Schizophrenia and other psychotic disorders involve positive, negative, and disorganized symptoms that distort thinking, perception, and behavior. Schizophrenia is a chronic condition defined by fundamental distortions in thought, perception, emotion, and behavior. It affects about 1% of the population and typically emerges in early adulthood. Treatment involves antipsychotic medications to reduce positive symptoms as well as psychosocial support. The causes are complex and involve genetic, neurological, developmental, and environmental factors.