This document discusses bacterial pathogenesis and infection. It covers several key topics:
1) Normal flora are microorganisms that normally live in or on the human body without causing disease. Opportunistic pathogens are normal flora that can cause disease under certain conditions if the host's immunity is compromised.
2) Bacterial infection is determined by factors of both the bacterium and host. The number and virulence of bacteria as well as the host's innate and acquired immunity impact whether infection occurs.
3) Bacterial pathogenicity is influenced by virulence factors like toxins, invasiveness, and the portal of entry. Virulence refers to an organism's ability to cause disease and is determined by its inv
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
Haemophilus is the name of a group of bacteria. There are several types of Haemophilus. They can cause different types of illnesses involving breathing, bones and joints, and the nervous system. One common type, Hib (Haemophilus influenzae type b), causes serious disease. It usually strikes children under 5 years old
Cholera is a serious bacterial disease that usually
causes severe diarrhea and dehydration. The disease is typically spread through contaminated water.
Modern sewage and water treatment have effectively eliminated cholera in most countries. It’s still a problem in countries like Asia, America and Africa. Mostly in India.
Countries affected by war, poverty, and natural disasters have the greatest risk for a cholera outbreak.
Taxonomy:
class : Gamma Proteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: v.cholerae, v.parahaemolyticus,
v. vulnificus, v. alginolyticus
MORPHOLOGY:
Gram negative, actively motile, short, rigid curved bacilli
Resembling letter “V”
about 34 genus
most common in water
1.5µ X 0.2 -0.4 µ in size
polar flagellum , strongly aerobic
Smear – fish in stream appearance
PATHOGENESIS:
Source: Ingestion of contaminated water, food,
fruits and vegetables etc.,
Incubation periods: 1-5 days
Symptoms: Watery diarrhoea, vomiting, thirst, dehydration, muscle cramps
Complications: muscular pain, renal failure, pulmonary edema, cardiac arrhythrnias
DIAGNOSIS:
Specimen: stool sample, water sample(envt)
Microscopy: a) Hanging drop : +ve
b) Gram stain :-ve
Culture: Mac conkey Agar :colourless to light pink
TCBS : yellow colonies
Serology: serological tests are no diagnostic value
TREATMENT:
Adequate replacement of fluids and electrolytes.
Oral tetracycline reduces the period of vibrio excreation.
PREVENTION:
Drink and use bottled water
Frequent washing
Sanitary environment
Defecate in water
Cook food thoroughly
Haemophilus is the name of a group of bacteria. There are several types of Haemophilus. They can cause different types of illnesses involving breathing, bones and joints, and the nervous system. One common type, Hib (Haemophilus influenzae type b), causes serious disease. It usually strikes children under 5 years old
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Introduction
Disease
Important Properties
Transmission & Epidemiology
Risk factor of reactivation
Pathogenesis
Clinical Findings
Laboratory Diagnosis
Approaches to the diagnosis of latent infections
Treatment
Prevention
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
Introduction
Disease
Important Properties
Transmission & Epidemiology
Risk factor of reactivation
Pathogenesis
Clinical Findings
Laboratory Diagnosis
Approaches to the diagnosis of latent infections
Treatment
Prevention
pathogenesis of microbial infections dr. ihsan alsaimarydr.Ihsan alsaimary
prof . dr. ihsan edan alsaimary
department of microbiology - college of medicine - university of basrah - basrah -IRAQ
ihsanalsaimary@gmail.com
00964 7801410838
Microbe-Human Interactions: Infection and DiseaseMELVIN FAILAGAO
Chapter 12 Microbe-Human Interactions: Infection and Disease
subtopics:
1. The progress of an infection
2. Epidemiology: The study of disease in Populations
3. Non specific host defenses
4. Defense mechanisms of the host in perspective
Pathogenesis of microbial infections dr. ihsan alsaimarydr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Host-parasite relationship is determined by the interaction between host factors and the infecting microorganisms. outcome of any microbial infection depends on the interaction between the host and the parasite.
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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7. Section 2 Bacterial infection
bacteriabacteria
Immune status
of the host
inbodyouterbody
细菌细菌
细菌细菌
细菌细菌
bacteriabacteria
bbacteriaacteria
bacteriabacteria
bacteriabacteria
toxins
Causedisease
8. Why do people get infectious diseases?
From the organism’s perspectives
The number of organisms
The virulence of these organisms
From the host’s perspective
Innate immunity
acquired immunity
Antibody-mediated
cell-mediated
9. Pathogenicity of bacteria
Pathogenicity and virulence: refer to an
organism's ability to cause disease.
LD50 (median lethal dose) or ID50 (median
infectious dose): refers to the number of
bacteria or amount of bacterial products, such
as toxins, that cause death or bacterial disease
in 50% of animals in a defined period after the
bacteria are administrated by a designated
route.
10. Pathogenicity of bacteria
pathogenicity ( decide by):
virulence factors of the bacterium
the number of infecting bacteria
route of entry into the body
11. Portals of Entry and the size of the
inoculum
If certain pathogen enter the wrong portal,they will
not be infectious.
Occasionally,an infective agent can enter by more
than one portal.e.g.mycobacterium tuberculosis.
12. Portals of entry
skin
respiratory system
ingestion system
genitourinary system
C. tetani
13. The size of the inoculum
The quantity of microbes in the inoculating dose.
14. The originate and progress of infection
A.The source of the infection
B.routes of pathogen transmission
C.Patterns of infection
15. A.The source of infection
Living reservoirs
Persons or animals with frank symptomatic
infection are obvious sources of infection
Nonliving reservoirs
16. Exogenous infections:
Patients
Carriers: those in whom pathogens are
present and may be multiplying, but who
shows no clinical response to their
presence.
Contaminated animals
Endogenous infections
Sources of infectious diseases
17. Carrier state
Definition of carriers: those in whom pathogens
are present and may be multiplying, but who
shows no clinical response to their presence
Definition of carrier state: a type of infections
causing no signs of symptoms, in which
pathogens multiply and may be transmitted to
other individuals
18. two major types of carrier:
Convalescent carriers: those who recover from
infectious disease and in whom the pathogens remain
and multiply without causing overt symptoms.
Healthy carriers: those who do not have the clinical
symptoms but carry pathogens indeed.
Typhoid Mary (Mary Mallon) 社会恶习的扩散者
19. B. Routes of pathogen
transmission
1.respiratory infections: the tiny particles of
liquid released into the air form aerosols or
droplets
2.wound infectons: in soil and feces of
human and animal
3.intestinal infections: contaminate drinking
water and food or when used to fertilize
crops
20. 4.contact infection:directly contact between
the skin and mucous membranes of the
infected person or animal and that of healthy
person
5.animal bites infections:the majority of
animal vectors are arthropods such as
fleas,mosquitos,flies,and ticks
21. acute infection
chronic infection
C. Patterns of infection
Apparent infection
1.apparent infection
When an infection causes pathological changes
leading to disease,it is often accompanied by a
variety of signs and symptoms
Infectons that come on rapidly,with severe but short-
lived effects,are called acute infections
The infection persists several months to several
years called chronic infection
22. Inapparent infection: also called
subclinical infection that has no
detectable clinical symptoms
24. Generalized infection
Bacteremia
Definition: a transitory disease in which bacteria present in
the blood are usually cleared from the vascular system with
no harmful effects.
Septicemia
Definition: a disease in which the blood serves as a site of
bacterial multiplication as well as a means of transfer of the
infectious agent from one site to another.
25. Toxemia
Definition: the presence of microbial toxins
in the blood
Pyemia
Definition: the presence of pyogenic bacteria
in the blood as they are being spread from
one site to another in the body
30. What is virulence
The ability of any agent of infection to
produce disease. The virulence of a
microorganism (such as a bacterium or virus)
is the measurement of the severity of the
capable of disease.
Invasiveness
Toxin
Virulence
33. 1.1 Material foundation of invasiveness
1.1.1 Adherence factor( 粘附因子 )
Definition of adherence:
The process by which bacteria stick to the
surfaces of host cells. Once bacteria have entered the
body, adherence is a major initial step in the infection
process. It is a general cellular microbiology
phenomenon take place at the early stage of infection.
The terms adherence, adhesion or attachment are
often used interchangeably
37. Microbe Adhesin Receptor
S. Aureus LTA Unknown
S. epidermidis Slime Unknown
Streptococcus, group A LTA-M protein
complex
Fibronectin
S. pneumoniae Surface protein N-acetylhexosamine-gal
E. coli Type 1 fimbriae d-Mannose
Colonization factor
antigen fimbriae
GM1 ganglioside
P fimbriae P blood group glycolipid
Other Enterobacteriaceae Type 1 fimbriae d-Mannose
N. gonorrhoeae Fimbriae GD1
ganglioside
T. pallidum P1
, P2
, P3
Fibronectin
Chlamydia sp. Cell surface lectin N-acetylglucosamine
M. pneumoniae Protein P1 Sialic acid
V. cholerae Type 4 pili Fucose and mannose
Examples of Bacterial Adherence Mechanisms
38. Examples of tissue tropism for bacterial infection
Bacteria TissueTissue
N. meningitidis Nasopharynx epithelium 、、 blood vessel endothelium
N. gonorrhoeae Urethro-epithelium
V. cholerae Enteric epithelium
B. pertussis Respiratory epithelium
H. pylori Gastric mucosa
Group A Streptococcus Nasopharynx epithelium
C. Jejuni Enteric epithelium
M. Pneumoniae Respiratory epithelium
41. 1.3.3 Microcolony( 微菌落 ) and biofilm( 生物膜 )
1.3.3.1 Microcolony
By microcolony we mean a colony of bacteria
visible only under a low power microscope, and its
formation is an event preceding mature of biofilm
formation.
43. Bacterial biofilms are highly interactive, ubiquitous
bacterial ecosystems consisting of individual bacterium
bound to a foreign surface by complex matrix of
extracellular polysaccharides. They can be thought of as
“bacterial communities or cities.” Within these
communities live groups of bacteria constituting multiple
species. Individual bacterium coalesce by linking
extracellular polysaccharides on their cell walls. In nature,
biofilms constitute a protected growth modality that
allows the bacteria to survive in hostile environments.
1.3.3.2 Bacterial biofilms( 生物膜 )
45. The characters of bacterial biofilm
※ There is a circulation system in biofilm, so bacterial
in this community can exchange nutrition and metabolic
product each other
※ Counteract the defense system of the host and toxic
effect of antibiotics
※ Transfer antibiotic resistant gene rapidly.
46. What is virulence
The ability of any agent of infection to
produce disease. The virulence of a
microorganism (such as a bacterium or virus)
is the measurement of the severity of the
capable of disease.
Invasiveness
Toxin
Virulence
48. An exotoxin is a soluble protein excreted by a
microorganism. An exotoxin can cause damage to the
host by destroying cells or disrupting normal cellular
metabolism. most G+
and few G-
bacteria produce
exotoxins. They are highly potent and can cause major
damage to the host. Exotoxins may be secreted, or,
similar to endotoxin, may be released during lysis of
the cell.
ExotoxinExotoxin
51. Thermolabile ( inactivated after treated
with 60 ~ 80 for 30 minutes).℃
Exception : staphylococcal enterotoxin can
resist
the treatment of 100 for 30 minutes℃ ,
and it is also resist the digestion of digestive
enzymes.
53. B subunit
( Binding )
• Determine the tissue
specificity of the toxin
• Powerful antigenicity
• can not be inactivated by
formaldehyde, while it can
be purified for subunit
vaccine.--Toxoid
A subunit
(Toxic)
• Determine the toxic
of the toxin
• weak antigenicity
• can be inactivated
by formaldehyde
A-B toxinsA-B toxins
54. Immunity
• Antitoxin
– An antibody that specifically interacts with and
neutralizes a toxin
– Application: treatment or urgent prevention
measure
• Toxoid
– An exotoxin modified so that it is no longer toxic
but is still able to induce antibody formation
– Application: vaccine
60. Toxin Gene Location
Subunit
Structure
Target Cell
Receptor Biologic Effects
Anthrax
toxins
Bacillus
anthracis
Plasmid Three
separate
proteins
(EF, LF,
PA)
Unknown,
probably
glycoprotein
EF + PA: increase in target cell
cAMP level, localized edema;
LF + PA: death of target cells
and experimental animals
Bordetella
adenylate
cyclase
toxin
Bordetella
sp.
Chromosomal A-B Unknown,
probably
glycolipid
Increase in target cell cAMP
level, modified cell function or
cell death
Botulinum
toxin
Clostridium
botulinum
Phage A-B Possibly
ganglioside
(GD1b
)
Decrease in peripheral,
presynaptic acetylcholine
release, flaccid paralysis
Cholera
toxin
Vibrio
cholerae
Chromosomal A-5B Ganglioside
(GM1
)
Activation of adenylate
cyclase, increase in cAMP
level, secretory diarrhea
Diphtheria
toxin
Corynebacte
rium
diphtheriae
Phage A-B Growth
factor
receptor
precursor
Inhibition of protein synthesis,
cell death
Heat-labile
enterotoxins
Escherichia
coli
Plasmid Similar or identical to
cholera toxin
Properties of A-B Type Bacterial Toxins
61. Pertussis
toxin
Bordetella
pertussis
Chromoso
mal
A-5B Unknown,
probably
glycoprotein
Block of signal transduction
mediated by target G
proteins
Pseudomon
as exotoxin
A
Pseudomon
as
aeruginosa
Chromoso
mal
A-B Unknown, but
different from
diphtheria toxin
Similar or identical to
diphtheria toxin
Shiga toxin Shigella
dysenteriae
Chromoso
mal
A-5B Glycoprotein or
glycolipid
Inhibition of protein
synthesis, cell death
Shigalike
toxins
Shigella sp.,
E. coli
Phage Similar or identical to Shiga
toxin
Tetanus
toxin
Clostridium
tetani
Plasmid A-B Ganglioside (GT1
)
and/or GD1b
Decrease in
neurotransmitter release
from inhibitory neurons,
spastic paralysis
Toxin Organism
Gene
Location
Subunit
Structure
Target Cell
Receptor Biologic Effects
Properties of A-B Type Bacterial Toxins
63. Physical and chemical properties
• LPS Lipopolysaccharide: Lipid A
• Heat -resistance : Resistance
64. Low
poor antigenpoor antigen , no toxoid
Endotoxin effects:Endotoxin effects: no tissue specificity
Fever-pyrogen 1 microgram/ kgFever-pyrogen 1 microgram/ kg
leukocytosisleukocytosis
hypotensionhypotension
Shwartzman phenomenon and disseminatedShwartzman phenomenon and disseminated
intravascular coagulation (DIC).intravascular coagulation (DIC).
Endotoxemia and shockEndotoxemia and shock
Toxicity
65. Lipid A of lipopolysaccharide
is responsible for endotoxin
activity
Pathogenesis of sepsis
(septicemia)
Endotoxin (LPS)-mediated toxicity
66. Fever,
leukopenia followed by leukocytosis,
activation of complement, thrombocytopenia,
disseminated intravasacular coagulation,
decreased peripheral circulation and perfusion to
major organs (multiple organ system failure),
Shock and death.
Peptidoglycan, teichoic and lipoteichoic acids of gram-
positive bacteria stimulate pyrogenic acute phase
responses and produce endotoxin-like toxicity
Back
Endotoxin-mediated toxicity
68. Low, no toxoid
Low, no tissue
specificity
High, antitoxin, toxoid
High, tissue specificity
Immunity
Toxicity
ResistanceHeat-resistance Sensitive
LPSProteincomposition
Secreted from living cells or Released upon
released upon bacterial lysis bacterial lysis
Release
Endotoxin
G -
Exotoxin
G + and G -
Properties
Origin
The difference between exotoxin
and endotoxin