This chapter discusses human patient simulation as a teaching method in nursing education. It defines simulation as using lifelike mannequins and computer software to recreate clinical scenarios for students to practice skills. Theoretical foundations for simulation include situated cognitive learning theory. Key frameworks that guide simulation include the Simulation Framework for Nursing Education and the Clinical Judgment Model. Resources needed for simulation include physical space, equipment, and support personnel. Proper scenario development and debriefing are important when using this method. Potential problems include overgeneralizing findings to real patients and incorrect attribution of responses.