This document provides information on Middle East Respiratory Syndrome Coronavirus (MERS-CoV), including:
- MERS-CoV is a novel coronavirus that was first identified in Saudi Arabia in 2012 and causes severe respiratory illness. About half of confirmed cases have been fatal.
- The virus is thought to originate from bats and possibly be transmitted by camels, though the animal reservoir is still unknown. Limited human-to-human transmission can occur in healthcare settings and among family contacts.
- Recommendations are provided for testing, treatment, prevention, and healthcare worker protocols for suspected MERS-CoV cases. Ongoing surveillance is needed as the virus poses a risk of spread outside the Middle East.
COVID-19
ALSO USEFUL FOR NEET, CET, JIPMER, AIIMS, OTHER MEDICAL ENTRANCES.
WATCH THE FULL VIDEO ON YOUTUBE:
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SUB-TOPICS INCLUDED ARE:
Introduction
Structure of SARS-CoV-2
Types of SARS-CoV-2
Transmission of SARS-CoV-2
Viability of the virus
Symptoms of COVID- 19
Diagnosis
Treatment
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COVID-19 : Introduction,Nomenclature,Incubation Period,Structure,Symptoms,Transmission,Flowchart,Diagnosis,Treatment,Drugs under testing,Prevention,Importance of Social Distancing,Effects in Lungs,Effects in Other organs,Replication,Severity,Stages,Comparison,Facts.
this is a very serious hemorrhagic virus even if, it is very rare in our settings , we should be aware of it and sometime include it in our differential of renal failure with hemorrhagic fever or cardiopulmonary stuffs.
This ppt contains all the information about the epidemiology of Severe Acute Respiratory Syndrome (SARS). It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
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MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS (MERS CoV)Dhruvendra Pandey
Middle East Respiratory Syndrome, countries affected by MERS virus, preventive and control strategies for MERS infection, recommendation for healthcare professionals and hospitals in case of MERS corona virus infection, time trend of different events in corona virus infection, MERS Cov is associated with camels, Saudi Arabia guideline for travellers to haj and umrah, MERS CoV Vaccine
Conférence IIRCO - Projection des conflits sur l'espace numériqueOPcyberland
Les conflits humains possèdent une composante numérique. La conférence explore les contextes de cyber-conflictualités, de concurrences et de duels projetés sur le cyberespace.
Elle est organisée par l'Université de Limoges, l'IIRCO et la chaire GCAC, Gestion des Conflits et de l'Après Conflit.
COVID-19
ALSO USEFUL FOR NEET, CET, JIPMER, AIIMS, OTHER MEDICAL ENTRANCES.
WATCH THE FULL VIDEO ON YOUTUBE:
https://youtu.be/1NQQvLH3xo0
SUBSCRIBE ON YOUTUBE !!
SUB-TOPICS INCLUDED ARE:
Introduction
Structure of SARS-CoV-2
Types of SARS-CoV-2
Transmission of SARS-CoV-2
Viability of the virus
Symptoms of COVID- 19
Diagnosis
Treatment
FOLLOW ON INSTAGRAM:
@stud_e_
https://www.instagram.com/stud_e_/
COVID-19 : Introduction,Nomenclature,Incubation Period,Structure,Symptoms,Transmission,Flowchart,Diagnosis,Treatment,Drugs under testing,Prevention,Importance of Social Distancing,Effects in Lungs,Effects in Other organs,Replication,Severity,Stages,Comparison,Facts.
this is a very serious hemorrhagic virus even if, it is very rare in our settings , we should be aware of it and sometime include it in our differential of renal failure with hemorrhagic fever or cardiopulmonary stuffs.
This ppt contains all the information about the epidemiology of Severe Acute Respiratory Syndrome (SARS). It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Creative Biolabs has extensive experience in coronavirus research. Provide comprehensive high-quality coronavirus (SARS-CoV-2, SARS-CoV, MERS-CoV, etc.) related services and products.
This slide provides a brief introduction to SARS-CoV-2. If you need more knowledge, products and services related to SARS-CoV-2, please follow us.
MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS (MERS CoV)Dhruvendra Pandey
Middle East Respiratory Syndrome, countries affected by MERS virus, preventive and control strategies for MERS infection, recommendation for healthcare professionals and hospitals in case of MERS corona virus infection, time trend of different events in corona virus infection, MERS Cov is associated with camels, Saudi Arabia guideline for travellers to haj and umrah, MERS CoV Vaccine
Conférence IIRCO - Projection des conflits sur l'espace numériqueOPcyberland
Les conflits humains possèdent une composante numérique. La conférence explore les contextes de cyber-conflictualités, de concurrences et de duels projetés sur le cyberespace.
Elle est organisée par l'Université de Limoges, l'IIRCO et la chaire GCAC, Gestion des Conflits et de l'Après Conflit.
Discover a wide range of scaffolding supplies at Turbo Scaffolding, having huge warehouses located in Sydney, Melbourne, Perth and Brisbane. For more details, visit - turboscaffolding.com.au
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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A basic overview of Accelerated Mobile Pages, Instant Articles and Apple News technologies - along with the steps on enabling and configuring AMP on a WordPress website. This talk was initially presented at the Melbourne SEO Meetup on the 1st of March 2016.
REVIEW Open AccessMERS coronavirus diagnostics,epidemio.docxmichael591
REVIEW Open Access
MERS coronavirus: diagnostics,
epidemiology and transmission
Ian M. Mackay1,2,3* and Katherine E. Arden2
Abstract
The first known cases of Middle East respiratory syndrome (MERS), associated with infection by a novel coronavirus (CoV),
occurred in 2012 in Jordan but were reported retrospectively. The case first to be publicly reported was from Jeddah, in
the Kingdom of Saudi Arabia (KSA). Since then, MERS-CoV sequences have been found in a bat and in many dromedary
camels (DC). MERS-CoV is enzootic in DC across the Arabian Peninsula and in parts of Africa, causing mild upper
respiratory tract illness in its camel reservoir and sporadic, but relatively rare human infections. Precisely how virus transmits
to humans remains unknown but close and lengthy exposure appears to be a requirement. The KSA is the focal point of
MERS, with the majority of human cases. In humans, MERS is mostly known as a lower respiratory tract (LRT) disease
involving fever, cough, breathing difficulties and pneumonia that may progress to acute respiratory distress syndrome,
multiorgan failure and death in 20 % to 40 % of those infected. However, MERS-CoV has also been detected in mild and
influenza-like illnesses and in those with no signs or symptoms. Older males most obviously suffer severe disease and
MERS patients often have comorbidities. Compared to severe acute respiratory syndrome (SARS), another sometimes- fatal
zoonotic coronavirus disease that has since disappeared, MERS progresses more rapidly to respiratory failure and acute
kidney injury (it also has an affinity for growth in kidney cells under laboratory conditions), is more frequently reported in
patients with underlying disease and is more often fatal. Most human cases of MERS have been linked to lapses in
infection prevention and control (IPC) in healthcare settings, with approximately 20 % of all virus detections reported
among healthcare workers (HCWs) and higher exposures in those with occupations that bring them into close contact
with camels. Sero-surveys have found widespread evidence of past infection in adult camels and limited past exposure
among humans. Sensitive, validated reverse transcriptase real-time polymerase chain reaction (RT-rtPCR)-based diagnostics
have been available almost from the start of the emergence of MERS. While the basic virology of MERS-CoV has advanced
over the past three years, understanding of the interplay between camel, environment, and human remains limited.
Keywords: Middle East respiratory syndrome, Coronavirus, MERS, Epidemiology, Diagnostics, Transmission
Background
An email from Dr Ali Mohamed Zaki, an Egyptian
virologist working at the Dr Soliman Fakeeh Hospital in
Jeddah in the Kingdom of Saudi Arabia (KSA) an-
nounced the first culture of a new coronavirus to the
world. The email was published on the website of the
professional emerging diseases (ProMED) network on
20thSeptember 2012 [1] (Fig. 1) and described the first
reported case.
corona is a pandemic disease in the world so many people are died because of this disease, it's not coming in a particular structure. it's having a different type of structure . how to prevent this disease maintain social distance, maintain hand hygiene, wear masks .nowady vaccines are available covishield ,covaxin, Pfizer, sputnik vaccine etc...this mainly helpful to prevent the corona
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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In the DSM-5, all types of substance abuse and dependence have been
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The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Middle East respiratory Syndrome Coronavirus
1. Middle East respiratory Syndrome Coronavirus
(MERS-CoV)
By
Dr. ASHRAF ELADAWY
Consultant Chest Physcian
TB TEAM Expert – WHO
September -2O13
2. Middle East respiratory Syndrome Coronavirus
(MERS-CoV)
Middle East Respiratory Syndrome (MERS) is viral
respiratory illness first reported in Saudi Arabia in 2012.
It is caused by a novel coronavirus called MERS-CoV.
Most people who have been confirmed to have MERS-
CoV infection developed severe acute respiratory illness.
They had fever, cough, and shortness of breath. About
half of these people died.
Background information
Human coronaviruses were first identified in the mid 1960s and are named
after the crown-like projections that can be seen on the surface of the virus.
These viruses cause respiratory infections of varying severity in humans and
animals.
in humans Coronaviruses may cause illness ranging from mild symptoms
such as common cold to more serious respiratory illnesses, such as Severe
Acute Respiratory Syndrome (SARS).
There are 4 main sub-groupings of coronaviruses, known as alpha, beta
,gamma and delta.
Infectious agent
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel
coronavirus (nCoV) first reported on 24 September 2012 by Egyptian
virologist Dr. Ali Mohamed Zaki in Jeddah, Saudi Arabia.
3. “Middle East Respiratory Syndrome Coronavirus” (MERS-CoV) is a Novel
coronavirus (particular strain of coronavirus that has not been previously
identified in humans).
Early reports compared the virus to severe acute respiratory syndrome
(SARS), and it has been referred to as Saudi Arabia's SARS-like virus
MERS-CoV used to be called “novel coronavirus,” or “nCoV” , however the
Coronavirus Study Group (CSG) of the International Committee on
Taxonomy of Viruses (ICTV) decided in May 2013 to call the novel
coronavirus “Middle East Respiratory Syndrome Coronavirus” (MERS-CoV)
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) belongs to the
genus Betacoronavirus as does SARS-CoV
MERS-CoV is not the same coronavirus that caused severe acute respiratory
syndrome (SARS) in 2003. However, like the SARS virus, the novel
coronavirus is most similar to those found in bats.
Although both viruses are capable of causing severe disease, current
information indicates that MERS-CoV does not appear to transmit easily
between people whereas the SARS virus was much more transmissible.
Source of the infection
No definitive animal host for the MERS-CoV has been confirmed to date but
bats and camels are suspects for now.
At this stage the exact origin is unclear, but studies of the virus’s genetic
material suggest that bat corona viruses are the nearest relatives.
4. In addition, scientists have recently discovered antibodies circulating
within the camel population, which may have been directed against either
the MERS virus, or a remarkably similar virus. Whether this finding has any
direct implications on infectivity and spread amongst the human
population remains to be seen
Global distribution of MERS-CoV cases...
Cases are all be linked to a point of origin in the Arabian Peninsula, in
particular, the Kingdom of Saudi Arabia (KSA).
Nine countries have now reported cases of human infection with MERS-
CoV
o Countries where cases acquired infection in-country from an
unknown source Jordan, KSA, Qatar, UAE (United Arab Emirates)
o Countries where cases are associated with travel or contact with a
returned infected traveler Germany, France, Tunisia, UK, Italy
o All reported cases have had some connection (whether direct or
indirect) with the Middle East and have been linked to four countries
in or near the Arabian Peninsula.
o In France, Italy, Tunisia and the United Kingdom, limited local
transmission has occurred in people who had not been to the Middle
East but who had been in close contact with laboratory-confirmed or
probable cases.
o No cases have been identified in the Egypt uptill now.
MERS Cases and Deaths
April 2012 – Present
5. Quick numbers
Total human cases of MERS-CoV: 130
Total deaths attributed to infection with MERS-CoV: 58
Current Case Fatality Rate (CFRd
): 45%
April 2012 – Present
Current as of September 30
Countries Cases (Deaths)
France 2 (1)
Italy 1 (0)
Jordan 2 (2)
Qatar 5 (3)
Saudi Arabia 108 (47)
Tunisia 3 (1)
United Kingdom (UK) 3 (2)
United Arab Emirates (UAE) 6 (2)
Total 130 (58)
Transmission...
The original source(s), route(s) of transmission to humans, and the mode(s)
of human-to-human transmission have not been determined.
Droplet and direct contact probably
Settings where infection has occurred :
1. Communities: Sporadic cases with unknown exposure
2. Families: contact with infected family members
3. Health care facilities: patients & health care workers
6. Evidence for limited person-to-person transmission in some clusters
The mechanism by which transmission occurred in all of these cases,
whether respiratory (e.g. coughing, sneezing) or contact (contamination of
the environment by the patient), is unknown.
All clusters reported to date have occurred among family contacts or in a
health care setting.
Human-to-human transmission is not sustained, has only been observed in
health care facilities and close family contacts and sustained transmission in
the community has not been observed.
So far there is only evidence of limited, non-sustained person-to-person
transmission
Given the severity of the illness caused by the virus it is considered prudent
to use a high level of personal protective equipment when caring for any
case with a confirmed diagnosis. Additional measures include isolation of
the patient and barrier nursing.
Transmission has occurred in health-care facilities, WHO recommends that
health-care workers consistently apply appropriate infection prevention and
control measures.
Any clusters of severe acute respiratory infection (SARI) in health-care
workers should be thoroughly investigated.
Incubation period
Persons who develop severe acute respiratory illness within 14 days after
traveling from the Arabian Peninsula or neighboring countries should be
evaluated according to current WHO guidelines
7. Clinical features
All of the laboratory confirmed cases had respiratory disease as part of the
illness, and most had severe acute respiratory disease requiring
hospitalization.
Common symptoms are acute, serious respiratory illness with fever, cough,
shortness of breath and breathing difficulties.
Pneumonia has been the most common clinical presentation
Most patients were reported to have at least one comorbidity.
Patients with comorbidities or immunosuppression might be at increased
risk for infection, severe disease, or both.
In people with immune deficiencies, the disease may have an atypical
presentation, such as diarrhoea ,may present atypically, and initially without
respiratory symptoms
Although most cases have been characterised by a severe illness, milder
illness has been detected
Most cases are in males older than 45-years with underlying medical
conditions. Disease in children seems to be milder. No deaths, and few cases
have occurred among those under the age of 21-years.
Complications: In fatal cases, Acute Respiratory Distress Syndrome (ARDS),
acute renal failure requiring hemodialysis, and disseminated intravascular
coagulation, pericarditis, heart failure, and multiple organ failure were
predominant.
Diagnosis
The main test for this particular coronavirus is a screening PCR tests
(polymerase chain reaction) test followed by a more specific confirmatory
test
Nasopharyngeal swabs may be less sensitive than specimens of the lower
respiratory tract according to WHO, June 2013.
Laboratory testing
Collect specimens for MERS-CoV testing from all PUIs (patient under investigation)
An upper respiratory specimen:
Nasopharyngeal AND oropharyngeal swab
8. A lower respiratory specimen:
Sputum, OR
Broncheoalveolar lavage, OR
Tracheal aspirate, OR
Pleural fluid
Patient samples from the lower respiratory tract, not just the
nasopharynx/throat.
if lower respiratory tract specimens are not possible both nasopharyngeal
and oropharyngeal swab specimens should be collected, as well as stool and
serum.
WHO criteria for “patient under investigation (PUI)” for MERS-CoV
infection:
The following people should be investigated and tested for MERS-CoV:
1. A patient with SARI (A person with an acute respiratory infection, which
may include history of fever or measured fever (≥ 38 °C, 100.4 °F) and
cough) AND indications of pulmonary parenchymal disease (e.g. pneumonia
or ARDS), based on clinical or radiological evidence of consolidation, who
requires admission to hospital. In addition,
clinicians should be alert to the possibility of atypical presentations in
patients who are immunocompromised.
AND any of the following:
a) The disease is in a cluster that occurs within a 14 day period, without
regard to place of residence or history of travel, unless another
aetiology has been identified.
b) The disease occurs in a health care worker who has been working in
an environment where patients with severe acute respiratory
infections are being cared for, particularly patients requiring intensive
care, without regard to place of residence or history of travel, unless
another aetiology has been identified.
9. c) The person has history of travel to the Middle Eastwithin 14 days
before onset of illness, unless another aetiology has been identified.
d) The person develops an unusual or unexpected clinical course,
especially sudden deterioration despite appropriate treatment,
without regard to place of residence or history of travel, even if
another aetiology has been identified, if that alternate aetiology does
not fully explain the presentation or clinical course of the patient.
2. Individuals with acute respiratory illness of any degree of severity who,
within 14 days before onset of illness, were in close physical contactwith a
confirmed or probable case of MERS-CoV infection, while that patient was
ill.
3. For countries in the Middle East, the minimum standard for surveillance
should be testing of patients with severe respiratory disease requiring
mechanical ventilation.
o Countries in the Middle East are also strongly encouraged to consider
adding testing for MERS-CoV to current testing algorithms as part of
routine respiratory disease surveillance and diagnostic panels for
pneumonia.
o Any patients currently in the hospital with unexplained SARI should be
considered for testing for MERS-CoV.
o It is not necessary to wait for test results for other pathogens before
testing for novel coronavirus.
Treatment
There is no specific treatment for novel coronavirus infection; care is
supportive.
Although the patient may be suspected to have novel coronavirus infection,
administer appropriate empiric antimicrobials as soon as possible for
community-acquired pathogens based on local epidemiology and guidance
until the diagnosis is confirmed
10. Vaccine availability
No vaccine is currently available.
Travel advice to the Middle East
Given that there have only been a relatively small number of confirmed
cases worldwide, WHO does not recommend any travel or trade restrictions
with respect to MERS-CoV.
Because of the risk of MERS, Saudi Arabia recommends that the following
groups should postpone their plans for Hajj and Umrah this year:
1. People over 65 years old
2. Children under 12 years old
3. Pregnant women
4. People with chronic diseases (such as heart disease, kidney disease,
diabetes, or chronic respiratory diseases)
5. People with weakened immune systems
6. People with cancer or terminal illnesses
The virus that causes MERS can spread from person to person through
close contact, so pilgrims living and traveling in crowded conditions may
be at risk.
How can people protect themselves from getting MERS-CoV?
o It is not possible to give specific advice on prevention, as neither the source
of the virus nor the mode of transmission is yet certain.
o Maintain good hand hygiene, Wash your hands often with soap and water
for 20 seconds, If soap and water are not available, use an alcohol-based
hand sanitizer.
o Practise proper cough and sneeze etiquette: Cover your mouth and nose
with your arm to reduce the spread of germs. Remember if you use a tissue,
dispose of it as soon as possible and wash your hands afterwards.
o Avoid touching your eyes, nose, and mouth with unwashed hands.
11. o Avoid close contact, when possible,with sick people.
o Clean and disinfect frequently touched surfaces, such as toys and
doorknobs.
What Health Care workers should do in case of a suspected MERS-CoV
infection:novel ?
1. Place the patient (suspect, confirmed and probable cases ) in a negative
pressure room if available, or in a single room from which the air does not
circulate to other areas .
2. Implement standard and transmission-based precautions (contact and
airborne), including the use of personal protective equipment (PPE).
12. 3. Airborne transmission precautions, including routine use of a P2 (N95)
respirator, disposable gown, gloves, and eye protection when entering
a patient care area;
4. Standard and contact precautions, including close attention to hand hygiene
5. If transfer of the patient outside the negative pressure room is necessary,
asking the patient to wear a correctly fitted submicron face (surgical) mask
while they are being transferred and to follow respiratory hygiene and
cough etiquette.
6. Appropriate specimens should also be collected for MERS-CoV PCR testing.
7. Investigate and manage the patient as for community acquired pneumonia,
administer appropriate empiric antimicrobials as soon as possible for
community-acquired pathogens based on local epidemiology and guidance
until the diagnosis is confirmed
8. The local Medical Officer of Health should be notified promptly of any
suspected (and probable or confirmed) cases.
This document is based on WHO and CDC guidance.
Based on the current situation and available information,
WHO encourages all Member States to enhance their surveillance for severe
acute respiratory infections (SARI) and to carefully review any unusual
patterns of SARI or pneumonia cases
There is a great possibility of transmitting the virus outside Saudi Arabia
because many people are working in Saudi Arabia, many people are visiting
Saudi Arabia for religious tourism
Countries in the Middle East in particular should maintain a high level of
vigilance and a low threshold for testing of suspect cases
At this point, several urgent actions are needed. The most important ones
are the need for countries to increase their levels of awareness among all
people but especially among staff working in their health systems and to
increase their levels of surveillance about this new infection
13. Health care facilities that provide care for patients with suspected MERS-
CoV infection should take appropriate measures to decrease the risk of
transmission of the virus to other patients and health care workers.
Health care facilities are reminded of the importance of systematic
implementation of infection prevention and control (IPC) when
MERS-CoV is suspected.
WHO does not advise special screening at points of entry.
Final Messages!
“The only thing more difficult than planning for an emergency is having to explain
why you didn’t.” Be
Proactive NOT Reactive!!!!
Protocol For Management of Severe acute respiratory
infections when MERS- CoV is suspected
(A) The following people should be investigated and tested for
MERS-CoV: (WHO 27 June 2013)
1. A patient with SARI (A person with an acute respiratory infection, which
may include history of fever or measured fever (≥ 38 °C, 100.4 °F) and
cough) AND indications of pulmonary parenchymal disease (e.g.
pneumonia or ARDS), based on clinical or radiological evidence of
consolidation, who requires admission to hospital.
In addition, clinicians should be alert to the possibility of atypical
presentations in patients who are immunocompromised.
AND any of the following:
I. The disease is in a cluster that occurs within a 14 day period, without
regard to place of residence or history of travel, unless another aetiology
has been identified.
II. The disease occurs in a health care worker who has been working in an
environment where patients with severe acute respiratory infections are
14. being cared for, particularly patients requiring intensive care, without
regard to place of residence or history of travel, unless another aetiology
has been identified.
III. The person has history of travel to the Middle Eastwithin 14 days before
onset of illness, unless another aetiology has been identified.
IV. The person develops an unusual or unexpected clinical course, especially
sudden deterioration despite appropriate treatment, without regard to
place of residence or history of travel, even if another aetiology has been
identified, if that alternate aetiology does not fully explain the presentation
or clinical course of the patient.
2. Individuals with acute respiratory illness of any degree of severity who,
within 14 days before onset of illness, were in close physical contactwith a
confirmed or probable case of MERS-CoV infection, while that patient was
ill.
3. For countries in the Middle East, the minimum standard for surveillance
should be testing of patients with severe respiratory disease requiring
mechanical ventilation.
(B) Recommendations for specimen collection (WHO -July 2013)
1. Lower respiratory tract specimens (sputum, brochoalveolar lavage,
endotracheal) are preferred for PCR testing as they are expected to have
greater sensitivity than other specimens
2. If patients do not have signs or symptoms of lower respiratory tract
infection and lower tract specimens are not possible , both nasopharyngeal
and oropharyngeal specimens should be collected. The two can be
combined in a single collection container and tested together.
3. If initial testing of a nasopharyngeal swab is negative in a patient who is
strongly suspected to have MERS-CoV infection, patients should be retested
using a lower respiratory specimen or a repeat nasopharyngeal specimen
with additional oropharyngeal specimen if lower respiratory specimens are
not possible.
4. Collect routine clinical specimens (e.g. blood and sputum bacterial cultures)
for community-acquired pneumonia, ideally before antimicrobial use.
15. 5. Collect respiratory specimens from the upper respiratory tract (i.e. nasal,
nasopharyngeal and/or throat swab) and lower respiratory tract (i.e.
sputum, endotracheal aspirate, bronchoalveolar lavage) for known
respiratory viruses (such as influenza A and B, influenza A virus subtypes H1,
H3, and H5 in countries with H5N1 viruses circulating among poultry)
6. It is not necessary to wait for test results for other pathogens before testing
for novel coronavirus.
7. Health care workers collecting clinical specimens should exercise
appropriate infection control measures including use of personal protective
equipment.
(C) Contact monitoring
Close contacts of confirmed or probable cases should be identified and monitored
for the appearance of respiratory symptoms for 14 days after last exposure to the
confirmed or suspected case, while the case was symptomatic. Any contact that
becomes ill in that period of time should be tested for MERS-CoV. regardless of
severity,
(D) Clinical management
Give supplemental oxygen therapy
o Give oxygen therapy to patients with signs of severe respiratory distress,
hypoxaemia (i.e. SpO2 < 90%) or shock.
o Initiate oxygen therapy at 5 L/min and titrate to SpO2 ≥ 90% in non-
pregnant adults and SpO2 ≥ 92–95 % in pregnant patients.
o Pulse oximeters, functioning oxygen systems and appropriate oxygen-
delivering interfaces should be available in all areas where patients with
SARI are cared for.
o DO NOT restrict oxygen because of concerns about a patient’s respiratory
drive.
Give empiric antimicrobials to treat suspected pathogens, including
community-acquired pathogens
16. o Although the patient may be suspected to have novel coronavirus
infection, administer appropriate empiric antimicrobials as soon as
possible for community-acquired pathogens based on local epidemi-
ology and guidance until the diagnosis is confirmed. Empiric therapy can
then be adjusted on the basis of laboratory testing results.
Patients with SARI should be treated cautiously with intravenous
fluids, because aggressive fluid resuscitation may worsen oxygenation,
Do not give high-dose systemic corticosteroids or other adjunctive
therapies for viral pneumonitis outside the context of clinical trials
Closely monitor patients with SARI for signs of clinical deterioration,
such as severe respiratory distress/respiratory failure or tissue
hypoperfusion/shock, and apply supportive care interventions
Recognize severe cases, when severe respiratory distress may not be
sufficiently treated by oxygen alone, even when administered at high
flow rates Wherever available, and when staff members are trained,
mechanical ventilation should be instituted early
Prevention of complications
o Reduce incidence of venous thromboembolism, Use pharmacological
prophylaxis (for example, heparin 5000 units subcutaneously twice daily)
o Reduce incidence of pressure ulcers, Turn patient every two hours
o Reduce incidence of stress ulcers and gastric bleeding, Give early enteral
nutrition (within 24–48 hours of admission), administer histamine-2
receptor blockers or proton-pump inhibitors
(E) Infection control
Standard precautions
o Apply routinely in all health-care settings for all patients. Standard
precautions include: hand hygiene and use of personal protective
equipment (PPE) to avoid direct contact with patients’ blood, body fluids,
secretions (including respiratory secretions) and non-intact skin.
o When providing care in close contact with a patient with respiratory
symptoms (e.g. coughing or sneezing), use eye protection, because sprays
of secretions may occur.
17. o Standard precautions include: prevention of needle-stick or sharps injury;
safe waste management; cleaning and disinfection of equipment; and
cleaning of the environment.
Droplet precautions
o Use a medical mask if working within 1 meter of the patient.
o Place patients in single rooms, or group together those with the same
etiological diagnosis.
o Limit patient movement and ensure that patients wear medical masks when
outside their rooms
Airborne precautions
o Airborne precautions should be used for aerosol-generating procedures,
which have been consistently associated with an increased risk of pathogen
transmission .
o The most consistent association of increased risk of transmission to
healthcare workers (based on studies done during the SARS outbreaks of
2002–2003) was found for tracheal intubation
o Ensure that healthcare workers performing aerosol-generating procedures
use PPE, including gloves, long-sleeved gowns, eye protection and
particulate respirators (N95 or equivalent). Whenever possible, use
adequately ventilated single rooms when performing aerosol-generating
procedures.
.