Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown and interconversion of carbohydrates in living organisms. The most important carbohydrate is glucose, a simple sugar (monosaccharide) that is metabolized by nearly all known organisms.
Complete Set of Metabolism of Carbohydrate in that second chapter, glycolysis.
This presentation covers complete glycolysis pathway with step wise animated reactions and it includes clinical aspects also. This presentation is good for MBBS students.
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
coordination between different metabolic pathways inside the body is called integration of metabolism. this presentation discuss about how metabolism can be regulated and integrated in liver, muscle and adipose tissue.
Metabolism of amino acids (general metabolism)Ashok Katta
Metabolism of amino acids (general metabolism).
Part - I of amino acid metabolism.
This presentation covers Transamination, deamination, formation and Transport of Ammoniaand etc.
Complete Set of Metabolism of Carbohydrate in that second chapter, glycolysis.
This presentation covers complete glycolysis pathway with step wise animated reactions and it includes clinical aspects also. This presentation is good for MBBS students.
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
coordination between different metabolic pathways inside the body is called integration of metabolism. this presentation discuss about how metabolism can be regulated and integrated in liver, muscle and adipose tissue.
Metabolism of amino acids (general metabolism)Ashok Katta
Metabolism of amino acids (general metabolism).
Part - I of amino acid metabolism.
This presentation covers Transamination, deamination, formation and Transport of Ammoniaand etc.
The Nature and Value of Sadhana (commentary on 'Reimagining the Buddha') - a talk by Kamalashila given on 5 Feb 2011 at the Men's Order Weekend, Padmaloka
Metabolic Fate of Pyruvate and Cori cycle and Alanine cycle Cori & Alanine cy...Amany Elsayed
Metabolic Fate of Pyruvate and Cori cycle and Alanine cycle Cori & Alanine cycle and Lactate Dehydrogenase Deficiency (LDHA) and Malate aspartate shuttle (cycle) and Glycerol phosphate shuttle and Mitochondrial shuttle
Cellular Energy Transfer (Glycolysis and Krebs Cycle) and ATPmuhammad aleem ijaz
This presentation is all about Cellular Energy Transfer with reference to Glycolysis and Kreb Cycle with all their stages involved.
It also includes ATP production in the body, its importance, structure.
Also contains a comparison of energy production in Krebs and Glycolysis cycle.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
2. CIFE
Fates of Catabolized Organic Nutrients
• Energy (ATP)
• Raw materials used in anabolism
• Structural proteins
• Enzymes
• Lipid storage
• Glycogen storage
3. CIFE
Glucose
• Glucose is the molecule ultimately used by body cells to
make ATP.
• Neurons and RBCs rely almost entirely upon glucose to
fullfill their energy needs.
• Excess glucose is converted to glycogen or fat and stored.
6. CIFE
Synthesis of New Organic Compounds
• In energy terms, anabolism is an “uphill” process that forms
new chemical bonds while catabolism is a downhill process that
provides energy by breaking chemical bonds
• Building new organic compounds requires both energy
(garnered from earlier catabolism) and raw materials.
7. CIFE
Organic Compounds
• Glycogen:
• a branched chain of glucose molecules
• most abundant storage carbohydrate
• Triglycerides:
• most abundant storage lipids
• Energy is primarily stored in the fatty acids
• Proteins:
• most abundant organic components in body
• perform many vital cellular functions
8. CIFE
Energy Extraction
• C-H bonds store the most energy
• C-C also store a lot of energy
• C-O bonds store very little energy
Macromolecules that we take in via our diet are mostly rich in C-
H and C-C bonds. In the body, these are broken down and turned
into C-O bonds that are then breathed out as carbon dioxide.
• In the process, some of the energy released by breaking those
bonds is captured to make ATP
9. CIFE
Carbohydrate Metabolism
• Generates ATP and other high-energy compounds by breaking
down carbohydrates:
glucose + oxygen carbon dioxide + water
• Occurs in small steps which release energy to convert ADP to
ATP
• Involves glycolysis, TCA cycle, and electron transport
• 1 molecule of glucose nets 36* molecules of ATP
10. CIFE
Glycolysis
• Breaks down glucose in cytosol into smaller molecules used by
mitochondria .
• Does not require oxygen so it is anaerobic.
• 1 molecule of glucose yields only 2 ATP.
• Yields very little energy on its own, but it is enough to power
muscles for short periods .
• Some bacteria are entirely anaerobic and survive by
performing only glycolysis.
• RBCs and working muscle tissue use glycolysis as their primary
source of ATP.
11. CIFE
Aerobic / Cellular Respiration Reactions
• Include the TCA cycle and electron transport.
• Occur in mitochondria:
• consume oxygen
• produce lots of ATP
• Much more efficient
12. CIFE
Overview – Aerobic metabolism
• Glycolysis:
• breaks 6-carbon glucose into two 3-carbon pyruvic acid .
• TCA cycle
• 3 carbon pyruvate is adapted into 2 carbon acetyl CoA
(probably the most important, most central molecule in
metabolism)
• Acetyl CoA is conveted into carbon dioxide and the
energy is captured in an intermediate called NADH
• Electron Transport
• Uses oxidative phosphorylation to turn NADH into ATP
• requires oxygen and electrons; thus the rate of ATP
generation is limited by oxygen or electrons
13. CIFE
ATP Production
• For 1 glucose molecule processed, cell gains 36 molecules of
ATP:
• 2 from glycolysis
• 4 from NADH generated in glycolysis (requires oxygen)
• 2 from TCA cycle (through GTP)
• 28 from electron transport
17. CIFE
Importance of Phosphorylated
Intermediates
1. Because the plasma membrane generally lacks transporters
for phosphorylated sugars, the phosphorylated glycolytic
intermediates cannot leave the cell.
• After the initial phosphorylation, no further energy is
necessary to retain phosphorylated intermediates in the cell,
despite the large difference in their intracellular and
extracellular concentrations.
18. CIFE
• 2. Phosphoryl groups are essential components in the
enzymatic conservation of metabolic energy. Energy
released in the breakage of phosphoanhydride bonds
(such as those in ATP) is partially conserved in the
formation of phosphate esters such as glucose 6-
phosphate.
• High-energy phosphate compounds formed in
glycolysis (1,3-bisphosphoglycerate and
phosphoenolpyruvate) donate phosphoryl groups to
ADP to form ATP.
19. CIFE
• 3. Binding energy resulting from the binding of phosphate
groups to the active sites of enzymes lowers the activation
energy and increases the specificity of the enzymatic reactions.
• The phosphate groups of ADP, ATP, and the glycolytic
intermediates form complexes with Mg2, and the substrate
binding sites of many glycolytic enzymes are specific for these
Mg2 complexes. Most glycolytic enzymes require Mg2 for
activity.
21. CIFE
Entry Into The Citric Acid Cycle
Glycolysis releases relatively little of the energy present in a glucose molecule; much more
is released by the subsequent operation of the citric acid cycle and oxidative
phosphorylation.
Following this route under aerobic conditions, pyruvate is converted to acetyl CoA by the
enzyme pyruvate dehydrogenase and the acetyl CoA then enters the citric acid cycle. The
pyruvate dehydrogenase reaction is an oxidative decarboxylation
Pyruvate dehydrogenase
pyruvate + NAD+ + CoA→ acetyl CoA + CO2 + NADH
22. CIFE
Conversion to fatty acid or ketone bodies.
• When the cellular energy level is high (ATP in
excess), the rate of the citric acid cycle decreases
and acetyl CoA begins to accumulate.
• Under these conditions, acetyl CoA can be used for
fatty acid synthesis or the synthesis of ketone bodies
23. CIFE
Conversion to Lactate
• The NAD+ used during glycolysis (in the formation of 1,3-bisphosphoglycerate
by glyceraldehyde 3-phosphate dehydrogenase); must be regenerated if
glycolysis is to continue.
• Under aerobic conditions, NAD+ is regenerated by the re-oxidation of NADH
via the electron transport chain.
• When oxygen is limiting, as in muscle during vigorous contraction, the re-
oxidation of NADH to NAD+ by the electron transport chain becomes
insufficient to maintain glycolysis.
• Under these conditions, NAD+ is regenerated instead by conversion of the
pyruvate to lactate by lactate dehydrogenase:
Lactate dehydrogenase
pyruvate + NADH + H+ lactate + NAD+
24. CIFE
Conversion to ethanol.
• In yeast and some other microorganisms under anaerobic conditions, the
NAD+ required for the continuation of glycolysis & is regenerated by a
process called alcoholic fermentation.
• The pyruvate is converted to acetaldehyde (by pyruvate decarboxylase) and
then to ethanol (by alcohol dehydrogenase), the latter reaction reoxidizing
the NADH to NAD+:
25. CIFE
Metabolism of Fructose
There are two pathways for the metabolism of fructose, one occurs in muscle and adipose tissue,
the other in liver :-
1. In muscle and adipose tissue, fructose can be phosphorylated by hexokinase (which is
capable of phosphorylating both glucose and fructose) to form fructose 6-phosphate which then
enters glycolysis.
2. In liver, the cells contain mainly glucokinase instead of hexokinase and this enzyme
phosphorylates only glucose. Thus in liver, fructose is metabolized instead by the fructose 1-
phosphate pathway
26. CIFE
Metabolism of Galactose
• The hydrolysis of the disaccharide lactose (in milk) yields galactose and glucose.
• Thus galactose is also a major dietary sugar for humans. Galactose and glucose
are epimers that differ in their configuration at C-4. Thus the entry of galactose into
glycolysis requires an epimerization reaction.
• This occurs via a four-step pathway called the galactose–glucose
interconversion pathway
28. CIFE
• In the second stage the acetyl groups are fed into the citric acid cycle, which
enzymatically oxidizes them to CO2; the energy released is conserved in the reduced
electron carriers NADH and FADH2.
• In the third stage of respiration, these reduced coenzymes are themselves oxidized, giving
up protons (H) and electrons.
• The electrons are transferred to O2—the final electron acceptor—via a chain of electron-
carrying molecules known as the respiratory chain.
• In the course of electron transfer, the large amount of energy released is conserved in
the form of ATP, by a process called oxidative phosphorylation
CITRIC ACID CYCLE
29. CIFE
“If citrate is added the rate of respiration is often increased .
. . the extra oxygen uptake is by far greater than can be
accounted for by the complete oxidation of citrate . . . Since
citric acid reacts catalytically in the tissue it is probable that
it is removed by a primary reaction but regenerated by a
subsequent reaction.”
—H. A. Krebs and W. A. Johnson, article in Enzymologia, 1937
30. CIFE
Catabolism of proteins, fats, and carbohydrates in the
three stages of cellular respiration.
Stage 1: oxidation of fatty acids, glucose, and some amino
acids yields acetyl-CoA.
Stage 2: oxidation of acetyl groups in the citric acid cycle
includes four steps in which electrons are abstracted.
Stage 3: electrons carried by NADH and FADH2 are funneled
into a chain of mitochondrial (or, in bacteria, plasma
membrane–bound) electron carriers—the respiratory
chain—ultimately reducing O2 to H2O. This electron flow
drives the production of ATP.
31. CIFE
Breakdown of Pyruvate:
• Each pyruvate
molecule loses a
carboxylic group in the
form of carbon
dioxide.
• The remaining two
carbons are then
transferred to the
enzyme CoA to
produce Acetyl CoA.
37. CIFE
ELECTRON TRANSPORT AND OXIDATIVE
PHOSPHORYLATION
• Electron transport and oxidative phosphorylation re-oxidize
NADH and FADH2 and trap the energy released as ATP.
• In eukaryotes, electron transport and oxidative phosphorylation
occur in the inner membrane of mitochondria whereas in
prokaryotes the process occurs in the plasma membrane.
41. Cytochrome oxidase
4 cyt. c (Fe2+) + 4 H+ + O2 → 4 cyt. c (Fe3+) + 2 H2O
The cytochrome oxidase reaction is complex; it transfers four electrons from four
cytochrome c molecules and four H+ ions to molecular oxygen to form two
molecules of water
Galactose 1-phosphate uridylyl transferase catalyzes the transfer of a uridyl
group from UDP-glucose to galactose 1-phosphate to form UDP-galactose
and glucose 1-phosphate
FIGURE 16–1 Catabolism of proteins, fats, and carbohydrates in the
three stages of cellular respiration. Stage 1: oxidation of fatty acids,
glucose, and some amino acids yields acetyl-CoA. Stage 2: oxidation
of acetyl groups in the citric acid cycle includes four steps in which
electrons are abstracted. Stage 3: electrons carried by NADH and
FADH2 are funneled into a chain of mitochondrial (or, in bacteria,
plasma membrane–bound) electron carriers—the respiratory chain—
ultimately reducing O2 to H2O. This electron flow drives the production
of ATP.
Source: Boundless. “Breakdown of Pyruvate.” Boundless Biology. Boundless, 08 Jan. 2016. Retrieved 14 Jan. 2016 from https://www.boundless.com/biology/textbooks/boundless-biology-textbook/cellular-respiration-7/oxidation-of-pyruvate-and-the-citric-acid-cycle-75/breakdown-of-pyruvate-359-11585/
The cytochrome oxidase reaction is complex; it transfers four electrons from four cytochrome c molecules and four H+ ions to molecular oxygen to form two molecules of water
Oxidative phosphorylation is ATP synthesis linked to the oxidation of NADH and FADH2 by electron transport through the respiratory chain.
This occurs via a mechanism originally proposed as the chemiosmotic hypothesis. Energy liberated by electron transport is used to pump H+ ions out of the mitochondrion to create an electrochemical proton (H+) gradient.
The protons flow back into the mitochondrion through the ATP synthase located in the inner mitochondrial membrane, and this drives ATP synthesis. Approximately three ATP molecules are synthesized per NADH oxidized and approximately two ATPs are synthesized per FADH2 oxidized.