Telomere, Functions & Role in Aging & CancerZohaib HUSSAIN
Why senescence occurs in eukaryotic organisms?
The major function of telomere is to cap the ends of chromosomes and protect the chromosomes from RED mechanism. As cells divide, telomeres continuously shorten with each successive cell division. Telomerase provides the necessary enzymatic activity to restore and maintain the telomere length. The vast majority of tumour's activate telomerase , and only few maintain telomeres by ALT mechanism relying on recombination. Telomere and telomerase are the attractive targets for anti-cancer therapeutics
This presentation describes the structure and function of telomeres ,their role in various disease.The structure and function of telomerase is also described ,together with its possible role in therapy .
Different researches shows that, g-quadruplex- kind of tandem repeats are present in vivo,
Telomeres having tandem repeats of d(TTAGGG) , herein G is either anti or sync.
5’- UTR (untranslated region) of mRNA (U–U–U–U tetrads, as well as G- and U-containing octads)
Promoter region of c-myc , c-kit and variant bcl-2 oncogenes.
inferior oncogenic expression & veiled binding target of telomere associated proteins ( TRF1, POT1) may help to combat the uncontrolled cellular growth by inducing apoptosis & inhibit the telomerase overactivity.
Telomere, Functions & Role in Aging & CancerZohaib HUSSAIN
Why senescence occurs in eukaryotic organisms?
The major function of telomere is to cap the ends of chromosomes and protect the chromosomes from RED mechanism. As cells divide, telomeres continuously shorten with each successive cell division. Telomerase provides the necessary enzymatic activity to restore and maintain the telomere length. The vast majority of tumour's activate telomerase , and only few maintain telomeres by ALT mechanism relying on recombination. Telomere and telomerase are the attractive targets for anti-cancer therapeutics
This presentation describes the structure and function of telomeres ,their role in various disease.The structure and function of telomerase is also described ,together with its possible role in therapy .
Different researches shows that, g-quadruplex- kind of tandem repeats are present in vivo,
Telomeres having tandem repeats of d(TTAGGG) , herein G is either anti or sync.
5’- UTR (untranslated region) of mRNA (U–U–U–U tetrads, as well as G- and U-containing octads)
Promoter region of c-myc , c-kit and variant bcl-2 oncogenes.
inferior oncogenic expression & veiled binding target of telomere associated proteins ( TRF1, POT1) may help to combat the uncontrolled cellular growth by inducing apoptosis & inhibit the telomerase overactivity.
It describes about Structure and function of telomere, Telomerase enzyme, How does telomerase works?, Telomere replication, What happens to telomeres as we age?, Factors contribute to telomere shortening
TA Sciences presents their latest product TA-65. To learn more about TA-65, check out their website at http://www.tasciences.com TA-65 can help your immune system, vision, male sexual performance, skin appearance and more!
Telomere structure stability, function in plant breedingSachin Dharwad
TELOMERE, TELOMERE STRUCTURE, ITS FUNCTION AND USE IN PLANT BREEDING. Telomere in plant breeding perspective. Case studies related to telomere in case of plant breeding. telomeres can be made use as markers in plant breeding.
Dr. Al Sears explains the Nobel Prize winning breakthrough telomere technology. This opened the way for Harvard researcher, Dr. Ronal DePinho to find a way to activate telomerase. Telomerase is the enzyme that signals your telomeres to grow longer, unfortunately, it shuts down while you are still in your mother's womb.
Once Nobel Prize winning research identified that telomeres are the protective tips at each end of the strands of your DNA, and as your cells replicate, gradully your telomeres grow shorter. They are the "aging-clocks" inside your DNA.
Once Dr. DePinho found a way to reactivate the telomerase enzyme, he turned old mice into young mice again.
Not long after, scientists discovered ways to do this in humans as well, and today, the discovery of the telomere and telomerase are the most important anti-aging breakthrough of our time.
TA-65 Telomerase Activator - Is it a key to unlocking the longevity puzzle?Ivan Joksimovic
TA-65 is a natural supplement without any active ingredients added. The only way to lengthen telomeres is through the activation of an enzyme called telomerase. Currently the only way to activate telomerase is to take TA-65 supplement. The telomerase-activating potency of TA-65 has been independently proven in rigorous tests by Geron and Sierra Sciences, two biotech companies specializing in telomere biology.
Telomeres are protective pieces of DNA material at the ends of chromosomes. Like the plastic tips on shoelaces, telomeres prevent chromosome ends from fraying and sticking to each other, which would damage genetic information to cause cancer, other diseases or premature ageing.
Evidence clearly shows that people with long telomeres age healthier and live longer.
Every time a cell divides, the telomeres get shorter. After they get too short, the cell no longer can divide and becomes inactive or dies. This process is related with aging and age related diseases.
Without telomeres, the protective caps at the chromosome - the part containing genes essential for life - would get shorter each time a cell divides. Cell division is needed so we can grow new skin, blood, bone and other cells when needed.
The only way to lengthen telomeres is through the activation of an enzyme called telomerase. Currently the only way to activate telomerase is to take TA-65 supplement.
Telomerase is natural enzyme that stabilizes telomere length by adding DNA repeats (TTAGGG) onto the telomeric ends of the chromosomes, thus compensating for the loss of telomeres when cell divide.
Buy TA-65 now for the best price!
http://www.ta65doctor.com/products-page/
www.ta65doctor.com
It describes about Structure and function of telomere, Telomerase enzyme, How does telomerase works?, Telomere replication, What happens to telomeres as we age?, Factors contribute to telomere shortening
TA Sciences presents their latest product TA-65. To learn more about TA-65, check out their website at http://www.tasciences.com TA-65 can help your immune system, vision, male sexual performance, skin appearance and more!
Telomere structure stability, function in plant breedingSachin Dharwad
TELOMERE, TELOMERE STRUCTURE, ITS FUNCTION AND USE IN PLANT BREEDING. Telomere in plant breeding perspective. Case studies related to telomere in case of plant breeding. telomeres can be made use as markers in plant breeding.
Dr. Al Sears explains the Nobel Prize winning breakthrough telomere technology. This opened the way for Harvard researcher, Dr. Ronal DePinho to find a way to activate telomerase. Telomerase is the enzyme that signals your telomeres to grow longer, unfortunately, it shuts down while you are still in your mother's womb.
Once Nobel Prize winning research identified that telomeres are the protective tips at each end of the strands of your DNA, and as your cells replicate, gradully your telomeres grow shorter. They are the "aging-clocks" inside your DNA.
Once Dr. DePinho found a way to reactivate the telomerase enzyme, he turned old mice into young mice again.
Not long after, scientists discovered ways to do this in humans as well, and today, the discovery of the telomere and telomerase are the most important anti-aging breakthrough of our time.
TA-65 Telomerase Activator - Is it a key to unlocking the longevity puzzle?Ivan Joksimovic
TA-65 is a natural supplement without any active ingredients added. The only way to lengthen telomeres is through the activation of an enzyme called telomerase. Currently the only way to activate telomerase is to take TA-65 supplement. The telomerase-activating potency of TA-65 has been independently proven in rigorous tests by Geron and Sierra Sciences, two biotech companies specializing in telomere biology.
Telomeres are protective pieces of DNA material at the ends of chromosomes. Like the plastic tips on shoelaces, telomeres prevent chromosome ends from fraying and sticking to each other, which would damage genetic information to cause cancer, other diseases or premature ageing.
Evidence clearly shows that people with long telomeres age healthier and live longer.
Every time a cell divides, the telomeres get shorter. After they get too short, the cell no longer can divide and becomes inactive or dies. This process is related with aging and age related diseases.
Without telomeres, the protective caps at the chromosome - the part containing genes essential for life - would get shorter each time a cell divides. Cell division is needed so we can grow new skin, blood, bone and other cells when needed.
The only way to lengthen telomeres is through the activation of an enzyme called telomerase. Currently the only way to activate telomerase is to take TA-65 supplement.
Telomerase is natural enzyme that stabilizes telomere length by adding DNA repeats (TTAGGG) onto the telomeric ends of the chromosomes, thus compensating for the loss of telomeres when cell divide.
Buy TA-65 now for the best price!
http://www.ta65doctor.com/products-page/
www.ta65doctor.com
Metagenome is the entire genetic information of microorganism at specific site/time. Analysis of metagenomic data could be achieved by two approaches; 1) amplicon (16s RNA gene) data analysis and whole genome metagenomics data analysis. Here we focus on 16S rRNA amplicon using Mothur Pipeline for analysis of metagenomics data.
The termination of a pregnancy, followed by the death of the embryo or fetus: as
A- spontaneous expulsion of a human fetus during the first 12 weeks of gestation, “ miscarriage”.
B- induced expulsion of a human fetus
C- expulsion of a fetus by a domestic animal often due to infection at any time before completion of pregnancy, “contagious abortion”.
It is the only treatment for end state organ failure, such as liver and heart failure and end stage renal disease. This can only be ensured through rigorous selection procedures, careful surgery and follow up of the donor to ensure the optimal management of untoward consequences.
Euthanasia is the practice of causing the death of a patient for medical reasons, such as an incurable disease associated with suffering or unbearable pain.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
6. TELOMERES & AGING
# The length of telomeres is
the most accurate indicator of
the speed the person is aging.
# It is not yet known whether
shorter telomeres are just a sign
of aging – like gray hair – or
contribute aging .