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Cell Adhesion and Cell Migration
The document discusses cell adhesion and migration. It outlines four classes of cell junctions: anchoring junctions, occluding junctions, channel-forming junctions, and signal-relaying junctions. Anchoring junctions like adherens junctions and desmosomes connect cells to each other and transmit stresses through connections to the cytoskeleton. Tight junctions form seals between cells and separate membrane domains. Cadherins are important cell adhesion molecules that mediate calcium-dependent cell-cell adhesion through homophilic binding. Regulation of cadherins and other cell adhesion molecules controls processes like epithelial-mesenchymal transition that are important for tissue development and cancer metastasis.
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