Depression is a serious illness that causes prolonged feelings of sadness, hopelessness, and lack of interest in life. It affects people both emotionally and physically by causing symptoms like fatigue, changes in appetite or sleep, and pain. While anyone can develop depression, certain factors like genetics, gender, and life stress increase one's risk. There is no single cause of depression but it is thought to involve biological changes in the brain. Treatment options include psychological therapies like cognitive behavioral therapy which aim to change negative thought patterns, as well as antidepressant medications which target chemical imbalances in the brain. Finding the right individualized treatment is important to recovery.