Hard gelatin capsules are solid dosage forms containing medicinal ingredients enclosed in gelatin shells. They come in two-piece hard shells or one-piece soft shells and can contain liquids, semisolids or powders. The document discusses the manufacturing process for hard capsules including production of the gelatin shell through dipping and drying, filling powder or liquid contents using various machines, and sealing. It notes advantages like masking tastes but also challenges like incompatibility with hygroscopic drugs. Various excipients, defects and special techniques are also outlined.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
COATING PROCESS : PRINCIPLE : Tablet Coating is the process of a coating composition to a moving bed of tablets with the concurrent use of heated air to facilitate evaporation of solvent . The distribution of coating is accomplished by the movement of tablets either perpendicular or vertical to the application of the coating composition
Granulation process may be defined as a process wherein small particles adhere together by forming bonds between them , resulting in the formation of large aggregates called granules.
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
COATING PROCESS : PRINCIPLE : Tablet Coating is the process of a coating composition to a moving bed of tablets with the concurrent use of heated air to facilitate evaporation of solvent . The distribution of coating is accomplished by the movement of tablets either perpendicular or vertical to the application of the coating composition
Granulation process may be defined as a process wherein small particles adhere together by forming bonds between them , resulting in the formation of large aggregates called granules.
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
Capsules are solid dosage forms in which the drug or a mixture of drugs with or without excipients is enclosed in Hard Gelatin Capsule Shells, in soft, soluble shells of gelatin, or in hard or soft shells of any other suitable material, of various shapes and capacities. They usually contain a single dose of active ingredient(s) and are intended for oral administration.
Advantages:
The drugs having unpleasant odour and taste can be administered by enclosing them in a tasteless shell.
They are smooth, become very slippery when moist and can be easily swallowed.
They are economical.
They are easy to handle and carry.
The capsules release the medicament as and when desired in gastro-intestinal tract.
Capsules are made from gelatin and hence they are therapeutically inert.
Capsule have elegant appearance so that it enhance patient acceptance.
The drug in the form of solid, liquid & viscous form can be encapsulated in capsule shell.
Capsule formulation provide better stability of drug as compare to uncoated tablet & liquid dosage form.
Disadvantages:
Capsule are not usually used for administration of extremely soluble materials such as potassium chloride, potassium bromide etc. since there is sudden release of such compound in stomach & causes irritation.
Capsule should not used for highly efflorescent material as material may cause the capsule to soften by losing water molecule to shell.
Capsule should not used for highly deliquescent powder as powder have tendency to absorb moisture from capsule shell & make it brittleness.
The capsule shells can absorb water from the environment and develop problems with drug stability and capsule shell can become tacky.
It is unsuitable for use with liquid formulations.
The mechanism involved for production of hard gelatin capsule shell are
The Capsule shell contains :
Dry Gelatin (Type A or B)
Plasticizer – Glycerine
Solvent – Demineralised water
Preparation of the gelatin solution (dipping solution): A concentrated solution of gelatin (35- 40%) is prepared by dissolving the gelatin in demineralized water which has been heated to 60– 70°C in jacketed pressure vessels. This is stirred until the gelatin has dissolved and vacuum is applied to removed entrapped air bubbles. At this stage, other processing aids may be added like plasticizer, colourant, opaquing agent etc. The viscosity of gelatin preparation has to be controlled as it may affect downstream manufacturing process & very importantly thickness of shell. cap Body.
Dipping
Spinning
Drying
Stripping & Trimming
Joining
The mechanism involved for production of hard gelatin capsule shell are
The Capsule shell contains :
Dry Gelatin (Type A or B)
Plasticizer – Glycerine
Solvent – Demineralised water
Preparation of the gelatin solution (dipping solution): A concentrated solution of gelatin (35- 40%) is prepared by dissolving the gelatin in demineralized water which has been heated to 60– 70°C.
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Solid unit dosage forms the drug is enclosed within the water-soluble shell or an envelope either a hard or soft shell. Shell is typically made of gelatin primarily intended for oral delivery and provides a rapid release of contents.
Generally, the shells are formed from gelatin.
Capsules. Their Types, manufacturing and packaging.pdfShakeelIjaz3
Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell, usually formed from gelatin.
The capsule may be considered a container drug delivery system that provides a tasteless and odorless dosage form without need for a secondary coating step, as may be required for tablets. Their availability in a wide variety of colors makes capsules aesthetically pleasing. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue, and bones of animals.
Gelatin capsule shells may be hard or soft, depending on their composition.
Hard Gelatin Capsules
Soft Gelatin Capsules
The shells may be composed of two pieces, a body and a cap, or they may be composed of a single piece. hard-shell capsules are two piece capsules whereas soft shell capsules are one piece capsules.
Hard Gelatin Capsules:
Most capsule products manufactured today are of the hard gelatin type.
The community pharmacist also uses hard gelatin capsules in theextemporaneous compounding. The empty capsule shells are made of gelatin, sugar, and water.
Normally, hard gelatin capsules contain 13% to 16% of moisture. However, if stored in an environment of high humidity, additional moisture is absorbed by the capsules, and they may become distorted and lose their rigid shape. In an environment of extreme dryness, some of the moisture normally present in the gelatin capsules is lost, and the capsules may become brittle and crumble when handled. Therefore, it is desirable to maintain hard gelatin capsules in an environment free from excessive humidity or dryness.
Advantages for HGC:
Hard gelatin capsules often have been assumed to have better bioavailability than tablets.
Hard shell capsules allow a degree of flexibility of formulation not obtainable with tablets.
Modern capsule filling equipment makes possible the multiple filling of diverse systems such as beads, granules, small tablets and powders.
Hard gelatin capsules are ideally suited for clinical trials and are widely used in preliminary drug studies. For comparative bioequivalence studies tablets can even be hidden in capsules to ensure the test being blinded.
Disadvantages of HGC:
The number of suppliers of shells is limited.
Filling equipment is slower than tableting.
Generally, hard gelatin capsule products tend to be more costly.
Highly soluble salts (e.g., iodides, bromides, and chlorides) generally should not be dispensed in hard gelatin capsules. Their rapid release may cause gastric irritation owing to the formation of a high drug concentration in localized areas.
Manufcaturing of HGC:
Hard gelatin capsule shells are manufactured in two sections, the capsule body and a shorter cap. The two parts overlap when joined, with the cap fitting snugly over the open end of the capsule body. Some capsule shells are designed to lock in place when closed. Hard gelatin shells are manufactured by a process in which stainless steel mold pins are
THE ROLE OF PHARMACOGNOSY IN TRADITIONAL SYSTEM OF MEDICINEDrugs of natural origin continue to be important for the treatment of many diseases worldwide.
Pharmacognosy a long-established pharmaceutical science, has played a diverse role in the discovery characterisation production and standardisation of these drugs.
herbal drugs play an important role as allopathic system drugs and also drugs of the traditional system of medicine
AYURVEDA- INDIAN SYSTEM OF MEDICINE
CHINESE MEDICINE
UNANI SYSTEM OF MEDICINE
SIDDHA SYSTEM OF MEDICINE
HOMEOPATHY
AYURVEDA- INDIAN SYSTEM OF MEDICINE
CHINESE MEDICINE
UNANI SYSTEM OF MEDICINE
SIDDHA SYSTEM OF MEDICINE
HOMEOPATHY
AYURVEDA- INDIAN SYSTEM OF MEDICINE
CHINESE MEDICINE
UNANI SYSTEM OF MEDICINE
SIDDHA SYSTEM OF MEDICINE
HOMEOPATHY
Ayurvedic medicine Ayurveda for short is one of the world's oldest holistic whole-body healing systems.
It was developed more than 3000 years ago in India.
It's based on the belief that health and wellness depend on a delicate balance between the mind body and spirit.
Its main goal is to promote good health not fight disease But treatments may be geared toward specific health problems.
The different dosage forms available under Ayurveda system are followingLIQUID DOSAGE FORMS
SOLID DOSAGE FORMS.
SEMI- SOLID DOSAGE
Ayurveda believe every person is made of five basic elements found in the universe space, air, fire, water, and earth.
These combine in the human body to form three life forces or energies, called doshas.
They control how your body works.
They are Vata dosha (space and air)
Pitta dosha (fire and water)
Kapha dosha (water and earth).
Vata DoshaThose who practice Ayurveda believe this is the most powerful of all three doshas.
It controls very basic body functions like how cells divide.
It also controls your mind, breathing, blood flow, heart function and ability to get rid of waste through your intestines.
If vata dosha is your main life force, you're thought to be more likely to develop conditions like anxiety, asthma, heart disease, skin problems, and rheumatoid arthritis.
Pitta DoshaThis energy controls your digestion, metabolism (how well you break down foods), and certain hormones that are linked to your appetite.
Things that can disrupt it are eating sour or spicy foods and spending too much time in the sun.
If it's your main life force, you're thought to be more likely to have disease, heart disease, high blood pressure, and infections.
Kapha DoshaThis life force controls muscle growth, body strength and stability, weight, and your immune system.
You can disrupt it by sleeping during the day, eating too many sweet foods, and eating or drinking things that contain too much salt or water.
If it's your main life energy, practitioners believe you may develop asthma and other breathing disorders, cancer, diabetes, nausea after eating, and obesity.
Ayurvedic TreatmentAn Ayurvedic practitioner will create a treatment plan specifically designed for you.
He'll take
FLAVONOIDSFLAVONOIDSClass of plant secondary metabolites
Word Flavonoids derived from the Latin word Flavus= yellow
Group of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable
Structure of flavonoids The flavonoids are possessing 15 carbon atoms and two benzene rings joined by a linear three-carbon chain the skeleton can be represented as the C6 - C3 - C6 system.
The three-carbon (-C3-) may be included through an oxygen bond between the two phenyl rings into
1- A five-membered heterocyclic ring (furan) as in aurones.
2- A six-membered heterocyclic ring (pyran) to give flavonoids which constitute the largest group. The flavonoid aglycone consists of a benzene ring (A) condensed with a six-membered ring (C) pyran ring, which at 2nd position adds a phenyl ring (B) as a substituent. C6-C3-C6 structure.
Crystalline solids sharp MP.
Solubility in H2O & alcohol (Flavonoid glycoside)
Non-glycosidic flavonoid: Aglycon part-sol in organic solvents
3. Color: Flavonones Flavanol Isoflavones- Colorless
Flavonols Flavones Yellow Chalchones aurones Orange
Anthocyanidine acid Red
In basic: Blue
4. Flavanols: optically active
15 C skeleton 2 benzene linked by heterocyclic pyran ring
Being phenolic dissolves in alkalies → Yellow sol +HCl → colorless
Glycosidic linkage located at 3 or 7 C
Flavanones, Flaonoes are unstable compounds on oxidation → Chalcones, leucocyanidines
Flavonoid + FeCl3→ green/ purple/ red-brown color
CLASSIFICATION OF FLAVONOIDSDepending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring.
B ring is linked in position 3 of the ring C are called isoavones
B ring is linked in position 4, neoavonoids.
The B ring is linked in position 2 and further subdivided on the basis of the structural features of the C ring.
These subgroups are avones, avonols, avanones, avanonols, avanols or catechins and anthocyanins.
Finally avonoids with open C rings are called chalcones.
Flavones (2-phenylchromen-4-one)
Have a double bond between positions 2 and 3 and a ketone in position 4 of the C ring. ex:- Apigenin, Luteolin
2. Flavonols (3-hydroxy-2-phenylchromen-4-one)
Have a hydroxyl group in position 3 of the C ring, which may also be glycosylated. Ex: Kaempferol, Rutin, Myricetin, Quercetin.
. Flavanones/ dihydroavones (2,3-dihydro-2-phenylchromen-4- one
Have C ring saturated; the double bond between positions 2 and 3 is saturated, ex: Hesperetin, Hespereidin, Naringenin
Subclassified: furanoavanones, prenylated avanones, pyranoavanones or benzylated avanones
4. Flavanonols (dihydroavonols)/ 3-hydroxy-2,3-dihydro-2-phenyl chromen-4-one
Are 3-hydroxy derivatives of avanones; ex:Taxifolin, Silymarin
1. Shinoda test to dry powder or extract add 5 ml95% ethanol few drops of conc HCI and 0.5 g magnesium turnings Pink colour observed.
2. To a small quantity of residue add lead acetate solution. The yellow-coloured precipitate is formed. The addition of an
Volatile Oils
The odorous volatile principles of plant and animal sources are known as volatile oils.
They evaporate when exposed to air at ordinary room temperature so also called as ethereal oils.
They represent the essence or active constituents of plant so called as essential oils.
Properties
1. Soluble in alcohol, ether, and lipid solvents and insoluble in water.
2. Generally lighter than water.
3. They have characteristic odour and high refractive index
4. Optically active compounds.
5. They are secreted in special structures such as ducts, cells, trichomes and Lysigenous glands.
6. Commonly found in dicot plant families such as Umbelliferae, Labiatae, Zingiberaceae etc and present in entire plant or any part of plant.
Types of volatile oils- On the basis of chemical nature
1. Aldehyde volatile oil- Cinnamon, Lemon peel
2. Alcohol V. O.- Cardamom, Coriander
3. Ester VO- Mustard
4. Hydrocarbon VO- Turpentine
5. Ketone VO- Camphor, Musk
6. Phenolic VO- Clove
Chemical tests.A thin section of drug treated with alcoholic solution of Sudan-III- gives red colour.
2. A thin section of drug treated with a drop of tincture alkane- gives red colour.
Introduction: Number of medicinal plants containing organic constituents in conjugation with a sugar moiety
It can be l or 2 such compounds are called as glycosides.
They exert therapeutically significant effects on humans and animals Traditionally used in modern medicine because of their cardiotonic, purgative, analgesic, anti-arrhythmic, and demulcent action.
Definition:-Glycosides are defined as organic compounds from plants and animal sources which on enzymatic hydrolysis give one or more sugar moieties along with a non-sugar moiety.
Sugar moiety is called glycon and non-sugar moiety is called a-glycon.
Classification Of GLYCOSIDES
BASED ON THE CHEMICAL NATURE OF NON-SUGAR MOIETY
BASED ON THE NATURE OF SUGAR MOIETY
BASED ON LINKAGE BETWEEN GLYCON AND AGLYCON PORTION.
BASED ON THE THERAPEUTIC NATURE OF GLYCOSIDE
BASED ON THE CHEMICAL NATURE OF NON SUGAR MOIETY
a) Anthraquinone glycoside anthraquinone moiety as aglycon. Ex: senna
b) Sterol or cardiac glycoside: aglycon portion is a steroid molecule. Ex: digitalis molecule
e) Saponine glycoside
e) Isothiocynate glycoside Ex: black mustard.
d) Cyanogentic glycoside Ex: white cherry bark
f) Flavonoid glycoside Ex: Ruta graveolens, citrus bio
g) Coumarin glycoside or Furano coumarine glycoside:- Ex: celery fruit cost
h) Aldehyde glycoside Ex: vanilla pods
i) Phenol glycoside Ex salcive
J) Steroidal glycoside
k) Glucosidal bitter or miscellaneous glycoside Ex salix species
Glucoside: sugar portion is glucose
Rhamnoside: sugar portion is rhamnose
Pentoside sugar portion is pentose
Fructoside sugar portion is fructose
Arabinoside sugar portion is arabinose
O-glycosides: Sugar molecule is combined with phenol or –OH group of aglycon, for example, higher plants: senna, rhubarb, Amygdaline, Salicin, cardiac glycosides, anthraquinone glycosides like sennosides etc.
Glycone –O H+HO − aglycone → Glycone −O− Aglycone + H2O
2. N-glycosides: Sugar molecule is combined with N of the –NH (amino group) of aglycon, for example, nucleosides
Glycone –OH+H N − aglycone → Glycone− N − Aglycone + H2O
3. S-glycosides: Sugar molecule is combined with the S or SH (thiol group) of aglycon, Isothiocyanate glycosides: for example, Sinigrin from black mustard
Glycone –OH+H S − aglycone → Glycone− S − Aglycone + H2O
4. C-glycosides: Sugar molecule is directly attached to the C—atom of aglycon, for example, Anthraquinone glycosides like Aloin, Barbaloin, Cascaroside and Flavone glycosides, etc. Cochineal colouring matter- carminic acid
Glycone –OH+H C − aglycone → Glycone− C − Aglycone + H2O
Chemical Tests for Anthraquinone Glycosides.
a) Borntrager’s test.
b) Modified Borntrager’s test.
Chemical Tests for Saponin Glycosides
a) Haemolysis test.
b) Foam test
Chemical Tests for Steroid & Triterpenoid Glycoside .
a) Liebermann Burchard test
b) Salkowaski test
c) Antimony trichloride test
d) Zimmermann test
Chemical Tests For Cardiac Glycoside
a) Keller-kiliani test
b) Legal test
c) Baljet test
ALKALOIDS
Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms.
This group also includes some related compounds with neutral and even weakly acidic properties.
Alkaloids are derived from plant sources they are basic they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action.
Function of alkaloids
they may function as stimulants or regulators in activities like growth, metabolism and reproduction.
They may act as reservoirs for protein synthesis
Properties of alkaloids
Alkaloids are colourless, crystalline, non-volatile, solids, a few such as coniine and nicotine are liquids and a few even coloured, viz. berberine is yellow.
the alkaloids are bitter in taste and have pronounced physiological activity
Classification of alkaloids
a. Taxonomic classification- On the basis of taxonomic profile of the drug. For ex. Solanaceous alkaloids.
b. Biogenetic classification- On the basis of amino acid precursor. For ex. Phenylalanine, Tyrosine alkaloids
c. Pharmacological classification- On the basis therapeutic activity of the alkaloid For ex. Morphine as analgesic, Quinine as antimalarial.
d. Chemical classification- On the basis of basic chemical structure of alkaloid. It is of further three types-
1. True alkaloid- The alkaloids which have all basic properties of alkaloids, derived from amino acid and contain Nitrogen in heterocyclic ring. Ex. Atropine, Morphine.
2. Proto alkaloid- The alkaloid in which nitrogen atom is not present in the ring, but it is present outside the ring I form of amino group, so also called amino alkaloids or biological amines. Ex. Ephedrine.
3. Pseudo alkaloids- Actually these are not alkaloids. These are not derived from amino acid and not give basic identification tests of alkaloids. These are Steroidal (Solanine), Terpenoidal (Diterpene alkaloid) and Purine alkaloid (Caffeine).
chemical classification of alkaloids
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
1. Mr Nandakishor B Deshmukh
Assistant Professor
Department of Pharmaceutics
Shraddha institute of Pharmacy, kondala zambre, washim
CAPSULES
7/8/2023
PROF N.B.DESHMUKH
1
2. CAPSULES
Introduction
Capsules are solid dosage forms in which one or more medicinal and inert
ingredients are enclosed in a small shell or container (usually of gelatin).
They are of various shapes and sizes and contain a single dose of one or more
active ingredients.
They are intended for oral administration. Capsules are also defined as
“gelatin or methylcellulose shell designed to hold solids and liquids for oral
administration
7/8/2023
PROF N.B.DESHMUKH
2
3. *There are two types of capsules, i.e., hard and soft. The hard capsule
is also called two piece as it consists of two pieces in the form of small
cylinders closed at one end.
The shorter piece is called the cap which fits over the open end o f
the longer piece, called the body.
Hard capsules are intended to contain solids . The soft gel atin
capsule is also called as one piece and is intended to hold liquids.
Capsules are available in many sizes to provide dosing flexibility.
Unpleasant drug tastes and odours can be masked by the tasteless
gelatin shell.
Capsules are solid preparations with hard and soft shells of various
shapes and capacities, usually containing a single dose of active
ingredients.
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4. Types of Capsules
Hard Gelatin Capsules
A base containing plasticiser and water is utilised to
manufacture hard capsules. Preservatives, colours, flavours,
and s ugars may also be present in the base.
Soft Gelatin Capsules
A liquid gelatin is utilised to manufacture soft capsules or
liquid gel caps. The liquid gelatin is later hardened in a humid
environment. Generally, these capsules are a continuous piece
of gelatin.
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5. Advantages
The advantages of capsules are:
They are tasteless, odourless, and can be easily administered.
They are attractive in appearance.
The drugs having unpleasant odour and taste are enclosed in a
tasteless shell.
They can be filled quickly and conveniently, therefore, the
physician can change the dose and combination of drugs to suit
the individual patient (this is an advantage over tablets).
The solubility of gelatin at gastric pH provides rapid release of in
the stomach.
They are economical.
They are easy to handle and carry.
They require minimum excipients.
Little pressure is required to compact the material.
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6. Disadvantages
The disadvantages of capsules are:
The hygroscopic drugs are not suitable for filling into capsules as
they will absorb the water present in capsule shell, rendering the
shell very brittle and ultimately leading it to crumble into pieces.
The concentrated solutions which require previous dilution are
unsuitable for capsules because if administered as such it will
lead to stomach irritation.
The capsules are not suitable for highly soluble substances like
potassium chloride, potassium bromide, ammonium chloride, etc.
They are also not suitable for highly efflorescent or deliquescent
materials.
They demand special storage conditions.
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7. HARD GELATIN CAPSULES
Introduction
Hard capsules have a rigid shell in two separate pieces fitted together,
hence are also called two-piece capsules .
There was a time when two -piece capsules could be filled only with dry
powders; but over the time, the manufacturers began filling capsules
with pellets, granules, pastes, and liquids.
Since hard capsules can be filled with substances in a variety of forms,
they are believed to be more versatile than soft gels.
The material types which can be filled into hard gelatin capsules are:
1)Dry Solids: Powders, pellets, granules, or tablets.
2)Semi-Solids: Suspensions or pastes.
3)Liquids: Non-aqueous liquids.
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8. Size of Capsules
Hard gelatin capsules are available in various sizes,
designated by numbers from 000 to 5. Relative sizes
of hard gelatin capsules are shown in the table.
The exact capacity of any capsule varies according to
the density and compressibility of the formulation.
Relative amounts of water, aspirin, and sodium
bicarbonate which can be filled in capsules of
different sizes are compared in
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10. For small scale preparation, manual filling
machines are available in the capacities of
24, 36, 96, 100, and 144 capsules, e.g.,
hand-operated capsule filling machine.
The sizes of hard gelatin capsules intended
for human consumption are shown in
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12. Gelatin: Gelatin is a heterogenous
product derived by irreversible hydrolytic
extraction of treated animal collagen.
Properties of gelatin depend on:
*Parent collagen,
*Method of extraction,
*pH value,
*Thermal degradation,
*Electrolyte content
Sources of Gelatin:
*Animal bones,
*Frozen pork skin,
*Hide portion
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13. .
.
Types of Gelatin:
Type A: It is derived from acid treated precursor. This type of gelatin possesses
an isoelectric point in region of pH 9.0.
Type B: it is derived from an alkali treated precursor of bones. This type of
gelatin possesses an isoelectric point in the region of pH 4.7.
Plasticizers: It increases the plasticity of the film. E.g. glycerine, sorbitol,
propylene glycol
Colouring Agents: These are used to impart colour to body and cap. E.g.
water soluble dyes, certified lakes and vegetable colours. They are used either
alone or in combination.
Opacifying agents: These are used to give opacity to the gelatin film. E.g.
Titanium dioxide.
Flavouring agents: These are used in a concentration not more than 2%. E.g.
ethyl vanillin, essential oils.
Sweetining agents: E.g. Sugar not more than 5%.
Preservatives: E.g. methyl paraben, potassium bisulphite.
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14. Formulation of Capsule Content
Glidants: e.g. talc, magnesium stearate, colloidal silica.
Fillers (diluents): e.g. lactose, starch, dicalcium
phosphate.
Disintegrants: e.g. crosspovidone, crosscarmalose
sodium.
Surfactants: e.g. sodium lauryl sulphate, sodium
socusta.
Hydrophilic agents: e.g. methyl cellulose, hydroxyl
ethyl cellulose
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15. Manufacturing of Hard Gelatin Capsule
Shell
*Dipping:
*Rotation
*Drying:
*Stripping
*Trimming
*Joining:
*Sorting:
*Printing:
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16. Filling of Hard Gelatin Capsules
Rectification: The empty capsules are oriented so that all point to the same
direction, that is, body end downward. In general, the capsules pass one at a time
through a channel just wide enough to provide a frictional grip at the cap end.
Separation of caps from bodies: This process also depends on the difference in
diameters between cap and body portions.
Dosing of fill material: Various methods are employed, which are described
below.
Filling (dosing of material) can be done by:
Auger fill principle (Gravitational forces)
Vibratory fill principle (Overfill/Scrape-off excess)
Piston tamp principle (Pressured measured):
Again there are two types of fillers:
Dosator machine, and
Dosing disc machine.
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17. Replacement of caps and ejection of filled
capsules: The cap and body bushing portions
are rejoined. Pins are used to push the filled
bodies up into the caps for closure, and to
push the closed capsules out of the bushings.
Compressed air also may be used to eject the
capsules
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18. Hand-Operated, Semi-Automatic, and Automatic
Equipments
The machines for capsule manufacturing may be hand
-operated, semi -automatic, or automatic. The various
machines used in manufacturing of hard gelatin
capsules are
Hand-Operated Capsule Filling Equipment: It
consists of (figure 4.5):
A bed having 200-300 holes,
A loading tray having 200-300 holes,
A powder tray,
A pin plate having 200-300 pins,
A sealing plate having a rubber top,
A lever, and
A cam handle.
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20. The operating steps are:
*The empty capsules are filled in the loading tray and placed over the bed.
*The cam handle is operated to separate the capsule caps from their bodies.
* The powder tray is placed in a proper position and filled with an accurate
quantity of powder with scraper.
* The excess of powder is collected on the platform of the powder tray.
* The pin plate is lowered and the filled powder is pressed by moving the pin
downwards.
* After pressing, the pin plate is raised and the remaining powder is filled into
the capsule bodies.
* The plate with the rubber top is lowered and the lever is operated to lock the
caps and bodies.
* The loading tray is then removed and the filled capsules are collected.
* With a 200 hole machine, about 5000 capsules can be filled in one hour,
whereas, in a machine having about 300 holes, about 7500 capsules can be
filled in one hour.
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21. Semi-Automatic Capsule Filling
Equipment:
*The capsules are transferred to the perforated capsule filling ring which is
rotated on a turntable.
*While rotating the ring is subjected to vacuum which pulls the bodies into
the lower half of the ring, leaving the caps in the upper half.
*The upper and lower halves of the capsule filling ring are separated
manually.
*This hopper contains a drill mechanism which is utilised to feed the
powder into the capsule bodies.
*The capsule cap is detached and the empty capsule body is held between
the thumb and forefinger and frequently pressed downward until it is fully
filled.
*The cap is th en replaced and the filled capsule is weighed using an empty
capsule of the same size as a tare.
*After the filling of capsule bodies, the cap and body rings are joined
together.
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23. Automatic Capsule Filling
Equipment
Machines developed for industrial use
automatically separate the caps from empty
capsules, fill the bodies, scrape off the excess
powder, replace the caps, seal the capsules as
desired, and clean the outside of the filled capsules
at up to 1,65,000 capsules per hour
The automatic capsule filling process normally
involves four simple steps:
Removal of caps,
Filling of the bodies,
Replacement of caps, and
Ejection of filled capsules
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24. (lubricant)
Ingredient A Ingredient B Ingredient C Ingredient D
Ingredient E
Packaging
Figure 4.7: Filling of Capsule by Automated Method
Milling/sieving
Empty
capsule
Powder
blend
Blending
Capsule check-
weighing
system
Finished
capsules
Capsule
cleaner/
de-
duster
Capsule
inspection
screen
Rejects
Capsule filler
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25. Special Techniques of Formulation of Hard
Gelatin Capsules
Imprinting on capsule s provides info rmation about the
company and enables product identification.
Special purpose capsules are given a special treatment to
decrease the ir solubility. This may cause delayed absorption of
the active ingredient , facilitating enteric properties.
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26. Manufacturing Defects
Deliquescent or Hygroscopic Powde rs: A gelatin capsule
contains water which is extracted or taken up by a hygroscopic
drug. This renders the capsule brittle, which leads to its cracking.
Addition of an absorbent (like magnesium carbonate, heavy or
light magnesium oxide ) overcomes this dif ficulty, provided the
capsules are packed in tightly closed glass capsule vials
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27. Eutectic Mixtures: Certain substances when mixed
together tend to liquefy or form a pasty mass due to the
formation of a mixture having a melting point lower than
the room temperature.
Addition of Inert Powders : When quantity of the drug to
be filled in capsules is very small, an inert substance or a
diluent is added to increase th e powder bulk, thus,
facilitating easy filling of capsules.
Use of Two Capsules : Some manufacturers separate
incompatible ingredients of the formulation by placing one
of the ingredients in smaller capsule, and then placing this
smaller capsule in a largercapsule containing the other
ingredients of the formulation
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28. *Filling of Granular Powder : Powders lacking adhesiveness and
most of the granular powders are difficult to fill in the capsules by
punch method. This is because they are not compressible and flow out
of the capsule as soon as they are lifted from the powder pile into which
they are punched. To overcome this difficulty
the non-adhesive powders should be moistened with alcohol and
the granular powders should be reduced to powder before filling into
capsules.
*Improper Flow of the Powder Mixture during the Filling
Operation: Addition of suitable quantities of glidants or lubricants is
helpful in improving the flow properties of the powder mixture.
*Segregation and Homogeneity: Generally, semi -automatic or
automatic machines performing capsule filling operation may face this
error. The segregation and inhomogeneity of the particles may occur as
a result of vibrations generated by these heavy-duty machines.
Utilisation of powder having
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29. Manufacturing Defects
Incompatibility: This defect may occur as a result of incompatibility among formulation
ingredients, formulation components, and the capsule shell. A thorough understanding of physical
and chemical properties of each ingredient is needed to prevent such defects. The excipients
generally used in the fillingof hard gelatin capsules are:
Diluents: Lactose, corn starch, and microcrystalline cellulose are the diluents used to
increase the powder bulk and thus to facilitate its easy and accurate handling during filling
operations.
Disintegrants: Corn starch, microcrystalline cellulose, sodium starch glycolate, and
croscarmellose are the disintegrants used for breaking down the powder bulk exposed to a
liquid medium.
Glidants: Colloidal silicon and talc are the glidants used to improve the powder flow by
reducing the inter-particle attraction and preventing agglomeration.
Lubricants: Magnesium and other metallic stearates are the lubricants used to minimise the
contact between powder particles and components of the filling machine.
Surfactants: Sodium lauryl sulphate is employed into the powder mixture to reduce the surface
tension and promote powder wetting with the discharge medium containing greater quantities of
hydrophobic constituents
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30. In-Process and Final Product Quality
Control Tests
1) Appearance, 2) Size and shape,
3) Unique identification markings, 4) Assay,
5) Content of active ingredients, 6) Content uniformity test,
7) Uniformity of mass, 8) Mass variation test,
9) Disintegration test, 10) Dissolution test, and
11) Moisture permeation test.
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