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By: Thinh Le
Introduction ,[object Object],[object Object]
Apoptosis vs Necrosis Apoptosis  •  Chromatin condensation •  Cell Shrinkage •  Preservation of Organelles and cell membranes •  Rapid engulfment by neighboring cells preventing inflammation Necrosis •  Nuclear swelling •  Cell Swelling •  Disruption of Organelles •  Rupture of cell and release of cellular contents •  Inflammatory response 1972 Kerr Wyllie Currie
Evolution of the Origin of  Programmed Cell Death (PCD) ,[object Object],[object Object]
Purpose of Apoptosis ,[object Object]
Inititation ,[object Object],[object Object],[object Object],[object Object],[object Object],Types of Induction: Cell surface death receptor mediated pathway (extrinsic) Mitochondrial-initiated pathway (intrinsic)
 
Caspases  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Important Proteins ,[object Object],[object Object],[object Object]
Mechanism (Extrinsic) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Death Inducing Signaling Complex
Mechanism (Extrinsic) cont. ,[object Object],[object Object]
Mechanism (Extrinsic) cont.
Mechanism (Intrinsic) ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Mechanism (Intrinsic) cont. ,[object Object]
Mechanism (Intrinsic) cont.
Review
Conclusion
References  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Apoptosis vs Necrosis Cell Death Mechanisms

Editor's Notes

  1. Before we go on, let look at the way cell dies There are different ways a cell die Necrosis (in Greek Νεκρός = Dead ) is the name given to accidental death of cells and living tissue .