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Chronic laryngitis 
Definition & aetiology : Chronic laryngitis is chronic inflammation of the laryngeal structures, most 
commonly the laryngeal mucosa. The inflammatory process can be either infectious or non-infectious, 
with a broad spectrum of aetiologies ranging from nonspecific diffuse hyperplastic 
laryngitis associated with various irritants such as smoking or voice abuse to extremely rare infective 
conditions such as histoplasmosis. 
Aetiology 
Upper & lower respiratory tract infection; 
Occupation with excess noise,asbestos workers, cement workers, shoe workers, hairdressing. 
Highly significant with age& smoking; 
Allergy 
Gastro-oesophageal reflex; 
Aetiology of chronic laryngitis is frequently multifactorial. 
Clinical presentation 
Dysphonia (alternation of voice quality). 
A sensation of something being in the pharynx. 
Difficulty in swallowing (dysphagia) 
Painful speaking( odynophonia) 
Persistent cough 
Throat clearing 
Halitosis 
Bitter taste 
Waterbrush 
Otalgia 
Operative assessment 
The initial outpatient assessment establishes if there are any discrete lesions such as leukoplakia, 
nodules, or polyps & if not , whether the diffuse changes are uniform, such as Reinke’s oedema or 
non-specific & possibly irregular as in chronic laryngitis. Once the finding have been categorized, 
next step stage is either initiation of treatment. Voice therapy by the speech & language therapists, 
or further assessment by microlaryngoscopy.
Four-point gradation of chronic laryngitis; 
Grade 
Grade I Mild erythema, stasis of secetions, string sign, 
pilling up of inter-arytenoid mucosa. 
Grade II Diffuse oedema & mucosal thickening but with 
little erythema 
Grade III Diffuse erythema, with granular friable mucosa 
or ulceration. 
Grade IV Discrete granuloma(s) with or without oedema 
or erythema. 
Histological features of chronic laryngitis 
Grade 
Grade I Thickened epithelium, hyperkeratosis, regular 
maturation retained. 
Grade II Cellular atypia, abnormal mitoses 
Grade III Severe dysplasia, epithelium has squamous cell 
carcinoma but without infiltration through the 
basement. 
Nonspecific laryngitis 
Nonspecific laryngitis is an extremely common condition which may present with a wide spectrum of 
signs & symptoms & severity. Patients invariably present with a degree of dysphonia & may have 
throat discomfort, awareness in the throat, i.e. globus type symptoms, throat clearing, halitosis. 
The most common aetiological factors are smoking, voice abuse, GERD. 
There are two theories of GERD. 
1. Direct reflex of acid from stomach & oesophagus crossing the upper oesophageal sphincter 
& causing an inflammatory effect on laryngopharynx. 
2. The indirect theory where chronic repetitive throat clearing & cough is caused by a vagally 
mediated response secondary to acid in the lower oesophagus.
Treatment 
1. Lifestyle changes 
Avoiding late evening eating & drinking; 
Reducing evening alcohol intake 
Avoiding foodstuffs giving reflux symptoms; 
Raising the head of the bed. 
2. Antacids; 
3. H2 antagonists; ranitidine 150mg twice daily; 
4. Proton pump inhitors; omeprazole 20mg twice daily for at least eight weeks; 
5. Fundiplication. 
Best clinical practice 
1. Chronic laryngitis frequently has a multifactorial aetiology. 
2. The main aetiological factors are smoking , voice abuse & gastro-oesophageal reflex. 
3. Following the clinical diagnosis,treat with proton pump inhibitor, voice therapy & smoking 
cessation therapy. 
4. Surgery should be used for discrete lesions only. 
5. Chronic infectious processes in the larynx are rare & frequently mimic squamous cell 
carcinoma. 
Treatment in the K.J.Lee 
1. Vocal hygiene- absolute silence not advised. 
2. Hydration of patients. 
3. Decongestant for nasal obstruction 
4. Cough suppression 
5. Mucolytic 
6. Avoid drying antihistamines 
7. H2 blockers or proton pump inhibitors if acid reflux detected or suspected. 
8. Steroid only for need to use voice (performance). Steroid mask symptoms; therefore, 
performer should be monitored closely to detect injury due to overuse.
Chronic laryngitis

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Physiology of swallowing
 

Chronic laryngitis

  • 1. Chronic laryngitis Definition & aetiology : Chronic laryngitis is chronic inflammation of the laryngeal structures, most commonly the laryngeal mucosa. The inflammatory process can be either infectious or non-infectious, with a broad spectrum of aetiologies ranging from nonspecific diffuse hyperplastic laryngitis associated with various irritants such as smoking or voice abuse to extremely rare infective conditions such as histoplasmosis. Aetiology Upper & lower respiratory tract infection; Occupation with excess noise,asbestos workers, cement workers, shoe workers, hairdressing. Highly significant with age& smoking; Allergy Gastro-oesophageal reflex; Aetiology of chronic laryngitis is frequently multifactorial. Clinical presentation Dysphonia (alternation of voice quality). A sensation of something being in the pharynx. Difficulty in swallowing (dysphagia) Painful speaking( odynophonia) Persistent cough Throat clearing Halitosis Bitter taste Waterbrush Otalgia Operative assessment The initial outpatient assessment establishes if there are any discrete lesions such as leukoplakia, nodules, or polyps & if not , whether the diffuse changes are uniform, such as Reinke’s oedema or non-specific & possibly irregular as in chronic laryngitis. Once the finding have been categorized, next step stage is either initiation of treatment. Voice therapy by the speech & language therapists, or further assessment by microlaryngoscopy.
  • 2. Four-point gradation of chronic laryngitis; Grade Grade I Mild erythema, stasis of secetions, string sign, pilling up of inter-arytenoid mucosa. Grade II Diffuse oedema & mucosal thickening but with little erythema Grade III Diffuse erythema, with granular friable mucosa or ulceration. Grade IV Discrete granuloma(s) with or without oedema or erythema. Histological features of chronic laryngitis Grade Grade I Thickened epithelium, hyperkeratosis, regular maturation retained. Grade II Cellular atypia, abnormal mitoses Grade III Severe dysplasia, epithelium has squamous cell carcinoma but without infiltration through the basement. Nonspecific laryngitis Nonspecific laryngitis is an extremely common condition which may present with a wide spectrum of signs & symptoms & severity. Patients invariably present with a degree of dysphonia & may have throat discomfort, awareness in the throat, i.e. globus type symptoms, throat clearing, halitosis. The most common aetiological factors are smoking, voice abuse, GERD. There are two theories of GERD. 1. Direct reflex of acid from stomach & oesophagus crossing the upper oesophageal sphincter & causing an inflammatory effect on laryngopharynx. 2. The indirect theory where chronic repetitive throat clearing & cough is caused by a vagally mediated response secondary to acid in the lower oesophagus.
  • 3. Treatment 1. Lifestyle changes Avoiding late evening eating & drinking; Reducing evening alcohol intake Avoiding foodstuffs giving reflux symptoms; Raising the head of the bed. 2. Antacids; 3. H2 antagonists; ranitidine 150mg twice daily; 4. Proton pump inhitors; omeprazole 20mg twice daily for at least eight weeks; 5. Fundiplication. Best clinical practice 1. Chronic laryngitis frequently has a multifactorial aetiology. 2. The main aetiological factors are smoking , voice abuse & gastro-oesophageal reflex. 3. Following the clinical diagnosis,treat with proton pump inhibitor, voice therapy & smoking cessation therapy. 4. Surgery should be used for discrete lesions only. 5. Chronic infectious processes in the larynx are rare & frequently mimic squamous cell carcinoma. Treatment in the K.J.Lee 1. Vocal hygiene- absolute silence not advised. 2. Hydration of patients. 3. Decongestant for nasal obstruction 4. Cough suppression 5. Mucolytic 6. Avoid drying antihistamines 7. H2 blockers or proton pump inhibitors if acid reflux detected or suspected. 8. Steroid only for need to use voice (performance). Steroid mask symptoms; therefore, performer should be monitored closely to detect injury due to overuse.