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Analytical and post analytical errors in laboratory
Analytical and post-analytical errors can occur in clinical chemistry laboratories. Analytical errors include issues like test systems not being calibrated properly, controls being out of range but results still reported, improper measurements or reagents, and instrument maintenance issues. This can lead to inaccuracies, imprecisions, insensitivities, and linearity problems. Post-analytical errors involve things like transcription mistakes in reporting results, reports going to the wrong location, illegible reports, or reports not being sent at all. Laboratories should develop systematic workflows, continuously monitor for errors, and strengthen defenses to minimize vulnerabilities and their impacts, which can include inadequate patient care, misdiagnosis, harm, or even death.
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Analytical and post analytical errors in laboratory
- 1. ANALYTICAL AND POST-ANALYTICAL ERRORIN CLINICAL CHEMISTRY LABORATORY Hanisha Erica P. Villaester, RMT
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- 3. Analytical Errors • TestSystem Not Calibrated • Results reported when control results out of range • Improper measurements of specimens and/or reagents • Reagents prepared incorrectly • Reagents stored inappropriately or used after expiration date • Instrument maintenance not dance • Dilution and pipetting errors
- 4. Analytical Errors • Inaccuracy •Imprecision Errors • Insensitivity • Linearity Issues
- 5. Analytical Errors • Inaccuracy •Invalidates reference ranges and cut-off points • May lead to inappropriate therapy or failure to treat • May lead to misdiagnosis • May lead to failure to diagnose • Imprecision Issues • Poor reproducibility invalidates patient monitoring using laboratory results
- 6. Analytical Errors • Insensitivity •A change in assay sensitivity leads to issue of detection • Affects robustness of results near the detection limit • Linearity Issues • A clear understanding of the linearity of a method is essential to ensure that grossly inaccurate results are not reported where there are high concentrations or activities of analytes
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- 8. Post-Analytical Error • Transcriptionerrors in reporting • Report sent to the wrong location • Report illegible • Report not sent
- 9. Summary • Pre-Analytical Errors •46 – 68.2% • Insufficient sample • Sample condition • Sample handling • Incorrect Identification • Incorrect sample • Analytical Error • 7 – 13.3 % • Equipment Malfunction • Sample Mix up • Interference • Post-Analytical • 18.5 – 47 % • Reporting and Interpreting • Improper date entrye
- 10. Impact of Errors •Inadequate or improper patient care • Inconvenience to patient • Misdiagnosis • Harm to patient • Death
- 11. WHAT SHOULD WEDO? • Develop systematic workflow • Identify critical processes • Continuous monitoring • Predict accidental events so preparation may be ahead • Strengthen defences and decrease vulnerability
- 12. References • Odell, M.(Feb 2014). CSE Senior Design 1. Retrieved from https://www.google.com.ph/url?sa=t&rct=j&q=&esrc=s&source=web&cd=35&cad =rja&uact=8&ved=0CDUQFjAEOB5qFQoTCNL0jbC99MYCFYUmlAodnY8CvQ&url=ht tp%3A%2F%2Franger.uta.edu%2F~odell%2FCSE_4316_Senior_Design_I%2FCSE%25 204316%2520Classic%2520Mistakes.ppt&ei=946yVZKdLIXN0ASdn4roCw&usg=AFQ jCNFgWECvcwF_hLS-nwPKhoXuOs0cAA&bvm=bv.98476267,bs.1,d.c2E
Editor's Notes
- #3 Analytical errors rates has decreased significantly as a result of standardization, automation and technological advancement thus improving the analytical reliability of Laboratory tests. Possible causes of analytical errors includes: incorrect measuring of the sample or reagents; usually these are dilution or pipetting errors; using reagents that have been improperly stored, or after their expiration date.