Hyphae
Tubular shape
ONE continuous cell
Filled with cytoplasm & nuclei
Multinucleate
Hard cell wall of chitin also in insect exoskeletons
Hyphae
Stolons – horizontal hyphae that connect groups of hyphae to each other
Rhizoids – rootlike parts of hyphae that anchor the fungus
Hyphae
Cross-walls called SEPTA may form compartments
Septa have pores for movement of cytoplasm
Form network called mycelia that run through the thallus (body)
Absorptive Heterotroph
Fungi get carbon from organic sources
Tips of Hyphae release enzymes
Enzymatic breakdown of substrate
Products diffuse back into hyphae
Modifications of hyphae
Fungi may be classified based on cell division (with or without cytokinesis)
Aseptate or coenocytic (without septa)
Septate (with septa)
Modifications of hyphae
Hyphal growth
Hyphae grow from their tips
Mycelium is an extensive, feeding web of hyphae
Mycelia are the ecologically active bodies of fungi
ASEXUAL & SEXUAL SPORES
REPRODUCTIVE STRUCTURES
REPRODUCTION
Most fungi reproduce Asexually and Sexually by spores
ASEXUAL reproduction is most common method & produces genetically identical organisms
Fungi reproduce SEXUALLY when conditions are poor & nutrients
Bacteria are the simplest, the smallest, and the most successful microorganisms.
They were first discovered by Anton Leeuwenhoek (1676).
In the five kingdom classification, they are placed in Kingdom Monera. Reproduction: Vegetative Reproduction, Sexual Reproduction & Asexual Reproduction.
1.INTRODUCTION
2.HISTORY
3.MORPHOLOGY
4.STRUCTURE
5.CLASSIFICATION
6.CHARACTERSTICS
7.DISEASES
8.CONCLUSION
REFRENCES
Mycoplasmas are prokaryotic , without cell wall & have been placed under the class Mollicutes & the order Mycoplasmatales.
Mycoplasma are the smallest microorganism which have been known to cause a number of disease in animals &human kind.
The cells are bounded by a soft trilamellar lipoproteinaceous unit membrane containing sterols. Because of their plasticity , they can pass through bacterial filters & have often been mistaken for viruses.
Morphology of Fungi || Fungi || Pharmaceutical Microbiology || B.Pharmacy || College Presentation
In This We Have To See
Introduction of Fungi
Morphology of Fungi
Moulds or Filamentous Fungi
Yeast
Yeast Like Fungi
Dimorphic Fungi
Important Microorganisms in Food Microbiology:
a. Yeast & Molds: Saccharomyces, Aspergillus & Penicillium
b. Bacteria: Bacillus, Clostridium, Flavobacterium,
Fungi is most abundantly found organism in earth, almost all parts of earth we found earth, here we represent some characteristic with their uses and disadvantages .
Fungi are eukaryotic organisms that include microorganisms such as yeasts, moulds and mushrooms. These organisms are classified under kingdom fungi.
This report will contain a few general discussions about the Kingdom Fungi and proceed to Focus on the Ascomycetes (Sac Fungi). Majority of the information in this slide came from online sources. If you feel the need to correct some parts, please let me know on the comments section.
Adenoviral conjunctivitis, also known as "pink eye is a common, self-limiting condition that typically is caused by adenovirus.
Adenoviruses can cause an array of clinical diseases, including conjunctivitis, respiratory disease, hemorrhagic cystitis and gastroenteritis.
Bacteria are unicellular, procaryotic microorganisms which have diverse shape size and structures. Bacteria are found almost everywhere on Earth. Even the human body is full of bacteria, and in fact is estimated to contain more bacterial cells than human cells. Most bacteria in the body are harmless, and some are even helpful. A relatively small number of species cause disease.
A microscope is an instrument used to observe very small organisms i.e. microorganisms. The microscope provides magnification and resolution which makes the image enlarged and fine. There are different types of microscopes ranging from simple to compound microscopes.
Mitochondria are membrane-bound cell organelles (mitochondrion, singular), known as the power house of the cell that generate most of the chemical energy needed to power the cell's biochemical reactions. Mitochondria generates most of the cell's supply of adenosine triphosphate (ATP), by a process called
“oxidative phosphorylation”.
Type II Hypersensitivity-Antibody mediated cytotoxic HypersensitivityAnup Bajracharya
Type II Hypersensitivity is antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens with the resultant cellular destruction, functional loss, or damage to tissues.
Dark-field microscopy is used to illuminate unstained samples causing them to appear bright against a dark background. This type of microscope contains a special condenser having a central blacked-out area.
Air pollution Basics for higher level school students - Undesirable and unwanted changes in the characteristics of air that are harmful to the health of humans and other living beings is air pollution.
Pentose phosphate pathway is an alternative pathway to glycolysis and TCA cycle for oxidation of glucose. It is a shunt of glycolysis. It is also known as hexose monophosphate (HMP) shunt or phosphogluconate pathway. It occurs in cytoplasm of both prokaryotes and eukaryotes. While it involves oxidation of glucose, its primary role is anabolic rather than catabolic. It is an important pathway that generates precursors for nucleotide synthesis and is especially important in red blood cells (erythrocytes).
It is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA.
Environmental impacts of coronavirus crisis, challenges aheadAnup Bajracharya
The worldwide disruption caused by the COVID-19 pandemic has resulted in numerous impacts on the environment and the climate. There is reduction in carbon emissions, visibility clearance in the environment.
Convalescent plasma therapy is the treatment in which plasma that is removed from the blood of a person who has recovered from a disease is transfused into a person with the disease that fight against the causative agents and make patient safe from the diseased condition.
Acid fast staining is differential staining technique which differentiate bacteria into two group- acid fast bacteria and non acid bacteria. It used to identify acid-fast organisms such as members of the genus Mycobacterium .
When fresh liquid medium is inoculated with a given number of bacteria and incubated for sufficient period of time, it gives a characteristic growth pattern of bacteria.
If the bacterial population is measured periodically and log of number of viable bacteria is plotted in a graph against time, it gives a characteristic growth curve which is known as growth curve or growth cycle.
Growth of bacteria is affected by many factors such as nutrition concentration and other environmental factors.
Some of the important factors affecting bacterial growth are:
Nutrition concentration
Temperature
Gaseous concentration
pH
Ions and salt concentration
Available water
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Fungi
• Fungi are
• eukaryotic,
• heterotrophic,
• unicellular to filamentous,
• spore bearing organisms
• that reproduce sexually and asexually.
3. General properties of fungi
• are eukaryotic cells contain membrane bound cell organelles including
nuclei, mitochondria, golgi apparatus, endoplasmic reticulum, lysosomes
etc.
• have a rigid cell wall which is made up of chitin.
• Cell membrane is made up of ergosterols
• lack chlorophyll and are therefore chemoheterotrophs (require organic
compounds for both carbon and energy sources) and not autotrophic.
• are osmiotrophic; they obtain their nutrients by absorption.
• obtain nutrients as saprophytes (live off of decaying matter) or as
parasites (live off of living matter).
• typically reproduce asexually and/or sexually by producing spores.
• grow either reproductively by budding or non-reproductively by hyphal tip
elongation.
• Food storage is generally in the form of lipids and glycogen.
5. Yeast
• Yeasts are microscopic,
unicellular fungi with a
single nucleus and
eukaryotic organelles.
• They are oval or round in
shape.
• They reproduce asexually
by a process of budding.
• In this process, a new cell
forms at the surface of the
original cell, enlarges, and
then breaks free to live
independently.
6. Mold
• The main body of mold is
made up of fine, branching
threads called hyphae.
• These hyphae intertwined
with each other to make up a
tangled web called
the mycelium.
• In some fungi hyphae is
divided into cell or
compartment by septum.
• Septum has a central pore
which allows the movement
of cytoplasm from one cell or
compartment to another.
7. Types of hyphae
• There are three types of hyphae among fungi.
• Coenocytic or non-septate hyphae
• Septate hyphae with uninucleated cell
• Septate hyphae with multinucleated cell
8. Characteristics Yeast Mold
Structure
Yeast are mostly unicellular and exist in
either individually or with buds
growing on them
Mold are multicellular with tubular and
filamentous hyphae
Structural Appearance Round or oval shaped Thread like filamentous
Color appearance Dull color and mostly monochromatic Wide variety of coloration
Habitat Most occur naturally in soil or ocean
Occur in any organic environment having
moist and humid atmosphere
Method of
reproduction Mainly by budding or binary fission
Mainly by spore formation (sexual and
asexual spore both)
Application or uses
Use in industries for ethanol
production, baking, food additive or
flavor etc
Used in biodegradation, bioremediation
as well as in antibiotic production
Oxygen requirement Aerobic and facultative anaerobes Strictly aerobic (obligate aerobes)
Examples
Saccharomyces cerevisiae, Candida
albicans, Cryptococcus neoformans Rhizopus, Mold, Penicillium, Aspergillus
9. Reproduction in fungi
• Fungi reproduce sexually and
asexually by spores.
• Asexual reproduction occurs
in the fungi when spores
form by mitosis.
• These spores can be
• conidia,
• sporangiospores,
• arthrospores (fragments of
hyphae), or
• chlamydospores (spores with
thick walls).
10. Reproduction in fungi
• During sexual
reproduction,
compatible nuclei unite
within the mycelium and
form sexual spores.
• Sexually opposite cells
may unite within a single
mycelium, or different
mycelia may be required.
• When the cells unite, the
nuclei fuse and form a
diploid nucleus.
11. Importance of fungi
• i. Important agents for biodegradation and bio-deterioration
• ii. Use in industrial fermentation process.
• Examples; Penicillium notatum is used for production of
penicillin antibiotics
• Aspergillus niger is used for prodution of citric acid
• Saccharomyces cerevisiae is used for alcohol production
• iii. Used in bioremediation (reduces toxic concentration)
• iv. Used in agriculture, horticulture and forestry, example;
biofertilizer and biopesticides
12. Classification of fungi.
• The kingdom fungi is classified into 4 division
1. Ascomycetes
2. Basidiomycetes
3. Zygomycetes
4. Deuteromycetes
13. Ascomycetes
• Sexual spore produced within a
sac like structure called ascus.
• Sexual spore are called ascospore
• Asexual reproduction occurs by
conidia
• Ascomycetes are also known as
sac mycetes.
• Hyphae are generally septated
• Examples: Saccharomyces,
Arthroderma
14. Basidiomycetes
• Sexual spore are produced
externally on a basidium
• Sexual spore are known as
basidiospore
• Asexual reproduction occurs
by budding, fragmentation or
conidia formation
• They are commonly called as
mushroom group
• Hyphae are generally septated
• Examples: Amanita, Agaricus
15. Zygomycetes
• Sexual spore are known as
Zygospore
• Zygospore is formed by
fusion of two similar cells.
• Asexual reproduction
occurs by sporangiospore
• Hypahe are generally
aseptated.
• Examples: Rhizopus, Mucor
16. Deuteromycetes
• No sexual stage is present
• Deuteromycetes are also
known as fungi imperfecti.
• Asexual reproduction
occurs by means of
conidia.
• Most of the human and
animal pathogens are
present in this class.
• Examples: Candida,
Cryptococcus,
Trichophyton,
Epidermophyton,
Histoplasma