The document discusses dissolution models and methods. It defines dissolution as the process by which a solid substance is solubilized in a solvent. Several theories of dissolution are described, including the diffusion layer model, Danckwert's model, and the interfacial barrier model. Factors that can affect dissolution, such as drug properties, formulation components, and test conditions are outlined. Both official and unofficial in vitro dissolution test models are reviewed, including common apparatus like the paddle and basket methods. Finally, the kinetics of dissolution are discussed and equations for modeling zero-order, first-order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas release are provided.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
Dissolution : Official and Non official methods, Alternative methods of dissolution testing and transport models, Drug release testing, Invitro drug release testing
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
drug execipent compatibilty studies is of prime importance for the better formulation of the new drug and also for reducing cost by verfication of the data at the earlier atage.
this presentation will give the brief explanation of the goal, importance, dteps involve to studi the drug execient compatibility studies with different examples suitable accordiingly.
Introduction to Nasal drug delivery system,Anatomy of Nasal cavity,Advantages n limitataions of Nasal DDS,Mechanism,factors affecting Nasal DDS,Formulation,methods to enhance Nasal DDS,Dosage forms,Evalaution
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
Evaluation methods for drug excipients and container interactionSagar Savale
Excipients are one of the three components that in combination produce the medicine that the patient will take.
In therapeutic terms, the API is of primary importance because without it there is no treatment and no product.
In term of drug manufacturing all three of them are equally important so we cannot neglect anyone of them.
The interactions between excipients and the other two components (the API and the manufacturing process), and/or between two or more excipients, are fundamental to the transformation of an API into a medicinal product.
What is dissolution? Dissolution is a process in which a solid substance get solubilizes in a particular solvent to yield a solution i.e. mass transfer from the solid surface to the liquid phase.
Dissolution apparatus, invivo-invitro corelation, factor affecting,BCS classification ..
Complete dissolution topic in this slide & easy way to write..
Cheak it now and give feedback
Dissolution : Official and Non official methods, Alternative methods of dissolution testing and transport models, Drug release testing, Invitro drug release testing
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
drug execipent compatibilty studies is of prime importance for the better formulation of the new drug and also for reducing cost by verfication of the data at the earlier atage.
this presentation will give the brief explanation of the goal, importance, dteps involve to studi the drug execient compatibility studies with different examples suitable accordiingly.
Introduction to Nasal drug delivery system,Anatomy of Nasal cavity,Advantages n limitataions of Nasal DDS,Mechanism,factors affecting Nasal DDS,Formulation,methods to enhance Nasal DDS,Dosage forms,Evalaution
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
Evaluation methods for drug excipients and container interactionSagar Savale
Excipients are one of the three components that in combination produce the medicine that the patient will take.
In therapeutic terms, the API is of primary importance because without it there is no treatment and no product.
In term of drug manufacturing all three of them are equally important so we cannot neglect anyone of them.
The interactions between excipients and the other two components (the API and the manufacturing process), and/or between two or more excipients, are fundamental to the transformation of an API into a medicinal product.
What is dissolution? Dissolution is a process in which a solid substance get solubilizes in a particular solvent to yield a solution i.e. mass transfer from the solid surface to the liquid phase.
Dissolution apparatus, invivo-invitro corelation, factor affecting,BCS classification ..
Complete dissolution topic in this slide & easy way to write..
Cheak it now and give feedback
It includes Introductory part about what is Dissolution...then Mechanism of Dissolution is elaborated...Theories of Dissolution also given..It also includes Factors affecting Dissolution profile..Along with References given below for easily searching..
Dissolution is a process in which a solid substance solubilizes in a given solvent.
Method for dissolution are-
1. Beaker methods
2. Open flow through compartment system
3.Dialysis concept
The objective of in vitro dissolution testing is to evaluate the variables that effect the rate and extent of release of a drug substance from the finished dosage form, and in turn, the in vivo performance of the drug product.
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Questions
• Q.1. write in detail about the various method of dissolution
testing? (20)
• Q.2. define dissolution. Discuss dissolution of drug from
solid dosage form. Write various modern methods for
testing of dissolution. (20)
• Q.3. discuss in detail various official & non-official models
for testing dissolution rate? (20)
• Q.4. Discuss factors affecting dissolution of drug. Describe
dissolution kinetics. (20)
3. Content
• Introduction
• Theories of Dissolution
• Invitro Dissolution Test Models
• Factors Affecting Dissolution
• Kinetics of Dissolution.
4. Introduction
Dissolution is a process in which a solid substance is solubilised
in a given solvent i.e., mass transfer from solid surface to liquid
phase.
(or)
It is a process by which drug released from solid dosage form
and immediately goes into molecular solution.
Rate of dissolution is the amount of drug substance that goes in
solution per unit time under standardized conditions of
liquid/solid interface, temperature and solvent composition.
It is a Rate Determining Step
If the drug is hydrophilic with high aqueous solubility then
dissolution is rapid and rate determining step
6. 1. Diffusion Layer Model/ Film theory
• Solution of the solid to form a thin layer at the solid/liq. interface is
called Stagnant film or Diffusion layer which is with saturated drug.
• Soluble solute form diffuses from the stagnant layer to the bulk of the
solution. This step is slower and rate-determining step in drug
dissolution.
• This rate of dissolution if the process is diffusion controlled and
involves no chemical reaction. It can be explained by Noyes –
Whitney Equation .
𝐝𝐂
𝐝𝐭
=
𝐤(𝐂 𝐬−𝐂 𝐛)
𝐕𝐡
where
dC/dt = dissolution rate of drug
Cs = conc. Of drug in stagnant layer
Cb= conc. Of drug in bulk of the solution at time t.
k = dissolution rate constant. (First order)
8. 2. Danckwert’s Model
• This model suggest that turbulence in
dissolution medium exists at the
solid/liquid interface.
• This theory is also called as Surface
Renewal Theory.
V
𝑑𝐶
dt
𝑑𝑚
𝑑𝑡
= 𝐴(𝐶𝑠 − 𝐶𝑏) 𝛾𝐷
• m = mass of solid dissolution,
• 𝛾 = rate of interfacial tension,
• D = diffusion coefficient of the drug
9. 3. Interfacial Barrier Model
• This model considers the phenomenon of drug dissolution as crystal dissolution.
The solid gets hydrated initially.
• a different interfacial barrier such a concept is given by the following equation..
G = Ki (cs - cb)
where
G = dissolution rate per unit area. g/cm², min
Ki = effective interfacial transport constant, min⁻¹
Cs = Concentration of drug in the stagnant layer
Cb = Concentration of drug in the bulk of the solution at time t
• In this theory, the diffusivity D may not be independent of saturation
concentration cs. Therefore the interfacial model
can be extended to both diffusion layer model and Danckwerts model.
10. Factors Influencing Dissolution
a) Factors related to Physicochemical Properties
of Drug
b) Factors related to Drug Product Formulation
c) Processing Factor
d) Factors Relating Dissolution Apparatus
e) Factors Relating Dissolution Test Parameters
11. a.) Factors related to Physicochemical Properties
of Drug
1. DRUG SOLUBILITY
Minimum aqueous solubility of 1% is required to avoid potential solubility limited
absorption problems.
2. SALT FORMATION
Surface area increases with decrease in particle size, higher dissolution rates may be
achieved through reduction of particle size.
3. PARTICLE SIZE
Since, surface area increases with decrease in particle size, higher dissolution rates
may be achieved through reduction of particle size. Direct relates to surface area
and dissolution rate.
4. SOLID STATE CHARACTERISTICS
Anhydrous forms dissolve faster than hydrated form because they are
thermodynamically more active than hydrates.
Amorphous forms of drug tend to dissolve faster than crystalline materials.
12. b.) Factors related to Drug Product Formulation
1. DILUENTS
particles form a layer on the outer surface of hydrophobic drug
particles resulting in imparting hydrophilic character to granules &
thus increase in effective surface area & rate of dissolution.
2. DISINTEGRANTS
3. BINDERS AND GRANULATING AGENTS
Large amt. of binder increase hardness & decrease disintegration
/dissolution rate of tablet.
4. METHOD OF GRANULATION
5. COMPRESSION FORCE
13. c.) Factors Relating Dissolution Apparatus
Agitation
d.) Factors Relating Dissolution Test Parameters
Temprature
Dissolution medium
pH
15. Type I.P. USP B.P. E.P.
Type 1
Paddle
apparatus
Basket
apparatus
Basket
apparatus
Paddle
apparatus
Type 2
Basket
apparatus
Paddle
apparatus
Paddle
apparatus
Basket
apparatus
Type 3
Reciprocating
cylinder
Flow through
cell apparatus
Flow through
cell apparatus
Type 4
Flow through
cell apparatus
Type 5
Paddle over
disk
Type 6
Rotating
cylinder
Type 7
Reciprocating
disk
Official Dissolution Apparatus
18. APPARATUS-2 (PADDLE)
DESIGN:
Vessel: -Same as basket apparatus
Shaft: -The blade passes through the shaft so that
the bottom of the blade fuses with bottom of the shaft.
Stirring elements: -Made of Teflon
For laboratory purpose
-Stainless steel 316
Water-bath:- Maintains at 37±0.5°C
Sinkers:- Platinum wire used to prevent
tablet/capsule from floating
video managerPharma Test DFC-820SP
Automated Dissolution System.mp4
video managerERWEKA Offline
System Overview.mp4
19. APPARATUS-3 (RECIPROCATING CYLINDER)
DESIGN:
Vessel: -Set of cylindrical flat bottom glass vessels
-Set of reciprocating cylinders
-stainless steel fittings(type 316) and
screens made of non-sorbing or
non-reactive materials.
Agitation type: -Reciprocating
-5-35 rpm
Volume of dissolution medium:-200-250ml
Water bath:- Maintain at 37±0.5°C
USE: Tablets, beads, controlled and
extended release formulations
20. APPARATUS-4 (FLOW THROUGH CELL)
DESIGN:
Reservoir : -For dissolution medium
Pump : -Forces dissolution medium through cell
-Holding a sample
-Flow rate 10-100ml/min
-Laminar flow is maintained
-Peristaltic/centrifugal pumps
are not recommended
Water bath:- Maintain at 37±0.5°C
USE:
Low solubility drugs, micro particulates,
implants, suppositories, controlled release
formulations
21. APPARATUS-5 (PADDLE-OVER-DISK)
DESIGN:
Vessel
Shaft
Stirring elements- rotating speed 25-50 rpm
Sample holder:-disk assembly that hold a product in such a way
that release surface is parallel with paddle
-Paddle is directly attached over disk assembly
-Samples are drawn between surface off the
medium and top of the paddle blade
Volume:900ml
Temperature:32°C
23. APPARATUS-6 (ROTATING CYLINDER)
DESIGN:
Vessel:- In place of basket, cylinder is used.
Shaft :-Stainless steel 316
Sample :- Mounted to cuprophan (inner porous
cellulosic material)
- An entire system adheres to cylinder.
- Dosage unit is placed in cylinder and
release from side out.
Water-bath: maintained at 32±0.5°C
USE:
Transdermal patches cannot be cut into small size.
Solid dosage forms, pH profile , small volumes
24. APPARATUS-7 (RECIPROCATING-DISK)
DESIGN:
Vessel:-Flat bottomed cylindrical vessel
-Volume of dissolution medium
Shaft :
Sample : -Placed on disk shaped holders
Agitation :-Reciprocation
-Reciprocating frequency 30 cycle/sec
Water-bath:-Maintain at 32±0.5°C
USE:
Transdermal patches
constant temp water bath
disk
dissolution
medium
shaft
25. • 1. ROTATING/STATIC
DISK METHOD
In this method ,the drug
is compressed in a non-
disintegrating disc
without excipients.
The disc is mounted in a
holder so that only one
face of the disc is
exposed to the dissolution
medium.
• 2. BEAKER METHOD:
Dissolution medium, 250ml of
0.1N HCl at 37°C placed in a
400ml beaker.
Agitation by three blade
polyethylene stirrer,5cm
diameter and rotates at 60 rpm.
Stirrer immersed to a depth of
2.7 cm in medium and in the
center.
UNOFFICIAL METHODS
26. 3.PERISTALSIS METHOD:
To stimulate hydrodynamic condition of GIT tract in an in-vitro
dissolution device.
Dissolution medium is pumped with peristaltic action through the
dosage form.
4.DIALYSIS METHOD:
Cell consist of 32mm inflated membrane.
The cell suspended , from the arm of the tablet disintegration
apparatus and containing the dosage form in
150ml of distilled water at 37°C.
Agitation by slight flexing and stretching
of the dialysis membrane as it enters and
Leaves. The bath. Rotated at 60rpm.
.
27. KINETICS OF DISSOLUTION
KINETICS FEATURE GRAPH PLOTTED
ZERO-ORDER Drug release rate is independent
of concentration of dissolved
substance
Qt = Q₀ + k₀t
Cumulative % of drug
release v/s time (hr.)
Straight line comes
FIRST- ORDER Rate is depends on
concentration of dissolve
substance.
log 𝑄𝑡 = log Q₀ +
𝑘𝑡
2.303
Log cumulative % of drug
remains to be dissolved v/s
time (hr.)
Straight line comes
28. •
KINETICS FEATURE GRAPH PLOTTED
HIGUCHI- MODEL
Describes the release
by dissolution and
change in surface area
and diameter of
dissolved particles.
Q = KH t½
Initial concentration -
%drug remaining v/s
time (hr.)
Straight line comes
HIXON-CROWEL Its suggest drug release
by diffusion
mechanism.
𝐾ℎ𝑐𝑡 = 𝑄₀1/3− 𝑄𝑡1/3
Cumulative % of drug
release v/s square root
of time (hr.)
Straight line comes
KORSMEYER-
PEPPAS
[Mt/M] = Kn t⁰ Log cumulative % of
drug remaining to be
dissolve v/s log time
(hr.)
Straight line comes
29. Dissolution rate under sink
condition follow zero order
dissolution rate.
First order under non sink condition
Zero order dissolution
Under sink condition
Time
Conc.ofdissolvedrug
30. References
• D.M. Brahmankar, “Bio-pharmaceutics And
Pharmacokinetics - A Treatise”, Vallabh
Prakashan, Page No. 20–31.
• Leon Shargel, “Applied Bio-pharmaceutics &
Pharmacokinetics”, 4th Edition, Page No. 132-136.
• www.slideshare.com
Roja Thoguta, Factors Effecting Dissolution &
Dissolution Testing.
Nilesh S. Jawalkar, Dissolution:-a Heart of
Pharmaceutics.
Mohammed Ameer Ahmed, Invitro Dissolution Testing
31.
32. IN-VITRO DISSOLUTION TESTING MODELS
• 1) NATURAL CONVECTION NON SINK METHODS:
a) Klein solveigmeter method
b) Nelson hanging pellet method
c) Levy static disk method
• 2) FORCED CONVECTION NON SINK METHODS:
a) Tumbling method
b) Levy or Beaker method
c) Rotating disk method
d) Particle size method
e) USP Rotating basket apparatus
f) USP Paddle apparatus
A. Non-sink Methods