Corona Virus: facts & myths

1. Coronavirus Facts and
Myths
Mariam Oweda Kamal
Eman Abdelrazik
Mohamed Emam

2. What is coronavirus?
● Coronaviruses are a family of enveloped RNA viruses that are
distributed widely among mammals and birds, causing principally
respiratory or enteric diseases but in some cases neurologic illness or
hepatitis (Lai and Holmes, 2001).

3. Why it is named coronavirus?

4. Coronavirus taxonomy
Miłek, J., & Blicharz-Domańska, K. (2018). Coronaviruses in avian species – review with focus on epidemiology and diagnosis in wild birds. Journal Of Veterinary
Research, 62(3), 249-255

5. Human coronavirus
HCoVs (HCoV-229E, HCoV-NL63, HCoV-
OC43 and HCoV-HKU1) are globally circulated
in the human population and contribute to
approximately one-third of common cold
infections in humans
develop into life-threatening respiratory
failure and acute respiratory distress
syndrome
wuhan coronavirus 2019

6. SARS-CoV vs. MERS-CoV
Severe acute respiratory syndrome
(SARS) was first recognized in china in
2002 it caused a world outbreak in
2002-2003, it quickly spread across 29
countries, infecting more than 8000
individuals with a mortality rate of 9.6
%.
Middle East Respiratory Syndrome
(MERS) was first reported in Saudi
Arabia in 2012, with a much higher
mortality rate of about 35%. all cases of
MERS have been linked through travel
to, or residence in, countries in and

7. Coronavirus structure
Positive sense single stranded RNA
Genome ∼30 000 nucleotides long
Pleomorphic viruses
80 × 160 nm diameter, with 12–24 nm
surface

8. Coronavirus Replication

9. Coronavirus pathogenesis

10. Wuhan Coronavirus Outbreak scenarios!

12. 2019-nCoV origin
Origin?!
Host !

16. Source: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

17. Source: Scientific American

18. Codon usage

19. Material and Methods
Host genome: coding sequences (CDS) of 6 Bat genomes and snake genome
extracted from NCBI refseq database
Virus genome: CDS of seafood wuhan coronavirus extracted from NCBI refseq
database
This work is under progress and is NOT peer-reviewed yet

20. Host-virus codon adaptation indices
This work is under progress and is NOT peer-reviewed yet