liquid dosage form

1. CLASS- B-PHARM- I SEM I
SUBJECT - PHARMACEUTICS- I
TOPIC NAME : LIQUID DOSAGE FORM
MR NANDAKISHOR B DESHMUKH
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACEUTICS
SHRADDHA INSTITUTE OF PHARMACY, KONDALA ZAMBRE, WASHIM

2. The use of liquid pharmaceuticals has been justified on the basis of ease of administration and rapid and efficient
absorption of drug

3. ADVANTAGE
• It is easier to swallow, therefore easier for children and old age people.
• Facilitate absorption of drug faster than solid dosage form as drug is already in solution
form.
• It is homogenous therefore give uniform dose than suspension or emulsion which need
shaking.
• Simple and fast to formulate
• It can be administered by various routes :
Oral, Parenteral (injection),enema for rectal use, otic(ear), nasal and ophthalmic
preparation.

4. DISADVANTAGE
• They are bulky, so difficult to transport and store.
• Water is commonly use vehicle, which is prone to microbial growth. So
addition of preservative is needed.
• When expose to direct sunlight it may undergo hydrolysis, so need to store in
cool and dark place.
• Drug stability reduce by hydrolysis or oxidation. So, they have shorter expire
date than solid dosage form.
• Other major sign of drug instability are color change, Precipitation, microbial
growth etc.

5. Excipients used Formulations of Liquid Dosage Forms
1.Viscosity controlling agents
2.Antioxidants
3.Flavours
4.Preservative
5.Chemical Stabilizer
6.Colouring agent
7.Vehicle:

6. Solubility is defined as amount of solute that can be dispersed molecularly in the given amount
of solvent under standard conditions of temperature, pressure and pH.
Terms Expression of solubility
Part by volume of solvent required to
dissolve 1 part by weight of solute
Very soluble Less than 1
Freely soluble From 1 to 10
Soluble From 10 to 30
Sparingly soluble From 30 to 100
Slightly soluble From 100 to 1000
Very slightly soluble From 1000 to 10,000

7. 1.pH Adjustments
2.Cosolvency
3.Complexation
4.Surface active agent
5.Solid Solutions