This document discusses various drying methods and processes. It defines drying as the removal of liquid from solids using heat. Common applications of drying include manufacturing granules, reducing bulk/weight, and food preservation. The drying process involves heat transfer, phase change of water to vapor, and vapor removal. Key drying methods are described, including tray drying, vacuum drying, fluidized bed drying, and freeze drying. Tray drying uses racks and forced hot air convection. Vacuum drying uses lower pressure to reduce boiling points. Fluidized bed drying suspends materials in an upward gas flow. Freeze drying sublimes ice directly to water vapor under vacuum.
An evaporator is a device in a process used to turn the liquid form of a chemical substance such as water into its gaseous-form/vapor.
A falling film evaporator is an industrial device to concentrate solutions, especially with heat sensitive components. The evaporator is a special type of heat exchanger.
It includes types of evaporator,introduction to falling film evaporator,working of falling film evaporator,applications,advantages .
An evaporator is a device in a process used to turn the liquid form of a chemical substance such as water into its gaseous-form/vapor.
A falling film evaporator is an industrial device to concentrate solutions, especially with heat sensitive components. The evaporator is a special type of heat exchanger.
It includes types of evaporator,introduction to falling film evaporator,working of falling film evaporator,applications,advantages .
introduction, theory of drying, applications of drying, construction & working about fluidised bed dryer,use of tray dryer,construction about vacuum dryer, construction & working about drum dryer, construction about spray dryer
The liquid food is generally preconcentrated by evaporation to economically reduce the water content. The concentrate is then introduced as a fine spray or mist into a tower or chamber with heated air. As the small droplets make intimate contact with the heated air, they flash off their moisture, become small particles, and drop to the bottom of the tower, and are removed. The advantages of spray drying include a low heat and short time combination which leads to a better quality product.
Pharmaceutical Dryers. Dryers are used in a variety of industries, such as the food processing, pharmaceutical, paper, pollution control and agricultural sectors. ... Direct dryers convectively heat a product through direct contact with heated air, gas or a combusted gas product.
in this ppt i descussed about evaporator.evaporation,Evaporation is the process by which an element or compound transitions from its liquid state to its gaseous state below the temperature at which it boils.
types of Evaporators
Open kettle or pan
Horizontal tube natural circulation evaporator
Vertical tube natural circulation evaporator
Long tube vertical evaporator
Falling film evaporator
Forced circulation evaporator
Open-pan solar evaporator
introduction, theory of drying, applications of drying, construction & working about fluidised bed dryer,use of tray dryer,construction about vacuum dryer, construction & working about drum dryer, construction about spray dryer
The liquid food is generally preconcentrated by evaporation to economically reduce the water content. The concentrate is then introduced as a fine spray or mist into a tower or chamber with heated air. As the small droplets make intimate contact with the heated air, they flash off their moisture, become small particles, and drop to the bottom of the tower, and are removed. The advantages of spray drying include a low heat and short time combination which leads to a better quality product.
Pharmaceutical Dryers. Dryers are used in a variety of industries, such as the food processing, pharmaceutical, paper, pollution control and agricultural sectors. ... Direct dryers convectively heat a product through direct contact with heated air, gas or a combusted gas product.
in this ppt i descussed about evaporator.evaporation,Evaporation is the process by which an element or compound transitions from its liquid state to its gaseous state below the temperature at which it boils.
types of Evaporators
Open kettle or pan
Horizontal tube natural circulation evaporator
Vertical tube natural circulation evaporator
Long tube vertical evaporator
Falling film evaporator
Forced circulation evaporator
Open-pan solar evaporator
Drying and dehydration are two important processes used to remove moisture from food, agricultural products, and industrial materials. While often used interchangeably, there are subtle distinctions between the two. Understanding these differences and the underlying mechanisms is crucial for effective preservation and quality control.
The process of freeze drying with greater emphasis on the uses in the fisheries food processing sector. The presentation shows the process involved and the different steps involved and the effect of the process on the food material.
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Lyophilization or freeze drying is a process in which water is removed from a product after it is frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase. The process consists of three separate, unique, and interdependent processes; freezing, primary drying (sublimation), and secondary drying (desorption).
The advantages of lyophilization include:
Ease of processing a liquid, which simplifies aseptic handling
Enhanced stability of a dry powder
Removal of water without excessive heating of the product
Enhanced product stability in a dry state
Rapid and easy dissolution of reconstituted product
Disadvantages of lyophilization include:
Increased handling and processing time
Need for sterile diluent upon reconstitution
Cost and complexity of equipment
The lyophilization process generally includes the following steps:
Dissolving the drug and excipients in a suitable solvent, generally water for injection (WFI).
Sterilizing the bulk solution by passing it through a 0.22 micron bacteria-retentive filter.
Filling into individual sterile containers and partially stoppering the containers under aseptic conditions.
Transporting the partially stoppered containers to the lyophilizer and loading into the chamber under aseptic conditions.
Freezing the solution by placing the partially stoppered containers on cooled shelves in a freeze-drying chamber or pre-freezing in another chamber.
Applying a vacuum to the chamber and heating the shelves in order to evaporate the water from the frozen state.
Complete stoppering of the vials usually by hydraulic or screw rod stoppering mechanisms installed in the lyophilizers.
There are many new parenteral products, including anti-infectives, biotechnology derived products, and in-vitro diagnostics which are manufactured as lyophilized products. Additionally, inspections have disclosed potency, sterility and stability problems associated with the manufacture and control of lyophilized products. In order to provide guidance and information to investigators, some industry procedures and deficiencies associated with lyophilized products are identified in this Inspection Guide.
It is recognized that there is complex technology associated with the manufacture and control of a lyophilized pharmaceutical dosage form. Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; scale-up and validation of the lyophilization cycle; and testing of the end product. This discussion will address some of the problems associated with the manufacture and control of a lyophilized dosage form.
Food Preservation by Drying - Premraja N.pptxPremraja N
This Presentation contains Information and knowledge about various drying methods for Food preservation for enhancing the shelf life of food by lowering the water activity.
various drying methods including, CONVECTIVE DRYING,AIR DRYING,FLUIDIZED BED DRYER,SPRAY DRYERS,
DIELECTRIC DRYING,
Ohmic heating, CABINET DRYER etc.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
2. Content
• Definition
• Applications of Drying
• Introduction to Drying Process
• Calculation
• Classification of Drying
oTray Dryer
oVacuum Dryer
oFluidised Bed Dryer
oFreeze Dryer (Lyophilisation)
3. Definition
• “Drying is defined as the removal of liquid from solids by
vaporisation with the aid of heat”
or
“Drying is defined as the removal of all or most of the
liquid or Other liquid from a material by the application
of heat to cause thermal vaporization.”
• There are different ways and mechanism to remove liquids.
Drying is accomplished by thermal technique and thus involve
the application of heat.
4. Applications of Drying
• Used in manufacturing of granules.
• Used to reduce the bulk & weight of material.
• It helps in the preservation of crude drugs or plant from mould
growth.
• It helps in the size reduction process.
• Drying makes materials more convenient in packaging,
transporting, preserving, fabricating, and improves quality of
products.
5. Introduction to Drying Process
• It can be described by three process…..
1. Energy transfer from an external source to the water or
organic solvent.
• Direct or indirect heat transfer.
2. Phase transformation from water solvent- from a liquid
state to vapour state.
3. Generated vapours is transfer to away from API/material.
6. Calculation
• The rate of drying of sample can measured by following
equation….
• Drying Rate =
𝑊𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑤𝑎𝑡𝑒𝑟 𝑖𝑛 𝑠𝑎𝑚𝑝𝑙𝑒 (𝑘𝑔)
𝑇𝑖𝑚𝑒 ℎ × 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝐷𝑟𝑦 𝑆𝑜𝑙𝑖𝑑 (𝑘𝑔)
• Loss on Drying =
𝑀𝑎𝑠𝑠 𝑜𝑓 𝑤𝑎𝑡𝑒𝑟 𝑖𝑛 𝑠𝑎𝑚𝑝𝑙𝑒 (𝑘𝑔)
𝑇𝑜𝑡𝑎𝑙 𝑀𝑎𝑠𝑠 𝑜𝑓 𝑤𝑒𝑡 𝑠𝑎𝑚𝑝𝑙𝑒 (𝑘𝑔)
× 100
• The measurement of moisture content is expressed in
• % moisture content =
𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑤𝑎𝑡𝑒𝑟 𝑖𝑛 𝑠𝑎𝑚𝑝𝑙𝑒
𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑑𝑟𝑦 𝑠𝑎𝑚𝑝𝑙𝑒
× 100
7. Classification of Drying
• Static Bed Dryer
I. Tray dryer
II. Freeze dryer
• Moving Bed Dryer
I. Drum dryer
• Fluidised Bed Dryer
• Vacuum Bed Dryer
• Pneumatic Bed Dryer
I. Spray dryer
8. Tray Dryer
• Principle- Tray type of dryer is operates by passing hot
air, over the surface of a wet solid . That spread over
trays arranged in racks, and due to forced convection
moisture is removed.
• Construction-
• It is a double walled cabinet with Single or Two
doors.
• The gap between two walls is filled with high density
fibre glass wool insulation material to avoid heat
transfer.
• Stainless steel trays are placed on the movable
trolleys.
10. Vacuum Dryer
• Vacuum Dryer:
In vacuum dryer, material is dried by the application of
vacuum. When vacuum is created the pressure that is
lower so that water boils at a lower temperature. Hence
water evaporates faster.
• It is a good example of conduction drier.
• The oven is connected through a condenser and liquid
receiver to a vacuum pump.
Advantages of vacuum oven:
• Drying takes place at a low temperature.
• There is little air present so, there is minimum risk of
oxidation.
11.
12. Fluidised Bed Dryer
• The equipment works on A principle of fluidization of the feed
materials.
• In fluidization process, hot air or gas flow is introduced
through the bed of solid particulates. ... Hence the bed is said
to be fluidized and the particles are suspended in the fluid.
• It is suitable to dry uniformly the processed material with
comparatively high moisture content to low moisture content.
• The wet powder is dried in a fluidized bed by heat exchange
with a gas.
13. Fluidised Bed Dryer construction…
Fluidized Bed Dryer Consists of A.....
• Compressed Air System,
• Pre-filter,
• Heating Device,
• A Perforated Platform,
• A Thermostat And A Timer.
15. Freeze Dryer
(LYOPHILIZATION)
• It is also called as sublimation drying process, In that process water
is sublimed & removed from the product after it is frozen at the
reduced pressure.
• Theory:
• Material is frozen in a container connected to a high vacuum
system.
• Under these conditions, heat transferred is used as latent heat of
sublimation to the product by means of radiant heat.
• Than water vapours are removed by condensation.
16. Construction:
• Chamber for vacuum drying: having shelves for keeping the
material.
• Vacuum source: vacuum pump is connected to the chamber.
• A heat source: heat is provided by conduction or radiation or
both.
• A vapour removal system: the condenser consists of large
cooled surface by solid carbon dioxide mixed with acetone or
ethanol
17. Working:
• Pre-treatment : first solution is concentrated under normal
vacuum dryer before introducing in the chamber.
• Pre-freezing : ampoules, vials & bottles having aqs. solution
is packed & frozen in cold shelves at a temperature below -
500C.
• Primary drying : The material is spread. Than temperature &
pressure is set. Than heat is supplied.
• Vapours are removed from the chamber. 98-99% moisture
removes during this drying.
18. • Secondary drying : remaining moisture is removed
by vacuum drying at 50-60 *C. Secondary drying takes
about 10-20 hrs.
• Than products are packed in aseptic condition
immediately after drying.
19. References
• R. M. Mehta, A textbook of “Pharmaceutics-1”, Sixth
Edition Reprint 2018, Vallabh Prakashan, Page No. 208-
223.
• www.google.com
• www.slideshare.net
o Introduction To Drying Processes Mr. R. R. Patil