The tonsils are lymphoid tissues located in the throat that help protect the respiratory and digestive tracts from infection. Common pathogens found in the tonsils include streptococcus and other bacteria. Acute tonsillitis is usually caused by streptococcus and presents with fever, sore throat, and painful swallowing. It is generally self-limiting but complications can include abscesses or spread of the infection. Chronic or recurrent tonsillitis may require treatment like antibiotics or tonsillectomy.
Immunity against microbial infections dr.ihsan alsaimarydr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Immunity against microbial infections dr.ihsan alsaimarydr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Enterococcus faecalis is a gram-negative bacteria that can is the cause of many diseases, mostly related to nosocomial infections. Read more at https://enterococcusfaecalis.xyz
Austin Tuberculosis: Research & Treatment is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Tuberculosis.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Tuberculosis. Austin Tuberculosis: Research & Treatment accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Tuberculosis.
Austin Tuberculosis: Research & Treatment strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
complete information of tuberculosis including OLD RNTCP and new RNTCP with the novel drug that is marketed; classification of tuberculosis (MDR XDR TDR). special population and tuberculosis treatment clinical presentation and diagnosis
Mycobacterium tuberculosis-importance of TB day,classification of Mycobacterium species,Details on Mycobacterium tuberculosis-morphology,culture,resistance,biochemical reactions,antigenic characters,mode of transmission,pathogenesis,complications,lab diagnosis,treatment,DOTS Strategy and prophylaxis
Enterococcus faecalis is a gram-negative bacteria that can is the cause of many diseases, mostly related to nosocomial infections. Read more at https://enterococcusfaecalis.xyz
Austin Tuberculosis: Research & Treatment is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Tuberculosis.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Tuberculosis. Austin Tuberculosis: Research & Treatment accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Tuberculosis.
Austin Tuberculosis: Research & Treatment strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
complete information of tuberculosis including OLD RNTCP and new RNTCP with the novel drug that is marketed; classification of tuberculosis (MDR XDR TDR). special population and tuberculosis treatment clinical presentation and diagnosis
Mycobacterium tuberculosis-importance of TB day,classification of Mycobacterium species,Details on Mycobacterium tuberculosis-morphology,culture,resistance,biochemical reactions,antigenic characters,mode of transmission,pathogenesis,complications,lab diagnosis,treatment,DOTS Strategy and prophylaxis
There are nearly 100 viruses of the herpes group that infect many different animal species.
Official name of herpesviruses that commonly infect human is Humans herpesvirus (HHV)
herpes simplex virus types 1 (HHV 1)
Herpes simplex virus type 2 (HHV 2)
Varicella-zoster virus (HHV 3)
Epstein-Barr virus, (HHV 4)
Cytomegalovirus (HHV 5)
Human herpesvirus 6 (HHV 6)
Human herpesvirus 7 (HHV 7)
Human herpesvirus 8 (HHV 8) (Kaposi's sarcoma-associated herpesvirus).
Herpes B virus of monkeys can also infect humans
hELMINTHS#corona virus#Aspergillosis#BUGANDO#CUHAS#CUHAS#CUHAS
The slide is about enteric fever, also called typhoid fever. It explains the relevant anatomy, pathogenesis, pathophysiology, presentation, diagnosis and treatment of the disease. It also specifies the prevention by way of lifestyle and vaccines
This presentation includes introduction, properties, transmission, epidemiology, pathogenesis, mechanism of infection, immunity and hypersensitivity, clinical manifestations, diagnosis, treatment, prevention and control of MYCOBACTERIUM TUBERCULOSIS.
1. Disease of Tonsils
Structure of Tonsils
Consists of paired aggregates of Lymphoid Tissues,located in the pocket formed by palatoglossus &
palatopharynx arch.
A complete circle of Lymphoid tissue surrounding the entrance of GIT&Respiratory tract.Lymphoid
tissue elsewhere adenoid,payer patches,appendix.Lymphoid follicle embedded in a stroma of
connective tissue.
Stratified squamous mucosal covering of the tonsil extends irregular convoluted into parenchyma
forming pits or crypt. Microorganism ,desquamated epithelium &food debris(follicle).
Normal flora
Group A Beta haemolytic Streptococcus. 40% people have this organism.
HI
α Haemolytic streptococci
Brahamella
Mycoplasma
Chlamydia
Anaerobe.
FNAC from core> No growth of pathogenic organism.
Recurrent Ts >HI & Staphylococcus, mixed Oganism.
Functions of Tonsils
No afferent lymphatic,Germinal centre are located immediately submucosaly.T&B cells.Bcell
generate of polymeric IgA which express on mucosa & also IgG which circulate in blood.
Polymeric IgA production markedly reduced by recurrent Ts. In Tonsillectomy no evidence of
impaired immunity.Extensive back up of the immune system.
Further Bacteria & virus may act synergistically. Latent Virus Epistein –Barr virus ,adenovirus, Herpes
simplex sensitizing the pathogenic Bacteria on the Tonsil.
2. Acute Ts
Inflammatory episode affecting the Tonsils may occur as an isolated or Generalized Pharyngitis as
URTI or as a part of systemic infection(Infectious mononucleosis).Severe Ts in IM.
Organism of acute Ts;Group A β Haemolitic Streptococcus.
Epidaemiology
Sore throat common presentation,not true Ts but also Pharyngitis.Commom in Automn& Winter.
Clinical Evaluation
Pyrexia ,sore throat, Painful swallow
O/EPharyngeal erythema with or without Tonsillar exudates, Painful cervical adenopathy.
Aetiology of inflammatory disease
Both Bacteria &virus play a part in Acute Inflammation either separately or together. Or Probable
factors that impair immune system of the patient render susceptible to episode of infection.there is
no evidence that viral Ts is more or less severe than bacterial Ts or that the duration of the illness
varies significantly in either ease(exception severe in IM)
Diagnosis of Causative agent
Throat swab for C/S shows 40% culture positive in asymptomatic carrier.Again organism culture
from surface of Ts. May varies from bacterial flora deep with Tonsillar crypts.
Treatment
Primary management principally supportive use of analgesic &adequate hydration.
Specific Treatment; No Bacteria are cultured , a viral aetiology is assumed.Average Duration of an
episode of acute Ts is 2 to 3 days.Indiscriminate antibiotic prescription resist organism, allergy,
anaphylaxis.
Efficacy of varies Antibiotic cephradine over penicillin for 7days ,benefit insufficient to justify their
use. A single dose of dexamethasone as adjuract therpy is significant benefit in reducing pain in
acute Pharyngitis.
3. Complications of Acute Ts
1) Systemic sepsis > septicaemia &septic arthritis.
2) GABHS > acute exanthematous reaction >Macular rash>scarlet fever.
3) Immune complex > RF &AGN.
Peritonsillar abscess
Peritonsillar abscess in which a collectin of pus forms in the potential space between the the
Tonsillar capsule & superior constrictor.
Organism GABHS ,Streptococcus viridians ,Staphylococcus aureus ,HI, Anaerobes.
Treatment
Hospitalization
I/V fluid
I/D of abscess
Antibiotic (cephradine+ Metronidazole)
Tonsillectomy following 2nd attack of quinsy.
Lemierre’s Syndrome
Potentially fatal complications of oropharyngeal function ,characterised by septic thrombophelibitis
in the internal jugular vein with metastatic absceses.
Fusiform Bacillus > severe neck pain, septicaemia, &2ndary to Tympanomastiod infection.
Treatment
Prolonged antibiotic >Beta lactm + metronidazole
Anticoagution if spreading thrombophilitis
Significant mortality.
4. Tonsillitis &psoriasis
Tonsillitis due to GAHBS & exacerbation of Psoriasis particularly of the guttate varity(small psoriasis)
by each episode of the acute Ts >immune phenomena>Tonsillectomy.(1/3 to1/2 of the patient
improved , 7% worsening)
Recurrent Ts
Acute episode appear to follow a pattern of recurring infection every few wks or months.This
sequence of episode may gradually abate &some Individual runs a course to several yrs.
Low dose penicillin if episode are happening close together.
Chr. Ts
Chr. Low grade infection, affecting the quality of life, throat discomfort,production of unpleasant
Psmelly yellowish debris may become inspissated Tonsillolith, low grade fever,Chr. Tonsil sepsis.
NO natural resolution.
Infectious mononucleosis
Severe Acute Pharyngotonsillar infection, seen in young adult , severe systemic upset,
Haemotological disturbance, Liver function disturbance, spleenomegaly,
Dx by monospot test(Heterophil antiboby,)Confirm by Antibody to EBV.
Treatment
Penicillin+ Metronidazole ,ampicillin must be avoided.
Short course Corticosteroid
No evidence of support to use antiviral drugs.