Depression is a state of low mood and loss of interest that affects thoughts, feelings, and physical health. It is characterized by feelings of sadness, anxiety, guilt, and fatigue. Depression is a common disorder that affects about 15% of the population. It has various causes such as genetic factors, neurotransmitter imbalances, life stressors, and lack of social support. Treatments include antidepressant medication, psychotherapy, and physical therapies like electroconvulsive therapy. Preventing depression involves managing stress, getting social support, and maintaining a healthy lifestyle.