This document provides an overview of depression, including its definition, types, epidemiology, etiology, pathophysiology, clinical manifestations, diagnosis, investigations, and treatment. Depression is defined as a common mental disorder characterized by depressed mood, loss of interest, feelings of guilt, sleep disturbances, low energy, and poor concentration. Major types include major depressive disorder, bipolar disorder, dysthymic disorder, and situational depression. Depression affects over 350 million people globally and is a leading cause of disability. Causes may include genetic, environmental, biochemical and neurological factors. Treatment involves antidepressant medications like SSRIs, TCAs, and MAOIs as well as psychotherapy and other non-pharmacological approaches.

1. WELCOME

2. DEPRESSION
By
Jessen George K
M pharm part 1
Pharmacy practice

3. CONTENTS
• INTRODUCTION
• DEFINITION
• TYPES OF DEPRESSION
• EPIDEMIOLOGY
• ETIOLOGY
• PATHOPHYSIOLOGY
• CLINICAL MANIFESTATIONS
• DIAGNOSIS
• INVESTIGATIONS
• TREATMENT
• CONCLUSION
• REFERENCES

4. INTRODUCTION
• Depression is a affective disorders.
• Affective disorders : mental illnesses characterized
by pathological changes in mood.
• Depression : pathologically depressed mood

5. DEFINITION
• DEPRESSION (By WHO) : Common mental
disorder that presents with depressed mood, loss of
interest or pleasure, feelings of guilt or low self-
worth, disturbed sleep or appetite, low energy, and
poor concentration.

6. TYPES OF DEPRESSION
• Major depressive disorder : recurrence of long
episodes of low moods, or one extended episode that
seems to be ‘never-ending.
- Atypical depression
- Post partum depression
- Catatonic depression
- Seasonal affective disorder
- Melancholic depression

7. • Manic depression (bipolar disorder)
Four ‘Episodes’ of Bipolar Disorder
- depressive episode
- manic episodes
- hypomanic episode
- mixed-mood states

8. • Dysthymic depression
- lasts a long time but involves less
severe symptoms.
- lead a normal life, but we may not be
functioning well or feeling good
• Situational depression
• Psychotic depression
• Endogenous depression

9. EPIDEMIOLOGY
• Globally more than 350 million people of all ages
suffer from depression. (WHO)
• For the age group 15-44 major depression is the
leading cause of disability in the U.S.
• Women are nearly twice as likely to suffer from a
major depressive disorder than men are.
• With age the symptoms of depression become even
more severe.
• About thirty percent of people with depressive
illnesses attempt suicide.

10. ETIOLOGY
• Genetic cause
• Environmental factors
• Biochemical factors : Biochemical theory of
depression postulates a deficiency of
neurotransmitters in certain areas of the brain
(noradrenaline, serotonin, and dopamine).
• Dopaminergic activity : reduced in case of
depression, over activity in mania.
• Endocrine factors
- hypothyroidism, cushing’s syndrome etc

11. • Abuse of Drugs or Alcohol
• Hormone Level Changes
• Physical illness and side effects of medications
DRUGS
• Analgesics
• Antidepressants
• Antihypertensives
• Anticonvulsants
• Benzodiazipine withdrawal
• Antipsychotics

12. PHYSICAL ILLNESS
• Viral illness
• Carcinoma
• Neurological disorders
• Thyroid disease
• Multiple sclerosis
• Pernicious anaemia
• Diabetes
• Systemic lupus erythematosus
• Addison’s disease

13. PATHOPHYSIOLOGY
• The Biogenic Amine Hypothesis
• The Receptor Sensitivity Hypothesis
• The Serotonin-only Hypothesis
• The Permissive Hypothesis
• The Electrolyte Membrane Hypothesis
• The Neuroendocrine Hypothesis

14. • The Biogenic Amine Hypothesis
- caused by a deficiency of monoamines,
particularly noradrenaline and serotonin.
- cannot explain the delay in time of onset of
clinical relief of depression of up to 6-8 weeks.
• The Receptor Sensitivity Hypothesis
- depression is the result of a pathological
alteration (supersensitivity and up-regulation) in
receptor sites.
- TCAs or MAOIs causes desensitization (the
uncoupling of receptor sites) and possibly down-
regulation (a decrease in the number of receptor sites).

15. • The Serotonin-only Hypothesis
- emphasizes the role of serotonin in depression
and downplays noradrenaline.
- But the serotonin-only theory has shortcomings:
- it does not explain why there is a delay in
onset of clinical relief
- it does not explain the role of NA in
depression.

16. • The Permissive Hypothesis
- the control of emotional behavior results from a
balance between noradrenaline and serotonin.
- If serotonin and noradrenaline falls to
abnormally low levels, the patient becomes depressed.
- If the level of serotonin falls and the level of
noradrenaline becomes abnormally high, the patient
becomes manic.

17. • The Electrolyte Membrane Hypothesis
- hypocalcemia may be associated with mania.
- hypercalcemia is associated with depression.
• The Neuroendocrine Hypothesis
- pathological mood states are explained or
contributed to by altered endocrine function.

18. CLINICAL MANIFESTATIONS
• DEPRESSIONS
o Thinking is pessimistic and in some cases suicidal.
o In severe cases psychotic symptoms such as
hallucinations or delusions may be present.
o Insomnia or hypersomnia, libido, weight loss, loss of
appetite.
o Intellectual or cognitive symptoms include a
decreased ability to concentrate, slowed thinking, & a
poor memory for recent events.

20. DIAGNOSIS
• ICD 10 Diagnostic criteria for a depressive
episode {who}
USUAL SYMPTOMS
• Depressed mood.
• Loss of interest and enjoyment.
• Reduced energy leading to increased
fatiguability and diminished activity.

21. COMMON SYMPTOMS
• Reduced concentration and attention.
• Reduced self esteem and self confidence.
• Ideas of guilt and unworthiness.
• Bleak and pessimistic views of future .
• Ideas or acts of self harm or suicide.
• Disturbed sleep.
• Diminished appetite.

22. MILD DEPRESSIVE EPISODE
• For at least 2 weeks, at least two of the usual
symptoms of a depressive episode plus at least two
common symptoms.
MODERATE DEPRESSIVE EPISODE
• For at least 2 weeks, at least two or three of the
usual symptoms of a depressive episode plus at
least three of the common symtoms.

23. SEVERE DEPRESSIVE EPISODE
• For at least 2 weeks all three of the usual
symptoms of a depressive episode plus at least 4
of the common symptoms some of which should be
of severe intensity.

24. INVESTIGATIONS
• RATING SCALES
o Beck depression inventory
o Hamilton depression rating scale
• DEXAMETHASONE SUPPRESSION TEST

25. TREATMENT
ANTIDEPRESSANTS
1. MAO inhibitors:
• Irreversible: Isocarboxazid, Iproniazid, Phenelzine
and Tranylcypromine.
• Reversible: Moclobemide and Clorgyline.
2. Tricyclic antidepressants (TCAs)
• NA and 5 HT reuptake inhibitors : Imipramine,
Amitryptiline, Doxepin, Dothiepin and
Clomipramine.
• NA reuptake inhibitors : Desimipramine,
Nortryptyline, Amoxapine.

26. 3. Selective Serotonin reuptake inhibitors:
• Fluoxetine, Fluvoxamine, Sertraline and Citalopram
4. Atypical antidepressants:
• Trazodone, Mianserin, Mirtazapine, Venlafaxine,
Duloxetine, Bupropion and Tianeptine

27. MAO Inhibitors
• Drugs act by increasing the local availability of NA or
5 HT.
• MAO is a Mitochondrial Enzyme involved in
Oxidative deamination of these amines.
o MAO-A: Peripheral nerve endings, Intestine and
Placenta (5-HT and NA).
o MAO-B: Brain and in Platelets (Dopamine).
o Selective MAO-A inhibitors (RIMA) have
antidepressant property (eg:Moclobemide).

28. • Side effects : postural hypotension, weight gain,
atropine like effects and CNS stimulation.
• Severe hypertensive response to tyramine containing
foods-cheese reaction
• Drug interaction : Ephedrine, Reserpine.
• Moclobemide (Rimarex) : 150 mg BDS-TDS
Max : 600 mg/day
• Less ADR as compared to irreversible MAOI

29. TCAs
• NA, 5 HT and Dopamine are present in Nerve
endings
• Normally, there are reuptake mechanism and
termination of action.
• TCAs inhibit reuptake and make more monoamines
available for action.
• In most TCA, other receptors (incl. those outside the
CNS) are also affected: blockade of H1-receptor,
Alpha-receptors, M-receptors.

31. • Imipramine (depsonil) : 50- 200 mg/day
- antidepressant action starts after few weeks,
whereas blockade starts immediately
• Amitryptyline (tryptomer) : 50- 200 mg/day

32. SSRIs
• First line drug in depression.
• Relatively safe and better patient acceptability.
• Some patients not responding to TCAs may respond
with SSRIs.
• SSRIs inhibit the reuptake mechanism and make
more 5 HT available for action.

33.  Relative advantages:
– No sedation, so no
cognitive or
psychomotor function
interference
– No anicholinergic
effects
– No alpha-blocking
action, so no postural
hypotension and suits
for elderly
– No seizure induction
– No arrhythmia
 Drawbacks:
– Nausea is common
– Interfere with
ejaculation
– Insomnia, dyskinesia,
headache and
diarrhoea
– Impairment of platelet
function – epistaxis

34. SSRIs – Pharmacokinetic comparison

35. Atypical antidepressants
1. Trazodone:
• Weak 5-HT uptake block, α – block, 5-HT2 antagonist
• No arrhythmia
• No seizure
• ADRs: Postural Hypotension
2. Venlafaxine:
• SNRI (Serotonin and NA uptake inhibitor)
• Fast in action
• No cholinergic, adrenergic and histaminic interference
• Raising of BP

36. 3. Mianserin
• Not inhibiting either NA or 5 HT uptake, but blocks
presynaptic alpha-2 receptors- increase release of NA
in brain.
• ADR : Blood dyscrasias, liver dysfunction.
4. Bupropion
• Inhibitor of DA and NA uptake (NDRI)
• Non-sedative but excitant property
• Used in depression and cessation of smoking
• Seizure may precipitated

39. NON – PHARMACOLOGIC THERAPY
• LIFESTYLE CHANGES
o Stress reduction
o Social support
o Sleep
• PSYCHOTHERAPY
o Cognitive behavioral therapy
o Interpersonal therapy
o Psychodynamic therapy

40. • ELECTROCONVULSIVE THERAPY – ECT
o Safe & effective disorder for all subtypes of major
depressive disorder.
o ADR : Cognitive dysfunction, cardiovascular
dysfunction, prolonged apnoea etc.

41. CONCLUSION
• Affective disorders remain one of the most commonly
occurring mental illnesses in adults.
• It is often undiagnosed and untreated.
• Both pharmacological and nonpharmacological
interventions acts as cornerstone in the treatment of
affective disorders.
• Pharmacist plays an important role in accomplishing
these treatment goals.

42. REFERENCES
• Clinical pharmacy and therapeutics
by Roger walker, Cate whittlesca
(page no : 424-435)
• Text book of therapeutics
by Eric T Herfintal
• Pharmacotherapy handbook
by Joseph T Dipiro (page no :1235-1253)
• Essentials of medical pharmacology
by K D Tripathi (page no : 423-444)
The datas were collected from various sources
Only for educational purpose

43. THANK YOU