Alu Bender Photo take care of the edges of light panels for Visual Communication industry. Composite panels are thick and their edges are not nice. Alu Bender Photo is able to process the edges in a revolutionary way.
La otitis, con sus diferentes formas de presentación, constituye una de las patologías mas frecuentes a las que tiene que enfrentarse un medico de Atención Primaria. A pesar de esta extraordinaria frecuencia surgen a menudo dudas acerca no solo del correcto tratamiento de cada caso concreto, sino también respecto al diagnóstico o la interpretación de determinados signos y síntomas. Muchas veces las diferencias de criterio entre un medico y otro o entre éstos y el especialista ORL añaden todavía mas incertidumbre al manejo de una patología que es relativamente sencilla tanto en su enfoque diagnóstico como terapéutico.
Anatomy of ear
Anatomy of tympanic membran
Discuss middle ear
Definition of CSOM
Types of CSOM
CSOM atticoantral
Etiology of atticoantral type
Pathology of atticoantral CSOM
Signs/ symptoms of atticoantral CSOM
Assessment
Treatment of atticoantral CSOM
Adult tympanic membrane is about 9mm in diameter
Tympanic membrane is obliquely placed, forms an acute angle with the EAC
Composed of three
Outer squamous cell epithelial layer
Middle mucosal layer
Inner Fibrous layer , which fives the tympanic membrane it’s shape
Tumors of ear including external canal, auricle, middle canal (GLOMUS TUMOR), inner ear ( ACOUSTIC NEUROMA).
Description includes definition, etiological factors, clinical menifestations and management including medical management, surgical management and nursing management.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
3. PATHOLOGY
• The keratin squames are shed from the complete
circumference of the deep ear canal forming a lamina.
• Geometrically patterned keratin plug within the lumen of
expanded ear canal.
• Normally the epithelium from the tympanic membrane
migrates to the posterior meatal wall.
• Failure of this migration or obstruction to the migration
by wax/foreign body causes keratosis. 3
4. SILENT TYPE
• There is no predisposing acute
infections involved.
• Caused by abnormal separation of
keratin.
• Persists even after removal. 4
5. INFLAMMATORY TYPE
• Due to acute inflammation of the ear
canal.
PATHOLOGY
• Causes increased epithelial turn over.
• Alteration of epithelial migration. 5
6. PRIMARY CHOLESTEATOMA
OF EAM
• Primarily there is an irregularity/erosion of the
bony wall – Post-traumatic or Post surgical.
• Squamous epithelium invades the bone.
• C/F – PAIN , Purulent Otorrhea , No CHL.
• Subjected to histopathology to r/o carcinoma,
necrotizing otitis externa etc. 6
8. CLINICAL FEATURES
• 1. Severe ear pain.
• 2. Mild to Moderate conductive hearing
loss.
• 3. Associated bronchiectasis / sinusitis
/primary ciliary dyskinesia are common.
•
• 4. Rarely otorrhoea. 8
9. EXAMINATION
• The canal is occluded by a plug of white
keratin debris which contains a small amount
of normal appearing brown cerumen in its
centre.
• There may be accompanying granulations and
widening of external auditory canal
• CT images of temporal bone will show
widening of external canal with bone erosion. 9
11. MANAGEMENT
• Treat the cause- impacted wax-syringing
inflammatory type- treat the infection.
foreign body- instrumentation.
• Use of keratolytic agents like 2% salicylic acid in alcohol.
• Surgical removal under General Anaesthesia.
• Canal plasty in recurrent cases.
• Mastoidectomy in patients with primary cholesteatoma
of external canal.
• Removed specimen should be sent for Histopathology
to rule out malignancy.
11
12. REFERENCES
• K B Bhargava , 9th edition, Sept 2011 , page no. 38, ‘Diseases of
external ear ‘
12