The circulatory system, also known as the cardiovascular system, moves substances to and from cells and helps regulate body temperature and pH. It consists of the heart, blood, and blood vessels. The heart begins beating around 21 days after conception at a rate near the mother's, which then accelerates over the first month. Blood vessels include arteries, which carry blood away from the heart, veins, which carry blood toward the heart, and capillaries, which connect arterioles and venules and closely interact with tissues. Deoxygenated blood returns to the heart through the superior and inferior vena cavae and is pumped through the pulmonary and systemic circuits to be oxygenated in the lungs before being distributed to the body

1. Cardiovascular System Denise Chan "Matters of the Heart" Andrew McCaskill

2. The circulatory system (scientifically known as the cardiovascular system ) is an organ system that moves substances to and from cells ; it can also help stabilize body temperature and pH (part of homeostasis). The main components of the circulatory system are the heart , the blood , and the blood vessels .

3. The human embryonic heart begins beating approximately 21 days after conception , or five weeks after the last normal menstrual period (LMP), which is the date normally used to date pregnancy. The human heart begins beating at a rate near the mother’s, about 75-80 beats per minute (bpm). The embryonic heart rate (EHR) then accelerates linearly for the first month of beating, peaking at 165-185 bpm . This acceleration is approximately 3.3 bpm per day, or about 10 bpm every three days, an increase of 100 bpm in the first month. Early development Patrick J. Lynch, medical illustrator; C. Carl Jaffe, MD, cardiologist

5. Anatomy All blood vessels have the same basic structure. The inner lining is the endothelium and is surrounded by connective tissue . Around this there is a layer of vascular smooth muscle , which is highly developed in arteries. Finally, there is a further layer of connective tissue known as the adventitia , which contains nerves that supply the muscular layer, as well as nutrient capillaries in the larger blood vessels. The hollow internal cavity in which the blood flows is called the lumen . Capillaries consist of little more than a layer of endothelium and occasional connective tissue. Laid end to end, the blood vessels in an average human body will stretch approximately 62,000 miles.

6. Arteries are muscular blood vessels that carry blood away from the heart. Its proper functioning is responsible for the delivery of oxygen and nutrients to all cells, maintenance of optimum pH, and the mobility of the elements, proteins and cells of the immune system. In developed countries, the two leading causes of death, myocardial infarction and stroke each may directly result from an arterial system that has been slowly and progressively compromised by years of deterioration.

7. Blood pressure The arterial system is the higher-pressure portion of the circulatory system. Arterial pressure varies between the peak pressure during heart contraction, called the systolic pressure , and the minimum, or diastolic pressure between contractions, when the heart rests between cycles. This pressure variation within the artery produces the pulse which is observable in any artery, and reflects heart activity. To withstand and adapt to the pressures within, arteries are surrounded by varying thicknesses of smooth muscle which have extensive elastic and inelastic connective tissues. The pulse pressure, i.e. Systolic vs. Diastolic difference, is determined primarily by the amount of blood ejected by each heart beat versus the volume and elasticity of the major arteries. Over time, elevated arterial blood sugar, cholesterol, and pressure, smoking, and other factors are all involved in damaging both the endothelium and walls of the arteries , resulting in atherosclerosis or Diabetes Mellitus.

8. Pulmonary arteries The pulmonary arteries carry deoxygenated blood that has just returned from the body to the lungs, where carbon dioxide is exchanged for oxygen. Systemic arteries Systemic arteries deliver blood to the arterioles, and then to the capillaries, where nutrients and gases are exchanged. The Aorta The aorta is the root systemic artery. It receives blood directly from the left ventricle of the heart via the aortic valve. As the aorta branches, and these arteries branch in turn, they become successively smaller in diameter, down to the arteriole. The arterioles supply capillaries which in turn empty into venules. Arterioles Arterioles, the smallest of the true arteries, help regulate blood pressure and deliver blood to capillaries. Types of Arteries

9. Structure The walls of capillaries are composed of only a single layer of cells , the endothelium . This layer is so thin that molecules such as oxygen, water and lipids can pass through them by diffusion and enter the tissues. Waste products such as carbon dioxide and urea can diffuse back into the blood to be carried away for removal from the body. Capillaries are the smallest of a body's blood vessels, measuring 5-10 μm. They connect arterioles and venules , and they are the blood vessels that most closely interact with tissues.

11. Most veins have one-way valves called venous valves to prevent backflow caused by gravity. They also have a thick collagen outer layer , which helps maintain blood pressure and stop blood pooling. The hollow internal cavity in which the blood flows is called the lumen . Veins are surrounded by helical bands of smooth muscles which help maintain blood flow to the right atrium. Fainting can be caused by failure of the skeletal-muscular pump. Long periods of standing can result in blood pooling in the legs , with blood pressure too low to ascend to the heart. In these cases the smooth muscles surrounding the veins become slack and fill with blood, absorbing a large portion of the total blood volume, keeping blood away from the brain and causing unconsciousness.

12. Notable veins and vein systems The pulmonary veins carry oxygenated blood from the lungs to the heart. ***The superior and inferior vena cavae carry deoxygenated blood from the upper and lower systemic circulations, respectively. ***A portal venous system is a series of veins or venules that directly connect two capillary beds. An example of such a system includes the hepatic portal vein. List of important named veins Pulmonary veins Portal vein Superior vena cava Inferior vena cava Femoral vein Jugular veins

13. William Harvey (April 1, 1578 – June 3, 1657) was an English medical doctor, who is credited with being the first to correctly describe, in exact detail, the properties of blood being pumped around the body by the heart. “ I profess both to learn and to teach anatomy, not from books but from dissections; not from positions of philosophers but from the fabric of nature.”

14. Having circulated through the body, all the relatively de-oxygenated blood collects in the venous system which coalesces into two major veins: the superior vena cava (roughly speaking from areas above the heart) and the inferior vena cava (roughly speaking from areas below the heart ). These two great vessels empty into the right atrium of the heart. The right atrium is the larger of the two atria, although both receive the same amount of blood. The blood is then pumped through the tricuspid valve , or right atrioventricular valve , into the right ventricle . From the right ventricle, blood is pumped through the pulmonary semi-lunar valve into the pulmonary artery . This blood enters the two pulmonary arteries (one for each lung) and travels through the lungs, where it is oxygenated and then flows into the pulmonary veins. PULMONARY CIRCUIT:

15. This oxygenated blood then enters the left atrium , which pumps it through the bicuspid valve , also called the mitral or left atrioventricular valve, into the left ventricle . The left ventricle is thicker and more muscular than the right ventricle because it pumps blood at a higher pressure. From the left ventricle, blood is pumped through the aortic semi-lunar valve into the aorta, a massive and thick-walled artery. The aorta arches and gives off major arteries to the upper body before piercing the diaphragm in order to supply the lower parts of the body with its various branches. Once the blood enters the peripheral tissues oxygen and nutrients are extracted from it and carbon dioxide and wastes added , and it will again be collected in the veins and the process will be repeated . http://www.smm.org/heart/heart/pumping.htm Systemic Circuit:

16. Heart Circulation: In Conclusion! PULMONARY CIRCUIT: (De-Oxygenated Blood) From Body  Superior/Inferior Vena Cava  Right Atria  via Tricuspid Valve  Right Ventricle  via Pulmonary Valve  Pulmonary Arteries  To Lungs (L&R) Systemic Circuit: (Oxygenated Blood) From Lungs  Pulmonary Vein  Left Atria  via Bicuspid Valve  Left Ventricle  via Aortic Semi-Lunar Valve  Aorta  to Body

17. The sinoatrial node (abbreviated SA node ) is the impulse generating (pacemaker) tissue located in the right atrium of the heart. It is a group of cells positioned on the wall of the right atrium, near the entrance of the superior vena cava. Although all of the heart's cells possess the ability to generate the electrical impulses (or action potentials), the sinoatrial node is what normally initiates it , sometimes called the primary pacemaker.. Cells in the SA node will naturally discharge (create action potentials) at about 70-80 times/minute . The atrioventricular node (abbreviated AV node) is an area of specialized tissue between the atria and the ventricles of the heart, which conducts the normal electrical impulse from the atria to the ventricles.

18. Acute myocardial infarction ( AMI or MI ), commonly known as a heart attack , is a disease state that occurs when the blood supply to a part of the heart is interrupted. The resulting ischemia or oxygen shortage causes damage and potential death of heart tissue. It is a medical emergency, and the leading cause of death for both men and women all over the world. Important risk factors are a previous history of vascular disease such as atherosclerotic coronary heart disease and/or angina a previous heart attack or stroke any previous episodes of abnormal heart rhythms or syncope older age—especially men over 40 and women over 50 smoking excessive alcohol consumption the abuse of certain illicit drugs high triglyceride levels high LDL ("Low-density lipoprotein") and low HDL ("High density lipoprotein") diabetes high blood pressureD obesity and chronically high levels of stress in certain persons.

19. The term myocardial infarction is derived from myocardium (the heart muscle) and infarction (tissue death due to oxygen starvation). The phrase "heart attack" is sometimes used incorrectly to describe sudden cardiac death, which may or may not be the result of acute myocardial infarction. Classical symptoms of acute myocardial infarction include chest pain, shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety or a feeling of impending doom. Patients frequently feel suddenly ill. Women often experience different symptoms than men. The most common symptoms of MI in women include shortness of breath, weakness, and fatigue. Approximately one third of all myocardial infarctions are silent, without chest pain or other symptoms.

20. The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. The are two sets of jugular veins: external and internal. The internal jugular runs with the common carotid artery and vagus nerve inside the carotid sheath. It provides venous drainage for the contents of the skull. The external jugular runs superficially to sternocleidomastoid. Both connect to the brachiocephalic veins, the external jugular joining more laterally than the internal. The brachiocephalic veins then join the subclavian veins from both sides then join to form the superior vena cava. The Jugular: The Main Brain Draining Vein

21. In human anatomy, the common carotid artery is an artery that supplies the head and neck; it divides in the neck to form the external and internal carotid arteries. The common carotid artery is a paired structure, meaning that there are two in the body, one for each half. The left and right common carotid arteries follow the same course with the exception of their origin. The right common carotid originates in the neck from the brachiocephalic trunk. The left arises from the aortic arch in the thoracic region.

22. Renal Artery The renal arteries normally arise off the side of the abdominal aorta and supply the kidneys with blood . The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys. The arterial supply of the kidneys is variable and there may be one or more renal arteries supplying each kidney. It is located above the renal vein.

23. The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. Because the inferior vena cava is on the right half of the body, the left renal vein is generally the longer of the two.

24. The hepatic portal vein, a large vein that carries blood from the digestive tract to the liver. The portal venous system is responsible for directing blood from parts of the gastrointestinal tract to the liver. Things absorbed in the small intestine, for example, would be taken to the liver for processing before being sent to the heart. Many drugs that are absorbed through the GI tract are substantially metabolized by the liver before reaching general circulation.

25. The subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. The subclavian veins are two large veins, one on either side of the body. Its diameter is approximately that of a man's small finger. Each subclavian drains the extremities and upper thorax.

26. The axillary artery is a large blood vessel that conveys oxygenated blood to the lateral aspect of the thorax, the axilla (armpit) and the upper limb. Its origin is the subclavian artery. The axillary vein is a large blood vessel that conveys blood from the lateral aspect of the thorax, axilla (armpit) and upper limb toward the heart. There is one axillary vein on each side of the body.

27. The common iliac arteries are two large arteries that originate from the aorta and supply all lower extremities. There are two divisions: the external iliac artery and internal iliac artery. The common iliac veins are formed by the external iliac veins and internal iliac veins and together, in the abdomen, form the inferior vena cava. They drain blood from the pelvis and lower limbs. Iliac artery and vein

28. The femoral vein is a blood vessel that accompanies the femoral artery. The femoral vein returns de-oxygenated blood to the inferior vena cavae. In anatomy, the femoral artery is a large artery in the muscles of the thigh that supplies the lower extremities with needed oxygen.

29. The pulmonary arteries carry blood from the heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood. Pulmonary hypertension occurs alone and as a consequence of a number of lung diseases. It can be a consequence of heart disease.

30. Patrick J. Lynch, medical illustrator; C. Carl Jaffe, MD, cardiologist. http://creativecommons.org/licenses/by/2.5/ Pulmonary Arteries Pulmonary Veins

31. 200 million RBSs are produced daily by the hematopoetic tissue in bone marrow About the same number of RBCs are broken down by the spleen and converted into bilirubin which (along with bile) help break down fats.

32. Multiple Allele Traits Traits that are controlled by more than two alleles. Blood type in humans is controlled by three alleles: A, B, and O www.biologycorner.com/bio2/specialgenetics.html Blood Transfusions Blood can only be transferred to a body of a person who's immune system will "recognize" the blood. A and B are antigens on the blood that will be recognized. If the antigen is unfamiliar to the body, your body will attack and destroy the transfused blood as if it were a hostile invader (which can cause death). O is like a blank, it has no antigens. O is called the universal donor because a person can receive a transfusion from O blood without having an immune response AB is the universal acceptor , because a person with AB blood has both the A and B antigens already in the body, A and B blood can be transfused to the person (as well as O) and the body will recognize it and not attack. Phenotype Genotype A AA or AO B BB or BO AB AB only O OO only

33. Conclusion: Circulatory System Blood Clotting Cascade The circulatory system, just like any other system, is a complex, interrelated, system with multiple parts that function as a whole. The circulatory system exhibits “irreducible complexity” in the highest degree. The heart without the complex arterial system would be useless. The arterial system alone would be useless without the venous system (and its many valves) to return the blood to the heart. The complexity of the heart alone is enough to astound anyone, let alone the system of vessels that accompany the passage of blood to every cell of the body. Considering the relatedness to every other system of the body makes the circulatory system the most essential system of the human body.