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Allergy rhinitis
1. B Y :
P R I M A D H I T Y O , S . K E D
R E Z D Y T O F A N , S . K E D
Allergy Rhinitis
2. Background
Allergic rhinitis is characterized by inflammation of
the nasal passages and subsequent sneezing, nasal
congestion, and rhinorrhea.
The disease course is chronic and relapsing.
3. Epidemiology
Incidence and Prevalence:
Allergic rhinitis affects more than 20% of the population in
the western countries, with an incidence of 10 in 100,000
children and 15 in 100,000 adults.
In the U.S., 15,000 to 25,000 in 100,000 people are
affected.
Demographics:
Allergic rhinitis occurs mostly in people under age 20 but
can affect persons of any age.
Women are affected more commonly than men.
4. Seasonal Perrenial
Pollens, especially from
grasses, trees, and
weeds, and some
outdoor molds ( eg,
Alternaria , Botrytis ,
Fusarium , Mucor ,
and Cladosporium
species)
Dust mites
Animal dander and hair; allergens originate
from the skin, urine, and saliva
Cockroaches
Molds ( eg , Penicillium , Aspergillus ,
Alternaria , and Cladosporium species) that
grow in damp indoor areas or are blown into
the house.
Certain foods, such as apples, celery, and
nuts, in some patients who are sensitive to
birch pollen; foods rarely cause chronic
rhinitis, but rhinitis may be part of an acute
anaphylactic reaction to food
Cigarette smoke
Nonspecific environmental pollutants
Causes
5. Risk factors
Family history of allergic rhinitis or another allergic
disorder
Coexisting allergies ( eg , asthma in adults or
children , atopic dermatitis )
Certain occupations, such as baking, which involves
exposure to yeast molds (Saccharomyces species);
agriculture or food processing involving contact with
castor beans, which contain ricin, a very strong
sensitizer to future allergic response; and plastic and
foam work involving exposure to isocyanates
6. Associated disorders
Asthma in adults or children
Atopic dermatitis
Serous otitis media
Chronic sinusitis
Allergic conjunctivitis
7. Diagnosis
Symptoms of nasal congestion; sneezing; rhinorrhea;
and itching of the nose, palate, and pharynx lasting more
than 10 days and the observation of a pale, edematous
nasal mucosa are suggestive of allergic rhinitis.
The presence of itching is characteristic of allergic
rhinitis as opposed to other types of rhinitis.
Recurrence or chronicity of symptoms and absence of
fever point to allergic rhinitis rather than upper
respiratory tract infection.
The diagnosis can be confirmed by a positive skin prick
test or radioallergosorbent test result.
8. Clinical Presentation
Onset of symptoms typically occurs during childhood or
adolescence.
Characteristic symptoms include the following:
Paroxysmal sneezing
Rhinorrhea
Nasal congestion
Decreased sense of smell and taste
Itching of the nose, palate, pharynx, eyes, and sometimes the ears
Sore throat caused by postnasal drip
Symptoms of seasonal allergic rhinitis are much more
pronounced in the spring and fall due to grass and weed
pollens.
Symptoms that worsen indoors and upon exposure to pets are
indicative of perennial allergic rhinitis.
9. Clinical Presentation
Other historical presentations:
History of atopic dermatitis or food allergies
Family history of allergic rhinitis or similar symptoms
10. Clinical Presentation
Signs:
Edematous, blanched nasal mucosa
Clear nasal secretions
Mouth breathing caused by nasal congestion
Dark circles under the eyes ('allergic shiners')
Nasal polyps may be present, although these also can occur
in patients with nonallergic rhinitis or alone with no
apparent underlying cause.
11. Clinical Presentations
Other physical examination factors:
The 'allergic salute' (wiping the nose upward with the palm of
the hand) is characteristic of allergic rhinitis in children and,
in severe cases, can lead to the formation of a transverse nasal
crease
The nasal allergic response may be associated with inflamed or
edematous conjunctivae with punctuate papules or with
palatal inflammation
Bronchial wheezing may indicate asthma in adults or children ,
which often accompanies allergic rhinitis
Eczema may accompany allergic rhinitis
12. Diagnostic Testing
Laboratory workup often is unnecessary if the
diagnosis is apparent based on the history and
physical examination findings.
Skin prick testing often will confirm allergy to a
particular inhalant and/or food
Intradermal skin testing may be performed to
identify allergens if a skin prick test result is negative
or equivocal and the clinical presentation is
suggestive of allergic rhinitis
13. Diagnostic Testing
Nasal smear often will show large numbers of eosinophils
in patients with allergic rhinitis, whereas the presence of
neutrophils suggests infection
Radioallergosorbent testing usually detects elevated total
and specific serum immunoglobulin (Ig) E levels in
patients with allergic rhinitis; peripheral blood
eosinophil counts are not useful in diagnosis
Office spirometry is reserved for patients in whom
coexisting small airway disease (eg , asthma in adults or
children ) is suspected
If chronic sinusitis is suspected, computed tomography
(CT) scan of the sinuses should be obtained
14. Differential Diagnosis
Upper Respiratory Tract Infection
Upper respiratory tract infections in adults or children are self
limited
infections usually caused by viruses
Features include clear to purulent rhinorrhea; sneezing;
inflamed, red nasal mucosa; fever; arthralgia; myalgia; and
sore throat
Symptoms typically last for 5 to 14 days
The diagnosis usually is apparent from the clinical history and
physical examination findings
15. Differential Diagnosis
Nonallergic rhinitis
Nonallergic rhinitis is triggered by various environmental
factors, such as strong odors, pollution, and other irritants
The condition usually is perennial
Features include nasal congestion, headaches, and often clear
rhinorrhea
Nasal polyps are common
16. Differential Diagnosis
Rhinitis medicamentosa:
Occurs when nonprescription topical decongestants are used
excessively
Patients have a history of chronic use of nasal decongestants or
cocaine
Severe nasal congestion is present
The nasal mucosa usually is very red
17. Treatment (Summary Approach)
The goals of management of patients with allergic
rhinitis are to identify the causative allergen(s) so
that exposure can be avoided and to reduce
symptoms to a level acceptable to the patient.
Patients should be advised about lifestyle changes
(environmental control measures) that will help
avoid or reduce exposure to allergens.
18. Treatment (Summary Approach)
Intranasal corticosteroids ( eg , beclomethasone, budesonide,
flunisolide , fluticasone ) are very effective, controlling all of
the main symptoms of allergic rhinitis, and should be
considered firstline therapy, especially in patients with
chronic allergic rhinitis.
Corticosteroids can be used alone or in combination with an
antihistamine or decongestant; combination therapy is
effective in preventing recurrent sinusitis and postnasal drip–
induced cough and is suitable for patients with severe nasal
congestion.
Corticosteroids also may be helpful in treating acute episodes
of severe congestion or sinus ostial blockage secondary to
allergy. Oral or injected (systemic) steroids rarely are required
and are not recommended for treatment of seasonal allergic
rhinitis
19. Treatment (Summary Approach)
Intranasal antihistamines ( eg, azelastine), which
have the advantage of helping to relieve nasal
congestion, also should be considered and are
particularly effective when the allergen exposure is
limited or short term. Intranasal antihistamines can
be used concomitantly with intranasal
corticosteroids and decongestants if necessary.
20. Treatment (Summary Approach)
Ipratropium is a useful adjunct for controlling profuse
rhinorrhea.
Oral antihistamines, particularly second-generation, non-
sedating agents ( eg, cetirizine , fexofenadine , loratadin), are
considered secondline therapy and are very effective in
controlling most symptoms of allergic rhinitis,
Oral decongestants, such as pseudoephedrine , may be used
concomitantly; combination antihistamine-decongestant
preparations are available.
Sedating oral antihistamines ( eg , promethazine or
chlorpheniramine ) are less expensive than nonsedating
antihistamines and can be used when sedation is not a
problem for the patient but are associated with a high risk of
cognitive dysfunction and anticholinergic (muscarinic)
adverse effects.
21. Treatment (Summary Approach)
Montelukast , a leukotriene-receptor antagonist, is
an alternative to oral antihistamines, but
monotherapy usually only results in moderate
improvement in symptoms.
Intranasal cromolyn sodium is considered thirdline
therapy and is suitable for patients with mild to
moderate allergic rhinitis and children. However,
cromolyn is used primarily for prophylaxis and
should be administered before exposure to a known
allergen.
22. Treatment (Summary Approach)
Immunotherapy is reserved for patients with severe,
treatment-refractory allergic rhinitis who experience
symptoms during most of the year.
Subcutaneous injections or sublingual oral therapy
are used most commonly. A weekly treatment
buildup period of 3 to 4 months is required followed
by continuous monthly maintenance therapy for 3 to
5 years.
Clinical benefits may be sustained for years after
discontinuation of treatment.
23. Follow-up
Monitoring
Patients who remain symptomatic and require medication
should have regular follow-up visits
Prognosis
Allergic rhinitis is a chronic condition that usually is lifelong,
although symptoms can decrease with age
The prognosis is affected adversely by other medical
conditions, such as asthma in adults or children , and by
exposure to perennial allergens, such as dust mites and molds
24. Complication
Epistaxis
Serous otitis media
Secondary sinusitis
Facial malformations in children with longstanding
allergic rhinitis and severe nasal congestion
Nasal speech
Eustachian tube dysfunction
Increased susceptibility to upper respiratory tract
infection in adults and children
Allergic conjunctivitis
Increased susceptibility to or exacerbation of asthma
25. Patient education
Patients with allergic rhinitis should be strongly
encouraged to quit smoking and to avoid exposure to
allergens to the extent possible
Patients with seasonal allergic rhinitis should be
advised to keep doors and windows closed and use
air conditioning, with special filters if possible, at
home and in vehicles; patients also may need to alter
outdoor activity depending on the time of year